Hubungan Rhinitis Alergi Terhadap Prestasi Belajar

Pendahuluan: rhinitis alergi merupakan bentuk rhinitis kronis yang paling sering ditemukan. Sekitar lebih dari 10% penduduk di dunia mengalami rhinitis alergi. Belum diketahui dengan jelas dampak rhinitis alergi terhadap performa akademik. Tujuan: Mengetahui dampak rhinitis alergi pada performa akademik. Metode: Menggunakan literature searching dengan mencari kata kunci rhinitis alergi, academic performance, dan quality of life pada database seperti NCBI, Pubmed, dan Google Scholar yang kemudian discreening judul dan abstraknya kemudian dijadikan sumber literature untuk literature review ini. Hasil: Ditemukan dampak negatif pada performa akademik penderita rhinitis alergi yang tidak terkontrol ataupun yang berat, sedangkan pada rhinitis alergi ringan ataupun terkontrol didapatkan performa akademik yang meningkat, yang dapat dikarenakan latar belakang penderita rhinitis alergi yang lebih sering berada di negara maju dan urban yang notabene memiliki kultur kompetitif tinggi. Kesimpulan: Terdapat hubungan yang bermakna antara rhinitis alergi dengan prestasi belajar

Quotation Accuracy of Systematic Review and Meta-Analysis Protocols on Acupuncture

Currently, published systematic review protocols (SR protocols) have increasingly become a new trend in fields such as acupuncture and are therefore a new source of quotations in these fields. Systematic reviews are considered the pinnacle of the evidence pyramid as they embody comprehensive literature searching. Quotations are key elements to achieve this goal as they can support the assertions of the original authors, but the ‘misquotation’ exists, too, and they can be misleading to the reader. The aim of this study was to examine the quotation accuracy of SR protocols in a meta-analysis on acupuncture research. We searched SCOPUS through 31 December, 2020, and each protocol and its citations were analyzed and classified as correct or incorrect. We used descriptive statistics to report the quotation errors and characteristics of the included protocols. The results showed 248 SR protocols, where 124 protocols received quotations and 38 quotations (31.4%) were erroneous. Only 11 (4.4%) of the published SRs and SR protocols had been published previously. Furthermore, the scientific journal in which the most SR protocols were published was Medicine (193; 77.8%), followed by BMJ Open (39; 15.7%). Authors from China (86.5%) were the most productive in publishing SRs and SR protocols. Finally, we concluded that the number of SR protocols and meta-analyses published in scientific journals and indexed by databases exceeds the publication capacity of the SRs associated with them, generating scientific literature that does not make any novel contribution to knowledge.

OP128 Improving Literature Searching For Evidence On Health Apps: The National Institute For Health And Care Excellence (NICE) MEDLINE And Embase (Ovid) Health Apps Search Filters

IntroductionLiterature searching for evidence on apps in bibliographic databases is challenging because they are often described with inconsistent terminology. Information Specialists from the United Kingdom's National Institute for Health and Care Excellence (NICE) have developed validated search filters for retrieving evidence about apps from MEDLINE and Embase (Ovid) reliably.MethodsMedical informatics journals were hand-searched to create a ‘gold standard’ set of app references. The gold standard set was divided into two sets. The development set provided the search terms for the filters. The filters were validated by calculating their recall against the validation set. Target recall was >90%.A case study was then conducted to compare the number-needed-to-read (NNR) of the filters with previous non-validated MEDLINE and Embase app search strategies used for the ‘MIB214 myCOPD app’ NICE topic. NNR is the number of references screened to find each relevant reference.ResultsThe MEDLINE and Embase filters achieved 98.6 percent and 98.5 percent recall against the validation set, respectively. In the case study they achieved 100 percent recall, reducing NNR from 348 to 147 in MEDLINE and from 456 to 271 in Embase.ConclusionsThe novel NICE health apps search filters retrieve evidence on apps from MEDLINE and Embase effectively and more efficiently than previous non-validated search strategies used at NICE.

