scholarly journals GASTROPROTECTIVE EFFECT OF SESBANIA GRANDIFLORA LINN. SEEDS EXTRACT.

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Pallavi. B ◽  
Sunil. N ◽  
Syed Mansoor Ahamed ◽  
Nandheesh R.
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Small Intestine ◽  
World Population ◽  
Total Acidity ◽  
Peptic Ulcers ◽  
Ulcer Index ◽  
Standard Drug ◽  
Sesbania Grandiflora ◽  
Gastroprotective Effect

Background: A peptic ulcer is a sore in the lining of the stomach or the first part of the small intestine. Ulcer can be developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Peptic ulcers are usually aggravated by an imbalance between destructive and defensive factors in the stomach, it affects nearly 10% of world population. The objective of the study was to investigate the protective effect of ethanolic extract of Sesbania grandiflora Linn. Seeds (SGEE) on peptic ulcer induced by ethanol in experimental rats. Objectives: Gastroprotective effect of Sesbania grandiflora Linn. Seeds extract on experimental Materials and Methods: The gastroprotective effect of SGEE was studied using ethanol (70% ) induced acute gastric ulcer models. The animals were divided into five groups, each group contains six animals. SGEE was administered in two doses, (200 mg/kg and 400 mg/kg, p.o). The parameters investigated include acid volume, pH, total acidity, ulcer index, total protein, glutathione, lipid peroxidase, catalase & histopathological studies. Results: 1. In gastroprotective effect study, SGEE significantly inhibited the development of ulcers induced by ethanol. The SGEE significantly reduced the acid volume, total acidity, total acidity, ulcer index, lipid peroxidation & increases in pH, glutathione & catalase level. Histopathogical studies also revealed that SGEE is gastro-protective. Ranitidine (100 mg/kg) is used as standard drug. Conclusion: All the observation implies that SGEE possess significant protective activity against ethanol induced gastric ulcer in experimental rats. 400 mg/kg doses has shown more protection compared to 200 mg/kg (dose dependent activity was obtained). Keywords: Antiulcer; Sesbania grandiflora; Ethanol; Ranitidine.

scholarly journals Effect of Trianthema triquetra Rottl. ex Willed (Aizoaceae) on ethanol-induced gastric ulcers in experimental rats

2021 ◽  
Author(s):  
Hira Ijaz ◽  
◽  
Saiqa Ishtiaq ◽  
Faryal Rubab ◽  
Ans Munir ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Disease Control ◽  
Gastric Wall ◽  
Gastric Volume ◽  
Gastric Ph ◽  
Control Group ◽  
Treated Animal ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug

Trianthema triquetra Rottl. Ex.Willed (T. triquetra) is a medicinal plant that belongs to the family Aizoaceae. The plant has been used traditionally as fodder, as a remedy for chronic ulcer, fever, and healing wounds. Therefore, the present study was intended to investigate the anti-ulcer ability of different fractions of T. triquetra to verify its folklore use in ulcer cure. Acute oral toxicity of all the fractions of T. triquetra was evaluated at a dose of 2g/kg b.wt. Anti-ulcer potential of nbutanol (TTB), chloroform (TTC), ethyl acetate (TTEA) and aqueous (TTA) fraction of crude methanolic extract of T. triquetra was assessed by using ethanol- induced gastric ulcer model in rats. Omeprazole at a dose of 20 mg/kg b.wt. was used as standard drug. After 1 hour of administration of all the fractions of T. triquetra, at a dosage of 300mg/kg b.wt., the gastric ulcer was induced in all animals by administering absolute ethanol (1mL/animal) orally except normal control group. After an hour, all the rats were sacrificed. Ulcer index, % age of ulcer inhibition, gastric pH, gastric volume, total acidity, gastric wall protein, gastric wall mucus and histopathology of the stomach wall of rats were assessed. All fractions of T. triquetra showed a substantial decrease in ulcer index and improvement in percentage inhibition compared to the disease control group. There was a rise in the amount of gastric wall mucus content, total protein content, gastric pH and a decrease in gastric volume and total acidity. Histopathological studies showed severe mucosal injury, leucocyte infiltration and edema in the disease control group compared to omeprazole and plant fractions treated animal groups. The present work encourages the conventional use of T. triquetra in the cure of ulcers.

