Antimicrobial and Antioxidant Isoflavonoid Derivatives from the Roots of Amphimas pterocarpoides

2013 ◽  
Vol 68 (8) ◽  
pp. 931-938 ◽  
Author(s):  
Edwige P. Fodja Saah ◽  
Valerie Tedjon Sielinou ◽  
Victor Kuete ◽  
Stephen T. Lacmata ◽  
Augustin E. Nkengfack
Keyword(s):  
Antioxidant Properties ◽  
2D Nmr ◽  
Antimicrobial Activities ◽  
Spectroscopic Methods ◽  
Chemical Transformations ◽  
Spectroscopic Evidence ◽  
Wide Range ◽  
Bacteria And Fungi

A new bis-isoflavone derivative, named amphiisoflavone (1), was isolated from the roots of Amphimas pterocarpoides, together with three known isoflavones, namely 8-methoxyisoformononetin (2), 6-methoxyisoformononetin (3) and isoformononetin (4). Chemical transformations carried out on compound 3 led to two new derivatives, 4´-acetoxy-6,7-dimethylisoflavone (3a) and 4´-O-prenyl- 6,7-dimethylisoflavone (3p), along with a known compound, 4´,6,7-trimethoxyisoflavone (3m). The structures of all compounds were elucidated from spectroscopic evidence, in particular by 1D and 2D NMR spectroscopic methods. These compounds were evaluated for their antioxidant properties and for their antimicrobial activities against a wide range of bacteria and fungi.

scholarly journals New Neuritogenic Steroid Glycosides from the Vietnamese Starfish Linckia Laevigata

2007 ◽  
Vol 2 (1) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Alla A. Kicha ◽  
Natalia V. Ivanchina ◽  
Anatoly I. Kalinovsky ◽  
Pavel S. Dmitrenok ◽  
Natalia V. Palyanova ◽  
...  
Keyword(s):  
Neuronal Differentiation ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Chemical Transformations ◽  
Steroid Glycosides ◽  
New Compounds ◽  
Neuritogenic Activity ◽  
Linckia Laevigata

Two new steroid glycosides, linckosides L1 (1) and L2 (2), were isolated, along with the previously known echinasteroside C (3) from the ethanolic extract of the Vietnamese blue starfish, Linckia laevigata. The structures of the new compounds were elucidated by spectroscopic methods (mainly 2D NMR) and chemical transformations. Lifetime observations and analyses of silver impregnated preparations on the culture of neuroblastoma C-1300 cells showed that glycosides 1, 2, and 3 are capable of inducing neuronal differentiation similar to that of neurotrophins and of enhancing substantially the neuritogenic activity of NGF.

New lupan-type triterpenoids

2016 ◽  
Vol 71 (11-12) ◽  
pp. 381-386 ◽  
Author(s):  
Pierre Mkounga ◽  
Hermine L.D. Maza ◽  
Blandine M.W. Ouahouo ◽  
Lydie N. Tyon ◽  
Hayato Ishikawa ◽  
...  
Keyword(s):  
Spectral Data ◽  
Manihot Esculenta ◽  
2D Nmr ◽  
Antimicrobial Activities ◽  
Wide Range ◽  
New Compounds ◽  
Chemical Evidence

Abstract Three new lupan-type triterpernoid derivatives, namely globimetulin A (1), B (2) and C (3), were isolated from the shoot of Globimetula dinklagei (Loranthaceae), a hemiparasitic plant growing on Manihot esculenta, along with five known compounds: friedelin (4), friedelan-3-ol (5), 28-hydroxyfriedelin (6), 4-hydroxy-3,5-dimethoxybenzoic acid (7) and (1R,5S,7S)-7-[2-(4-hydroxyphenyl)ethyl]-2,6-dioxabicyclo[3.3.1]nonan-3-one (8). The structures of the new compounds were elucidated by detailed analyses of their MS, IR, 1D and 2D NMR spectral data and chemical evidence. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms, but none of them exhibited noticeable activity.

