scholarly journals Intravenous Immunoglobulin for Treatment of Patients with COVID-19: A Case-control Study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Rozita Khodashahi ◽  
HamidReza Naderi ◽  
Alireza Sedaghat ◽  
Abolghasem Allahyari ◽  
Soroush Sarjamee ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Case Control Study ◽  
Case Control ◽  
Therapeutic Effects ◽  
C Reactive Protein ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Significant Difference ◽  
Before And After ◽  
Control Study

Background: It seems that the risk of developing complications associated with coronavirus disease 2019 (COVID-19) is higher among individuals with weakened immune systems. Objectives: Therefore, this study was carried out to determine the effectiveness of intravenous immunoglobulin (IVIG) for the treatment of patients not entering the intubation phase compared to those entering the intubation phase. Methods: This descriptive case-control study was performed on 26 patients with COVID-19 referring to Imam Reza hospital in Mashhad, Iran, in March 2020. For subjects with COVID-19 not responding to the standard three-drug protocol (i.e., ribavirin, hydroxychloroquine, and lopinavir/ritonavir), three doses of IVIG (0.4 g/kg/day) were added to the protocol. The patients were divided into two groups of subjects not entering the intubation phase and those entering the intubation phase and compared in terms of different variables. Results: The comparison of laboratory findings showed a significant difference before and after receiving IVIG regarding oxygen saturation (P < 0.005), white blood cell (P = 0.001), hemoglobin level (P = 0.0002), lymphocyte count (P = 0.03), and C-reactive protein (P = 0.001). In general, 53.8% and 46.2% of the patients were discharged and expired, respectively. All the subjects not entering the intubation phase were recovered; nevertheless, only one case entering the intubation phase was recovered, and 92.3% of the patients expired. A significant difference was observed between the patients not entering the intubation phase and those entering the intubation phase in terms of mortality (χ2 = 22.28; P < 0.005). Conclusions: In summary, the obtained results of the current study confirmed the therapeutic effects of IVIG on patients with COVID-19. Moreover, better treatment results, shorter hospital stay, and lower mortality rates were observed among COVID-19 patients who did not enter the intubation phase in comparison with those entering the intubation phase.

scholarly journals Eosinopenia and elevated C-reactive protein facilitate triage of COVID-19 patients in fever clinic: A retrospective case-control study

2020 ◽  
Vol 23 ◽  
pp. 100375 ◽  
Author(s):  
Qilin Li ◽  
Xiuli Ding ◽  
Geqing Xia ◽  
Heng-Gui Chen ◽  
Fenghua Chen ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
C Reactive Protein ◽  
Retrospective Case ◽  
Reactive Protein ◽  
Control Study

scholarly journals Colorectal Cancer and Serum C-reactive Protein Levels: a Case-control Study Nested in the JACC Study

2005 ◽  
Vol 15 (Supplement_II) ◽  
pp. S185-S189 ◽  
Author(s):  
Yoshinori Ito ◽  
Koji Suzuki ◽  
Koji Tamakoshi ◽  
Kenji Wakai ◽  
Masayo Kojima ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Control Study

scholarly journals Subclinical Elevation of Plasma C-Reactive Protein and Illusions/Hallucinations in Subjects with Parkinson’s Disease: Case–control Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85886 ◽  
Author(s):  
Hideyuki Sawada ◽  
Tomoko Oeda ◽  
Atsushi Umemura ◽  
Satoshi Tomita ◽  
Ryutaro Hayashi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Disease Case ◽  
Control Study

scholarly journals A study to observe quantitative levels of C- Reactive Protein in Cerebrospinal fluid in patients with Meningitis as an add-on routine investigation- a case-control study

2021 ◽  
Vol 9 (4) ◽  
pp. 235-240
Author(s):  
Manoj Kumar ◽  
◽  
Chandrashekhar Tiwari ◽  
Nandita Prabhat ◽  
Pooja Dhaon ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Viral Meningitis ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Control Study

Introduction: C-reactive protein (CRP) is a member of the class of acute phase reactants as itslevel rises dramatically during inflammatory processes occurring in the body. Measuring and chartingCRP values can prove useful in determining the disease progress. Aim: To estimate the CRP level inCerebrospinal fluid (CSF) of patients with meningitis; and to evaluate whether CRP levels could beused to differentiate the various types of meningitis in adults. Materials and Methods: This studywas a case-control study. 80 enrolled patients were subjected to a protocol that included detailedclinical history including duration of illness, symptoms and signs, history or any treatment history.Written informed consent was taken from the patients/guardian. Results: Meningitis was morecommon in the 18-30 years age group. Mean values of CSF CRP were- viral meningitis (2.70 mg/L)and pyogenic meningitis (91.13 mg/L) and control group (1.54 mg/L). CSF CRP can be used as adiagnostic tool to differentiate between pyogenic and viral meningitis as it is significantly raised inpyogenic meningitis in comparison to viral meningitis (p-value <0.0001). Conclusion: CRP in CSF isa valuable, rapid, bedside diagnostic test for differentiating between pyogenic and viral meningitis;with reasonably good sensitivity, specificity and positive predictive value. The absence of CRP in CSFrather than its presence is more important for the diagnosis of viral meningitis.

scholarly journals C-reactive protein gene 1846C>T polymorphism is associated with increased risk and clinical features of lung cancer: a case–control study

2019 ◽  
Vol 39 (6) ◽  
Author(s):  
Chen Chen ◽  
Jing-Ni Liu ◽  
Jian-Qiang Zhao ◽  
Bao Zang
Keyword(s):  
Lung Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Lung Carcinogenesis ◽  
C Reactive Protein ◽  
Chinese Han ◽  
Reactive Protein ◽  
Potential Marker ◽  
Increased Risk ◽  
Control Study

AbstractChronic inflammation plays an important role in lung carcinogenesis. Recently, several studies investigated the association of C-reactive protein (CRP) gene 1846C>T polymorphism and lung cancer (LC) risk, but with conflicting findings. In the present study, we conducted this case–control study with 408 LC patients and 472 healthy controls in a Chinese Han population. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLR) method. Our data found that CRP gene 1846C>T polymorphism increased the risk of LC. Subgroup analyses obtained significant associations among the groups of males, ≥50 years old, smoking, and non-drinkers. Bioinformatics analysis showed that the expression levels of CRP in LC tissues were significantly increased compared with normal tissues. Additionally, the present study found CRP mRNA high expression was associated with worse survival in LC patients. Furthermore, our data indicated that TT genotype of 1846C>T polymorphism was associated with a larger size of tumor and was related with lymphatic metastasis in LC patients. In conclusion, the present study suggests that CRP gene 1846C>T polymorphism is associated with increased risk of LC. CRP gene 1846C>T polymorphism may be a potential marker for the diagnosis of LC.

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