Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

Background: Proximal femoral fractures are very common in elderly patients. These fractures are thought to be associated with osteoporosis. Vitamin D is a possible risk factor for osteoporosis. So, this study was done to evaluate the association of serum vitamin D level with types of femoral fractures in elderly patients.Methods: The study was done between September 2013 to August 2016, 75 patients with age >60 years (male and female both) with proximal femoral fractures were studied. Serum 25-hydroxy vitamin D, calcium, phosphate, alkaline phosphatase levels, liver function test, renal function test, hemoglobin and complete blood counts of all the patients were assessed.Results: On assessment of serum vitamin D in proximal femoral fracture in elderly patients, it shows an increase incidence of proximal femoral fractures in patients with low serum vitamin D level. Fracture of neck of femur was most common among all. Type of fracture has no significant statistical relationship with serum vitamin D levels.Conclusions: Osteoporosis and serum vitamin D level depends on age and sex of the patient. But type of proximal femoral osteoporotic fracture has no association with either grade of osteoporosis or serum vitamin D level.

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Evaluation of Serum Glucagon-Like Peptide 1 and Vitamin D Levels in Elderly Patients with Bone Fractures

Medical Principles and Practice ◽

10.1159/000502132 ◽

2019 ◽

Vol 29 (3) ◽

pp. 219-224

Author(s):

Özhan Pazarci ◽

Halef Okan Dogan ◽

Seyran Kilinc ◽

Yalkin Çamurcu

Keyword(s):

Vitamin D ◽

Elderly Patients ◽

Bone Fracture ◽

Bone Fractures ◽

Serum Vitamin ◽

Serum Levels ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1

Objectives: To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fractures. Materials and Methods: This study included 56 patients and 31 control subjects. The patients included were those aged ≥65 years who were admitted to our hospital with a diagnosis of bone fracture. The control group comprised age-matched, healthy individuals. Levels of serum vitamin D and GLP-1 were measured and compared between the 2 groups. Results: Significant differences were noted between the groups in terms of serum levels of vitamin D (p < 0.001) and serum levels of GLP-1 (p < 0.001). A positive correlation was observed between serum levels of vitamin D and GLP-1. Conclusion: Serum levels of GLP-1 were found to be significantly lower in elderly patients with bone fracture compared to healthy adults. In addition, a significant correlation was found between decreased vitamin D and GLP-1 levels. These results may therefore demonstrate the protective effects of GLP-1 on bone structure and metabolism, similar to those of vitamin D.

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Elderly patients with trochanteric hip fracture have lower serum Vitamin D levels compared to patients with cervical hip fracture

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2010.03.023 ◽

2011 ◽

Vol 52 (1) ◽

pp. e15-e18 ◽

Cited By ~ 7

Author(s):

Olga E. Dretakis ◽

Andrew N. Margioris ◽

Christos Tsatsanis ◽

Konstantin E. Dretakis ◽

Niki Malliaraki ◽

...

Keyword(s):

Vitamin D ◽

Hip Fracture ◽

Elderly Patients ◽

Serum Vitamin ◽

Lower Serum ◽

Serum Vitamin D ◽

Vitamin D Levels

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Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000662 ◽

2020 ◽

Vol 90 (3-4) ◽

pp. 346-352

Author(s):

Vincenzo Pilone ◽

Salvatore Tramontano ◽

Carmen Cutolo ◽

Federica Marchese ◽

Antonio Maria Pagano ◽

...

Keyword(s):

Bariatric Surgery ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Inverse Correlation ◽

Model Assessment ◽

Cross Sectional ◽

Serum Vitamin D ◽

Female Sex ◽

Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

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Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development

PEDIATRICS ◽

10.1542/peds.2011-2644d ◽

2012 ◽

Vol 129 (3) ◽

pp. X11-X11

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Maternal Serum ◽

Neurocognitive Development ◽

Serum Vitamin D ◽

Vitamin D Levels

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Faculty Opinions recommendation of Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3437965.3141061 ◽

2010 ◽

Author(s):

Leonard Bacharier ◽

Avraham Beigelman

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Children With Asthma

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Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

Pakistan Journal of Medicine and Dentistry ◽

10.36283/pjmd9-4/004 ◽

2020 ◽

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Serum Vitamin ◽

Persistent Asthma ◽

Food Allergies ◽

P Value ◽

Serum Vitamin D ◽

Asthma Exacerbations ◽

Vitamin D Levels ◽

Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to ﬁnd out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically signiﬁcant. Results: Children who had exposure to animal dander had signiﬁcantly lower asthma exacerbations per year (p-value <0.046). There was no signiﬁcant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no signiﬁcant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

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