The Structure Elucidation and Antimicrobial Activities of Nonsterol Triterpenoids from Ixeris chinensis

2014 ◽  
Vol 69 (9-10) ◽  
pp. 1021-1025 ◽  
Author(s):  
Qing-Hu Wang ◽  
Na-Ren-Chao-Ke-Tu Han ◽  
Na-Yin-Tai Dai ◽  
Xiao-Lan Wu ◽  
Wen-Quan Tai ◽  
...  
Keyword(s):  
Petroleum Ether ◽  
Structure Elucidation ◽  
Petroleum Ether Extract ◽  
2D Nmr ◽  
Antimicrobial Activities ◽  
Spectroscopic Methods ◽  
Ether Extract ◽  
Esi Ms ◽  
Nmr Techniques ◽  
First Time

Abstract An investigation of the petroleum ether extract from Ixeris chinensis Nakai has led to the isolation of a new compound, 3-O-acetyl-22,28-cyclobauer-7-en-3β-ol (1), together with four known compounds which have been isolated from this plant for the first time, namely taraxast-20-en-3β-ol (2), 3-O-acetyl-taraxast-20-en-3β-ol (3), taraxast-20(30)-en-3β-ol (4), and 3-O-acetyl-taraxast-20(30)- en-3β-ol (5). The structures of the isolated compounds have been elucidated on the basis of spectroscopic methods including UV, IR, ESI-MS, 1D NMR, 2D NMR techniques, and by comparison with data reported in the literature. All compounds have been evaluated for their activity against various bacteria and shown to give good results

scholarly journals Isolation and Identification of Saccharomyces cerevisiae from Caterpillar Frass and their Probiotic Characterization

2019 ◽  
Vol 16 (1) ◽  
pp. 179-186 ◽  
Author(s):  
Ujwala Vinayak Khisti ◽  
Suyash Arun Kathade ◽  
Mayur Arjun Aswani ◽  
Pashmin Kaur Anand ◽  
Nirichan Kunchirman Bipinraj
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Pathogenic Bacteria ◽  
Antimicrobial Activities ◽  
Yeast Cells ◽  
Isolation And Identification ◽  
Yeast Cultures ◽  
Isolation And Characterization ◽  
Wide Range ◽  
Probiotic Yeast ◽  
Bacteria And Fungi

Probiotics are live microorganisms which upon ingestion confer health benefits to the host and are widely applied for human and animal welfare. The present study reports the isolation of yeast cells from caterpillar frasses and its probiotic characterization. Out of four yeast cultures isolated, all found to be non-hemolytic and cultures designated as CV-I, CV-II CV-III and CV-IV showed good bile tolerance at 1.2%. These cultures possessed the ability to grow pH range of 1.5 – 10, exhibited auto-aggregation and co-aggregation capabilities, which are essential for growth in alimentary canal and reduction of pathogen adherence on the intestinal epithelial cells. All cultures exhibited good tolerance to temperature up to 42°C. Isolate CV-I showed wide range of antimicrobial activities against pathogenic bacteria and fungi. This study is the first report of isolation and characterization of probiotic yeast from caterpillar frass. The isolate CV-I has been identified as Saccharomyces cerevisiae by molecular methods. This culture is an ideal candidate for further probiotic exploration.

Synthesis and Antimicrobial Activity of Novel 1, 2, 4-Triazolopyrimidofuro- quinazolinones from Natural Furochromones (Visnagenone and Khellinone)

2020 ◽  
Vol 16 ◽  
Author(s):  
Ameen Ali Abu-Hashem ◽  
Hoda A. R. Hussein ◽  
Ahmed S. Aly
Keyword(s):  
2D Nmr ◽  
Antimicrobial Activities ◽  
New Drugs ◽  
Pharmacological Activities ◽  
Efficient System ◽  
Wide Range ◽  
Nmr Techniques ◽  
Analgesic Activities ◽  
New Compounds

