Elderly patients with trochanteric hip fracture have lower serum Vitamin D levels compared to patients with cervical hip fracture

Background/Aims: There is growing evidence supporting the role of innate immune deregulation and inflammation in the pathogenesis of myelodysplastic syndromes (MDS). Vitamin D (VD) is known to be involved in various immune and epigenetic processes. This analysis aimed to evaluate serum VD levels in patients with MDS and to analyze associations between serum VD levels and disease characteristics. Methods: Serum levels of 25-hydroxyvitamin D3 (25(OH)-D3), the major form of VD in human serum, were measured by chemiluminescence immunoassay in 62 unselected patients with MDS. Associations between serum 25(OH)-D3 levels and disease characteristics were analyzed using Kendall’s tau and two-sided p values. Results: The median serum 25(OH)-D3 level was markedly reduced (17.5 ng/mL). Patients with lower-risk disease features had lower serum 25(OH)-D3 levels than patients with higher-risk disease features with regard to medullary blast counts (16 vs. 31 ng/mL, p < 0.001), the revised international prognostic scoring system (13 vs. 30.5 ng/mL, p = 0.001), and blood counts. Conclusions: We show that patients with lower-risk disease characteristics exhibit lower serum VD levels than patients with higher-risk disease characteristics. Whether these findings might reflect innate immune deregulation has to be investigated in further studies.

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Coronavirus in HIP Fractures CHIP 2: Is Vitamin D Deficiency Associated with Increased Mortality from COVID-19 Infections in A Hip Fracture Population?

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2021.3.6.1159 ◽

2021 ◽

Vol 3 (6) ◽

pp. 111-116

Author(s):

A. Mahmood ◽

F. Rashid ◽

D. Hawkes ◽

W. J. Harrison

Keyword(s):

Vitamin D ◽

Hip Fracture ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Primary Outcome Measure ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Fracture Population ◽

The Impact ◽

The Relationship

Purpose: There is controversy as to whether vitamin D deficiency is associated with increased mortality from coronavirus infection. The aim of the study was to assess the relationship between vitamin D levels and 30-day mortality in hip fracture patients co-infected with COVID-19. Methods: This was a national observational audit conducted between 23 March 2020 (start of UK lockdown) and 31st December 2020. The cohort consisted of patients aged >60 years presenting with a hip fracture. Patients were included if they had a vitamin D level done during the admission episode, diagnosis of COVID-19 infection via a viral reverse transcriptase PCR swab, and a hip fracture. There were 517 patients included in the study from 43 different hospital trusts. The primary outcome measure was 30-day mortality. Secondary outcomes were the percentage of patients who had vitamin D deficiency, the percentage of patients who were prescribed Vitamin D, and the impact of vitamin D prescribing on mortality Results: Vitamin D deficiency was not associated with a higher 30-day mortality. Low serum vitamin D was observed in 56% of the patients on admission. Vitamin D was prescribed prior to admission in 28% and during admission in a further 49%. Pre-hospital vitamin D therapy reduced the chance of vitamin D deficiency. Starting vitamin D before or on admission did not affect the mortality rates. Conclusion: Vitamin D deficiency was common, but not associated with a higher 30-day mortality in the hip fracture population co-infected with COVID-19.

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Comparison of Vitamin D Levels in AMI patients and Healthy Individuals

10.53350/pjmhs211581896 ◽

2021 ◽

Vol 15 (8) ◽

pp. 1896-1898

Author(s):

Aisha Bashir ◽

Asima Karim ◽

Asia Kanwal ◽

Asma Salam

Keyword(s):

Vitamin D ◽

Cell Biology ◽

Serum Vitamin ◽

Healthy Controls ◽

Healthy Individuals ◽

Lower Serum ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Mean

Background: Research reports that serum Vitamin D levels are deficient in AMI patients. Aim: To compare serum Vitamin D levels between AMI patients and healthy controls. Methods: Study design was Cross Sectional Comparative. The study was conducted at Department of Physiology & Cell Biology, University of Health Sciences, Lahore 2018 to 2019. Serum vitamin D levels were measured in 80 study subjects. Among 80 study subjects, 40 had AMI and 40 were healthy controls. Results: The serum Vitamin D levels less than 20ng/ml were considered deficient. Mann Whitney U test was used to compare the groups. The mean serum Vitamin D levels of the AMI patients were significantly lower (7±2.47ng/ml) as compared to healthy controls (17.17±4.8ng/ml) at (p=0.000). Conclusion: AMI patients have significantly lower serum Vit. D levels as compared to healthy individuals. Keywords: Acute myocardial infarction, Serum Vitamin D

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Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

Journal of Experimental and Clinical Medicine ◽

10.5835/jecm.omu.31.02.003 ◽

2014 ◽

Vol 31 (2) ◽

pp. 77-80

Author(s):

Fatma Uçar ◽

Sümeyya Akyol ◽

Gulfer Ozturk ◽

Zeynep Ginis ◽

Gonul Erden ◽

...

