scholarly journals Selenium in the Prevention and Treatment of Hepatocellular Carcinoma: From Biomedical Investigation to Clinical Application

2020 ◽  
Author(s):  
Chien-Shan Cheng ◽  
Ning Wang ◽  
Yibin Feng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Application ◽  
Prevention And Treatment ◽  
Biomedical Investigation

Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic-related Liver Diseases and Hepatocellular Carcinoma

2019 ◽  
Vol 20 (3) ◽  
pp. 197-214 ◽  
Author(s):  
Isabel Sánchez-Crisóstomo ◽  
Eduardo Fernández-Martínez ◽  
Raquel Cariño-Cortés ◽  
Gabriel Betanzos-Cabrera ◽  
Rosa A. Bobadilla-Lugo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Anticancer Agents ◽  
Liver Diseases ◽  
Membrane Receptors ◽  
New Drugs ◽  
Sexual Hormones ◽  
Steroid Nucleus ◽  
Alcoholic Fatty Liver ◽  
Prevention And Treatment

Background: Liver ailments are among the leading causes of death; they originate from viral infections, chronic alcoholism, and autoimmune illnesses, which may chronically be precursors of cirrhosis; furthermore, metabolic syndrome may worsen those hepatopathies or cause Non-alcoholic Fatty Liver Disease (NAFLD) that may advance to non-alcoholic steatohepatitis (NASH). Cirrhosis is the late-stage liver disease and can proceed to hepatocellular carcinoma (HCC). Pharmacological treatment options for liver diseases, cirrhosis, and HCC, are limited, expensive, and not wholly effective. The use of medicinal herbs and functional foods is growing around the world as natural resources of bioactive compounds that would set the basis for the development of new drugs. Review and Conclusion: Plant and food-derived sterols and triterpenoids (TTP) possess antioxidant, metabolic-regulating, immunomodulatory, and anti-inflammatory activities, as well as they are recognized as anticancer agents, suggesting their application strongly as an alternative therapy in some chronic diseases. Thus, it is interesting to review current reports about them as hepatoprotective agents, but also because they structurally resemble cholesterol, sexual hormones, corticosteroids and bile acids due to the presence of the steroid nucleus, so they all can share pharmacological properties through activating nuclear and membrane receptors. Therefore, sterols and TTP appear as a feasible option for the prevention and treatment of chronic metabolic-related liver diseases, cirrhosis, and HCC.

Clinical application of protein induced by vitamin K antagonist-II as a biomarker in hepatocellular carcinoma

Tumor Biology ◽  
2016 ◽  
Vol 37 (12) ◽  
pp. 15447-15456 ◽  
Author(s):  
Hao Xing ◽  
Cunling Yan ◽  
Liming Cheng ◽  
Nianyue Wang ◽  
Shuyang Dai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Application ◽  
Vitamin K ◽  
Vitamin K Antagonist

scholarly journals Non-coding RNA in drug resistance of hepatocellular carcinoma

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Bisha Ding ◽  
Weiyang Lou ◽  
Liang Xu ◽  
Weimin Fan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Resistance ◽  
Clinical Application ◽  
Circular Rna ◽  
Potential Clinical Application ◽  
Cancer Occurrence ◽  
Non Coding Rna ◽  
The Future ◽  
Non Coding Rnas

Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in cancer occurrence and progression. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of HCC. In addition, accumulating evidence has demonstrated that they can serve as biomarkers in diagnosis, treatment, and prognosis of HCC. In this review, we first overviewed up-to-date findings regarding miRNA and lncRNA in drug resistance of HCC, then summarized specific mechanisms that they modulate chemoresistance of HCC, and finally discussed their potential clinical application in overcoming the obstacle of HCC chemoresistance in the future.

scholarly journals Clinical application of cisplatin-phosphatidylcholine-lipiodol suspension for hepatocellular carcinoma.

1991 ◽  
Vol 55 ◽  
pp. 300
Author(s):  
Yoshiro Okano ◽  
Yasuhiro Tomita ◽  
Tsuyoshi Hashimoto ◽  
Kenji Hirai ◽  
Kyuichi Tanikawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Application

scholarly journals Dietary Agents and Phytochemicals in the Prevention and Treatment of Hepatocellular Carcinoma: Review Article

Med Phoenix ◽  
2017 ◽  
Vol 2 (1) ◽  
pp. 52-62
Author(s):  
Mohammad Ahmad ◽  
Anuradha Mishra ◽  
Afreen Usmani ◽  
Md. Parwez Ahmad
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Epigallocatechin Gallate ◽  
Cancer Chemoprevention ◽  
Scientific Data ◽  
Anticancer Properties ◽  
Treatment And Prevention ◽  
Liver Cancers ◽  
Prevention And Treatment ◽  
Dietary Agents

Amongst all types of primary liver cancers, hepatocellular carcinoma (HCC) is the commonest form of liver cancer in the world. Cancer chemoprevention using dietary supplements and phytochemicals has attracted increasing attention in recent years. Numerous study reports suggest the role of phytochemicals and dietary compounds in the prevention and treatment of liver cancer. Certain dietary agents and related phytochemicals present in grapes, pomegranate, vegetables, beans, turmeric, soy, rice bran, and fish oils are reported to have chemopreventive potentials against hepatocellular carcinoma. Phytochemicals such as Carotenoids, Epigallocatechin gallate (EGCG), Curcumin, Resveratrol, Rutoside, Quercetin, Chrysin and Silibinin have possible therapeutic importance in tumor suppression during the initial phases of carcinogenesis. Many phytochemicals which are still under investigation lack the scientific data in support of anticancer properties of these compounds rather than anti-oxidant mechanism. So, emphasis should be given on the investigation of plausible molecular mechanism behind anticancer activity. This review summarizes the use of these dietary agents and phytochemicals in the treatment and prevention of HCC and also highlights the mechanisms responsible for their effects.Med Phoenix Vol.2(1) July 2017, 52-62

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