scholarly journals Legionella Pneumonia Due to Non-Legionella pneumophila Serogroup 1

2020 ◽  
Author(s):  
Akihiro Ito ◽  
Tadashi Ishida
Keyword(s):  
Legionella Pneumophila ◽  
Legionella Pneumonia

scholarly journals An unusual presentation of Legionella pneumonia in a returning traveller

2019 ◽  
Vol 12 (8) ◽  
pp. e230130
Author(s):  
Robert John Shorten ◽  
Jane Norman ◽  
Louise C Sweeney
Keyword(s):  
Bone Marrow ◽  
Critical Care ◽  
Legionella Pneumophila ◽  
Bone Marrow Aspiration ◽  
Severe Pneumonia ◽  
Cell Leukaemia ◽  
Hairy Cell ◽  
Acute Presentation ◽  
Legionella Pneumonia ◽  
The Uk

A male patient in his mid-60s presented with a severe pneumonia following return to the UK after travel to Crete. He was diagnosed with Legionnaire’s disease (caused by an uncommon serogroup of Legionella pneumophila). He was pancytopenic on admission, and during a long stay on critical care he was diagnosed with a disseminated Aspergillus infection. Bone marrow aspiration revealed an underlying hairy cell leukaemia that undoubtedly contributed to his acute presentation and subsequent invasive fungal infection.

scholarly journals Urinary antigene and PCR can both be used to detect Legionella pneumophila in children’s hospital-acquired pneumonia

2019 ◽  
Vol 29 (2) ◽  
Author(s):  
Sayed-Yousef Mojtahedi ◽  
Aliakbar Rahbarimanesh ◽  
Samileh Noorbakhsh ◽  
Hossein Shokri ◽  
Saeedreza Jamali-Moghadam-Siyahkali ◽  
...  
Keyword(s):  
Legionella Pneumophila ◽  
Pediatric Intensive Care ◽  
Antigen Test ◽  
Urinary Antigen ◽  
Urinary Antigen Test ◽  
Legionella Pneumonia ◽  
Hospital Acquired Pneumonia ◽  
The Difference ◽  
Underlying Diseases ◽  
Hospital Acquired

Legionella pneumophila is the causative agent of more than 95% cases of severe Legionella pneumonia. Nosocomial pneumonias in different hospital wards is an important medical and pharmaceutical concern. This study aimed to detect Legionella with two methods: polymerase chain reaction (PCR) and detection of urine antigenic test (UAT) in patients suffering from nosocomial pneumonia admitted to pediatric intensive care unit (PICU) of children hospitals. This study was conducted in PICU wards of Rasool Akram and Bahrami children hospitals, Tehran, Iran during 2013 - 2014. In patients diagnosed with hospital-acquired pneumonia, intratracheal secretion samples for PCR and urine sample for UAT were taken. Simultaneously, PCR and urinary antigen test were conducted using commercial kits. The results of urinary antigen test and PCR were analyzed by SPSS v.19 for statistical comparison. In this study, 96 patients aging 2.77 years on average with two age peaks of less than 1 year and 7-8 year were enrolled. More than half of the patients were under 1 year old. The most common underlying diseases were seizure, Acute Lymphoblastic Lymphoma, Down syndrome and metabolic syndromes. The positivity rate of Legionella urinary antigen test was 16.7% and positivity rate of PCR test was 19.8%. There were no significant associations between the results obtained by both assays with age, gender or underlying diseases. In conclusion, PCR is a better detection method for Legionella infection than urinary antigen test, but the difference between the two methods was not significant.

scholarly journals Legionella Pneumonia Associated with Adult Respiratory Distress Syndrome Caused by Legionella Pneumophila Serogroup 3

2005 ◽  
Vol 44 (1) ◽  
pp. 73-78 ◽  
Author(s):  
Tsuyoshi NOZUE ◽  
Hiroo CHIKAZAWA ◽  
Shuji MIYANISHI ◽  
Takeo SHIMAZAKI ◽  
Rie OKA ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Adult Respiratory Distress Syndrome ◽  
Legionella Pneumophila ◽  
Distress Syndrome ◽  
Legionella Pneumonia

scholarly journals Legionella pneumonia due to non-Legionella pneumophila serogroup 1: usefulness of the six-point scoring system

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Akihiro Ito ◽  
Tadashi Ishida ◽  
Yasuyoshi Washio ◽  
Akio Yamazaki ◽  
Hiromasa Tachibana
Keyword(s):  
Legionella Pneumophila ◽  
Scoring System ◽  
Legionella Pneumonia

scholarly journals Nosocomial legionella pneumonia: demonstration of potable water as the source of infection

