Pulmonary Crystal-Storing Histiocytoma

2005 ◽  
Vol 129 (9) ◽  
pp. 1159-1163
Author(s):  
Diana N. Ionescu ◽  
Diane M. Pierson ◽  
Gefei Qing ◽  
Maomi Li ◽  
Thomas V. Colby ◽  
...  
Keyword(s):  
Lymphoproliferative Disorder ◽  
Plasma Cells ◽  
Lung Tumor ◽  
Full Description ◽  
Electron Microscopic ◽  
Hematologic Disorder ◽  
Rare Manifestation ◽  
Microscopic Features ◽  
Plasma Cell Dyscrasias ◽  
Definition Of

Abstract We describe the case of a 50-year-old woman with a lung tumor composed of crystal-storing histiocytes. These cells and associated plasma cells failed to show clonal light chain restriction, and the patient had no associated hematologic disorder. The differential diagnosis included crystal-storing histiocytosis, characterized by accumulation of crystallized immunoglobulins, a rare manifestation of monoclonal gammopathies/plasma cell dyscrasias. Crystal-laden histiocytes have previously been described in many organs. Four reports have described crystal-storing histiocytosis in the lung, always associated with a lymphoproliferative disorder. The present patient, 1 other case from our archive, and 1 case reported in the literature, all without an association with lymphoproliferative disorder, make a full description and definition of this lesion appropriate. The morphology, immunohistochemical profile, and electron microscopic features are described herein, and the term pulmonary crystal-storing histiocytoma is proposed. A practical algorithm is presented for the assessment of solitary lung masses composed of large histiocytic cells.

scholarly journals Regeneration of experimental long bone defect after implantation in its cavity of osteoplastic material “Calc-i-oss®”

2016 ◽  
Vol 33 (02) ◽  
pp. 099-102
Author(s):  
O. Korenkov
Keyword(s):  
Bone Tissue ◽  
Morphological Characteristics ◽  
Compact Bone ◽  
Long Bone ◽  
Electron Microscopic ◽  
Time In Literature ◽  
Microscopic Features ◽  
Definition Of ◽  
Osteoplastic Material ◽  
Long Bone Defect

Abstract Introduction: There is a significant divergence of data on the rate of resorption and replacement by the bone tissue of osteoplastic materials based on β-tricalcium phosphate in cancellous bone. At the same time in literature missing morphometric and electron microscopic features of bone tissue of the regenerate of compact substance of bone in these conditions. This study was aimed at the assessment of the healing of compact bone tissue defect after implantation of osteoplastic material “Calc-i-oss®” with the definition of the dynamics of resorption and morphological characteristics of bone tissue of the regenerate. Material and Methods: In the middle third of the diaphysis of the femur of rats there was reproduced the perforated defect to the bone-brain channel that was filled with osteoplastic material “Calc-i-oss®”. After surgery the fragments of injured bones were studied at the 60th and 120th day by methods of light microscopy with morphometry and scanning electron microscopy. Results: The conducted research revealed no inflammatory reaction at the site of the defect, signs of necrobiosis and necrosis of osteocytes in adjacent to the site of implantation maternal bone. The site of defect was filled with lamellar bone tissue high in osteoblasts, osteocytes and with integrated into its structure remains of “Calc-i-oss®”. On the surface and inside the implant there were found osteogenic cells and bone foci. It was established that the osteoplastic material throughout the observation period is subjected to development and replacement by bone tissue of the regenerate, the ratio of which on the 60th day of the experiment was 25.72 ± 2.06% to 74.28 ± 2.06%, and on the 120th day - 18.31 ± 1.54% to 81.69 ± 1.54%. Conclusion: Osteoplastic material “Calc-i-oss®” exhibits biocompatibility, osteoconductive properties, ability to resorption and is replaced by bone tissue, with which it integrates well.