scholarly journals Evaluation of antiulcer activity of ethanolic leaf extract of Coccinia grandis in indomethacin induced gastric ulcer model

2019 ◽  
Vol 8 (4) ◽  
pp. 629
Author(s):  
Barathane Datchanamurthy ◽  
Mythireyi D. ◽  
Dhivyashanthi C. M.
Keyword(s):  
Gastric Ulcer ◽  
Side Effects ◽  
Leaf Extract ◽  
Common Adverse Effect ◽  
Antiulcer Activity ◽  
Peptic Ulcers ◽  
Ulcer Index ◽  
Standard Drug ◽  
Coccinia Grandis ◽  
Ethanolic Leaf Extract

Background: Gastric mucosal ulceration is the most common adverse effect with NSAIDS. Antacids, H2 blockers and PPIs are considered novel in treating ulcers but are not devoid of side effects. Hence, there a need for a drug which is effective against NSAID induced ulcers with no side effects. Coccinia grandis plant is traditionally used for the treatment of gastric/peptic ulcers. Hence, this study has been undertaken to scientifically validate the antiulcer activity of Coccinia grandis leaves against indomethacin induced gastric ulcer model.Methods: Following preparation of the extract, 24 Wistar rats were divided into 4 groups with 6 rats in each group (n=6). Group 1 received 1% CMC, group 2 received 1% CMC +indomethacin 40 mg/kg, group 3 received ethanolic leaf extract of Coccinia grandis 200 mg/kg +indomethacin 40 mg/kg and group 4 received omeprazole (2 mg/kg) +indomethzacin 40 mg/kg for 7 days. Calculation of ulcer score was done using ulcer index and percentage protection.Results: The ulcer index score (2.12±0.21) and percentage protection (69.71%) was comparable with the standard drug (1.76±0.11, 74.85%) respectively.Conclusions: The ethanolic leaf extract of Coccinia grandis showed significant antiulcer activity against indomethacin-induced gastric ulcer. Further studies are warranted to elucidate the exact mechanism of antiulcer activity.

Evaluation of the Antiulcer Activity of Ethanolic Leave Extracts of Saraca indica against Ethanol, Pylorus Ligature and Indomethacin Induced Ulcer in Albino Rats

2020 ◽  
Vol 16 (8) ◽  
pp. 1191-1196
Author(s):  
Pritt Verma ◽  
Shravan K. Paswan ◽  
Vishal K. Vishwakarma ◽  
Priyanshi Saxena ◽  
Chandana V. Rao ◽  
...  
Keyword(s):  
Mucosal Injury ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Cellulose Solution ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
High Doses

Background: To evaluate the antiulcer activity of ethanolic leaves extract of Saraca indica against ethanol, pylorus ligature and indomethacin in albino rats. Materials and Methods: Ulcer was produced by ethanol, pylorus ligature and indomethacin in albino rats. Five groups (n=6) of rats were orally pre-treated with carboxymethyl cellulose solution, and ranitidine (80 mg/kg) respectively. In ethanol induced ulcer, the animals were treated with 200 and 400 mg/kg b.w. ethanolic leave extracts of Saraca indica in 0.3% CMC solution, 60 minutes before oral administration of absolute ethanol to produce gastric mucosal injury. In indomethacin induced ulcer, the drug was administered orally at the dose of 30 mg/kg b.w. After 7-9 hours of administration of indomethacin (30 mg/kg); the animals were sacrificed with high doses of anesthesia. In the pylorus ligature method, volume of free acidity, gastric secretion, pH and total acidity were estimated. In all three models, the ulcer index and % protection were estimated. Results: The anti ulcer activity of ethanolic leave extracts of Saraca indica in ethanol, indomethacin and pylorus ligature models is evident from the significant (P<0.001) reduction in ulcer index. In pylorus ligature model, significant (P<0.001) reduction in total acidity gastric volume and increase in pH were observed when compared with the standard drug. Conclusion: Ethanolic leave extracts of Saraca indica were found to be significantly protective against ethanol, indomethacin and pylorus ligature induced gastric ulcers in the experimental albino rats. The result obtained suggest that ethanolic leave extracts of Saraca indica possesses significant anti-ulcer activity.

