scholarly journals Do (Ab)Users of Psychedelics Have Tendencies to Abuse High Authority? An Internet Snapshot Study

2017 ◽  
Vol 9 (11) ◽  
pp. 148
Author(s):  
Ahmed Al-Imam ◽  
Ban A. AbdulMajeed
Keyword(s):  
Middle East ◽  
Thematic Analysis ◽  
Social Communication ◽  
Psychiatric Patients ◽  
Medical Professionals ◽  
Demographic Parameters ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substances ◽  
Different Populations ◽  
Developed World

BACKGROUND: Hallucinogenic substances, also known as psychedelics and entheogens, represent a subset of novel psychoactive substances. The epidemiology of (ab)use and electronic commerce of Psychedelics has been well-mapped in the developed world. However, countries from the developing world are yet to be explored. Principles of psychology including thematic psychoanalysis were not implemented before in connection with psychedelics.MATERIALS & METHODS: This study is based on an internet snapshot technique; it will explore and analyse the comments of psychedelics’ (ab)users in relation to the possibility of abuse of some granted power (authority); several demographic parameters of (ab)users will be explored. The snapshot will implement thematic analysis and psychoanalysis of comments found on drug fora and social communication media.RESULTS: The highest contribution of psychedelic users existed in the developed world, while the developing countries including the Middle East contributed the least. More than half (57%) of Psychedelic (ab)users tend to misuse power, which may indicate an existing psychopathology.CONCLUSION: Psychedelic users tend to mishandle the use of authority. The prevalence of psychedelic (ab)users in the Middle East is considered to be minimal. Additional analyses are required and in different populations of students, academics, medical professionals, psychiatric patients, prisoners, terrorists, and military organisations.

scholarly journals The Preferred Terminology Implemented by Psychedelic Users Existing on Online Platforms: A Cross-sectional Analysis

2017 ◽  
Vol 9 (11) ◽  
pp. 140
Author(s):  
Ahmed Al-Imam
Keyword(s):  
Middle East ◽  
Thematic Analysis ◽  
Social Communication ◽  
Psychiatric Patients ◽  
Medical Professionals ◽  
Cross Sectional ◽  
Online Platforms ◽  
Different Populations ◽  
Sectional Analysis ◽  
Developed World

BACKGROUND: The epidemiologic magnitude of the NPS (ab)use has been thoroughly explored and geographically mapped in the developed world. However, there are still untapped geographic locations primarily in the developing countries including the Middle East. Historically, mapping has been done via observational analytics, cross-sectionally and longitudinally, in addition to few experimental studies.MATERIALS & METHODS: The study is cross-sectional; it will implement the internet snapshot technique, in addition to the application of thematic analysis and psychoanalysis of comments of NPS (ab)users on the online drug fora and social communication media. The data collected will be analysed for the purpose of concluding a statistical inference in relation to the terms most preferred by substance (ab)users towards hallucinogenic substances.RESULTS: The population was dominated by right-handed males; most of which were either heterosexual or bisexual. Psychedelics users have a preference for specific terms; psychedelic (73%), entheogen (12%), hallucinogen (11%), spiritual aids (3%), mysticomimetic (1%), psychotomimetic (<1%), medicines (<1%), and trip (<1%). Right-handed users who used the term psychedelic were a majority (53%), while right-handed individuals using the terms entheogen and hallucinogen contributed to 8% for each.CONCLUSION: This study is in line with other studies confirming the minute contribution of the Middle East to the global NPS phenomenon. Additional studies are mandatory for different populations including; students, academics and researchers, medical professionals, psychiatric patients, military and para-military organisations, delinquent and prisoners, and even terrorists.

scholarly journals Knowledge and (Ab)Use in Connection with Novel Psychoactive Substances: A Cross-Sectional Analysis of Iraqi Medical Students

2017 ◽  
Vol 9 (11) ◽  
pp. 61
Author(s):  
Ahmed Al-Imam ◽  
Farah Al-Mukhtar ◽  
Aisha Shafiq ◽  
Manolia Irfan ◽  
Mustafa M Saleh
Keyword(s):  
Medical Students ◽  
Middle East ◽  
Western Europe ◽  
Psychiatric Patients ◽  
Developed Countries ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substances ◽  
Undergraduate Medical Students ◽  
Cross Sectional ◽  
The University

