scholarly journals Biochemical Measurement of Injury and Inflammation in Musculoskeletal Surgeries

10.5772/26097 ◽  
2012 ◽  
Author(s):  
Dinesh Kumbhare ◽  
William Parkinson ◽  
R. Brett ◽  
Anthony Adili
Keyword(s):  
Biochemical Measurement

Serum Vitamin B12 Concentrations among Mothers and Newborns and Follow-up Study to Assess Implication on the Growth Velocity and the Urinary Methylmalonic Acid Excretion

2009 ◽  
Vol 79 (56) ◽  
pp. 297-307 ◽  
Author(s):  
Laila Hussein ◽  
Sahar Abdel Aziz ◽  
Salwa Tapouzada ◽  
Boehles
Keyword(s):  
Early Diagnosis ◽  
Growth Velocity ◽  
Methylmalonic Acid ◽  
Post Partum ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Postnatal Life ◽  
Negative Consequences ◽  
Metabolic Marker ◽  
Biochemical Measurement

Objective:Cobalamin (B12) deficiency has been reported in infants born to mothers with low cobalamin intake. Early diagnosis of vitamin B12 deficiency in infants is critical for the prevention of neurobehavioral disorders. We investigated the relationship between serum vitamin B12 level in newborns and in their healthy mothers who consumed an omnivorous diet. Anthropometry was studied longitudinally to assess the growth velocity of the infants. Urinary methylmalonic acid (MMA) excretion of 6-month old infants was compared retrospectively as the biomarker correlated with the initial serum vitamin B12 concentrations. Methods: Serum cobalamin and blood hemoglobin were determined in 84 pairs of newborns and their mothers. Urinary MMA excretion was measured in the same subjects during the first 6 months of the post partum period. Results: At birth, median serum cobalamin levels were 152.0 pmol/L in the mothers and 296.6 pmol/L in the newborns. Maternal and neonatal serum cobalamin levels had no effect on growth velocity during the first six months of postnatal life. Serum maternal and neonatal cobalamin levels were inversely associated with urinary MMA excretion. Conclusion: Early diagnosis of vitamin B12 status in neonates and infants is crucial, particularly in nutritionally deprived areas. Biochemical measurement of plasma cobalamin or its metabolic marker MMA is highly recommended. Urinary MMA measurement in cobalamin diagnostics provides an advantage in that blood sampling is not required. A vitamin B12 taskforce should be created to alleviate vitamin deficiency and its negative consequences.

Quantitative Radioisotope Measurement of Duodenogastric Reflux in Patients with Ulcer or Gastrectomized for Ulcer

1985 ◽  
Vol 24 (03) ◽  
pp. 107-110
Author(s):  
M. Pääkkönen ◽  
S. Aukee ◽  
K. Korhonen ◽  
A. Pääkkönen ◽  
E. Länsimies ◽  
...  
Keyword(s):  
Gamma Camera ◽  
Background Activity ◽  
Bile Reflux ◽  
Duodenogastric Reflux ◽  
Upper Limit ◽  
Visual Evidence ◽  
Biochemical Measurement

SummaryIn this work the duodenogastric reflux was quantified as the amount of radioactivity entering the stomach after an i.v. administration of 99mmTc-HIDA in ulcer patients and in patients who had undergone BI gastrectomy. The results were compared with visual evidence of gastric activity in the gamma camera images and biochemical determination of gastric bile reflux. The method is useful in quantifying the reflux if the activity is above the background activity. It allows the determination of an upper limit for the reflux when the reflux is evident visually. Only two or three images are needed for the quantitation. No correlation was found between biochemical measurement of fasting bile reflux in the stomach and radioisotopic quantification.

scholarly journals Inconsistencies in measurement of fish condition: a comparison of four indices of fat reserves for Atlantic herring (Clupea harengus)

2010 ◽  
Vol 68 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Lindsay R. McPherson ◽  
Aril Slotte ◽  
Cecilie Kvamme ◽  
Sonnich Meier ◽  
C. Tara Marshall
Keyword(s):  
Clupea Harengus ◽  
Physiological Status ◽  
Atlantic Herring ◽  
Fish Condition ◽  
Fat Reserves ◽  
Mesenteric Fat ◽  
Morphometric Index ◽  
Biochemical Measurement ◽  
Biochemical Indices ◽  
The Relationship

Abstract McPherson, L. R., Slotte, A., Kvamme, C., Meier, S., and Marshall, C. T. 2011. Inconsistencies in measurement of fish condition: a comparison of four indices of fat reserves for Atlantic herring (Clupea harengus). – ICES Journal of Marine Science, 68: 52–60. Condition is often equated to the magnitude of fat reserves, which can be represented by biochemical, bioenergetic, or morphometric indices. Biochemical indices are technically more demanding, but are direct measures of fat, in contrast to morphometric indices which are easier to measure but are only surrogates of physiological status or condition. This study compared Fulton's K (K), a common morphometric index, with two bioenergetic indices, mesenteric fat and muscle fat content, measured by a commercial fatmeter in Atlantic herring. Fatmeter values and K were also compared with a biochemical measurement of muscle fat. The relationship between K and mesenteric fat was inconsistent and often non-existent. The relationship between K and fatmeter values was stronger for fish with inactive gonads, and the biochemical measure displayed a much stronger correlation with fatmeter values than with K. Studies need explicitly to define condition and ideally validate it against a benchmark, such as a biochemical index.