scholarly journals Evaluation of a poly-herbal preparation for the treatment of peptic ulcer

2017 ◽  
Vol 12 (2) ◽  
pp. 11
Author(s):  
Zaman Hayat ◽  
Mueen Ahmad Chaudhry ◽  
. Alamgeer
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Treated Group ◽  
Ulcer Formation ◽  
Ulcer Index ◽  
Herbal Formulation ◽  
High K ◽  
Ulcer Model ◽  
Dose Dependent ◽  
Gross Examination

<p class="Abstract">The aim of this study was to validate the traditional uses of ulcerene, a poly-herbal formulation in ethanol, aspirin and stress-induced gastric ulcer model of rat. The extent of gastric ulcer formation was studied, using ulcer score, ulcer index, percentage cure through gross examination and histopathological evaluation. A significant (p&lt;0.001) dose-dependent anti-ulcerant effect was observed in ulcerene (50 and 100 mg/kg)-treated group with highest effectiveness against ethanol-induced ulcer. The concentration-dependent spasmolytic effect was seen in spontaneously contracting, high K<sup>+</sup> (80 mM) and carbachol (1 µM)-induced jejunum contractions (10, 0.3 and 1 mg/mL), similar to dicyclomine (10, 1 and 3 µM), indicated non-specific spasmolytic mechanism behind the effect. By considering these results, ulcerene can be suggested for the treatment of peptic ulcer.</p>

GASTRIC ULCER OF THE PYLORUS SIMULATING. HYPERTROPHIC PYLORIC STENOSIS

PEDIATRICS ◽  
1950 ◽  
Vol 6 (6) ◽  
pp. 897-907
Author(s):  
ARTHUR R. C. COLE
Keyword(s):  
Differential Diagnosis ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Pyloric Stenosis ◽  
Recent Literature ◽  
Hypertrophic Pyloric Stenosis ◽  
Diagnostic Procedures ◽  
Peptic Ulcers ◽  
Infancy And Childhood ◽  
History Of

A brief review of the natural history of peptic ulcer in infancy and childhood is given. The symptomatology, differential diagnosis and diagnostic procedures are presented. The diagnosis of peptic ulcer should be considered more often in infancy and childhood and the proper diagnostic procedures instituted. A case of gastric ulcer simulating hypertrophic pyloric stenosis is presented. A summary of 31 cases with peptic ulcers found at autopsy at the Babies Hospital from January 1, 1924 to January 1, 1950 is given. From a summary of coexistent disease found in the autopsy cases at the Babies Hospital and reports from the recent literature, it would appear that diseases of the central nervous, gastrointestinal and respiratory systems are commonly present in cases which have shown peptic ulcer at autopsy.

scholarly journals Gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana on aspirin and histamine-induced gastric ulcer in rats

2020 ◽  
Vol 8 (1) ◽  
pp. 70
Author(s):  
Ibrahim Abubakar ◽  
Hassan Muhammad Yankuzo ◽  
Yusha'u Shuaibu Baraya ◽  
Mu'azu Abubakar Gusau
Keyword(s):  
Protective Effect ◽  
Ph Value ◽  
Gastrointestinal Diseases ◽  
Gastric Volume ◽  
Total Acidity ◽  
Gastric Lesions ◽  
Ulcer Index ◽  
Ulcer Disease ◽  
Gastroprotective Effect ◽  
Ulcer Model