BACKGROUND: The extent of (ab)use of the Novel Psychoactive substances has been thoroughly mapped in the developed world, particularly in the US, Canada, UK, Western Europe, Australia, and New Zealand. However, there are still untapped geographic locations particularly in the developing world including the Middle East.MATERIALS AND METHODS: This study is observational in nature and cross-sectional in design; it is based on a survey that will aim is to estimate the level of knowledge and the extent of (ab)use of psychoactive substances, traditional and novel, in a population of undergraduate medical students from Iraq. There will be an implementation of inferential statistical analyses for the purpose of hypothesis testing. Ethical approvals were granted from the College of Medicine at the University of Baghdad and the University of Hertfordshire.RESULTS: There was some degree of knowledge in connection with psychoactive substances among a population of medical students. However, the extent of (ab)use is still minimal when compared to that of the developed countries. In general, the knowledge and the extent of NPS (ab)use did not vary substantially as the students progressed through the medical college.CONCLUSION: The use of observational analytic tools for assessing the diffusion of the phenomenon of psychoactive and novel psychoactive substances is indispensable. The extent of knowledge and (ab)use of NPS in the Middle East may still be considered minute or insignificant. Further analyses are required in the Middle East; different populations are to be targeted including; students, academics, researchers, medical and paramedical staff, psychiatric patients, prisoners, military and para-military organisations, and even terrorists.

scholarly journals Knowledge and (Ab)Use in Connection with Novel Psychoactive Substances: A Cross-Sectional Analysis of Psychedelic Users Existing on Online Platforms

2017 ◽  
Vol 9 (11) ◽  
pp. 51
Author(s):  
Mohammed-Lutfi Al-Imam ◽  
Ahmed Al-Imam
Keyword(s):  
Religious Affiliation ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substances ◽  
Cross Sectional ◽  
Web Based ◽  
Online Platforms ◽  
Level Of Knowledge ◽  
The Uk ◽  
Sectional Analysis ◽  
Developed World

BACKGROUND: The prevalence of use and misuse of novel psychoactive substances (NPS) has been escalating at an exponential rate in the past two decades. Studies on NPS are highly concentrated in relevance to the developed world, while few have been undertaken in the developing countries.MATERIALS & METHODS: This study is observational and cross-sectional in nature; it relies on a web-based survey distributed to a population of (ab)users of psychedelics and NPS; this community was accessible via dedicated online platforms psychedelics users located on the Facebook social communication medium. The aim of the study is to estimate the level of knowledge and the extent of (mis)use in connection with psychoactive substances, including the novel ones (NPS).RESULTS: The number of participants who responded to the survey reached 458 responders. The level of knowledge and (ab)use was relatively high. The majority of participating individuals were Caucasians males from the developed world including the US, the UK, India, and western European countries. The primary religious affiliation was either agnosticism or atheism. Approximately, 26% were diagnosed with the neuropsychiatric condition.CONCLUSION: The NPS phenomenon is still a major concern primarily in the developed world. Additional studies are required in virtual and non-virtual populations. The targeted populations should include; students, medical professionals, academics, patients with psychiatric and neurological abnormalities, convicts and criminals, and even terrorists.

scholarly journals Novel Psychoactive Substances in Young Adults with and without Psychiatric Comorbidities

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Giovanni Martinotti ◽  
Matteo Lupi ◽  
Tiziano Acciavatti ◽  
Eduardo Cinosi ◽  
Rita Santacroce ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Psychiatric Patients ◽  
Clinical Effects ◽  
Psychiatric Diseases ◽  
Novel Psychoactive Substances ◽  
Young Population ◽  
Psychoactive Substances ◽  
Paired Sample ◽  
Psychiatric Population ◽  
Substances Of Abuse

Objective. Comorbidities between psychiatric diseases and consumption of traditional substances of abuse (alcohol, cannabis, opioids, and cocaine) are common. Nevertheless, there is no data regarding the use of novel psychoactive substances (NPS) in the psychiatric population. The purpose of this multicentre survey is to investigate the consumption of a wide variety of psychoactive substances in a young psychiatric sample and in a paired sample of healthy subjects.Methods. A questionnaire has been administered, in different Italian cities, to 206 psychiatric patients aged 18 to 26 years and to a sample of 2615 healthy subjects matched for sex, gender, and living status.Results. Alcohol consumption was more frequent in the healthy young population compared to age-matched subjects suffering from mental illness (79.5% versus 70.7%;P<0.003). Conversely, cocaine and NPS use was significantly more common in the psychiatric population (cocaine 8.7% versus 4.6%;P=0.002) (NPS 9.8% versus 3%;P<0.001).Conclusions. The use of novel psychoactive substances in a young psychiatric population appears to be a frequent phenomenon, probably still underestimated. Therefore, careful and constant monitoring and accurate evaluations of possible clinical effects related to their use are necessary.