Chronic Kidney Disease Among Workers Exposed To Perfluorooctanoic Acid (PFOA)

Background: Perfluorooctanoic acid (PFOA), a class of perfluorocarbons, are synthetic environmental contaminants. Their long biological half-lives and their poor ability to metabolize likely add to any chronic health effects they may pose, such as chronic kidney disease (CKD). The causal relationship between PFOA and CKD is still unclear, so it is necessary to look for some evidence regarding this relationship. The search for evidence is also complemented by a seven-step occupational disease assessment to establish occupational diseases. Aim: This study aims to justify chronic kidney disease of workers exposed to perfluorooctanoic acid can be diagnosed as occupational diseases.Methods: Searching literature for the evidence-based has been conducted with a clinical question through “PICO” method. Then continued with literature searching using the electronic database “PubMed”, “JSTOR”, and “Scopus” search engine. The keyword is “PFOA” “perfluoroalkyl substances” “perfluorooctanoic acid” “chronic kidney” “chronic kidney disease” “CKD” and combined with MeSH terms and Boolean operation. The inclusion criteria are research on humans, English language, and the exclusion is retracted articles.Result: From the five literatures obtained, there are differences in results. A study of workers exposed to perfluorooctanoic acid in a DuPont chemical plant with chronic kidney disease was (Standardized Mortality Ratios (SMR) = 3.11, 95% CI: 1.66, 5.32). Study in China found that perfluorooctanoic acid is not associated with renal function and higher risk of CKD (OR = 0.73, 95% CI: 0.57, 0.95; p=0.019).Conclusion: There are insignificant associations between perfluorooctanoic acid and chronic kidney disease.

Video killed the multiple-choice quiz: capturing pharmacy students’ literature searching skills using a screencast video assignment

Background: In a flipped, required first-year drug information course, students were taught the systematic approach to answering drug information questions, commonly utilized resources, and literature searching. As co-coordinator, a librarian taught three weeks of the course focused on mobile applications, development of literature searching skills, and practicing in PubMed. Course assignments were redesigned in 2019 based on assessment best practices and replaced weekly multiple-choice quizzes used in prior iterations of the course.Case Presentation: Following two weeks of literature searching instruction, students were assigned a drug information question that would serve as the impetus for the search they conducted. Students (n=66) had one week to practice and record a screencast video of their search in PubMed. Students narrated their video with an explanation of the actions being performed and were assessed using a twenty-point rubric created by the course coordinator and librarian. The librarian also created general feedback videos for each question by recording screencasts while performing the literature searches and clarifying troublesome aspects for students. The librarian spent about twenty-four hours grading and six hours writing scripts, recording, and editing feedback videos.Conclusion: Most students performed well on the assignment and few experienced technical difficulties. Instructors will use this assignment and feedback method in the future. Screencast videos proved an innovative way to assess student knowledge and to provide feedback on literature searching assignments. This method is transferrable to any medical education setting and could be used across all health professions to improve information literacy skills.

Processes for updating guidelines: protocol for a systematic review

Background: National Clinical Guidelines are systematically developed statements, based on a thorough evaluation of the evidence, to assist practitioner and service users’ decisions. Clinical guidelines require updating to ensure validly of the recommendations contained within. The purpose of this systematic review is to describe the most recent guideline update processes, including prioritisation methods, used by international or national groups who provide methods guidance for developing and updating clinical guidelines. Methods: A combination of searching a pre-defined list of international and national organisations that provide methods guidance for developing and updating clinical guidelines, together with grey literature searching, will be undertaken to identify relevant handbooks. This will be supplemented by a systematic literature search of Medline (EBSCO), Embase (OVID) and The Cochrane Methodology Register. As guideline development methodology has evolved considerably, the overall search span for this systematic review will be the last 10-years (2011-2021). Publications eligible for inclusion are methodological handbooks that provide updating guidance, including prioritisation methods, for clinical practice guidelines and peer-reviewed articles that describe or have implemented updating guidance, including prioritisation methods. Using Covidence, two reviewers will independently review titles/abstracts and full texts. Where disagreements occur, discussions will be held to reach consensus and where necessary, a third reviewer will be involved. Methodological handbooks will be quality assessed (using the GIN-McMaster Guideline Development Checklist) independently by two reviewers and any disagreements will be resolved by deliberation, or if necessary, a third reviewer. Data will be extracted by one reviewer and checked for inaccuracies/omissions by a second. A narrative synthesis will be undertaken. Conclusions: Updating clinical guidelines is an iterative process that is both resource intensive and time-consuming. The findings of this systematic review will support clinical guideline developers to ensure appropriate investment of resources.