1988 ◽  
Vol 101 (3) ◽  
pp. 647-654 ◽  
Author(s):  
B. Ruf ◽  
D. Schürmann ◽  
I. Horbrach ◽  
K. Seodel ◽  
H. D. Pohle
Keyword(s):  
Monoclonal Antibodies ◽  
Water Supply ◽  
Legionella Pneumophila ◽  
Water Samples ◽  
Potable Water ◽  
Supply System ◽  
University Hospital ◽  
Environmental Isolates ◽  
Legionella Pneumonia ◽  
Source Of Infection

SUMMARYFrom January 1983 until December 1985, 35 cases of sporadic nosocomial legionella pneumonia, all caused byLegionella pneumophila, were diagnosed in a university hospital.L. pneumophilaserogroup (SG) 1 was cultured from 12 of the 35 cases and compared to correspondingL. pneumophilaSG 1 isolates from water outlets in the patients' immediate environment by subtyping with monoclonal antibodies. The corresponding environmental isolates were identical to 9 out of 12 (75%) of those from the cases. However, even in the remaining three cases identical subtypes were found distributed throughout the hospital water supply. From the hospital water supply four different subtypes ofL. pneumophilaSG 1 were isolated, three of which were implicated in legionella pneumonia. Of 453 water samples taken during the study 298 (65.8%) were positive for legionellae. Species ofLegionellaother thanL. pneumophilahave not been isolated. This may explain the exclusiveness ofL.pneumophilaas the legionella pneumonia-causing agent. Our results suggest that the water supply system was the source of infection.

Nosocomial Legionella Pneumonia in the Neonate

PEDIATRICS ◽  
1993 ◽  
Vol 92 (3) ◽  
pp. 450-453
Author(s):  
ROBERT E. HOLMBERG ◽  
ANDREW T. PAVIA ◽  
DIANNE MONTGOMERY ◽  
J. MICHAEL CLARK ◽  
LARRY D. EGGERT
Keyword(s):  
Nosocomial Pneumonia ◽  
Legionella Pneumophila ◽  
Community Acquired Pneumonia ◽  
Early Exposure ◽  
Normal Children ◽  
American Legion ◽  
Legionella Pneumonia ◽  
Antibody Titers

Since first being identified in 1976 as the cause of epidemic pneumonia at a Philadelphia American Legion convention, Legionella pneumophila has been recognized as an important cause of community-acquired and nosocomial pneumonia in adults1,2 Reports of Legionella pneumonia in childhood are unusual, however. The incidence of Legionella infection in children is unknown, as the diagnosis is rarely considered. Serosurveys in normal children have shown that by 5 years of age, 20% to 50% of children have at least 1:64 antibody titers to Lp1, suggesting that early exposure may be common.3,4 Nevertheless, fewer than 4% of normal children with community-acquired pneumonia have a fourfold rise in convalescent antibody to Legionella.3-6

scholarly journals Extreme Rhabdomyolysis, Acute Renal Failure, and Protracted Ileus in a Case of Legionella Pneumonia

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
C. Laivier ◽  
M.-O. Bleuze ◽  
P. Hantson ◽  
J. Devos
Keyword(s):  
Risk Factors ◽  
Legionella Pneumophila ◽  
Kidney Injury ◽  
Chronic Alcoholism ◽  
Mechanical Obstruction ◽  
Apparent Discrepancy ◽  
Previous Abdominal Surgery ◽  
Legionella Pneumonia ◽  
History Of ◽  
Limited Period

A 53-year-old man developed aLegionella pneumophilapneumonia complicated by rhabdomyolysis, acute kidney injury, and protracted ileus. Risk factors were smoking and chronic alcoholism, but the patient had no history of previous abdominal surgery. Hemodialysis was required for a period of 5 weeks with a full renal recovery. Pneumonia required respiratory support but for a limited period of 6 days. The protracted course of the ileus led to explorative laparotomy despite negative computed tomography findings. No cause of mechanical obstruction was found at surgery and common etiologies of intestinal obstruction were excluded. Parenteral nutrition was needed for a total of 4 weeks, before recovery of intestinal motility. This case illustrates the apparent discrepancy between the pulmonary symptoms and the extrapulmonary manifestations that could be seen as a consequence of an exaggerated immune response.

scholarly journals Legionella Pneumonia due to Exposure to 24-hour Bath Water Contaminated by Legionella pneumophila Serogroup-5

