scholarly journals Effect of a single preoperative dose of oral antibiotic to reduce the incidence of surgical site infection following below-knee dermatological flap and graft repair

2019 ◽  
pp. 28-35 ◽  
Author(s):  
Helena Rosengren ◽  
Clare Heal ◽  
Petra Buettner
Keyword(s):  
Surgical Site Infection ◽  
Antibiotic Prophylaxis ◽  
Controlled Trial ◽  
Study Groups ◽  
High Dose ◽  
Antibiotic Administration ◽  
Oral Antibiotic ◽  
Site Infection ◽  
Double Blind

Background: Surgical site infection (SSI) rates for below-knee dermatological surgery are unacceptably high, particularly following complex flap and graft closures. The role of antibiotic prophylaxis for these surgical cases is uncertain. Objective: To determine whether SSI following complex dermatological closures on the leg could be reduced by antibiotic prophylaxis administered as a single oral preoperative dose. Methods: A total of 115 participants were randomized to 2 g of oral cephalexin or placebo 40-60 minutes prior to surgical incision in a prospective, randomized, double-blind, placebo-controlled trial at a primary care skin cancer clinic in North Queensland, Australia. Results: Overall 17/55 (30.9%) controls and 14/55 (25.5%) intervention participants developed infection (P = 0.525). There was no difference between the study groups in adverse symptoms that could be attributed to high-dose antibiotic administration (P = 1).

The impact of low-dose versus high-dose antibiotic prophylaxis regimens on surgical site infection rates after cesarean delivery

2019 ◽  
Vol 301 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Mauricio La Rosa ◽  
Chasey Omere ◽  
Tiffany Redfern ◽  
Mahmoud Abdelwahab ◽  
Nicholas Spencer ◽  
...  
Keyword(s):  
Surgical Site Infection ◽  
Antibiotic Prophylaxis ◽  
Cesarean Delivery ◽  
Low Dose ◽  
High Dose ◽  
Site Infection ◽  
Infection Rates ◽  
The Impact

scholarly journals 411: The impact of low dose versus high dose antibiotic prophylaxis regimens on surgical site infection rates after cesarean delivery

2017 ◽  
Vol 216 (1) ◽  
pp. S244-S245
Author(s):  
Mauricio La Rosa ◽  
Chasey Omere ◽  
Tiffany Redfurn ◽  
Mahmoud Abdelwahab ◽  
Nicholas Spencer ◽  
...  
Keyword(s):  
Surgical Site Infection ◽  
Antibiotic Prophylaxis ◽  
Cesarean Delivery ◽  
Low Dose ◽  
High Dose ◽  
Site Infection ◽  
Infection Rates ◽  
The Impact

scholarly journals The effect of triclosan-coated sutures on the rate of surgical site infection after hip and knee arthroplasty: a double-blind randomized controlled trial of 2546 patients

2018 ◽  
Vol 100-B (3) ◽  
pp. 296-302 ◽  
Author(s):  
A. P. Sprowson† ◽  
C. Jensen ◽  
N. Parsons ◽  
P. Partington ◽  
K. Emmerson ◽  
...  
Keyword(s):  
Surgical Site Infection ◽  
Knee Arthroplasty ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Site Infection ◽  
Double Blind ◽  
Suture Group ◽  
Double Blinded ◽  
Complication Of Surgery

AimsSurgical site infection (SSI) is a common complication of surgery with an incidence of about 1% in the United Kingdom. Sutures can lead to the development of a SSI, as micro-organisms can colonize the suture as it is implanted. Triclosan-coated sutures, being antimicrobical, were developed to reduce the rate of SSI. Our aim was to assess whether triclosan-coated sutures cause a reduction in SSIs following arthroplasty of the hip and knee.Patients and MethodsThis two-arm, parallel, double-blinded study involved 2546 patients undergoing elective total hip (THA) and total knee arthroplasty (TKA) at three hospitals. A total of 1323 were quasi-randomized to a standard suture group, and 1223 being quasi-randomized to the triclosan-coated suture group. The primary endpoint was the rate of SSI at 30 days postoperatively.ResultsThe baseline characteristics of age, gender and comorbidities were well matched in the two groups. The rates of superficial SSI were 0.8% in the control group and 0.7% in the intervention group (p = 0.651), and when deep and superficial SSIs were combined the rates were 2.5% and 1.8 (p = 0.266). The length of stay in hospital and the rates of medical complications did not differ significantly between the groups (p = 1.000).ConclusionThis trial provided no evidence that the use of triclosan-coated sutures at THA and TKA leads to a reduction in the rate of SSI. Cite this article: Bone Joint J 2018;100-B:296–302.

