scholarly journals Selective Synthesis of Ortho-substituted 3-Cyclohexyl-2-phenyl-1,3-thiazolidin-4-one Sulfoxides and Sulfones by S-Oxidation with Oxone

2015 ◽  
Vol 7 (2) ◽  
pp. 73 ◽  
Author(s):  
Kevin Cannon ◽  
Deepa Gandla ◽  
Samantha Lauro ◽  
Lee Silverberg ◽  
John Tierney ◽  
...  
Keyword(s):  
Biological Activity ◽  
High Temperature ◽  
Aromatic Ring ◽  
Selective Oxidation ◽  
1H Nmr ◽  
Room Temperature ◽  
Selective Synthesis ◽  
Wide Range ◽  
Synthetic Routes ◽  
S Oxidation

1,3-thiazolidin-4-ones, also known as thiazolidin-4-ones, are known to have a very wide range of biological activity. The corresponding S-oxides may show enhanced activity, and therefore viable synthetic routes to these S-oxides are required. S-oxidation of 3-cyclohexyl-2-phenyl-1,3-thiazolidin-4-ones with Oxone® was investigated. For all compounds evaluated, selective oxidation to the sulfoxide was realized using 3 equivalents of Oxone® at room temperature. Alternatively, the sulfone was prepared selectively at high temperature by increasing the equivalents of Oxone® used; the extent of this selectivity was affected by the substituent of the aromatic ring. In those cases in which the reaction produced a mixture of the sulfoxide and sulfone, the ratio of the products was quantified by 1H NMR.

scholarly journals Selective Synthesis of Ortho-Substituted 2-Aryl-3-phenyl-1,3-thiazolidin-4-one Sulfoxides and Sulfones by S-Oxidation with Oxone®

2017 ◽  
Vol 9 (4) ◽  
pp. 87
Author(s):  
Kevin C. Cannon ◽  
Alaa Alkurdi ◽  
Humayra Himel ◽  
Iryna Kurochka ◽  
Sabrina Liu ◽  
...  
Keyword(s):  
High Temperature ◽  
Aromatic Ring ◽  
Selective Oxidation ◽  
Room Temperature ◽  
Selective Synthesis ◽  
S Oxidation

S-oxidation of 2-aryl-3-phenyl-1,3-thiazolidin-4-ones with Oxone® was investigated. For all compounds evaluated, selective oxidation to the sulfoxide was realized using 3 equivalents of Oxone® at room temperature. Attempts to selectively prepare the sulfones of ortho-substituted 2-aryl-3-phenyl-1,3-thiazolidin-4-ones at high temperature by increasing the equivalents of Oxone® used were typically unsuccessful. These results contrast significantly with ortho-substituted 2-aryl-3-cyclohexyl-1,3-thiazolidin-4-ones evaluated previously. The extent of this selectivity was affected by the substituent and its position on the C2 aromatic ring. The ratio of the sulfoxide and sulfone products was quantified by isolating the products by liquid chromatography.Please find the scheme in PDF file.

scholarly journals Selective Synthesis of Substituted 3-Aryl-2-phenyl-1,3-thiazolidin-4-one Sulfoxides and Sulfones by S-Oxidation with Oxone

2017 ◽  
Vol 9 (4) ◽  
pp. 1
Author(s):  
Kevin C. Cannon ◽  
Miguel Costa ◽  
Matthew Pepper ◽  
John Toovy ◽  
Rachel S. Selinsky ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
High Temperature ◽  
Aromatic Ring ◽  
Selective Oxidation ◽  
Room Temperature ◽  
Selective Synthesis ◽  
S Oxidation

S-oxidation of 3-aryl-2-phenyl-1,3-thiazolidin-4-ones with Oxone® was investigated. For all compounds evaluated, selective oxidation to the sulfoxide was realized using 3 equivalents of Oxone® at room temperature. Alternatively, the sulfone was prepared selectively in most of the compounds evaluated at high temperature by increasing the equivalents of Oxone® used; the extent of this selectivity was affected by the substituent and its position on the N3 aromatic ring. The ratio of the sulfoxide and sulfone products was quantified by isolating the products by liquid chromatography.

scholarly journals Europium monoxide as a basis for creating a high-temperature spin injector in the semiconductor spintronics

2020 ◽  
Vol 6 (3) ◽  
pp. 113-123
Author(s):  
Arnold S. Borukhovich
Keyword(s):  
Magnetic Field ◽  
Solid Solution ◽  
Composite Material ◽  
High Temperature ◽  
External Magnetic Field ◽  
Room Temperature ◽  
Spin Electronics ◽  
Wide Range ◽  
Semiconductor Spintronics ◽  
Europium Monoxide

The results of the creation of a high-temperature spin injector based on EuO: Fe composite material are discussed. Their magnetic, electrical, structural and resonance parameters are given in a wide range of temperatures and an external magnetic field. A model calculation of the electronic spectrum of the solid solution Eu–Fe–O, responsible for the manifestation of the outstanding properties of the composite, is performed. The possibility of creating semiconductor spin electronics devices capable of operating at room temperature is shown.

