Protective Potential of Canthium dicoccum Methanolic Extract Against Hepatic Injury in Rats

ABSTRACTObjective: To investigate the hepatoprotective activity of aqueous methanolic extract of polyherbal formulation and individual extracts of Calotropisprocera, Gymnema sylvestre, and Lawsonia inermis leaves.Methods: The hepatoprotective activity of the formulation and extracts were assessed on the basis of histopathological changes in liver of carbontetrachloride-induced hepatotoxic rats.Results: The result of present studies strongly indicates that the hepatoprotective property of polyherbal formulation as evidenced by less damagedhepatocytes cells.Conclusion: Polyherbal formulation revealed excellent hepatoprotective profile as compared to individual plants due to synergistic effect producedby different phytochemicals present in the formulation.Keywords: Calotropis procera, Gymnema sylvestre, Lawsonia inermis, Carbon tetrachloride.

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Hepatoprotective Potential ofSargassum muticumagainst STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway

Analytical Cellular Pathology ◽

10.1155/2019/7958701 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Mohammed M. Safhi ◽

Mohammad Firoz Alam ◽

Sivagurunathan Moni Sivakumar ◽

Tarique Anwer

Keyword(s):

Glucose Level ◽

Hepatic Injury ◽

Caspase 3 ◽

Methanolic Extract ◽

Caspase 9 ◽

Serum Enzyme ◽

Cytokine Network ◽

Apoptosis Pathway ◽

Group 2 ◽

Enzyme Markers

Liver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus (DM). The methanolic extract ofSargassum muticum(MESM) plays a hepatoprotective role in streptozotocin- (STZ-) induced hepatic injury. In this study, STZ exposure induced diabetes that augmented hepatic damage, which was reflected in serum enzyme markers, the cytokine network, and caspase-3 and caspase-9 levels in Group 2. Exposure to the MESM tremendously modulated the levels of hepatic enzyme markers ALP, ACP, ALT, and AST in Groups 3 and 4. The cytokine network was well regulated by suppressing the release of cytokines, and the levels of caspase-3 and caspase-9 were also reduced in Groups 3 and 4. The present study suggests that MESM treatment at 200 and 500 mg protected the liver and also minimizes the glucose level. Thus, the MESM plays a key role in rejuvenating the liver and can modulate diabetes’s pathogenic effect by reducing the glucose level.

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Hepatoprotective effect on methanolic extracts of Tagetes erecta leaves and Tridax procumbens against drug induced hepatic injury

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v12i2.4701 ◽

2021 ◽

Vol 12 (2) ◽

pp. 1415-1421

Author(s):

Aithamraju Satish Chandra ◽

Shanmugapandiyan P

Keyword(s):

Hepatic Injury ◽

Methanolic Extract ◽

Hepatoprotective Activity ◽

Vehicle Control ◽

Tagetes Erecta ◽

Drug Induced ◽

Methanolic Extracts ◽

Tridax Procumbens ◽

Biochemical Level ◽

Hepatic Markers

The current study was undertaken to evaluate the preclinical efficacy of methanolic extract of Tagetes erecta (METE) and methanolic extract of Tridax procumbens (METP) against Isoniazid and Rifampicin (INH-RIF) induced hepatic injury. Animals were randomly divided into seven groups, vehicle (control) or INH-RIF (50 mg/kg, i.p.), METE (200 and 400mg/kg, p.o.), METP (200 and 400mg/kg, p.o.) and standard silymarin for 28 days. INH-RIF intoxicated rats displayed significant (p<0.05) elevation in serum hepatic markers, lipid peroxidation and decrease in antioxidants like SOD, CAT, Gpx and GSH in liver tissue. Treatment with METE & METP (200 and 400 mg/kg, p.o.) restored the altered biochemical level to normalcy. Thus, the outcome of the study reveals that METE & METP showed promising hepatoprotective activity in INH-RIF induced hepatic damage mediated by its membrane stabilizing and antioxidant effect. All the methanolic plant extracts produce significant hepatoprotective activity against drug induced hepatic injury.

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Site of Lysosome Production During Hepatic Injury

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100063652 ◽

1969 ◽

Vol 27 ◽

pp. 348-349

Author(s):

Nalin J. Unakar

Keyword(s):

Electron Microscopy ◽

Golgi Apparatus ◽

Mouse Liver ◽

Hepatic Injury ◽

Close Approximation ◽

Experimental Conditions ◽

Toxic Injury

The increased number of lysosomes as well as the close approximation of lysosomes to the Golgi apparatus in tissue under variety of experimental conditions is commonly observed. These observations suggest Golgi involvement in lysosomal production. The role of the Golgi apparatus in the production of lysosomes in mouse liver was studied by electron microscopy of liver following toxic injury by CCI4.

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