The rise in several deadly diseases like infections by multidrug-resistant bacteria implies re-inventing the wheel on drug discovery. Perhaps, extensive research has been dedicated to identifying alternatives to mitigating the effects of antibiotics resistance. Over the years, plants have contributed significantly to traditional medicine, proven effective in human health care, and were extensively used as alternative antibiotics in certain conditions. Thus, the current studys primary purpose is to determine the phytochemical contents and the antimicrobial activity of T. occidentalison microorganisms, including Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. The result of the phytochemical analysis conducted on the leaf and seed of T. occidentalisrevealed alkaloids, tannin, steroids, flavonoids, phenol, and saponins. However, it was found that tannins and phenol were mainly deposited in the plants seed. Also, the antimicrobial analysis conducted revealed that S. aureus was more vulnerable to the ethanol, acetone, and hot aqueous extracts of T. occidentalis. At the same time, P. aeruginosa and C. Albicans showed sensitivity to ethanol and acetone exposure but failed to react to the hot aqueous extracts. The study concludes that the observed biological reactions shown by the aqueous extracts of T. occidentaliscorroborate the traditional application of this plant as an alternative antibiotic.
Phytochemical Analysis of Nigella sativa L. Utilizing GC-MS Exploring its Antimicrobial Effects against Multidrug-Resistant Bacteria