Somatostatin Analogue Therapy in MEN1-Related Pancreatic Neuroendocrine Tumors from Evidence to Clinical Practice: A Systematic Review

Introduction: Neuroendocrine neoplasms (NENs) are relatively rare and complex tumors that can be sporadic or hereditary, as in the context of multiple endocrine neoplasia type 1 (MEN1) where patients display a 70% lifelong risk of developing a pancreatic NENs (pNENs). To date, specific personalized treatment for pNENs in patients with MEN1 are lacking. The aim of this study was to systematically analyze the efficacy and safety of somatostatin analogue (SSA) treatment in patients affected by MEN1-related pNENs. Materials and Methods: We performed a systematic review of the literature, searching for peer-reviewed articles on SSA (octreotide or lanreotide) treatment in MEN1 associated with pNENs. Results: We selected 20 studies with a pooled population of 105 MEN1 patients with pNENs. Females were 58.5%, median age was 44 years (18–73). TNM stage at diagnosis was stage I-II in 84.8% and stage IV in 15.2%. The overall response rate (SD+PR+CR) was achieved in 88.3% of cases, with stable disease in 75.6% and objective response in 12.7% of patients. The safety profile was favorable with both SSA agents. Conclusions: SSAs appear to be an effective and safe treatment option for MEN1-related pNEN, either at localized or advanced stages.

Effects of Lipoic Acid on Ischemia-Reperfusion Injury

Ischemia-reperfusion (I/R) injury often occurred in some pathologies and surgeries. I/R injury not only harmed to physiological functions of corresponding organ and tissue but also induced multiple tissue or organ dysfunctions (even these in distant locations). Although the reperfusion of blood attenuated I/R injury to a certain degree, the risk of secondary damages was difficult to be controlled and it even caused failures of these tissues and organs. Lipoic acid (LA), as an endogenous active substance and a functional agent in food, owns better safety and effects in our body (e.g., enhancing antioxidant activity, improving cognition and dementia, controlling weight, and preventing multiple sclerosis, diabetes complication, and cancer). The literature searching was conducted in PubMed, Embase, Cochrane Library, Web of Science, and SCOPUS from inception to 20 May 2021. It had showed that endogenous LA was exhausted in the process of I/R, which further aggravated I/R injury. Thus, supplements with LA timely (especially pretreatments) may be the prospective way to prevent I/R injury. Recently, studies had demonstrated that LA supplements significantly attenuated I/R injuries of many organs, though clinic investigations were short at present. Hence, it was urgent to summarize these progresses about the effects of LA on different I/R organs as well as the potential mechanisms, which would enlighten further investigations and prepare for clinic applications in the future.

COMPARISON FOR CARICA PAPAYA AND GENGIGEL LEAVES EXTRACTION FOR GINGIVITIS HEALING EFFECTIVENESS IN ORTHODONTIC APPLICATION

Background: Gingivitis is the infection disease with tooth loss effect. Using fixed orthodontic appliance in dentistry can give gingivitis impact with its’ designed way. To determine the effectiveness of papaya leaf extraction and gengigel in gingivitis treatment with fixed orthodontic application in letrature review explanation Methods: Literature searching with Science Direct, NCBI (PubMed), and Google Scholar databases and getting 530 articles. Articles are screened to be 67 articles and selected by inclusion and exclusion criteria getting 37 articles. 37 Articles are ready to be analysed. Results:There is effectiveness of papaya leaf extract and gengigel in patients using fixed orthodontic appliances for giving anti inflammation effect, wound healing and enhance blood circulation. Conclusion: The conclusion is papaya and gengigel leaf extraction giving gingivitis healing effect in fixed orthodontic treatment