scholarly journals The Potential Role of Nutraceuticals in Inflammation and Oxidative Stress

2020 ◽  
Author(s):  
Sevda Inan
Keyword(s):  
Oxidative Stress ◽  
Potential Role ◽  
And Oxidative Stress

Potential role of pulses in the development of functional foods modulating inflammation and oxidative stress

2022 ◽  
pp. 287-309
Author(s):  
Helena Ferreira ◽  
Elisabete Pinto ◽  
Ana M. Gil ◽  
Marta W. Vasconcelos
Keyword(s):  
Oxidative Stress ◽  
Functional Foods ◽  
Potential Role ◽  
And Oxidative Stress

scholarly journals Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress

2018 ◽  
Vol 9 ◽  
Author(s):  
Maria Sole Chimenti ◽  
Flavia Sunzini ◽  
Laura Fiorucci ◽  
Elisabetta Botti ◽  
Giulia Lavinia Fonti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Psoriatic Arthritis ◽  
Cytochrome C ◽  
Potential Role ◽  
And Oxidative Stress

scholarly journals Reversion of down-regulation of intestinal multidrug resistance-associated protein 2 in fructose-fed rats by geraniol and vitamin C: Potential role of inflammatory response and oxidative stress

2019 ◽  
Vol 68 ◽  
pp. 7-15 ◽  
Author(s):  
Felipe Zecchinati ◽  
Maria Manuela Barranco ◽  
Maite Rocío Arana ◽  
Guillermo Nicolás Tocchetti ◽  
Camila Juliana Domínguez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multidrug Resistance ◽  
Vitamin C ◽  
Inflammatory Response ◽  
Potential Role ◽  
Down Regulation ◽  
And Oxidative Stress

scholarly journals Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163827 ◽  
Author(s):  
Sabina Ranjit ◽  
Narasimha M. Midde ◽  
Namita Sinha ◽  
Benjamin J. Patters ◽  
Mohammad A. Rahman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Potential Role ◽  
Cytochromes P450 ◽  
Monocytic Cells ◽  
And Oxidative Stress

The potential role of Punica granatum treatment on murine malaria-induced hepatic injury and oxidative stress

2015 ◽  
Vol 115 (4) ◽  
pp. 1427-1433 ◽  
Author(s):  
Taghreed A. Hafiz ◽  
Murad A. Mubaraki ◽  
Saleh Al-Quraishy ◽  
Mohamed A. Dkhil
Keyword(s):  
Oxidative Stress ◽  
Hepatic Injury ◽  
Potential Role ◽  
Punica Granatum ◽  
And Oxidative Stress

scholarly journals Exploring Biologic Correlates of Cancer-Related Fatigue in Men With Prostate Cancer: Cell Damage Pathways and Oxidative Stress

2020 ◽  
Vol 22 (4) ◽  
pp. 514-519
Author(s):  
Kristin Dickinson ◽  
Adam J. Case ◽  
Kevin Kupzyk ◽  
Leorey Saligan
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Potential Role ◽  
Cell Damage ◽  
Cellular Responses ◽  
Preliminary Evidence ◽  
Cancer Related Fatigue ◽  
Targeted Treatments ◽  
And Oxidative Stress

The pathobiology of cancer-related fatigue (CRF) remains elusive, hindering the development of targeted treatments. Radiation therapy (RT), a common treatment for men with prostate cancer, induces cell damage through the generation of free radicals and oxidative stress. We hypothesized that disruption in cellular responses to this surge of nonphysiological oxidative stress might contribute to CRF in men with prostate cancer treated with RT. We evaluated the potential role of three cell damage pathways (apoptosis, autophagy, necrosis) and oxidative stress in CRF in men with prostate cancer receiving RT. Fatigue was measured by the Functional Assessment of Cancer Therapy-Fatigue (FACT-F) questionnaire. Gene expression was measured in whole blood using RT2 profiler™ PCR arrays. Data were collected at two time points: either baseline or Day 1 of treatment (T1) and completion of treatment (T2). Participants were grouped into either the fatigued or nonfatigued phenotype at T2 using the recommended FACT-F cut-off score for clinical significance. We observed significant upregulation of seven genes related to three cell damage pathways in the fatigued group from T1 to T2 and no significant changes in the nonfatigued group. We also observed significant downregulation of two genes related to oxidative stress in the fatigued group compared to the nonfatigued group at T2. These collective results provide preliminary evidence that cell damage might be upregulated in the CRF phenotype. Validation of these findings using a larger and more diverse sample is warranted.

scholarly journals Inter-Relationship between Platelet-Derived Microparticles and Oxidative Stress in Patients with Venous Thromboembolism

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1217
Author(s):  
Salvatore Santo Signorelli ◽  
Gea Oliveri Conti ◽  
Maria Fiore ◽  
Maria Grazia Elfio ◽  
Antonio Cristaldi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Venous Thromboembolism ◽  
Potential Role ◽  
Thiobarbituric Acid ◽  
Thiobarbituric Acid Reactive Substances ◽  
Circulating Microparticles ◽  
Galectin 3 ◽  
And Oxidative Stress ◽  
Control Study

