Gram Negative Bacillary Brain Abscess: Clinical Features And Therapeutic Outcome

ABSTRACT Morganella morganii is a gram negative aerobe , found often as intestinal commensal. It is commonly implicated in Urinary tract infections and pyogenic infections, but rarely causes CNS infections especially brain abscess. There are very few published reports of Morganella morganii as a causative pathogen in brain abscess. High index of suspicion of this pathogen is important in cases of brain abscess secondary to otogenic infections. This paper reports an unusual case of Morganella morganii, subspecies morganii, biogroup A Brain abscess .The paper also reviews other infections caused by Morganell morganii.

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Neurological infections

10.1093/med/9780199664368.003.0015 ◽

2016 ◽

Author(s):

Sathiji Nageshwaran ◽

Heather C Wilson ◽

Anthony Dickenson ◽

David Ledingham

Keyword(s):

Mycobacterium Tuberculosis ◽

Lyme Disease ◽

Bacterial Meningitis ◽

Fungal Infection ◽

Brain Abscess ◽

Clinical Features ◽

Parasitic Infection ◽

Chronic Meningitis ◽

Neurological Infections

This chapter reviews the clinical features and management of meningitis (community-acquired bacterial meningitis and chronic meningitis), Mycobacterium tuberculosis, encephalitis and myelitis, Lyme disease, brain abscess and parameningeal infection, neurological infections in the immunocompromised, fungal infection, parasitic infection, and bacterial neurotoxins.

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Clinical characteristics and therapeutic outcome of Gram-negative bacterial spinal epidural abscess in adults

Yearbook of Medicine ◽

10.1016/j.ymed.2011.08.016 ◽

2011 ◽

Vol 2011 ◽

pp. 50-51

Author(s):

N.M. Khardori

Keyword(s):

Clinical Characteristics ◽

Epidural Abscess ◽

Therapeutic Outcome ◽

Spinal Epidural Abscess ◽

Gram Negative ◽

Spinal Epidural

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Two intriguing Bilophila wadsworthia cases from Hungary

Journal of Medical Microbiology ◽

10.1099/jmm.0.45678-0 ◽

2004 ◽

Vol 53 (11) ◽

pp. 1167-1169 ◽

Cited By ~ 5

Author(s):

Edit Urbán ◽

Anna Hortobágyi ◽

Károly Szentpáli ◽

Elisabeth Nagy

Keyword(s):

Brain Abscess ◽

Gram Negative ◽

Human Faeces ◽

First Report ◽

Obligately Anaerobic ◽

Negative Bacillus ◽

Gram Negative Bacillus

Bilophila wadsworthia, an obligately anaerobic Gram-negative bacillus, was first isolated from appendicitis specimens and human faeces. The two cases described here are the first report of the isolation of B. wadsworthia in Hungary, and include the first isolation from chronic mastoiditis complicated with a brain abscess.

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Review of Clinical Features, Microbiological Spectrum, and Treatment Outcomes of Endogenous Endophthalmitis over an 8-Year Period

Journal of Ophthalmology ◽

10.1155/2012/265078 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 18

Author(s):

Zenith H. Y. Wu ◽

Rose P. S. Chan ◽

Fiona O. J. Luk ◽

David T. L. Liu ◽

Carmen K. M. Chan ◽

...

Keyword(s):

Treatment Outcomes ◽

Clinical Features ◽

Outcome Measure ◽

Visual Outcome ◽

Endogenous Endophthalmitis ◽

Light Perception ◽

Gram Negative ◽

Finger Counting ◽

The Mean

Purpose. To evaluate the clinical features, microbiological spectrum, and treatment outcomes of endogenous endophthalmitis.Methods. Retrospective review of consecutive cases with infective endogenous endophthalmitis presenting from 2000 to 2007. The main outcome measure was the visual outcome at the latest follow-up visit. Other outcome measures included microbiological investigations, anatomical and clinical outcomes.Results. 22 eyes of 21 patients were included, and the mean follow-up duration was 2.7 years. Eyes with fungal endogenous endophthalmitis were more likely to have visual acuity of finger counting or better at presentation compared with those with bacterial endogenous endophthalmitis (odds , ). Gram-negative microorganisms accounted for 50% of infections, while fungal and gram-positive organisms accounted for 27.3% and 22.7%, respectively. Despite treatment, the visual outcome was poor in general as 10 (45.5%) eyes had no light perception at the latest follow-up visit and 6 (27.3%) eyes required enucleation or evisceration. Contrary to previous studies, fungal endogenous endophthalmitis did not appear to have better visual outcome compared with bacterial endogenous endophthalmitis.Conclusion. Gram-negative microorganisms were the main causative pathogens of endogenous endophthalmitis in Hong Kong. The visual prognosis of endogenous endophthalmitis is generally poor as almost 50% of eyes were blind despite treatment.

