scholarly journals Properties of Ganoderma lucidum triterpenes

2019 ◽  
Vol 73 ◽  
pp. 345-352
Author(s):  
Ewa Seweryn ◽  
Anna Ziała ◽  
Andrzej Gamian
Keyword(s):  
Fatty Acids ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chronic Diseases ◽  
Ganoderma Lucidum ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
Medicinal Mushroom ◽  
Asian Countries ◽  
Medicinal Properties

Ganoderma lucidum has been used for promoting longevity and health in traditional Chinese medicine (TCM) in Asian countries. Its pharmacological effects are widely known, as indicated by its inclusion in the American Herbal Pharmacopoeia. It was found that G. lucidum contains several bioactive compounds, including triterpenes, polysaccharides, peptidoglycans, flavonoids, sterols, fatty acids and nucleotides. It is well-known medicinal mushroom that has been widely used for the treatment of several chronic diseases. It has been reported that triterpenes are responsible for the major medicinal properties and demonstrated therapeutic efficiency of G. lucidum. The present review mainly focuses on the pharmacological properties of the triterpenes underlying antioxidative, anticancer, anti-inflammatory, antidiabetes and hepatoprotective activities.

System Pharmacological Mechanism and Compatibility Laws of Jianghuang from Traditional Chinese Medicine In Blood-Regulating Formulae

2020 ◽  
Author(s):  
Zhiqiang Liu ◽  
Bolong Wang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Kegg Pathway ◽  
Inflammatory Diseases ◽  
Enrichment Analysis ◽  
Pathway Enrichment Analysis ◽  
Pharmacological Effects ◽  
Ppi Network ◽  
Pathway Enrichment ◽  
Pharmacological Mechanism

Abstract Background: Jianghuang (JH) is a popular ingredient in blood-regulating traditional Chinese Medicine (TCM) that could be effective for the treatment of various diseases. We demonstrate the compatibility laws and system pharmacological mechanisms of the key formula containing JH by leveraging data mining of bioinformatics databases.Material/Methods: The compatibility laws of blood-regulating formulae containing JH from the Chinese Traditional Medicine Formula Dictionary were analyzed using a generalized rule induction (GRI) algorithm implemented. The putative target gene and miRNA were retrieved via a combination of the Arrowsmith knowledge discovery tool and FunRich 3.1.3. System pharmacological mechanisms are traced by their protein-protein interaction (PPI) network, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was conducted using Uniprot, the Human Protein Atlas (HPA), STRING 11.0, and KOBAS 3.0.Results: We found that the JH-CX-DG formula (Ligusticum chuanxiong-Angelica sinensis) could represent a key formula containing JH in blood-regulating TCM formulae. The JH-CX-DG formula was observed to directly target AKT, TLR4, caspase-3, PI3K, mTOR, p38 MAPK, VEGF, iNOS, Nrf2, BDNF, NF-κB, Bcl-2, and Bax 13 targets and regulate targets through 13 miRNA. The PPI network and KEGG pathway enrichment analysis showed that the JH-CX-DG formula possess potential pharmacological effects including anti-inflammatory, improving microcirculation, and anti-tumor through the regulation of multiple pathways including PI3K/Akt, MAPK, Toll-like receptor, T cell receptor, EGFR, VEGFR, Apoptosis, HIF-1 (p < 0.05).Conclusion: The JH-CX-DG formula can exert beneficial pharmacological effects through multi-target and multi-pathway interactions. It can be effectively administered for the treatment of inflammatory diseases, microcirculation disorders, cardiovascular disease, and cancer. We found a new effective drug formula through analyzing the compatibility law and systemic pharmacological mechanism of JH. Our study provides a theoretical basis and directions for subsequent research on the JH-CX-DG formula.

Pharmacological Properties of Biocompounds from Spores of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes): A Review

2016 ◽  
Vol 18 (9) ◽  
pp. 757-767 ◽  
Author(s):  
Carlos Ricardo Soccol ◽  
Lucas Yamasaki Bissoqui ◽  
Cristine Rodrigues ◽  
Rosalia Rubel ◽  
Sandra R.B.R. Sella ◽  
...  
Keyword(s):  
Ganoderma Lucidum ◽  
Pharmacological Properties ◽  
Medicinal Mushroom

scholarly journals Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yongwang Yan ◽  
Xu Zhou ◽  
Kangxiao Guo ◽  
Feng Zhou ◽  
Hongqi Yang
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Peripheral Neuropathy ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chlorogenic Acid ◽  
Pharmacological Properties ◽  
Prevention And Treatment ◽  
Main Component

Chlorogenic acid (CA) is a phenolic compound commonly found in human plant-based diets. CA is the main component of many traditional Chinese medicine preparations, and in recent years, it has been found to have hypoglycemic, hypolipidemic, anti-inflammatory, antioxidant, and other pharmacological properties. Specifically, CA relieves the effects of, and prevents, diabetes mellitus (DM). In addition, CA is also beneficial against complications arising from DM, such as diabetic nephropathy (DN), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN). Herein, we review the use of CA in the prevention and treatment of DM and its complications, providing a background for further research and medical uses.

