Immune Response Activation and Immunomodulation

2019 ◽  
Keyword(s):  
Immune Response ◽  
Response Activation

New developments in drugs enhancing the immune response: activation of lymphocytes and accessory cells by muramyl-dipeptides

1979 ◽  
pp. 133-160 ◽  
Author(s):  
R. H. Gisler ◽  
F. M. Dietrich ◽  
G. Baschang ◽  
A. Brownbill ◽  
G. Schumann ◽  
...  
Keyword(s):  
Immune Response ◽  
New Developments ◽  
Accessory Cells ◽  
Response Activation

scholarly journals Immune response activation following hyperthermic intraperitoneal chemotherapy for peritoneal metastases: A pilot study

2020 ◽  
Vol 11 (6) ◽  
pp. 397-404
Author(s):  
Giammaria Fiorentini ◽  
Donatella Sarti ◽  
Alberto Patriti ◽  
Emilio Eugeni ◽  
Francesco Guerra ◽  
...  
Keyword(s):  
Immune Response ◽  
Pilot Study ◽  
Intraperitoneal Chemotherapy ◽  
Hyperthermic Intraperitoneal Chemotherapy ◽  
Peritoneal Metastases ◽  
Response Activation

scholarly journals The Production and characterization of Polyclonal Antibodies Against Interferon Alpha in Mice

2021 ◽  
Vol 3 (4) ◽  
Author(s):  
Mehreen Fatima ◽  
Fatima Khalid ◽  
Azra Quraishi
Keyword(s):  
Immune Response ◽  
Autoimmune Diseases ◽  
Interferon Alpha ◽  
Polyclonal Antibodies ◽  
Mouse Serum ◽  
Interferon Production ◽  
Dot Blot ◽  
Western Blots ◽  
Response Activation

The polyclonal antibodies are used extensively for research purposes in many areas of biology, such as immunoprecipitation, histochemistry, enzyme linked immunosorbent assays (ELISA), diagnosis of disease and western blots. Typically, an animal’s immune system will generate a large group of antibodies that recognize several epitopes of a particular antigen. Interferon alpha plays an important role in immune response activation and therefore is of interest in studies related to autoimmune diseases. In this paper the production of antibodies against interferon was studied in order to quantify interferon production to analyze interferon levels in autoimmune disorders in the future. For the antibody production, one month old laboratory grade mice were injected with interferon alpha in combination with a Freund’s complete adjuvant for a course of five weeks after which the antibodies were obtained in mouse serum. Confirmation of the production of anti-interferon alpha antibodies was carried out by the Elisa, immune dot blot and western blot analysis. An interferon alpha of approximately 20.5-21.5 KDa was detected in immunedot blot test.  These antibodies may be produced in these mouse models commercially and could be used in future for treatment of autoimmune diseases by managing the interferon levels in the patients. Copyright(c) The Authors

The importance of eukaryotic ferritins in iron handling and cytoprotection

2015 ◽  
Vol 472 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Paolo Arosio ◽  
Fernando Carmona ◽  
Raffaella Gozzelino ◽  
Federica Maccarinelli ◽  
Maura Poli
Keyword(s):  
Immune Response ◽  
Innate Immunity ◽  
Animal Models ◽  
Storage Proteins ◽  
Eukaryotic Cells ◽  
Intracellular Iron ◽  
Iron Storage ◽  
Iron Incorporation ◽  
Iron Storage Proteins ◽  
Response Activation

Ferritins, the main intracellular iron storage proteins, have been studied for over 60 years, mainly focusing on the mammalian ones. This allowed the elucidation of the structure of these proteins and the mechanisms regulating their iron incorporation and mineralization. However, ferritin is present in most, although not all, eukaryotic cells, comprising monocellular and multicellular invertebrates and vertebrates. The aim of this review is to provide an update on the general properties of ferritins that are common to various eukaryotic phyla (except plants), and to give an overview on the structure, function and regulation of ferritins. An update on the animal models that were used to characterize H, L and mitochondrial ferritins is also provided. The data show that ferritin structure is highly conserved among different phyla. It exerts an important cytoprotective function against oxidative damage and plays a role in innate immunity, where it also contributes to prevent parenchymal tissue from the cytotoxicity of pro-inflammatory agonists released by the activation of the immune response activation. Less clear are the properties of the secretory ferritins expressed by insects and molluscs, which may be important for understanding the role played by serum ferritin in mammals.

scholarly journals Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus

2014 ◽  
Vol 59 (3) ◽  
pp. 354-361 ◽  
Author(s):  
Guy R. Adami ◽  
Alexander C.F. Yeung ◽  
Grant Stucki ◽  
Antonia Kolokythas ◽  
Herve Y. Sroussi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune Response ◽  
Lichen Planus ◽  
Innate Immune Response ◽  
Oral Lichen Planus ◽  
Innate Immune ◽  
Oral Lichen ◽  
Response Activation

Nanoparticles and Immune Cells

2019 ◽  
Vol 25 (37) ◽  
pp. 3960-3982
Author(s):  
Romina Mitarotonda ◽  
Exequiel Giorgi ◽  
Martín F. Desimone ◽  
Mauricio C. De Marzi
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Immune Cells ◽  
Human Exposure ◽  
Daily Life ◽  
Continuous Exposure ◽  
Biomedical Field ◽  
Industrial Settings ◽  
Response Activation

Nanoparticles have gained ground in several fields. However, it is important to consider their potentially hazardous effects on humans, flora, and fauna. Human exposure to nanomaterials can occur unintentionally in daily life or in industrial settings, and the continuous exposure of the biological components (cells, receptors, proteins, etc.) of the immune system to these particles can trigger an unwanted immune response (activation or suppression). Here, we present different studies that have been carried out to evaluate the response of immune cells in the presence of nanoparticles and their possible applications in the biomedical field.

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