Galectin-3 in Middle-Aged Patients with First Episode of Non-valvular Atrial Fibrillation: a Speckle-tracking Study

2017 ◽  
Vol 20 (3) ◽  
pp. 224-227
Author(s):  
Alev Kılıçgedik ◽  
Süleyman Çağan Efe ◽  
Ahmet Seyfettin Gürbüz ◽  
Emrah Acar ◽  
Mehmet Fatih Yılmaz ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Speckle Tracking ◽  
First Episode ◽  
Middle Aged ◽  
Aged Patients ◽  
Galectin 3

scholarly journals Burden of premature atrial beats in middle-aged endurance athletes with and without lone atrial fibrillation versus sedentary controls

2019 ◽  
Vol 27 (14) ◽  
pp. 1555-1563
Author(s):  
Alberto Cipriani ◽  
Riccardo Vio ◽  
Giulio Mastella ◽  
Nicolò Ciarmatori ◽  
Alvise Del Monte ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Paroxysmal Atrial Fibrillation ◽  
Multivariable Analysis ◽  
Endurance Athletes ◽  
Ecg Monitoring ◽  
Middle Aged ◽  
Sports Activity ◽  
Lone Atrial Fibrillation ◽  
Aged Patients ◽  
And Gender

Background The burden of premature atrial beats (PABs) at 24-h electrocardiographic (ECG) monitoring correlates with the risk of atrial fibrillation. It is unknown whether prolonged and intense exercise increases the burden of PABs, thus contributing to the higher prevalence of atrial fibrillation observed in middle-aged athletes. Methods We compared the burden of PABs at 24-h ECG monitoring off therapy in 134 healthy middle-aged (30–60-year-old) competitive athletes who had practised 9 (7-11) h of endurance sports for 8 (4-15) consecutive years, 134 age- and gender-matched healthy sedentary individuals, and 66 middle-aged patients (20 athletes and 46 non-athletes) with ‘lone’ paroxysmal atrial fibrillation. Results More than 50 PABs/24 h or ≥1 run of ≥3 PABs were recorded in 23/134 (17%) healthy athletes and in 29/134 (22%) sedentary controls ( p = 0.61). Healthy athletes with frequent or repetitive PABs were older (median 50 years vs. 43 years, p < 0.01) and had practised sport for a longer time (median 10 years vs. 6 years, p = 0.03). At multivariable analysis only age (odds ratio 1.11, 95% confidence interval 1.04–1.20, p < 0.01) remained an independent predictor of a higher burden of PABs. Also among patients with ‘lone’ paroxysmal atrial fibrillation, there was no difference in the prevalence of >50 PABs/24 h or ≥1 run of ≥3 PABs between athletes (40%) and controls (48%, p = 0.74) . Conclusions Middle-aged endurance athletes, with or without paroxysmal atrial fibrillation, did not show a higher burden of PABs at 24-h ECG monitoring than sedentary controls. Age, but not intensity and duration of sports activity, predicted a higher burden of PABs among healthy athletes.

Mitral Annular Calcification Predicts Cardiovascular Morbidity and Mortality in Middle-aged Patients With Atrial Fibrillation

CHEST Journal ◽  
2011 ◽  
Vol 140 (4) ◽  
pp. 902-910 ◽  
Author(s):  
Tatjana S. Potpara ◽  
Zorana M. Vasiljevic ◽  
Bosiljka D. Vujisic-Tesic ◽  
Jelena M. Marinkovic ◽  
Marija M. Polovina ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Middle Aged ◽  
Mitral Annular Calcification ◽  
Aged Patients ◽  
Cardiovascular Morbidity And Mortality ◽  
Annular Calcification

scholarly journals Assessment of progression of atrial fibrillation in middle-aged individuals with hypertension in combination with comorbid extracardial diseases

2019 ◽  
Vol 2 (30) ◽  
pp. 23-27
Author(s):  
L. D. Khidirova ◽  
D. A. Yakhontov
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Fibrillation ◽  
Left Ventricle ◽  
Abdominal Obesity ◽  
Test System ◽  
Control Group ◽  
Chronic Obstructive ◽  
Middle Aged ◽  
Aged People ◽  
Galectin 3