Ganoderma lucidum Polysaccharide Strengthens Antioxidant Defense Systems against Exercise-Induced Oxidative Stress in Liver of Mice

2014 ◽  
Vol 675-677 ◽  
pp. 1577-1579
Author(s):  
Lin Luo ◽  
Feng Yan ◽  
Bei Bei Wang
Keyword(s):  
Oxidative Stress ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Ganoderma Lucidum ◽  
Antioxidant Defense ◽  
Defense Systems ◽  
Medicinal Fungus ◽  
Traditional Remedy ◽  
Antioxidant Defense Systems ◽  
Exercise Induced

Ganoderma lucidum(G. lucidum), a medicinal fungus called ‘‘Lingzhi’’ in China is one of the most famous fungi in traditional Chinese medicine. For hundreds of years, this mushroom has been known as a traditional remedy for treatment of several diseases, such as hepatitis, hypertension, chronic bronchitis, bronchial asthma, cancer and others. Polysaccharide is an important pharmacological ingredient extracted from fruit bodies and mycelium ofG. lucidum. It has been extensively documented thatG. lucidumpolysaccharides (Gl-PS) had wide bioactivities, such as anti-aging, anti-tumor, hypoglycemic, immunomodulatory and immunotherapeutic activities [1]. In our previous studies, Gl-PS has been proven to have significant anti-hypoxia and anti-fatigue effects in mice [2], which suggesting that it might be beneficial to exercise-induced oxidative stress. Therefore, the purpose of this study was to investigate the effects of Gl-PS against exercise-induced oxidative stress in liver of mice.

scholarly journals Advances in Modern Pharmacology Research of Tabanus

2021 ◽  
Vol 5 (5) ◽  
pp. 117-119
Author(s):  
Yue Qu ◽  
Zhenyuan Hu ◽  
Yue Zhao
Keyword(s):  
Salivary Gland ◽  
Platelet Aggregation ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Special Focus ◽  
Pharmacological Effects ◽  
Active Components ◽  
Development And Utilization ◽  
The Rich ◽  
Further Development

Tabanus is a traditional Chinese medicine. In recent years, various protein active components derived from the Tabanus salivary gland have been explored, and many promising components were found to have therapeutic effect. The rich active components in its salivary gland have pharmacological effects, such as anti-platelet aggregation, anti-inflammatory, anti-infection, immunosuppression, anti-angiogenic, and anti-tumor effects. This paper summarizes findings from the related articles about Tabanus in recent years with a special focus on its pharmacological effects so as to provide reference for its further development and utilization.

scholarly journals MAJOR BIOACTIVE TRITERPENOIDS FROM GANODERMA SPECIES AND THEIR THERAPEUTIC ACTIVITY: A REVIEW

2019 ◽  
pp. 22-30 ◽  
Author(s):  
ZAHOOR AHMAD BHAT Bhat ◽  
ABDUL HAMID WANI ◽  
MOHD YAQUB BHAT ◽  
ABDUL RASHID MALIK
Keyword(s):  
Human Immunodeficiency Virus ◽  
Biological Activity ◽  
Chinese Medicine ◽  
Ganoderma Lucidum ◽  
Therapeutic Effects ◽  
High Grade ◽  
Therapeutic Activity ◽  
Immunodeficiency Virus ◽  
Medicinal Properties ◽  
Anti Inflammation

Ganoderma a traditional Chinese medicine popularly used for complementary cancer therapy and longevity for centuries. The vast amount of study has been performed on the medicinal properties of Ganoderma lucidum. G. lucidum contains various compounds with a high grade of biological activity, which increase the immunity. Several of these substances belong to the triterpenoids and polysaccharides. Proteins, sterols, phenols, lipids, etc., are also present. Ganoderma triterpenes are important secondary metabolites of G. lucidum. Ganoderma triterpenes are limestone-tetracyclic terpenes which have been reported to possess antioxidant, antitumor, anti-human immunodeficiency virus, anticancer, anti-inflammation, cytotoxic, hepatoprotective, and neuroprotective activities. This review deals with most important triterpenes isolated from Ganoderma and their therapeutic effects.

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