2005 ◽  
Vol 44 (6) ◽  
pp. 662-665 ◽  
Author(s):  
Masamichi MINESHITA ◽  
Yoshitaka NAKAMORI ◽  
Yasushi SEIDA ◽  
Setsuko HIWATASHI
Keyword(s):  
Legionella Pneumophila ◽  
Legionella Pneumonia ◽  
Bath Water

scholarly journals 642. Trends and cost burden of Legionella urine antigen test

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S381-S381
Author(s):  
Victor-mauricio Ordaz ◽  
Hallye M Lewis ◽  
Pradeep Bathina
Keyword(s):  
Legionella Pneumophila ◽  
Medical Center ◽  
Cost Burden ◽  
Inpatient Hospitalization ◽  
Legionella Pneumonia ◽  
Urine Antigen ◽  
Mississippi Medical ◽  
Serotype 1 ◽  
Minimum Age ◽  
The Cost

Abstract Background Legionella urine antigen (LUAg) testing is used to identify the pathogen Legionella pneumophila serotype 1 which accounts for 50 to 70% of Legionella pneumonia and has 80% sensitivity and 95% specificity. The 2019 ATS/IDSA CAP guidelines recommend against routinely testing urine for LUAg except when indicated by epidemiological factors or severe cases of CAP; however, the recommendation is based on a low quality of evidence. In 2014 & 2015 there were 32 and 39 cases, respectively in the state of Mississippi. The purpose of this study was to evaluate the trends of ordering LUAg, positive results and estimate the cost burden at the University of Mississippi Medical Center (UMMC). Methods We performed a retrospective study of all patients who received the LUAg test at UMMC from January 3, 2013 to December 31, 2019. Patient Cohort Explorer was used to obtain de-identified patient data from EPIC. We obtained the number of encounters and patients on whom the LUAg test was performed during their inpatient hospitalization. Coding and billing offices provided the cost per LUAg test. Results LUAg test was ordered 2,642 times on 2350 patients between 2013 and 2019. 22 LUAg test results were positive in 21 patients. 2,627 tests were done on patients admitted in the hospital. Of the 1,181 tests ordered in female patients, 11 were positive and of the 1461 tests done in male patients, 11 were positive. The minimum age for ordered test was under 1 year while the oldest patient is 89 years old with a median age of 57 years. The youngest patient to be positive is 21 and the oldest patient was 72 years. 1,471 tests were done in African American patients and 1084 tests in Caucasian patients. At the end of study period 1901 were alive and 741 deceased. The median length of stay for the patient receiving the test was 7 days with 1726 patients discharged within 10 days. 174, 255, 301, 433, 467, 395, 613 tests were ordered respectively from 2013 to 2019. At self pay cost of $132.82 in 2019 USD, the total cost of 2642 tests was $350,910.44. About $15,950.47 was spent for each positive LUAg test during the study period. Conclusion Incidence of pneumonia from Legionella in Mississippi is low. Based on our study, we recommend to follow the current ATS/IDSA guidelines and order the test in select patients as recommended, in efforts to reduce diagnostic costs. Disclosures All Authors: No reported disclosures

scholarly journals Clinical Utility of aLegionella pneumophilaUrinary Antigen Test in a Large University Teaching Hospital

2003 ◽  
Vol 14 (2) ◽  
pp. 85-88 ◽  
Author(s):  
Michel Dionne ◽  
Todd Hatchette ◽  
Kevin Forward
Keyword(s):  
Legionella Pneumophila ◽  
Clinical Utility ◽  
University Teaching ◽  
University Hospital ◽  
Legionella Pneumonia ◽  
Urinary Antigen Testing ◽  
The Cost ◽  
Low Prevalence ◽  
Antigen Testing ◽  
Test Result

OBJECTIVE: To determine the clinical utility of diagnosing Legionella pneumonia by urinary antigen testing (LPUAT) in a low prevalence centre.DESIGN: The results of LPUATs were abstracted and analyzed from the authors' laboratory information system. Medical records were reviewed in detail for all positive tests and a random sample of 50 negative tests.SETTING: The Queen Elizabeth II Health Sciences Centre, a large university hospital complex.POPULATION STUDIED: Patients who were admitted from the emergency room with pneumonia or who had developed pneumonia in hospital and who had a LPUAT performed between April 1998 and October 2000.MAIN RESULTS: One thousand one hundred fifty-four tests were performed on 1007 patients. Seven patients had nine positive LPUATs. Three of these patients had confirmedLegionella pneumophilapneumonia. Three others had probable or possibleL pneumophilapneumonia. There was one probable false positive. Six of the seven patients were already on empirical anti-L pneumophilatherapy. Of the 50 negative tests reviewed in detail, 31 patients were on one of the antibiotics of choice forL pneumophilaat the time the test was ordered; in 21 (68%) of these patients the negative result did not lead to a change in therapy.CONCLUSIONS: The cost to diagnose each case of Legionella pneumonia by LPUAT was approximately $5,770 and most patients were already on appropriate antibiotics. In patients with negative tests, antibiotics were often not changed in response to the test result. Rigorous screening of patients is required to increase pretest probability for LPUAT to be justified.

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