Oral antibiotic prophylaxis in patients with cancer: A double-blind randomized placebo-controlled trial

1983 ◽  
Vol 102 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Philip A. Pizzo ◽  
Kathleen J. Robichaud ◽  
Brenda K. Edwards ◽  
Cathie Schumaker ◽  
Barnett S. Kramer ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Controlled Trial ◽  
Oral Antibiotic ◽  
Double Blind ◽  
Patients With Cancer ◽  
Oral Antibiotic Prophylaxis

scholarly journals IMPACT OF ORAL ANTIBIOTIC PROPHYLAXIS ON SURGICAL SITE INFECTION AFTER RECTAL SURGERY: RANDOMIZED CONTROLLED TRIAL

2019 ◽  
Vol 18 (1) ◽  
pp. 74-81
Author(s):  
Yu. A. Shelygin ◽  
M. A. Nagudov ◽  
A. A. Ponomarenko ◽  
E. G. Rybakov ◽  
M. A. Suhina
Keyword(s):  
Surgical Site Infection ◽  
Anastomotic Leakage ◽  
Controlled Trial ◽  
Rectal Surgery ◽  
Generation Cephalosporin ◽  
Control Group ◽  
Oral Antibiotic ◽  
Site Infection ◽  
Oral Antibiotics ◽  
Bowel Cleansing

AIM: to evaluate the efficacy of preoperative oral antibiotics in reduction of surgical site infection (SSI) in rectal surgery. METHODS: patients undergoing rectal resection were assigned randomly to 2 groups: control (standard preoperative care and intravenous injection of 3d generation cephalosporin) and oral antibiotics group (the above was complemented by three-knit oral metronidazole 500 mg and erythromycin 500 mg after beginning of mechanical bowel cleansing at 5.00, 8.00 and 10.00 p.m.). The primary endpoint was the overall rate of SSI. RESULTS: between November 2017 and October 2018, 104 patients (48 in the oral antibiotics group and 56 in control group) were enrolled for this study. The incidence of SSIs was 19.6% (11/56) in control group and 4.1% (2/48) in the oral antibiotics group(р=0.01). Both groups had no statistically significant differences in intensity of SSIs and rate of anastomotic leakage. CONCLUSION: preoperative oral antibiotic significantly reduced the risk of SSIs following rectal surgery. The study needs to be continued for evaluation of preoperative oral antibiotics impact to intensity of SSIs and rate of anastomotic leakage.

scholarly journals Analysing the Effect of Prophylaxis Antibiotic Administration on Pediatric Clean Surgery Based on Post Operative Response of Neutrophil, Monocyte, and Lymphocyte, and Surgical Site Infection Rate

2018 ◽  
Vol 5 (1) ◽  
pp. 3430-3434
Author(s):  
Andrizal Yoesoef ◽  
Erjan Fikri ◽  
Aznan Lelo
Keyword(s):  
Surgical Site Infection ◽  
Infection Rate ◽  
Tissue Injury ◽  
Wound Complication ◽  
Developed Countries ◽  
Antibiotic Administration ◽  
Site Infection ◽  
Surgical Wound ◽  
Surgical Site Infection Rate ◽  
Double Blind

Insignificant administration of antibiotic leads to higher health cost and increase of antibiotic resistance. National prophylaxis antibiotic guideline on clean surgery amongst developed countries are varies meanwhile most developing countries still do not have any and adopt the established guidelines, not to mention there is not many specific guidelines for pediatric procedure. In Indonesia, 30% to 80% antibiotic usage was proven unnecessary. This study analysed the effect prophylaxis antibiotic administration on pediatric clean surgery based on post operative response of neutrophil, monocyte, and lymphocyte, as the parameters of cell-mediated inflammatory response on tissue injury or infection, and surgical site infection rate. A double blind randomized clinical trial was conducted from May 2013 to April 2014 at multi-hospital in Medan, Indonesia. Total sample is 42 subjects, distributed evenly into 2 groups. Post operative blood sample was examined on 3rd day and surgical wound was evaluated until 30th day. Both groups were comparable in patients’ demographic, clinical characteristic, and surgery procedure. Post operative rates of neutrophil, monocyte, and lymphocyte are not statistically different between groups (P = 0.083, P = 0.121, dan P = 0.486). Pre and post operative difference rates of neutrophil, monocyte, and lymphocyte are not statistically different between groups (P = 0.065, P = 0.294, dan P = 0.367). Surgical wound complication was 2.4% of total 42 sample (P = 1,00) with 0% surgical site infection event on both groups. This study recommends prophylaxis antibiotic administration on pediatric clean surgery is not necessary.

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