scholarly journals Examination of the Clinical Queries and Systematic Review “hedges” in EMBASE and MEDLINE

Author(s):  
Susan M. Bradley

Introduction – This investigation sought to determine whether the methodological search filters in place as Clinical Queries limits in OvidSP EMBASE and OvidSP MEDLINE had been modified from those written by Haynes et al. and whether the translations of these in PubMed and EBSCO MEDLINE were reliable. The translated National Library of Medicine (NLM) Systematic Reviews hedges in place in OvidSP MEDLINE and EBSCO MEDLINE were also examined. Methods – Search queries were run using the Clinical Queries and Systematic Reviews hedges incorporated into OvidSP EMBASE, OvidSP MEDLINE, PubMed, and EBSCO MEDLINE to determine the reliability of these limits in comparison with the published hedge search strings. Results – Five of the OvidSP EMBASE Clinical Queries hedges produced results that were different from the published search strings. Three of the EBSCO MEDLINE and five of the PubMed translated Clinical Queries hedges yielded markedly different results (>10% difference) than those obtained using the OvidSP MEDLINE hedge counterparts. The OvidSP MEDLINE Systematic Reviews subject subset hedge was found to have a major error, which has been corrected. Discussion – Translations of hedges to appropriate syntax for other database platforms may result in significantly different search results. The platform searched should ideally be the one for which the hedges were written and tested. Regardless, the hedges in place may not be the same as the published hedge search strings. Quality control testing is needed to ensure that the hedges in place as limits are the same as those that have been published.