Purpose. To assess the progression of atrial fibrillation in middle-aged people with hypertension in combination with comorbid extracardiac diseases.Materials and methods. In an observational cohort study, 308 patients aged 45–65 years with atrial fibrillation (paroxysmal and persistent forms) with hypertension in combination with extracardiac pathology were observed: diabetes mellitus (n = 40), thyrotoxicosis (n = 42), hypothyroidism (n = 59), abdominal obesity (n = 64) and chronic obstructive pulmonary disease (n = 47). The control group consisted of 56 patients with hypertension + AF without concomitant extracardiac disease. The level of MMP-9 was determined using the Human MMP-9 (total) Immunoassay test-system (USA); NT-proBNP —  using the NTproBNP-IFA-Best reagent kit; galectin-3 —  with ELISA —  Bender MedSystems (Austria). Echocardiography was performed using an Acuson Aspen apparatus (USA), 24-hour ECG monitoring with Schiller Medilog Holter system. All statistical calculations were carried out in the program Rstudio 0.99.879 (RStudio, USA).Results. In patients with hypertension and atrial fibrillation, the combination of diabetes mellitus (p = 0.041) and abdominal obesity (p = 0.004) is the most prognostic factor for AF progression. In groups of patients with diabetes mellitus, hypothyroidism and abdominal obesity, the most pronounced indicators of diastolic dysfunction of the left ventricle were: E/A, LVMI (men); the size of the left atrium and the end-diastolic size of the left ventricle are increased in all clinical groups. The prognostic value of biomarkers of fibrosis and remodeling of galectin-3 and MMP-9, and NT-proBNP in the progression of atrial fibrillation in patients with hypertension in combination with extracardial diseases is shown.Conclusion. There is no doubt that in case of hypertension, the decompensation of long-term hypertrophic myocardium is based on a violation of the balanced growth of its various structures and the formation of fibrosis and myocardial dystrophy, which was confirmed in the present study. The detected elevated levels of MMP-9, galectin-3 and NT-proBNP, as well as ultrasonic signs of myocardial remodeling, confirmed that they statistically significantly affect the progression of atrial fibrillation. In this regard, a personalized approach to a patient with atrial fibrillation in combination with comorbid pathology is required, especially in middle-aged people at the stage of comorbidity formation, under the conditions of received diagnostic information on the electrical function of the heart and assessment of the functional capabilities of CVS during its transition to various levels of functioning.

Echocardiographic predictors of atrial fibrillation in middle-aged patients without overt heart disease

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Borizanova-Petkova ◽  
N Georgieva ◽  
E Kinova ◽  
A Goudev ◽  
V Koleva
Keyword(s):  
Atrial Fibrillation ◽  
Heart Disease ◽  
Sinus Rhythm ◽  
Global Longitudinal Strain ◽  
Surrogate Marker ◽  
Left Ventricular ◽  
Volume Index ◽  
Control Group ◽  
Middle Aged ◽  
Aged Patients

Abstract Background Left atrial volume index (LAVi) has been established as a surrogate marker for chronically elevated left ventricular (LV) filling pressure. Moreover it is a powerful predictor of atrial fibrillation (AF) in different pathologies. However, there is limited data for additional and sensitive echocardiographic predictors of AF in patients without over heart disease. Purpose To investigate middle- aged AF patients without overt heart disease and to identify additional echocardiographic predictors of AF. Methods A total of 936 consecutive patients with AF, who had been admitted for sinus rhythm restoriation in our hospital for the period January 2016- December 2018, were screened for participation in the study. Only 70 patients met the inclusion criteria- stable sinus rhythm, age between 40–60 years, without over heart disease. They were separated in 2 groups: with new onset AF (n=33) and recurrent AF (n=37); 30 healthy subjects were enrolled in the control group. All patients underwent two dimensional echocardiographic assessment with volumetric and speckle tracking analyses. Results There were significant differences between all groups in: LAVi; LA total (LATEF), passive (LAPEF) and active (LAAEF) emptying fractions; LA reservoir (LASr), conduit (LAScd) and contractile (LASct) strain; LV global longitudinal strain (GLS), but not in other LV indices – table. Multiple regression analysis demonstrated that LAVi (B=0.012, p=0.05, 95% CI: 0.000–0.023), LASr (B=−0.055, p=0.0001, 95% CI: −0.071 to −0.039), LASct (B=0.041, p=0.001, 95% CI: 0.016–0.066) are independent predictors of AF. Conclusion In middle- aged patients without overt heart disease LASr and LASct have additive value beyond LAVi in prediction of AF. Funding Acknowledgement Type of funding source: None

Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM

Diabetes ◽  
1997 ◽  
Vol 46 (8) ◽  
pp. 1354-1359 ◽  
Author(s):  
S. Lehto ◽  
T. Ronnemaa ◽  
S. M. Haffner ◽  
K. Pyorala ◽  
V. Kallio ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Middle Aged ◽  
Aged Patients

Long Term Clinical and Echocardiographic Outcomes in Middle Aged Patients Undergoing the Ross Procedure

2019 ◽  
Vol 3 (sup1) ◽  
pp. 53-53
Author(s):  
Jamie Romeo ◽  
Grigorios Papageorgiou ◽  
Francisco da Costa ◽  
Hans Sievers ◽  
Ad Bogers ◽  
...  
Keyword(s):  
Ross Procedure ◽  
Middle Aged ◽  
Aged Patients

scholarly journals Morphology of the Undersurface of the Anterolateral Acromion and Its Relationship to Surrounding Structures

2021 ◽  
Vol 9 (1) ◽  
pp. 232596712097748
Author(s):  
Yusuke Ueda ◽  
Akimoto Nimura ◽  
Keisuke Matsuki ◽  
Kumiko Yamaguchi ◽  
Hiroyuki Sugaya ◽  
...  
Keyword(s):  
Deep Layer ◽  
Micro Computed Tomography ◽  
Middle Aged ◽  
Aged Patients ◽  
Coracoacromial Ligament ◽  
3 Dimensional ◽  
Bony Surface ◽  
Inferior Aspect ◽  
Histologic Evaluation ◽  
Arthroscopic Subacromial Decompression

Background: A better understanding of the morphology underneath the acromion is needed to prevent complications after arthroscopic subacromial decompression. The precise correlations between the morphologic features underneath the acromion and the surrounding structures including the attachment of the coracoacromial ligament (CAL) and the origin of the deltoid middle head have not yet been determined in the absence of artifacts on the bony surface caused by dissection techniques. Moreover, anatomic findings in previous studies using only older-aged cadavers or dried bones may not reflect the morphologic features of younger and healthy specimens. Purpose: To characterize the anterolateral structures morphologically in the inferior aspect of the acromion, assess the relationships of these structures with surrounding structures without dissection artifacts on the bony surface, and verify the cadaveric data in the asymptomatic shoulders of living middle-aged patients. Study Design: Descriptive laboratory study. Methods: We initially analyzed the relationship between the morphology of the anterolateral structures and surrounding structures in 18 cadaveric shoulders (mean age, 81.8 years), 15 of which were subjected to macroscopic investigation of the CAL attachment and 3-dimensional micro—computed tomography investigation with radiopaque markers and 3 of which were subjected to histologic examination. We also analyzed the morphology underneath the anterolateral acromion in 24 asymptomatic shoulders of middle-aged patients (mean age, 54.8 years) to verify the cadaveric data. In both the cadaveric shoulders and the asymptomatic shoulders of live patients, the long axis, width, and height of the anterolateral prominence were measured by use of 3-dimensional CT imaging. Results: In cadavers, the anterolateral prominence underneath the acromion corresponded to the attachment of the CAL. Histologic evaluation revealed that the CAL was continuous to the deep layer of the deltoid middle head in the lateral acromion. The study in asymptomatic shoulders of middle-aged patients revealed bony prominences similar to those observed in cadavers. Conclusion: The anterolateral prominence, which corresponds to the attachment of the CAL below the acromion, may be a native structure below the acromion. Moreover, the CAL is continuous to the deep layer of the deltoid middle head in the lateral acromion.

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