Background: Previous and recent scientific research has shown that triazolopyrimidine and furochromones have a wide range of pharmacological activities in the treatment of numerous diseases, including anticancer, antiviral, anti-depressant, antimicrobial, anti-inflammatory, and analgesic activities. Objective: Preparation of new drugs used as antimicrobial activities derived from a natural furochromones as (1- hydrazinyl or methylthio),-furopyrimidoquinazolinone, 1, 2, 4-triazolopyrimidofuroquinazolin-5-one, and quinazolinepyrimidofuro- quinazoline-8, 10-dione and study of their biological activity as antimicrobial. Method: A series of novel N’-furopyrimidoquinazoline-hydrazide; 1, 2, 4-triazolopyrimidofuroquinazolin-5-one; furopyrimidoquinazolin-3-one and quinazoline-pyrimidofuroquinazoline-8, 10-dione derivatives were synthesized from substituted (methylthio)-furopyrimidoquinazolinone (3a-b) and 1-hydrazinyl-furopyrimidoquinazolinone (4a-b) as the starting material. Results: All compounds were synthesized in good yields (71-95%) in a gradually efficient system under the mild condition and some of the procedures were used a microwave oven. The new compounds have been confirmed by means of different spectroscopic ways such as IR, 1D and 2D -NMR techniques and mass spectrum. The in vitro to antimicrobial activities were evaluated for the prepared compounds using many types of bacteria (Gram positive and Gram negative) and fungi. Conclusion: 1, 2, 4-triazolopyrimidofuroquinazolin-5-one derivatives (10a-f, 8a-b, 7a-b and 6a-d) showed the most efficient antimicrobial activities compared with the cefotaxime sodium and nystatin as standard drugs.

scholarly journals Novel Synthetic Strategy of Cyclic Dithiocarbamates Catalyzed by Triton-B

2019 ◽  
Vol 31 (5) ◽  
pp. 1091-1094 ◽  
Author(s):  
R. Kishore ◽  
M. Kamboj ◽  
M. Shukla ◽  
N. Srivastava
Keyword(s):  
Pathogenic Bacteria ◽  
Phase Transfer ◽  
Antimicrobial Activities ◽  
Spectroscopic Methods ◽  
Mild Conditions ◽  
Synthetic Strategy ◽  
Green Approach ◽  
Bacteria And Fungi ◽  
Ethyl Bromopyruvate

A simple, rapid and green methodology to synthesize cyclic dithiocarbamates (compounds 1-9) was developed by the reaction of 1° amines, CS2 and ethyl 3-bromo-2-oxopropanoate (ethyl bromopyruvate) facilitated by Triton-B as phase transfer catalyst. These compounds (1-9) were characterized with the help of elemental analysis, IR, NMR and mass spectroscopic methods This efficient green approach requires mild conditions and gives good yield of product. In vitro antimicrobial activities of these compounds are reported against the pathogenic bacteria and fungi.

Nanocrystalline chloroxine possesses broad-spectrum antimicrobial activities and excellent skin tolerability in mice

Nanomedicine ◽  
2022 ◽  
Author(s):  
Jiří Trousil ◽  
Jana Matějková ◽  
You-Shan Dai ◽  
Tomáš Urbánek ◽  
Miroslav Šlouf ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Skin Irritation ◽  
Antimicrobial Activities ◽  
Great Promise ◽  
Good Tolerability ◽  
Wide Range ◽  
Skin Tolerability ◽  
Skin Conditions ◽  
Bacteria And Fungi

Background: Antimicrobial submicrometer particles are being studied as promising interventions against a wide range of skin conditions, such as fungal or bacterial infections. Aims: To submicronize chloroxine, the crystalline compound 5,7-dichloro-8-hydroxyquinoline, by nanoprecipitation and characterize the resulting assemblies. Methods: The chloroxine particles were stabilized by a nonionic surfactant and were studied by a broth microdilution assay against 20 medically important bacteria and fungi. The intervention was studied using a murine model of skin irritation. Results & conclusions: Chloroxine nanoparticles with a diameter of 600–800 nm exhibit good tolerability in terms of skin irritation in vivo and good antimicrobial activity. Thus, the fabricated formulation shows great promise for interventions for both cutaneous infection control and prophylaxis.

scholarly journals Isolation and In Silico Anti-COVID-19 Main Protease (Mpro) Activities of Flavonoids and a Sesquiterpene Lactone from Artemisia sublessingiana

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Roza I. Jalmakhanbetova ◽  
Yerlan M. Suleimen ◽  
Masayoshi Oyama ◽  
Eslam B. Elkaeed ◽  
Ibrahim. H. Eissa ◽  
...  
Keyword(s):  
Sesquiterpene Lactone ◽  
In Silico ◽  
Ethanol Extract ◽  
2D Nmr ◽  
Antimicrobial Activities ◽  
Spectroscopic Methods ◽  
Binding Modes ◽  
Free Energies ◽  
Aerial Parts ◽  
Main Protease