2011 ◽  
Vol 6 (2) ◽  
pp. 55
Author(s):  
Heather Ganshorn

Objective – To determine whether the methodological search filters in OvidSP MEDLINE and OvidSP EMBASE also known as Clinical Queries hedges had been modified from the originals which were written by the McMaster University Health Information Research Unit Hedges Group (the Haynes Group) and whether the translations of these hedges by the National Library of Medicine used in PubMed and EBSCO MEDLINE were reliable. The hedges examined are for the clinical categories of diagnosis, therapy, etiology, prognosis, clinical prediction guides, and reviews. The author also examined the translated National Library of Medicine (NLM) Systematic Reviews hedges in OvidSP MEDLINE and EBSCO MEDLINE. Design – Validity of hedges used in various databases. Setting – OvidSP MEDLINE, OvidSP EMBASE, EBSCO MEDLINE and PubMed were studied. Subjects – The Clinical Queries hedges designed to facilitate enhanced retrieval of particular types of studies in the above-mentioned databases were compared. Methods – The author ran the Clinical Queries hedges in OvidSP MEDLINE, OvidSP EMBASE and PubMed. Next, she manually entered the original Haynes Group published hedge search strings for each clinical query in these databases, and compared the results to the Clinical Queries. The author also compared the results obtained from the Ovid MEDLINE Clinical Queries versus the hedges in PubMed and EBSCO MEDLINE. The percentage difference in number of hits between the Ovid platform and the other platform was calculated. Where the difference was greater than 10%, the author modified the search string and re-tested it. There was no gold standard for comparison, so it was not possible to make calculations such as sensitivity, specificity, precision, or accuracy. For the testing of the Review hedges, the author used the Cochrane Database of Systematic Reviews as a gold standard to compare search results. She also compared the results in OvidSP MEDLINE to the results in EBSCO MEDLINE and PubMed. Main Results – Comparing the 27 OvidSP Clinical Queries limits to the equivalent Haynes search strings, the author found identical results, suggesting that the OvidSP hedges have not been changed from Haynes’ original search strings. However, when the OvidSP MEDLINE hedges were compared to PubMed and EBSCO, there were discrepancies. If the hedges were translated exactly, one should expect the result sets to be nearly identical, with the exception of records that had not yet been uploaded to OvidSP and EBSCO (PubMed contains records that are not yet fully indexed). However, other problems became evident. While the majority of searches yielded similar numbers of records, there were discrepancies of >10% in the number of hits for five of the Clinical Queries. Some of the hedges involved truncated search terms that, in PubMed, generated a message indicating that only the first 600 variations of the word root would be used. The author modified these hedges in order to obtain potentially more accurate results, though as she does not have a gold standard set for comparison, the modified hedges could not be thoroughly evaluated. Three of the EBSCO MEDLINE Clinical Queries hedges also generated significantly different results from OvidSP MEDLINE. The author was able to modify these hedges to generate similar results to those found in PubMed. The author’s examination of the various systematic review hedges identified other problems. For these hedges, it was possible to use the Cochrane Database of Systematic Reviews as a simple gold standard to assess the reliability of these filters. The Haynes Clinical Queries Review hedge is used in OvidSP EMBASE. The author found that this hedge’s sensitive filter retrieved 100% of the Cochrane Reviews, while the optimized filter retrieved all reviews but one. However, the specific filter retrieved only 16% of the Cochrane reviews. The author notes that the Haynes hedges were developed using a subset of journals that did not include the Cochrane Database of Systematic Reviews. The Clinical Queries Review hedge in MEDLINE appeared to have better results. In OvidSP, the sensitive and optimized hedges found all but one record, while the specific hedge found 83% of the records, a result that was mirrored in EBSCO MEDLINE and PubMed. Conclusion - Users of OvidSP MEDLINE can be confident that the Clinical Queries limits are true translations of the hedges published by Haynes et al., as they were found to give identical results to manual entry of these hedges. However, users cannot be confident that these queries will give the same results in PubMed, due to differences in syntax between the two interfaces. Users of EBSCO MEDLINE can be less confident that the Clinical Queries have been perfectly translated from the original Haynes queries, as three of these queries were found to yield significantly different results from the OvidSP MEDLINE search. The author recommends that OvidSP be the search interface of choice when using these hedges in MEDLINE. The National Library of Medicine’s (NLM) Systematic Reviews hedge has been translated into OvidSP and EBSCO, but has never been validated. The author found significant errors in this hedge in the OvidSP version, which were rectified after she contacted Ovid. However, Ovid was reluctant to share its translation of the hedge, as this is proprietary information. The author recommends that for this reason, it is best to use PubMed to search for systematic reviews, as the search string for its hedge is publicly available. The author also notes that this issue of proprietary information is very problematic for librarians, as it makes it impossible for them to assess the hedges they are using from vendors, or to identify the source of the problem when they get unusual results.