Keyword(s):

Vitamin D ◽

Elderly Patients ◽

Subclinical Hypothyroidism ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels

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Association of Serum Vitamin D Levels With Inflammatory Response Following Hip Fracture: The Baltimore Hip Studies

The Journals of Gerontology Series A ◽

10.1093/gerona/62.12.1402 ◽

2007 ◽

Vol 62 (12) ◽

pp. 1402-1406 ◽

Cited By ~ 21

Author(s):

R. R. Miller ◽

G. E. Hicks ◽

M. D. Shardell ◽

A. R. Cappola ◽

W. G. Hawkes ◽

...

Keyword(s):

Vitamin D ◽

Hip Fracture ◽

Inflammatory Response ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels

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Association of Average Telomere Length with Body-Mass Index and Vitamin D Status in Juvenile Population with Type 1 Diabetes / Povezava Povprečnih Dolžin Telomerov Z Indeksom Telesne Teže in Vitaminom D Pri Mladostnikih S Sladkorno Boleznijo Tipa 1

Slovenian Journal of Public Health ◽

10.1515/sjph-2015-0011 ◽

2015 ◽

Vol 54 (2) ◽

pp. 74-78 ◽

Cited By ~ 1

Author(s):

Tine Tesovnik ◽

Jernej Kovac ◽

Tinka Hovnik ◽

Primoz Kotnik ◽

Tadej Battelino ◽

...

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Type 1 Diabetes ◽

Serum Vitamin ◽

Serum Levels ◽

Glycated Haemoglobin ◽

Lower Serum ◽

Serum Vitamin D ◽

Vitamin D Levels

Abstract Background. Type 1 diabetes (T1D) is an autoimmune chronic disease where hyperglycemia, increased risk of oxidative stress, advanced glycation end-products and other genetic and environmental factors lead to T1D complications. Shorter telomeres are associated with hyperglycemic levels and lower serum vitamin D levels. Methods. Average telomere length (ATL) in whole blood DNA samples was assessed with qPCR method in 53 Slovenian T1D children/adolescents (median age 8.7 years, 1:1.3 male/female ratio). Body mass index standard deviation score (BMI-SDS), glycated haemoglobin and serum level of vitamin D metabolite (25-(OH)-D3) and the age at the onset of T1D were collected from the available medical documentation. Results. Results indicate shorter ATL in subjects with higher BMI-SDS when compared to those with longer ATL (0.455 ± 0.438, -0.63 ± 0.295; p=0.049). Subjects with higher BMI-SDS had lower serum vitamin D levels when compared to those with lower BMI-SDS (40.66 ± 3.07 vs. 52.86 ± 4.85 nmol/L; p=0.045). Vitamin D serum levels did not significantly differ between subjects with longer/shorter ATL. Conclusion. T1D children/adolescents with shorter ATL tend to have higher BMI-SDS. Lower serum vitamin D levels were associated with higher BMI-SDS, while associations between vitamin D serum levels, age at the onset of T1D, glycated haemoglobin and ATL were not observed. Additional studies with more participants are required to clarify the role of the telomere dynamics in T1D aetiology and development of complications.

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Evaluation of association of vitamin D level with types of proximal femoral fractures in elderly patients

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20184392 ◽

2018 ◽

Vol 4 (6) ◽

pp. 950

Author(s):

Afroz Ahmed Khan ◽

Vipin Kumar ◽

Ashok Kumar Yadav ◽

Robin Singh ◽

Karn Singh Chauhan ◽

...

Keyword(s):

Vitamin D ◽

Elderly Patients ◽

Serum Vitamin ◽

Femoral Fractures ◽

Proximal Femoral Fracture ◽

Proximal Femoral Fractures ◽

Neck Of Femur ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Function Test

Background: Proximal femoral fractures are very common in elderly patients. These fractures are thought to be associated with osteoporosis. Vitamin D is a possible risk factor for osteoporosis. So, this study was done to evaluate the association of serum vitamin D level with types of femoral fractures in elderly patients.Methods: The study was done between September 2013 to August 2016, 75 patients with age >60 years (male and female both) with proximal femoral fractures were studied. Serum 25-hydroxy vitamin D, calcium, phosphate, alkaline phosphatase levels, liver function test, renal function test, hemoglobin and complete blood counts of all the patients were assessed.Results: On assessment of serum vitamin D in proximal femoral fracture in elderly patients, it shows an increase incidence of proximal femoral fractures in patients with low serum vitamin D level. Fracture of neck of femur was most common among all. Type of fracture has no significant statistical relationship with serum vitamin D levels.Conclusions: Osteoporosis and serum vitamin D level depends on age and sex of the patient. But type of proximal femoral osteoporotic fracture has no association with either grade of osteoporosis or serum vitamin D level.

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Low serum vitamin D levels increase the risk of hip fracture in postmenopausal women

Nature Clinical Practice Endocrinology &#38 Metabolism ◽

10.1038/ncpendmet0986 ◽

2008 ◽

Vol 4 (12) ◽

pp. 646-646

Keyword(s):

Vitamin D ◽

Hip Fracture ◽

Postmenopausal Women ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Low Serum

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