Fine Structural Classification of Chromophobe Adenomas of the Human Pituitary Gland

1975 ◽  
Vol 33 ◽  
pp. 378-379
Author(s):  
K. Kovacs ◽  
E. Horvath
Keyword(s):  
Pituitary Adenomas ◽  
Secretory Activity ◽  
Microscopic Investigation ◽  
Uranyl Acetate ◽  
Electron Microscopic Investigation ◽  
Electron Microscopic ◽  
Human Pituitary ◽  
Cytoplasmic Staining ◽  
Human Pituitary Gland ◽  
Microscopic Features

Chromophobe pituitary adenomas arise from adenohypophysial cells and fail to exhibit cytoplasmic staining with conventional acid or basic dyes by light microscopy. The aim of the present work was to study the electron microscopic features of these tumors, to separate them into distinct entities and to correlate their fine structural appearances with secretory activity.Among 48 surgically removed various pituitary adenomas 30 tumors were found which, based on the tinctorial characteristics of the cytoplasm, corresponded to chromophobe adenomas. For electron microscopic investigation pieces of these tumors were fixed in 2.5 per cent glutaraldehyde in Sorensen's buffer, post fixed in 1 per cent osmium tetroxide in Millonig's buffer, dehydrated in graded ethanol and embedded in Epon 812. Ultrathin sections were stained with uranyl acetate and lead citrate.By electron microscopy it was possible to separate chromophobe adenomas into 3 distinct entities: 1) adenomas consisting of sparsely granulated growth hormone cells (7 cases).

Ultrastructural Study of Apocrine Differentiation in Human Mammary Carcinoma: Correlation of Granule Content With Sex Steroid Binding

1980 ◽  
Vol 38 ◽  
pp. 742-743
Author(s):  
S. E. Levine ◽  
A. D. Brinkhous ◽  
K. S. McCarty ◽  
J. A. Mossier ◽  
K.S. McCarty
Keyword(s):  
Ultrastructural Study ◽  
Ductal Carcinoma ◽  
Apocrine Carcinoma ◽  
Electron Microscopic ◽  
Granular Eosinophilic Cytoplasm ◽  
Eosinophilic Cytoplasm ◽  
Apocrine Differentiation ◽  
Microscopic Features ◽  
Membrane Bound ◽  
Epithelial Lesions

A variant of ductal carcinoma of the human breast which has been designated apocrine carcinoma has distinctive light and electron microscopic features. Such tumors comprise approximately 0.5% of breast carcinomas. Abundant cytoplasmic membrane bound vesicles (400-600 nm) with dense homogeneous osmophilic cores characterize these tumors. These granules are also seen in apocrine metaplastic breast epithelial lesions1 and appear to be responsible for the finely granular eosinophilic cytoplasm observed by light microscopy. A high content of intermediate affinity non-saturable 4S progesteroneestrogen binding protein (PEBP) in apocrine carcinoma has been reported.2 The present ultrastructural study evaluates the presence of apocrine granules in infiltrating ductal carcinoma (NOS) to determine if a correlation exists between apocrine granule content and the quantity of PEBP present.

scholarly journals HETEROGENEITY OF ANTIBODY-FORMING CELLS

1969 ◽  
Vol 129 (5) ◽  
pp. 1029-1044 ◽  
Author(s):  
Cesare Bosman ◽  
Joseph D. Feldman ◽  
Edgar Pick
Keyword(s):  
Lymph Nodes ◽  
Plasma Cells ◽  
Specific Antigen ◽  
Cell Suspensions ◽  
Electron Microscopic ◽  
Cytoplasmic Vacuoles ◽  
Draining Lymph Nodes

Cell suspensions from draining lymph nodes of immune and nonimmune rats were reacted in vitro with 125I-labeled antigens. In light microscopic radioautographs of smears, 17% of the immunized cells were tagged by specific antigen; 2.0% of control cells were positive. In electron microscopic radioautographs, 90% of the labeled elements from immune donors were lymphocytes, blast and plasma cells; 10% were monocytes-macrophages or other elements, including naked nuclei. 15% of the labeled cells from control materials were lymphocytes and plasma cells, while 85% were monocytes-macrophages and naked nuclei. Within cell suspensions derived from immunized animals there were almost twice as many lymphocytes marked by isotope as plasma cells, and the lymphocytes ranged in morphology from mature monoribosomal elements to immature polyribosomal cells. Antibody-forming cells fixed labeled antigen at their surfaces. The monocyte-macrophage class was distinguished by a high mean grain count and by distribution of grains within cytoplasmic vacuoles and lysosomes.