2012 ◽  
Vol 7 (3) ◽  
pp. 95
Author(s):  
Kate Kelly

Objective – To determine whether the use of PubMed methods-based filters and topic-based filters, alone or in combination, improves physician searching. Design – Mixed methods, survey questionnaire, comparative. Setting – Canada. Subjects – Random sample of Canadian nephrologists (n=153), responses (n=115), excluded (n=15), total (n=100). Methods – The methods are described in detail in a previously published study protocol by a subset of the authors (Shariff et al., 2010). One hundred systematic reviews on renal therapy were identified using the EvidenceUpdates service (http://plus.mcmaster.ca/EvidenceUpdates) and a clinical question was derived from each review. Randomly-selected Canadian nephrologists were randomly assigned a unique clinical question derived from the reviews and asked, by survey, to provide the search query they would use to search PubMed. The survey was administered until one valid search query for each of the one hundred questions was received. The physician search was re-executed and compared to searches where either or both methods-based and topic-based filters were applied. Nine searches for each question were conducted: the original physician search, a broad and narrow form of the clinical queries therapy filter, a broad and narrow form of the nephrology topic filter and combinations of broad and narrow forms of both filters. Significance tests of comprehensiveness (proportion of relevant articles found) and efficiency (ratio of relevant to non-relevant articles) of the filtered and unfiltered searches were conducted. The primary studies included in the systematic reviews were set as the reference standard for relevant articles. As physicians indicated they did not scan beyond two pages of default PubMed results, primary analysis was also repeated on search results restricted to the first 40 records. The ability of the filters to retrieve highly-relevant or highly-cited articles was also tested, with an article being considered highly-relevant if referenced by UpToDate and highly-cited if its citation count was greater than the median citation count of all relevant articles for that question – there was an average of eight highly-cited articles per question. To reduce the risk of type I error, the conservative method of Bonferroni was applied so that tests with a p less than 0.003 were interpreted as statistically significant. Main Results – Response rate 75%. Physician-provided search terms retrieved 46% of relevant articles and a ratio of relevant to non-relevant articles of 1:16 (p less than 0.003). Applying the narrow forms of both the nephrology and clinical queries filters together produced the greatest overall improvement, with efficiency improving by 16% and comprehensiveness remaining unchanged. Applying a narrow form of the clinical queries filter increased efficiency by 17% (p less than 0.003) but decreased comprehensiveness by 8% (p less than 0.003). No combination of search filters produced improvements in both comprehensiveness and efficiency. When results were restricted to the first 40 citations, the use of the narrow form of the clinical queries filter alone improved overall search performance – comprehensiveness improved from 13% to 26 % and efficiency from 5.5% to 23%. For highly-cited or highly-relevant articles the combined use of the narrow forms of both filters produced the greatest overall improvement in efficiency but no significant change in comprehensiveness. Conclusion – The use of PubMed search filters improves the efficiency of physician searches and saves time and frustration. Applying clinical filters for quick clinical searches can significantly improve the efficiency of physician searching. Improved search performance has the potential to enhance the transfer of research into practice and improve patient care.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ana Penedones ◽  
Carlos Alves ◽  
Francisco Batel-Marques

Abstract Background This scoping review aims to identify, review and characterize the published recommendations to conduct and/or to report a systematic review in medical interventions area. Methods A search was carried out in PubMed, EMBASE and Cochrane Library databases, using systematic reviews search filters. The search comprises all recommendations to conduct and/or report a systematic review. Data on methods were extracted from each recommendation. A descriptive analysis was performed. Results Eighty-three recommendations were identified. Approximately 60% of retrieved references were published in the last 6 years. Recommendations to both conduct and report a systematic review were issued in 47% studies. The guidance presented in each recommendation to conduct and/ or report a systematic review varied. Almost 96% of the recommendations offer guidance on systematic review methods section. The need and time for updating was only recommended in 29% of recommendations. Forty percent of recommendations endorsed their methods to any subject related to medical interventions. Half of the studies did not specify the design of studies to be included in a systematic review. Conclusions Several recommendations to conduct and/or report a systematic review were published and offered different guidance. Further research on the impact of such heterogeneity can improve systematic reviews quality.


2021 ◽  
Vol 109 (1) ◽  
Author(s):  
Alison C. Bethel ◽  
Morwenna Rogers ◽  
Rebecca Abbott

Background: Systematic reviews are comprehensive, robust, inclusive, transparent, and reproducible when bringing together the evidence to answer a research question. Various guidelines provide recommendations on the expertise required to conduct a systematic review, where and how to search for literature, and what should be reported in the published review. However, the finer details of the search results are not typically reported to allow the search methods or search efficiency to be evaluated.Case Presentation: This case study presents a search summary table, containing the details of which databases were searched, which supplementary search methods were used, and where the included articles were found. It was developed and published alongside a recent systematic review. This simple format can be used in future systematic reviews to improve search results reporting.Conclusions: Publishing a search summary table in all systematic reviews would add to the growing evidence base about information retrieval, which would help in determining which databases to search for which type of review (in terms of either topic or scope), what supplementary search methods are most effective, what type of literature is being included, and where it is found. It would also provide evidence for future searching and search methods research.