scholarly journals Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N-Diethyl-Substituted Amido Moieties

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Olayinka O. Ajani ◽  
Oluwole B. Familoni ◽  
Feipeng Wu ◽  
Johnbull O. Echeme ◽  
Zheng Sujiang
Keyword(s):  
Antibacterial Activity ◽  
Mass Spectra ◽  
Room Temperature ◽  
Biological Activities ◽  
Chemical Structures ◽  
Wide Range ◽  
Synthetic Routes ◽  
Mic Value ◽  
C Nmr

Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities. We have synthesized a series of α-tolylsulfonamide, 1–11 and their substituted N,N-diethyl-2-(phenylmethylsulfonamido) alkanamide derivatives, 12–22 in improved and excellent yields in aqueous medium at room temperature through highly economical synthetic routes. The chemical structures of the synthesized compounds 1–22 were confirmed by analytical and spectral data such as IR, 1H- and 13C-NMR, and mass spectra. The in vitro antibacterial activity of these compounds along with standard clinical reference, streptomycin, was investigated on two key targeted organisms. It was observed that 1-(benzylsulfonyl)pyrrolidine-2-carboxylic acid, 2 emerged as the most active compound against Staphylococcus aureus at MIC value of 1.8 μg/mL while 4-(3-(diethylamino)-3-oxo-2-(phenylmethylsulfonamido) propyl)phenyl phenylmethanesulfonate, 22 was the most active sulfonamide scaffold on Escherichia coli at MIC value of 12.5 μg/mL.

scholarly journals Europium monoxide as a basis for creating a high-temperature spin injector in the semiconductor spintronics

2020 ◽  
Vol 6 (3) ◽  
pp. 113-123
Author(s):  
Arnold S. Borukhovich
Keyword(s):  
Magnetic Field ◽  
Solid Solution ◽  
Composite Material ◽  
High Temperature ◽  
External Magnetic Field ◽  
Room Temperature ◽  
Spin Electronics ◽  
Wide Range ◽  
Semiconductor Spintronics ◽  
Europium Monoxide

The results of the creation of a high-temperature spin injector based on EuO: Fe composite material are discussed. Their magnetic, electrical, structural and resonance parameters are given in a wide range of temperatures and an external magnetic field. A model calculation of the electronic spectrum of the solid solution Eu–Fe–O, responsible for the manifestation of the outstanding properties of the composite, is performed. The possibility of creating semiconductor spin electronics devices capable of operating at room temperature is shown.

Selective synthesis of E-isomers of aldoximes via a domino aza-Michael/retro-Michael reaction

2012 ◽  
Vol 66 (4) ◽  
Author(s):  
Wei Chen ◽  
Wei-Guo Yu ◽  
Hai-Bo Shi ◽  
Xiao-Yan Lu
Keyword(s):  
1H Nmr ◽  
Room Temperature ◽  
Stereoselective Synthesis ◽  
Michael Reaction ◽  
Selective Synthesis ◽  
Reaction Conditions ◽  
High Yields ◽  
Diastereomeric Purity ◽  
Benzylidene Malononitrile

AbstractA highly stereoselective synthesis of E-isomer of aldoximes was developed through a base-catalysed domino aza-Michael/retro-Michael reaction of hydroxylamine and 2-(R-benzylidene)malononitrile. This reaction generates (E)-aldoxime diastereomer in high yields (eight examples, isolated yields of 82-93 %), excellent diastereomeric purity (diastereomeric ratio higher than 95: 5 by 1H NMR), and proceeds under mild reaction conditions (aqueous NaOH, pH 12, room temperature, 4 h).

Piezoresistivity and Electrical Conductivity of SiC Thin Films Deposited by High Temperature PECVD

2013 ◽  
Vol 740-742 ◽  
pp. 657-660 ◽  
Author(s):  
Oleg Jakovlev ◽  
Tino Fuchs ◽  
Franziska Rohlfing ◽  
Helmut Seidel
Keyword(s):  
Thin Films ◽  
High Temperature ◽  
Room Temperature ◽  
Elevated Temperatures ◽  
Strong Dependence ◽  
Harsh Environment ◽  
Flow Ratio ◽  
Mems Sensors ◽  
Four Point Bending ◽  
Wide Range

We introduce a novel high temperature PECVD process and use it for the deposition of silicon carbide thin films on oxidized silicon wafers at 900°C substrate temperature. A variation of the atomic composition over a wide range is achieved by altering the flow ratio of the precursors silane (SiH4) and acetylene (C2H2). XPS analysis is performed to verify the silicon to carbon ratio in the deposited layers. The resistivity of the obtained thin films shows a strong dependence on the Si/C-ratio. Four point measurements show the resistivity ranging between 5•10-3Ωcm for C-rich layers and >107Ωcm for near stoichiometric layers. We investigate the piezoresistivity of the SiC layers at room temperature under compressive and tensile strain using the four point bending method. The same method is used to analyze selected layers at elevated temperatures up to 600°C. Based on the results we evaluate the applicability of the obtained thin films for strain transducing in harsh environment MEMS sensors.