Background: Peptic ulcer disease remains endemic in our society affecting about four million people every year worldwide. Hannoa klaineana is used traditionally in the treatment of various gastrointestinal diseases including ulcer.Aim: This study aims at evaluating the gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana (Simaroubaceae).Methods: The gastroprotective effect of ethylacetate fraction of the Hannoa klaineana (50, 100 and 200mg/kg b.wt) was evaluated using aspirin and histamine induced ulcer models.Results: In aspirin-induced ulcer model, the ethylacetate fraction of the Hannoa klaineana demonstrated significant (p<0.001) decreased in mean ulcer index with the maximum protective effect (99.84%) at 200 mg/kg against the gastric damages. While histamine-induced ulcer model, the solvent fraction significantly (p<0.001) decreased mean ulcer index with the protective effect up to 99.83% against the gastric lesions. In both models, a significant (p<0.001) increased in pH value coupled with significant (p<0.001) decreased in gastric volume, free and total acidity in rats pre-treated with varying doses of the ethylacetate fraction was found.Conclusion: The mechanism of gastroprotective effects of ethylacetate fraction of the Hannoa klaineana could be attributed to its ability to stimulate prostaglandins secretion or possess prostaglandins like-substances or suppression of histamine-induced vasospastic effect and gastric secretion.   

scholarly journals Evaluation of Gastroprotective Activity of Cemot Leaves (Passiflora foetida L.) Extracted by Ultrasonic Assisted Extraction (UAE) Against Ethanol-Induced Gastric Lesions in Rats

2020 ◽  
Vol 25 (2) ◽  
pp. 108
Author(s):  
Elsa Trinovita ◽  
Fatmaria Fatmaria
Keyword(s):  
Gastric Ulcer ◽  
Ethanol Extract ◽  
Peptic Ulcers ◽  
Gastroprotective Activity ◽  
Ulcer Index ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
Passiflora Foetida ◽  
Method Of Extraction

Peptic ulcers are one of the global health problems in the world. However, most of these drugs have unwanted side effects and drug interactions that this research focuses on the use of plant products as an anti gastric ulcer. The phytochemical of Passiflora foetida L. leaves or better known by the name of the Central Borneo with 'Cemot' such as flavonoids, alkaloids, and tannin has potential as a gastroprotective. This study used the method of extraction of non-conventional, namely the UAE, because it has advantages compared with other conventional methods. This study aims to investigate the gastroprotective activities of ethanol extract of Passiflora foetida leaves-UAE. Cemot extract was obtained by UAE method using a concentration of ethanol (70%), the ratio of sample/liquid (10g/mL) for 3 minutes. Three groups of rats treated with a respective dose of the extract (50, 100 and 200 mg/kg BW), one group of rats treated with omeprazole 36 mg/kg BW for seven days before peptic ulcer induction using ethanol. The activity gastroprotective with measurement of lesion of gastric ulcer index and the percentage of inhibition ulcer. Group of rats treated with 200 mg/kg BW extract showed a decreased the ulcer index and ulcer inhibition than the other extract dosage groups, respectively 2.83 and 35.34%. Conclusion: Based on the results of this study concluded that the cemot extract has potential as a gastroprotective.

scholarly journals Gastroprotective Effect of Green Algae Extract (Ulva lactuca L) on Gastric Rats

2020 ◽  
Vol 7 (2) ◽  
pp. 73
Author(s):  
Wahyu Widyaningsih ◽  
Siti Nurasih Afdaliah
Keyword(s):  
Gastric Ulcer ◽  
Green Algae ◽  
Negative Control ◽  
Ulva Lactuca ◽  
P Value ◽  
Ulcer Index ◽  
Gastroprotective Effect ◽  
Group I ◽  
Significant Difference ◽  
Protection Ratio