2021 ◽  
pp. 175045892199469
Author(s):  
Veronica Phillips ◽  
Eleanor Barker

This article aims to provide an overview of the structure, form and content of systematic reviews. It focuses in particular on the literature searching component, and covers systematic database searching techniques, searching for grey literature and the importance of librarian involvement in the search. It also covers systematic review reporting standards such as PRISMA-P and PRISMA, critical appraisal and tools and resources to support the review and ensure it is conducted efficiently and effectively. Finally, it summarizes the requirements when screening search results for inclusion in the review, and the statistical synthesis of included studies’ findings.


2020 ◽  
Vol 25 (44) ◽  
pp. 4695-4701 ◽  
Author(s):  
Georgios Karaolanis ◽  
Zachary F. Williams ◽  
Chris Bakoyiannis ◽  
Dimitrios Hadjis ◽  
Mitchell W. Cox ◽  
...  

: The widespread adoption of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA) is due to the obvious advantages of the procedure compared to the traditional open repair. However, these advantages have to be weighed against the increased risk of renal dysfunction with EVAR. The evaluation of the perioperative renal function after EVAR has been hampered by the lack of sensitive and specific biochemical markers of acute kidney injury (AKI). The purpose of this study was to summarize all novel renal biomarkers and to evaluate their clinical utility for the assessment of the kidney function after EVAR. A systematic review of the current literature, as the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines, was performed to identify relevant studies with novel renal biomarkers and EVAR. Pubmed and Scopus databases were systemically searched. Studies reporting on thoracic endovascular aortic repair (TEVAR), case reports, case series, letters to the editor, and systematic reviews were excluded. Neutrophil-Gelatinase-Associated Lipocalin, Cystatin C, Liver-type fatty-acid-binding protein were the most common among the eligible studies while Interleukin-18, Retinol binding protein, N-acetyle-b-D-glucosaminidase and microalbumin have a sparse appearance in the literature. These biomarkers have been assessed in plasma as well as urine samples with each sample material having its own advantages and drawbacks. Which of these biomarkers has the most potential for assessing postoperative renal failure after EVAR, remains to be proved. The few studies presented in the literature show the potential clinical utility of these biomarkers, but larger studies with longer follow-up are required to determine the precise relationship between these biomarkers and postoperative acute kidney injury.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ryan Chow ◽  
Eileen Huang ◽  
Allen Li ◽  
Sophie Li ◽  
Sarah Y. Fu ◽  
...  

Abstract Background Postpartum depression (PPD) is a highly prevalent mental health problem that affects parental health with implications for child health in infancy, childhood, adolescence and beyond. The primary aim of this study was to critically appraise available systematic reviews describing interventions for PPD. The secondary aim was to evaluate the methodological quality of the included systematic reviews and their conclusions. Methods An electronic database search of MEDLINE, Embase, and the Cochrane Library from 2000 to 2020 was conducted to identify systematic reviews that examined an intervention for PPD. A Measurement Tool to Assess Systematic Reviews was utilized to independently score each included systematic review which was then critically appraised to better define the most effective therapeutic options for PPD. Results Of the 842 studies identified, 83 met the a priori criteria for inclusion. Based on the systematic reviews with the highest methodological quality, we found that use of antidepressants and telemedicine were the most effective treatments for PPD. Symptoms of PPD were also improved by traditional herbal medicine and aromatherapy. Current evidence for physical exercise and cognitive behavioural therapy in treating PPD remains equivocal. A significant, but weak relationship between AMSTAR score and journal impact factor was observed (p = 0.03, r = 0.24; 95% CI, 0.02 to 0.43) whilst no relationship was found between the number of total citations (p = 0.27, r = 0.12; 95% CI, − 0.09 to 0.34), or source of funding (p = 0.19). Conclusion Overall the systematic reviews on interventions for PPD are of low-moderate quality and are not improving over time. Antidepressants and telemedicine were the most effective therapeutic interventions for PPD treatment.


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