scholarly journals USING OF 3-ARYLISOCOUMARINS IN 3-ARYLISOQUINOLONS SYNTHESIS

2017 ◽  
pp. 18-30 ◽  
Author(s):  
O. Shablykina ◽  
V. Moskvina ◽  
V. Savchenko ◽  
V. Khilya
Keyword(s):  
Molecular Weight ◽  
High Pressure ◽  
Biological Activity ◽  
High Temperature ◽  
Heterocyclic System ◽  
Low Molecular Weight ◽  
Reaction Conditions ◽  
Activity Data ◽  
Wide Range ◽  
Volatile Amines

The review systematizes and analyzes the literature data (100 sources) regarding the recyclization of 3-arylisocoumarins (3-aryl-1H-isochromen-1-ones) under the action of primary N-nucleophiles that leads to the formation of 3-arylisoquinolones (3-arylisoquinolin-1(2H)-ones). This reaction may be carried out with a wide range of primary aminogroup-containing compounds: ammonia, primary aliphatic, aromatic, and heteroaromatic amines, hydrazine, and hydroxylamine. This transformation is not hindered by the presence of active functional groups (hydroxyl, acetal, carboxyl, ester, nitrile groups, or additional aminogroup) neither in 3-arylcoumarin nor in the primary amine. A special attention has been paid to reaction conditions (temperature regime, duration, solvent, catalysts), which may vary greatly. In particular, it is pointed out that in most cases to carry out high-temperature recyclization of 3-arylisocoumarins with ammonia and volatile amines with low molecular weight the use of closed reactors and high-pressure flasks was required. The cases of successful recyclization of 11,12-dihydrodibenzo[c,h]chromen-6-ones, indeno[1,2-c]isochromen-5(11H)-ones, isochromeno[4,3-c]chromen-6,11-dione and 5H-benzofuro[3,2-c]isochromen-5-one are reviewed separately. The polycondensated heterocyclic system of these compounds contains a 3-arylisocoumarin fragment. The biological activity data is presented for the compounds obtained via this transformation – 3-arylisoquinolin-1(2H)-ones, and also polycondensated systems that contain this fragment, e.g. 11,12-dihydrobenzo[c]phenanthridin-6(5H)-ones and 6H-indeno[1,2-c]isoquinoline-5,11-diones. The opportunities to use 3-arylisoquinolin-1(2H)-ones in the synthesis of other compounds of isoquinoline family, e.g. natural benzo[c]phenanthridinealocoloids, are demonstrated.

Application of TEM to Deformation, Wear, and Fracture of Ceramics

1974 ◽  
Vol 32 ◽  
pp. 472-473
Author(s):  
B. J. Hockey
Keyword(s):  
Wear Resistance ◽  
High Temperature ◽  
Mechanical Behavior ◽  
Brittle Materials ◽  
High Temperature Strength ◽  
Wide Range ◽  
Corrosive Environments ◽  
Further Development

Ceramics, such as Al2O3 and SiC have numerous current and potential uses in applications where high temperature strength, hardness, and wear resistance are required often in corrosive environments. These materials are, however, highly anisotropic and brittle, so that their mechanical behavior is often unpredictable. The further development of these materials will require a better understanding of the basic mechanisms controlling deformation, wear, and fracture.The purpose of this talk is to describe applications of TEM to the study of the deformation, wear, and fracture of Al2O3. Similar studies are currently being conducted on SiC and the techniques involved should be applicable to a wide range of hard, brittle materials.

Mechanical Properties and Dislocation Structure of Single Crystal Cdte Deformed in Compression at 300°C

1976 ◽  
Vol 34 ◽  
pp. 592-593
Author(s):  
Ernest L. Hall ◽  
J. B. Vander Sande
Keyword(s):  
Mechanical Properties ◽  
Single Crystal ◽  
Dislocation Structure ◽  
Room Temperature ◽  
Elevated Temperatures ◽  
Strain Curve ◽  
Optical Devices ◽  
Semiconductor Compound ◽  
Wide Range ◽  
Sample Orientation

The present paper describes research on the mechanical properties and related dislocation structure of CdTe, a II-VI semiconductor compound with a wide range of uses in electrical and optical devices. At room temperature CdTe exhibits little plasticity and at the same time relatively low strength and hardness. The mechanical behavior of CdTe was examined at elevated temperatures with the goal of understanding plastic flow in this material and eventually improving the room temperature properties. Several samples of single crystal CdTe of identical size and crystallographic orientation were deformed in compression at 300°C to various levels of total strain. A resolved shear stress vs. compressive glide strain curve (Figure la) was derived from the results of the tests and the knowledge of the sample orientation.

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