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Clinical Characteristics and Outcome of Primary Brain Abscess: a Retrospective Analysis

10.21203/rs.3.rs-915473/v1 ◽

2021 ◽

Author(s):

Junying Huang ◽

Haining Wu ◽

Honghong Huang ◽

Weiqi Wu ◽

Bowen Wu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Klebsiella Pneumoniae ◽

Brain Abscess ◽

Clinical Characteristics ◽

Clinical Symptoms ◽

Multivariate Logistic Regression Analysis ◽

Enteric Bacteria ◽

Focal Neurological Deficit ◽

Gram Negative ◽

Classical Triad

Abstract Background: Patients with primary brain abscess often present with atypical symptoms, and the outcome is varied. We investigated the demographic, laboratory, and neuroimaging features of patients with brain abscess at our hospital and identified factors associated with their outcome.Methods: We retrospectively collected the data of patients diagnosed with primary brain abscess at our hospital between January 2011 and December 2020. Their clinical characteristics, predisposing factors, laboratory and neuroimaging findings, treatment, and outcome were analyzed. Results: Of the 57 patients diagnosed with primary abscess, 51 (89.47%) were older than 40 years and 42 (73.68%) were male. Only eight patients (14.04%) showed the classical triad of headache, fever, and focal neurological deficit. Fourteen patients (24.56%) had comorbidities, of which diabetes mellitus was the most common. Positive pus cultures were obtained in 46.15% of the patients, and gram-negative enteric bacteria were found in 33.33% of them, with Klebsiella pneumoniae being the most frequently observed. Surgical treatment, most commonly in the form of stereotactic drainage, was received by 54.39% of the patients. Good outcomes were achieved in 75.44% of the patients. Multivariate logistic regression analysis showed that patients with headache were more likely to have a poor outcome (odds ratio 6.010, 95% confidence interval 1.114–32.407, p = 0.037).Conclusions: Male patients and those older than 40 years were more susceptible to brain abscess than female patients and those younger than 40 years, respectively. Only a few patients showed the classical triad of clinical symptoms. Diabetes mellitus was the most common comorbidity. Positive pus culture results were uncommon, with gram-negative enteric bacteria, especially Klebsiella pneumoniae, being the main organisms found. Most patients had a good outcome, and the presence of headache may influence the outcome.

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Successful Response to Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy in a Patient with Metastatic Carotid Body Paraganglioma

Case Reports in Oncology ◽

10.1159/000520851 ◽

2021 ◽

pp. 1827-1833

Author(s):

Hiroki Yamada ◽

Toshirou Fukushima ◽

Takashi Kobayashi ◽

Shintaro Kanda ◽

Tomonobu Koizumi ◽

...

Keyword(s):

Bone Metastases ◽

Neuroendocrine Tumor ◽

Clinical Features ◽

Carotid Body ◽

Distant Metastasis ◽

Radical Surgery ◽

Primary Lesion ◽

Therapeutic Outcome ◽

Low Grade ◽

Metastatic Lesions

Carotid body paraganglioma is a rare neuroendocrine tumor presenting with low-grade histological and clinical features. However, the tumor has the potential to produce distant metastasis, and due to its rarity, little information is available regarding chemotherapy for such metastatic lesions. Here, we report a case of carotid body paraganglioma with development of pulmonary and bone metastases 10 years after radical surgery for the primary lesion in the neck. The lesions showed a good response to cyclophosphamide, vincristine, and dacarbazine chemotherapy. A beneficial therapeutic outcome by chemotherapy is extremely rare in patients with metastatic carotid body paraganglioma.

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