The emergence of the COVID-19 pandemic declared the huge need of humanity for new and effective antiviral drugs. The reported antimicrobial activities of Artemisia sublessingiana encouraged us to investigate the ethanol extract of its aerial parts which led to the isolation of six flavonoids and a sesquiterpenoid. The structures of the isolated compounds were elucidated by EI-MS, 1D, and 2D NMR spectroscopic methods to be (1) eupatilin, (2) 3′,4′-dimethoxyluteolin, (3) 5,7,3′-trihydroxy-6,4′,5′-trimethoxyflavone, (4) hispidulin, (5) apigenin, (6) velutin, and (7) sesquiterpene lactone 8α,14-dihydroxy-11,13-dihydromelampolide. The isolated compounds were in silico examined against the COVID-19 main protease (Mpro) enzyme. Compounds 1–6 exhibited promising binding modes showing free energies ranging from −6.39 to −6.81 (kcal/mol). The best binding energy was for compound 2. The obtained results give hope of finding a treatment for the COVID-19 pandemic.

scholarly journals Elaboration of Whey Protein-Based Films in Food Products: Emphasis on the Addition of Natural Edible Bio-nanocomposites With Antioxidant and Antimicrobial Activity

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Sayed Mahdi Hossaeini Marashi ◽  
Mohammad Hashemi ◽  
Enayat Berizi ◽  
Mojtaba Raeisi ◽  
Seyyed Mohammad Ali Noori
Keyword(s):  
Shelf Life ◽  
Whey Protein ◽  
Antioxidant Properties ◽  
Meat Products ◽  
Food Products ◽  
Antimicrobial Activities ◽  
Edible Films ◽  
Poultry Meat ◽  
Wide Range ◽  
The Impact

: Food spoilage is one of the major elements of food insecurity that has acquired significant attention over recent decades due to global human population growth. Several studies have investigated increasing shelf life of food products using natural and environmentally friendly compounds. Whey protein (WP) can be an important additive material because it is well-known for its high value of nutrition and well characteristics for the formation of edible films. Furthermore, natural bioactive compounds have been incorporated with WP-based films to confer their antioxidant and antimicrobial activities. Herein, nanotechnology has been effectively potentiated the antimicrobial and antioxidant properties of WP films. A wide range of bioactive agents has been embedded in the WP films, such as essential oils (EOs), TiO2, nano-clay, and even lactic acid bacteria. The current paper reviews the antioxidant and antimicrobial effects of different types of WP films and their applications in food products. This study also discussed the impact of WP films on shelf life, chemical and microbiological quality indices of meats, processed meats, poultry meat products, and fish.

Antimycobacterial cycloartane derivatives from the roots of Trichilia welwistchii C. DC (Meliaceae)

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Armelle Tontsa Tsamo ◽  
Edwige P. Fodja Saah ◽  
Moses K. Langat ◽  
Pierre Mkounga ◽  
Alain François Kamdem Waffo ◽  
...  
Keyword(s):  
2D Nmr ◽  
Spectroscopic Methods ◽  
Moderate Activity ◽  
Chemical Transformations ◽  
Nmr Analysis ◽  
Pure Compound ◽  
Weak Activity ◽  
Synthetic Reaction ◽  
First Time ◽  
Related Compounds

Abstract Chemical investigation of the roots of Trichilia welwitschii yielded a cycloartane type terpenoid 28,29-bis-norcycloart-24-en-3β,4α,6α-triol (1), isolated as pure compound for the first time, three coumarins and three sterols. New cycloartane derivatives (1a) and (1b+1c) were obtained by hemi-synthetic reaction of compound 1. The structures of 1a–c were established by spectroscopic methods including 1D and 2D-NMR analysis, HR-EIMS, chemical transformations and by comparison of these data with those of related compounds. Evaluated for their antimycobacterial potential, compound 1 and 1b+1c were determined to show significant activities against Mycobacterium tuberculosis MIC values of 6.25 μg mL−1 while compound 1a displayed weak activity showing MIC > 100 μg mL−1. Compounds 2–4 displayed moderate activity with MIC values range from 12.5 to 50 μg mL−1.

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