scholarly journals Novel Psychoactive Substances: Systematic Review and Evidence-Based Analysis of Literature

2017 ◽  
Vol 9 (11) ◽  
pp. 1
Author(s):  
Ahmed Al-Imam ◽  
Ban A. AbdulMajeed
Keyword(s):  
Middle East ◽  
Critical Analysis ◽  
Research Output ◽  
Developed Countries ◽  
Research Quality ◽  
Evidence Based ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substances ◽  
Publication Type ◽  
Level Of Evidence

BACKGROUND: The research output within the discipline of novel psychoactive substances (NPS) has been evolving since the end of the last decade. The introduction of the concept of evidence-based Medicine led to a revolutionary growth of all fields of medical research. The enhancements of research quality were also paralleled by the development of tools for critical analysis of literature.MATERIALS & METHODS: The aim of the study is to assess the NPS research output, by means of evaluation of the level-of-evidence and the implemented statistical analyses. An extensive database of near 600 published manuscript was created; the papers were selected from the PubMed/Medline database by using pre-specified keywords. Each manuscript will be systematically scanned for; the first author, research institution, country, year of publication, type of study, statistical analysis, level-of-evidence, and journals of publication. Research efforts from the Middle East were also observed and quantified.RESULTS: Teams of NPS researchers included members in the range of one to twenty-nine, with and an average of 4.75 authors per publication. Research output was densely mapped in the developed countries including the UK (53%), US (19%), Italy (14%), Germany (14%), and Sweden (10%); the Middle East contribution was minimal (<1%). The top two research institutes were; King’s College London (UK) and Sapienza University of Rome (Italy). Studies included; Cross-sectional analyses (15%), Reviews (18%), and Analytic chemistry (36%). A considerable number of publications (34%) had no statistics at all, while only 14% had inferential statistics. Top journals of publication were; Journal of Psychopharmacology, Current Neuropharmacology, and Drug and Alcohol Dependence.CONCLUSION: Research output should always be assessed for quality control purposes. This study represents an innovative and systematic method of critical analysis of NPS literature. Future study efforts should be respondent to this study to achieve a better quality of research.

Prospettiva e Valore della matrice Cheratinica nella valutazione dell'utilizzo di Nuove Sostanze Psicoattive nella popolazione che afferisce ai SERD

MISSION ◽  
2020 ◽  
pp. 39-44
Author(s):  
Concettina Varango ◽  
Francesca Musarella ◽  
Mara Cella ◽  
Antonella Varango
Keyword(s):  
Novel Psychoactive Substances ◽  
Psychoactive Substances

Questo articolo nasce dall'esigenza di informare un pi&ugrave; ampio pubblico sul pericolo rappresentato da queste sostanze, far conoscere le NPS (Novel Psychoactive substances) agli operatori del settore (personale di laboratorio, personale delle unit&agrave; di emergenza/ urgenza, operatori sanitari, ricercatori, ecc.) al fine di agevolare l'analisi di campioni sconosciuti e divulgare i dati scientifici che cominciano ad emergere da studi clinici e preclinici sui loro effetti tossici e farmacologici.&nbsp;Dal 2009 sono comparsi nel gruppo delle N.P.S., i nuovi oppioidi sintetici, molecole estremamente potenti che comportano una seria minaccia per la salute pubblica. Si tratta di prodotti dalla notevole potenza (il fentanyl, per esempio, capostipite di questa famiglia, ha un'azione circa 100 volte maggiore rispetto a quella della morfina) che vengono utilizzati sia per s&eacute; sia come adulteranti di partite di sostanze classiche, soprattutto eroina, causando scie di decessi per overdose.&nbsp;

Responses to External Emotions or their Transitions at Central to Peripheral Nervous System Levels: A Methodological Contribution to Mental Health

2020 ◽  
Vol 16 (2) ◽  
pp. 138-152
Author(s):  
Bingren Zhang ◽  
Chu Wang ◽  
Chanchan Shen ◽  
Wei Wang
Keyword(s):  
Healthy Volunteers ◽  
Psychiatric Patients ◽  
Event Related Potentials ◽  
Emotional Stimuli ◽  
Non Invasive ◽  
Related Potentials ◽  
Different Populations ◽  
Invasive Techniques ◽  
Psychiatric Problems ◽  
Different Levels