Background: Hypercoagulative conditions play a key role in venous thromboembolism (VTE). Inflammation is currently linked to VTE, but the potential role of circulating microparticles and oxidative stress (OxS) must be elucidated. The aim of this study was to evaluate platelet-derived microparticles and surrogate OxS biomarkers in patients diagnosed with VTE through a case–control study. Methods: Platelet-derived microparticles (MPs), pro-thrombinase-induced clotting time assay (PiCT), phospholipids (PLPs), malondialdehyde (MDA), 4-hydroxynonenale (4-HNE), thiobarbituric acid reactive substances (TBARs), superoxide dismutase (SOD), and galectin-3 (Gal-3) were measured in VTE patients and in healthy controls. Results: PLPs, 4-HNE, TBARs, and Gal-3 were higher in VTE patients compared to controls; conversely, SOD was lower. A significant non-linear regression between OxS biomarkers and the markers of platelet degranulation was found. Conclusion: Our results suggest that OxS and platelet degranulation are concomitant pathophysiological mechanisms in VTE.

scholarly journals Potential Role of Microfibrillar-Associated Protein 4, Fibrotic Indices and Oxidative Stress in Hepatocellular Carcinoma

2018 ◽  
Vol 86 (4) ◽  
pp. 44 ◽  
Author(s):  
Mohamed Salama ◽  
Manal Nomir ◽  
Maryan Fahmi ◽  
Amal El-Gayar ◽  
Mamdouh El-Shishtawy
Keyword(s):  
Oxidative Stress ◽  
Hepatocellular Carcinoma ◽  
Potential Role ◽  
Control Group ◽  
Significant Elevation ◽  
Cirrhotic Patients ◽  
Mechanisms Of Persistence ◽  
And Oxidative Stress ◽  
Related Mortality

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. In an attempt to understand some potential mechanisms of persistence and oncogenicity of Hepatitis C virus (HCV)-related HCC, microfibrillar-associated protein 4 (MFAP4), fibrotic indices and oxidative status biomarkers were assessed in the sera of 50 patients with HCV-associated HCC, 25 patients with HCV-related liver cirrhosis and 15 healthy individuals. Serum oxidized Coenzyme Q10 (CoQ10) and malondialdehyde showed significant elevation in HCC patients compared to the control group (p < 0.001), as well as cirrhotic patients (p < 0.05 and p < 0.001, respectively), while serum glutathione content and superoxide dismutase activity were significantly decreased in HCC patients compared to the control group (p < 0.001). Serum MFAP4, aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factors (FIB-4) and Forns index showed significant increase in HCC patients compared to the control group (p < 0.001), while only APRI and FIB-4 were significantly different between HCC and cirrhotic patients (p < 0.05), with a sensitivity of 86% and 92%, respectively, at cut off ≥0.7 for APRI and ≥1.57 for FIB-4. Therefore, increasing oxidative stress and fibrosis might mediate HCV induced cirrhosis and HCC. APRI and FIB-4 may be used as a simple non-expensive formula for the screening of HCC rather than MFAP4.

Maillard Reaction, mitochondria and oxidative stress: Potential role of antioxidants

2010 ◽  
Vol 58 (3) ◽  
pp. 220-225 ◽  
Author(s):  
M. Edeas ◽  
D. Attaf ◽  
A.-S. Mailfert ◽  
M. Nasu ◽  
R. Joubet
Keyword(s):  
Oxidative Stress ◽  
Maillard Reaction ◽  
Potential Role ◽  
And Oxidative Stress

Inhibition of microRNA-155 Alleviates Neurological Dysfunction Following Transient Global Ischemia and Contribution of Neuroinflammation and Oxidative Stress in the Hippocampus

2020 ◽  
Vol 25 (40) ◽  
pp. 4310-4317 ◽  
Author(s):  
Lichao Sun ◽  
Shouqin Ji ◽  
Jihong Xing
Keyword(s):  
Oxidative Stress ◽  
Brain Edema ◽  
Severity Score ◽  
Global Ischemia ◽  
Signal Pathways ◽  
Neurological Severity Score ◽  
Tnf Α ◽  
Transient Global Ischemia ◽  
And Oxidative Stress

Background/Aims: Central pro-inflammatory cytokine (PIC) signal is involved in neurological deficits after transient global ischemia induced by cardiac arrest (CA). The present study was to examine the role of microRNA- 155 (miR-155) in regulating IL-1β, IL-6 and TNF-α in the hippocampus of rats with induction of CA. We further examined the levels of products of oxidative stress 8-isoprostaglandin F2α (8-iso PGF2α, indication of oxidative stress); and 8-hydroxy-2’-deoxyguanosine (8-OHdG, indication of protein oxidation) after cerebral inhibition of miR-155. Methods: CA was induced by asphyxia and followed by cardiopulmonary resuscitation in rats. ELISA and western blot analysis were used to determine the levels of PICs and products of oxidative stress; and the protein expression of NADPH oxidase (NOXs) in the hippocampus. In addition, neurological severity score and brain edema were examined to assess neurological functions. Results: We observed amplification of IL-1β, IL-6 and TNF-α along with 8-iso PGF2α and 8-OHdG in the hippocampus of CA rats. Cerebral administration of miR-155 inhibitor diminished upregulation of PICs in the hippocampus. This also attenuated products of oxidative stress and upregulation of NOX4. Notably, inhibition of miR-155 improved neurological severity score and brain edema and this was linked to signal pathways of PIC and oxidative stress. Conclusion: We showed the significant role of blocking miR-155 signal in improving the neurological function in CA rats likely via inhibition of signal pathways of neuroinflammation and oxidative stress, suggesting that miR-155 may be a target in preventing and/or alleviating development of the impaired neurological functions during CA-evoked global cerebral ischemia.

Sign in / Sign up

Export Citation Format

Share Document