scholarly journals Therapeutic Effects of TianDiJingWan on the Aβ25–35-Induced Alzheimer’s Disease Model Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Zhijie Li ◽  
Qing Tong ◽  
Huifang Xu ◽  
Li Hu ◽  
Rong Zhao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Disease Model ◽  
Male Rats ◽  
Sham Operation ◽  
Therapeutic Effects ◽  
Medicine Prescription ◽  
Chinese Medicine Prescription ◽  
Biochemical Measurement ◽  
Kidney Essence ◽  
Chinese Medicine Theory

The main purpose of this study was to demonstrate the therapeutic effects and mechanism of TDJW, a modern Chinese medicine prescription developed based on the basic traditional Chinese medicine theory of “tonifying the kidney essence,” on the Aβ25–35-induced AD rats. The AD model was established by the intracerebroventricular administrations of Aβ25–35into the hippocampus CA1 tissue of SD male rats. 72 rats were randomly divided into six groups: sham operation, AD model, donepezil, high TDJW group, medium TDJW group, and low TDJW group. After oral administration of TDJW, the results of Morris water maze and step-down test showed that the learning and memory abilities of AD rats were significantly improved. And biochemical measurement demonstrated that Ach and Glu in hippocampus tissues of AD rats were increased as well. Moreover, the Aβdeposits and p-Tau aggregations in hippocampus CA1 tissues of AD rats were attenuated as observed in the micrographs of immunohistochemistry study, and the results of ELISA indicated that the expressions of TNF-α, IL-1β, and IL-6 in hippocampus tissues were significantly decreased. In conclusion, the present study demonstrated that TDJW could be used as a promising therapeutic agent for the clinical applications of AD treatment in patients.

Biochemical Measurement of Glycogen: Method to Investigate the AMPK-Glycogen Relationship

2018 ◽  
pp. 57-67
Author(s):  
Elite Possik ◽  
Arnim Pause
Keyword(s):  
Biochemical Measurement

scholarly journals Biochemical Measurement of Neonatal Hypoxia

10.3791/2948 ◽  
2011 ◽  
Author(s):  
Megan S. Plank ◽  
Teleka C. Calderon ◽  
Yayesh Asmerom ◽  
Danilo S. Boskovic ◽  
Danilyn M. Angeles
Keyword(s):  
Neonatal Hypoxia ◽  
Biochemical Measurement

scholarly journals Preclinical evaluation of human secretoglobin 3A2 in mouse models of lung development and fibrosis

2014 ◽  
Vol 306 (1) ◽  
pp. L10-L22 ◽  
Author(s):  
Yan Cai ◽  
Melissa E. Winn ◽  
John K. Zehmer ◽  
William K. Gillette ◽  
Jacek T. Lubkowski ◽  
...  
Keyword(s):  
Growth Factor ◽  
Lung Development ◽  
Therapeutic Agent ◽  
Ex Vivo ◽  
Clinical Settings ◽  
Biochemical Measurement ◽  
Lung Airways ◽  
Further Development ◽  
Embryonic Lungs

Secretoglobin (SCGB) 3A2 is a member of the SCGB gene superfamily of small secreted proteins, predominantly expressed in lung airways. We hypothesize that human SCGB3A2 may exhibit anti-inflammatory, growth factor, and antifibrotic activities and be of clinical utility. Recombinant human SCGB3A2 was expressed, purified, and biochemically characterized as a first step to its development as a therapeutic agent in clinical settings. Human SCGB3A2, as well as mouse SCGB3A2, readily formed a dimer in solution and exhibited novel phospholipase A2 inhibitory activity. This is the first demonstration of any quantitative biochemical measurement for the evaluation of SCGB3A2 protein. In the mouse as an experimental animal, human SCGB3A2 exhibited growth factor activity by promoting embryonic lung development in both ex vivo and in vivo systems and antifibrotic activity in the bleomycin-induced lung fibrosis model. The results suggested that human SCGB3A2 can function as a growth factor and an antifibrotic agent in humans. When SCGB3A2 was administered to pregnant female mice through the tail vein, the protein was detected in the dam's serum and lung, as well as the placenta, amniotic fluids, and embryonic lungs at 10 min postadministration, suggesting that SCGB3A2 readily crosses the placenta. The results warrant further development of recombinant SCGB3A2 as a therapeutic agent in treating patients suffering from lung diseases or preterm infants with respiratory distress.

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