Gastric ulcer is a disease of the digestive tract characterized by mucous damage to secretion of gastric acid and pepsin. One of the potential gastroprotector plants is green algae. The purpose of this study was to examine the gastroprotective effect of ethanol extract of green algae (EEGH) Ulva lactuca L on the gastric of ethanol-induced rats. This study used 36 rats, divided into 6 groups. Group I is a normal group. Group II negative control, ethanol 96% induced. Group III positive control, given comparison of ranitidine dose of 15.75 mg/kgBW. Groups IV, V and VI were given multilevel EEGH, namely 125, 250 and 500 mg/kgBW. The treatment was carried out for 14 days, on the 14th day ethanol 96% was induced and then dissected. Research data on gastric ulcer index and protection ratio were analyzed using One Way ANOVA with a confidence level of 95%. The results of the EEGH statistical test dose of 500 mg/kgBW with negative controls showed a significant difference with p value of 0.013 (p<0.05). The EEGH 500 mg/kgBW has the ability as an effective gastroprotector, as seen from the gastric ulcer index value of 0.5 and the protection ratio of 78.94%.Keywords: Ethanol, gastroprotector, protection ratio, ulcer index, Ulva lactuca L.78,94%. 

scholarly journals Gastro-protective effects of methanol extract of Tephrosia calophylla

2018 ◽  
Vol 8 (6-s) ◽  
pp. 141-145
Author(s):  
C Ramesh ◽  
A. Prameela Rani
Keyword(s):  
Protected Area ◽  
Methanol Extract ◽  
Research Work ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Total Acidity ◽  
Protective Effects ◽  
Ulcer Index ◽  
Standard Drug ◽  
Soxhlet Apparatus

Objective: The present research work was designed to investigate gastro protective potentials of methanol extract of Tephrosia calophylla. Methods: The aerial parts of Tephrosia calophylla were dried under shade, powdered and deffated with petroleum ether and then marc left over was subjected to methanol extraction using soxhlet apparatus. Antiulcer activity of methanol extract was determined against stress induced and aspirin induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study. Results: Methanol extract of Tephrosia calophylla have significantly reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compare to vehicle control and there by significantly increased percentage inhibition of ulcers and protected area which was evident by significant rise in pH of gastric content. The effect of extracts was dose dependent and results were comparable to that of standard drug omeprazole. Conclusion: The results obtained from the present work suggest that the methanol extract of Tephrosia calophylla possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats. Keywords: Tephrosia calophylla, Anti ulcer activity, Ethanol, Aspirin Ulcer index, pH, total acidity, Percentage inhibition and percentage of protected area.

scholarly journals Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3312
Author(s):  
Felipe Leonardo Fagundes ◽  
Quélita Cristina Pereira ◽  
Melina Luzzi Zarricueta ◽  
Raquel de Cássia dos Santos
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Acetic Acid ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Defense Mechanisms ◽  
Ischemia Reperfusion ◽  
Peptic Ulcers ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Peptic ulcer episodes cause damage to the stomach and intestine, with inflammatory cell infiltration and oxidative stress as the main players. In this study, we investigated the potential of anthocyanidin malvidin for preventive and curative peptic ulcer treatment. The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy. Expression levels of oxidative and inflammatory genes were measured to investigate the mechanism of anthocyanin activity. At a dose of 5 mg·kg−1, Malvidin prevented gastric ulcer induction by ethanol, NSAID and repaired the tissue after 6 days of IR. Moreover, the anthocyanidin accelerated the healing of acetic acid-induced ulcer, increased the gene expression of EGF and COX-1, and downregulated MMP-9. Anthocyanin treatment mitigated the effect of polypharmacy on inflammation and oxidative stress observed in the intestine. Additionally, the compound downregulated cytokine expression and TLR4 and upregulated HMOX-1 and IL-10, exhibiting protective activity in the mouse gut. Malvidin thus prevented gastric and duodenal ulcers due to prominent anti-inflammatory and antioxidative effects on the gastrointestinal tract that were related to gene expression modulation and an increase in endogenous defense mechanisms.

Sign in / Sign up

Export Citation Format

Share Document