A Scanning Electron Microscopic Study of the Normal Human Stapes

1979 ◽  
Vol 88 (6_suppl4) ◽  
pp. 2-14 ◽  
Author(s):  
Malcolm D. Graham ◽  
Rodney Perkins
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Electron Microscopic ◽  
Scanning Electron Microscopic Study ◽  
Scanning Electron Microscopic ◽  
Microscopic Features ◽  
Microscopic Studies ◽  
Normal Human ◽  
Temporal Bones ◽  
Scanning Electron

The structure of the normal human stapes was studied with the scanning electron microscope. Specimens were obtained 48 hours after death from adult human temporal bones free from obvious inflammatory disease. The specimens were fixed, dissected, critical-point dried and coated with gold. In this scanning electron microscopic study an attempt has been made to systematically demonstrate the average scanning electron microscopic features of various areas of the normal human stapes. An emphasis has been placed upon demonstrating as clearly as possible the details previously unclear or unrecognized and duplication of many excellent earlier light and electron microscopic studies has not been attempted. The typical appearance of the stapes head, neck, arch, crura and footplate has been presented. It is apparent that there exists a high degree of structural specialization particularly in the stapes arch and footplate area.

Solitary Ovarian Plasmocytoma: A Rare localization of Extramedullary Plasmocytoma. A Case Report

2021 ◽  
Vol 4 (5) ◽  
pp. 01-04
Author(s):  
Salma Fares ◽  
Adil Taoufik ◽  
Aissam Maataoui ◽  
Kaoutar Sokori ◽  
Ouadie Qamouss
Keyword(s):  
Plasma Cells ◽  
Female Genital Tract ◽  
Malignant Neoplasm ◽  
Solitary Plasmacytoma ◽  
Adequate Treatment ◽  
Complete Surgical Resection ◽  
Plasma Cell Dyscrasias ◽  
Extramedullary Plasmocytoma ◽  
Work Up

Background: Solitary plasmacytoma is a rare malignant neoplasm of plasma cells accounting 5-10% of all plasma cell dyscrasias with extramedullary plasmocytoma in 3- 5%. Their localization in the female genital tract is quite rare, either as solitary plasmacytomas or as part of a disseminated MM. Solitary ovarian plasmocytoma is extremely rare. Case: A 52-year-old woman, presented presented postmenopausal recurring episodes of metrorrhagia with left ovarian mass. She was diagnosed with solitary ovarianplasmocytoma without systemicdisease. The patient underwent complete surgery resection and a full work up to rule out multiple myeloma that objectived a small serum monoclonal protein that had resolved postoperatively. At 17 months of follow-up, the patient is still alive and doing well with no signs of recurrence or progression to mutliple myeloma. Although rare, solitary plasmacytoma of the ovary can occur without any overt symptoms or laboratory abnormalities tests and require prompt and adequate treatment and rigorous monitoring due to their ability to relapse or progress to MM. Complete surgical resection followed by activesurveillance is appropriate.

Scanning Electron Microscopic Features of Extubated Monoka Stents

2017 ◽  
Vol 33 (2) ◽  
pp. 90-92 ◽  
Author(s):  
Mohammad Javed Ali ◽  
Farhana Baig ◽  
Mekala Lakhsman ◽  
Milind N. Naik
Keyword(s):  
Electron Microscopic ◽  
Scanning Electron Microscopic ◽  
Microscopic Features ◽  
Scanning Electron

scholarly journals CYTOLOGY OF IMMUNOLOGIC MEMORY

1968 ◽  
Vol 128 (2) ◽  
pp. 293-307 ◽  
Author(s):  
Cesare Bosman ◽  
Joseph D. Feldman
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Plasma Cells ◽  
Keyhole Limpet Hemocyanin ◽  
Blast Cell ◽  
Lymphoid Organs ◽  
Immunologic Memory ◽  
Electron Microscopic

Pairs of rats were immunized with keyhole limpet hemocyanin (KLH) and simultaneously labeled with thymidine-methyl-3H or 5-iodo-2'-deoxyuridine-125I. From 10–50 days later, their lymphoid organs were examined 3 days after anamnestic stimulation with KLH or after primary injection of BGG. Light and electron microscopic study of the labeled cells revealed that immunologic memory resided in the mature resting monoribosomal lymphocyte which, upon stimulation, transformed to an immature polyribosomal lymphocyte and mitotically active blast cell. These latter elements differentiated into plasma cells directly or after mitosis.

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