Background: Responses to external emotional-stimuli or their transitions might help to elucidate the scientific background and assist the clinical management of psychiatric problems, but pure emotional-materials and their utilization at different levels of neurophysiological processing are few. Objective: We aimed to describe the responses at central and peripheral levels in healthy volunteers and psychiatric patients when facing external emotions and their transitions. Methods: Using pictures and sounds with pure emotions of Disgust, Erotica, Fear, Happiness, Neutral, and Sadness or their transitions as stimuli, we have developed a series of non-invasive techniques, i.e., the event-related potentials, functional magnetic resonance imaging, excitatory and inhibitory brainstem reflexes, and polygraph, to assess different levels of neurophysiological responses in different populations. Results: Sample outcomes on various conditions were specific and distinguishable at cortical to peripheral levels in bipolar I and II disorder patients compared to healthy volunteers. Conclusions: Methodologically, designs with these pure emotions and their transitions are applicable, and results per se are specifically interpretable in patients with emotion-related problems.

scholarly journals Human Neuronal Cell Lines as An In Vitro Toxicological Tool for the Evaluation of Novel Psychoactive Substances

2021 ◽  
Vol 22 (13) ◽  
pp. 6785
Author(s):  
Valeria Sogos ◽  
Paola Caria ◽  
Clara Porcedda ◽  
Rafaela Mostallino ◽  
Franca Piras ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Cell ◽  
In Vitro Study ◽  
Dependent Manner ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substances ◽  
Concentration Dependent Manner ◽  
Mechanisms Of Toxicity ◽  
Neuronal Cell Lines

Novel psychoactive substances (NPS) are synthetic substances belonging to diverse groups, designed to mimic the effects of scheduled drugs, resulting in altered toxicity and potency. Up to now, information available on the pharmacology and toxicology of these new substances is very limited, posing a considerable challenge for prevention and treatment. The present in vitro study investigated the possible mechanisms of toxicity of two emerging NPS (i) 4′-methyl-alpha-pyrrolidinoexanophenone (3,4-MDPHP), a synthetic cathinone, and (ii) 2-chloro-4,5-methylenedioxymethamphetamine (2-Cl-4,5-MDMA), a phenethylamine. In addition, to apply our model to the class of synthetic opioids, we evaluated the toxicity of fentanyl, as a reference compound for this group of frequently abused substances. To this aim, the in vitro toxic effects of these three compounds were evaluated in dopaminergic-differentiated SH-SY5Y cells. Following 24 h of exposure, all compounds induced a loss of viability, and oxidative stress in a concentration-dependent manner. 2-Cl-4,5-MDMA activates apoptotic processes, while 3,4-MDPHP elicits cell death by necrosis. Fentanyl triggers cell death through both mechanisms. Increased expression levels of pro-apoptotic Bax and caspase 3 activity were observed following 2-Cl-4,5-MDMA and fentanyl, but not 3,4-MDPHP exposure, confirming the different modes of cell death.

scholarly journals Emergence of novel psychoactive substances among clients of a needle exchange programme in Budapest

2014 ◽  
Vol 155 (35) ◽  
pp. 1383-1394 ◽  
Author(s):  
József Rácz ◽  
Róbert Csák
Keyword(s):  
Warning System ◽  
Needle Exchange ◽  
Novel Psychoactive Substances ◽  
The Novel ◽  
Sources Of Information ◽  
Psychoactive Substances ◽  
Blue Point ◽  
Use Patterns ◽  
Frequent Use ◽  
Exchange Programme

In this paper the authors summarize experience of a drug service provider with the injecting use of novel psychoactive substances. Among clients of the needle exchange programme of Blue Point Drug Counselling and Outpatient Centre, the authors observed the spread of the novel substances since 2009. The extensive spread of the novel substances caused substantial change in injecting use patterns, thus in the usage of the needle exchange programme. The novel psychoactive substances appeared consecutively, so that this setting gave a unique opportunity to observe and track the emergence of these substances. The authors summarize the characteristics which are important for medical practice (risks, frequent use, severe psychopathological conditions) as well as special risks associated with these substances (substances with unknown composition and effect). They highlight the importance and role of the early warning system, monitoring the online sources of information and testing of samples containing novel psychoactive substances. Orv. Hetil., 2014, 155(35), 1383–1394.

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