Anti-mullerian Hormone and Vitamin D as a predictor of Ovarian reserve and Ovarian response in Infertile women undergoing IVF

2019 ◽  
Vol 12 (7) ◽  
pp. 3527
Author(s):  
Hiba H. Kadhim ◽  
Salman A. Ahmed
Keyword(s):  
Vitamin D ◽  
Ovarian Reserve ◽  
Ovarian Response ◽  
Infertile Women

scholarly journals Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors

2017 ◽  
Vol 35 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Alberta Maria Fabris ◽  
Maria Cruz ◽  
Carlos Iglesias ◽  
Alberto Pacheco ◽  
Azadeh Patel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Ovarian Response ◽  
Vitamin D Levels ◽  
Oocyte Donors

scholarly journals The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

2019 ◽  
Author(s):  
Shan-Jie Zhou ◽  
Ming-Jia Zhao ◽  
Cui Li ◽  
Xing Su
Keyword(s):  
Ovarian Reserve ◽  
Predictive Accuracy ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Ovarian Response ◽  
Antral Follicle ◽  
The Other ◽  
Single Variable ◽  
Infertile Women ◽  
Better Than

Abstract Aim of the present study was to explore the evaluative effectiveness of age, ovarian volume, antral follicle count (AFC), serum follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), FSH/LH ratio and ovarian response prediction index (ORPI) to determine which could most advantageously assess ovarian reserve and response.Methods This research enrolled 319 consecutive infertile women who had undergone IVF-ET/ICSI treatments. Abovementioned variables were measured and calculated. Receiver Operating Characteristic Curve analysis was used to analyze the predictive accuracy of variables and to calculate cut-off values and corresponding sensitivity and specificity.Results Our study revealed that the significant variables for evaluating a decline in ovarian reserve include age, total volume of bilateral ovary, FSH, and ORPI. Moreover, the area under the curve (AUC) of ORPI was higher than other three variables (AUC = 0.903), and the cut-off value of ORPI was 0.245 (sensitivity 90.1%, specificity 73.9%). The significant variables forecasting excessive ovarian response were age, AFC, AMH, ORPI, FSH and FSH/LH ratio, and the significant variables forecasting low ovarian response were AMH and FSH/LH ratio. ORPI and FSH/LH ratio presented better effectiveness in evaluating ovarian response. When they were used to predict excessive response, the cut-off values of ORPI and FSH/LH ratio was 0.886 (sensitivity 84.7%, specificity 67.3%) and 1.753 (sensitivity 56.2%, specificity 67.6%), respectively. When used to predict low response, the cut-off value of FSH/LH ratio was 2.983 (sensitivity 75.0%, specificity 83.8%).Conclusions ORPI performed better than did the other variables in evaluating ovarian reserve and predicting excessive ovarian response, and the FSH/LH ratio performed better than did the other variables in predicting low ovarian response. Consequently, we agreed that the evaluative effectiveness of a combined index exceeded that of a single variable for evaluating the ovarian reserve and response of infertile women.

scholarly journals Vitamin D does not have any Impact on Ovarian Reserve Markers in Infertile Women

2017 ◽  
pp. 1
Author(s):  
Ümit Görkem ◽  
Ferit Kerim Küçükler ◽  
Cihan Toğrul ◽  
Şebnem Gülen
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Waist Circumference ◽  
Body Mass ◽  
Ovarian Reserve ◽  
Hip Circumference ◽  
Infertile Women ◽  
Significant Difference ◽  
Ovarian Reserve Markers ◽  
Ovarian Syndrome

<p><strong>Objective:</strong> To evaluate the potential role of vitamin D on ovarian reserve markers in infertile women with different reserve patterns.</p><p><strong>Study design:</strong> This prospective cross-sectional study included the infertile women attending the Hitit University Hospital. The initial examination included the measurements of waist circumference and hip circumference, body mass index, and waist/hip ratio. A total of 171 women were divided into three groups according to ovarian reserve patterns: (i) adequate ovarian reserve pattern (AOR, n=77), (ii) high ovarian reserve pattern (polycystic ovarian syndrome, n=62), and (iii) diminished ovarian reserve pattern (DOR, n=32). The serum estradiol (E2), follicle stimulating hormone, total testosterone, 17-hydroxy-progesterone (17(OH) P), dehydroepiandrosterone sulfate, anti-mullerian hormone, and hydroxycholecalciferol (25(OH) D) levels were analyzed. </p><p><strong>Results:</strong> No significant difference between three different groups was detected in terms of body mass index, waist circumference, hip circumference, waist/hip ratio, E2 and 17OHP levels (p&gt;0.05, for all). One-hundred-sixty-nine (98.2%) women in all groups had vitamin D concentration below 30 ng/mL as a cut-off value. The circulating 25 (OH) D levels did not show a significant difference between all ovarian reserve groups (p=0.804). No correlation between 25(OH) D and anti-mullerian hormone levels was documented in women with AOR, polycystic ovarian syndrome and DOR patterns (r=-0.099 p=0.393, r=0.034 p=0.794 and r=0.157 p=0.390 respectively). 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group (r=-0.355 p=0.002, r=-0.305 p=0.007 and r=-0.322 p=0.004 respectively).</p><p><strong>Conclusions:</strong> There is no association between 25 (OH) D and ovarian reserve markers. 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group.</p>

scholarly journals The Evaluative Effectiveness of a Combined Index Exceeded That of a Single Variable for the Ovarian Reserve and Response of Infertile Women

2019 ◽  
Author(s):  
Shan-Jie Zhou ◽  
Ming-Jia Zhao ◽  
Cui Li ◽  
Xing Su
Keyword(s):  
Ovarian Reserve ◽  
Predictive Accuracy ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Ovarian Response ◽  
Antral Follicle ◽  
The Other ◽  
Single Variable ◽  
Infertile Women ◽  
Better Than

Abstract Background: Aim of the present study was to explore the evaluative effectiveness of age, ovarian volume, antral follicle count (AFC), serum follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), FSH/LH ratio and ovarian response prediction index (ORPI) to determine which could most advantageously assess ovarian reserve and response. Methods: This research enrolled 319 consecutive infertile women who had undergone IVF-ET/ICSI treatments. Abovementioned variables were measured and calculated. Receiver Operating Characteristic Curve analysis was used to analyze the predictive accuracy of variables and to calculate cut-off values and corresponding sensitivity and specificity. Results: Our study revealed that the significant variables for evaluating a decline in ovarian reserve include age, total volume of bilateral ovary, FSH, and ORPI. Moreover, the area under the curve (AUC) of ORPI was higher than other three variables (AUC = 0.903), and the cut-off value of ORPI was 0.245 (sensitivity 90.1%, specificity 73.9%). The significant variables forecasting excessive ovarian response were age, AFC, AMH, ORPI, FSH and FSH/LH ratio, and the significant variables forecasting low ovarian response were AMH and FSH/LH ratio. ORPI and FSH/LH ratio presented better effectiveness in evaluating ovarian response. When they were used to predict excessive response, the cut-off values of ORPI and FSH/LH ratio was 0.886 (sensitivity 84.7%, specificity 67.3%) and 1.753 (sensitivity 56.2%, specificity 67.6%), respectively. When used to predict low response, the cut-off value of FSH/LH ratio was 2.983 (sensitivity 75.0%, specificity 83.8%). Conclusions: ORPI performed better than did the other variables in evaluating ovarian reserve and predicting excessive ovarian response, and the FSH/LH ratio performed better than did the other variables in predicting low ovarian response. Consequently, we agreed that the evaluative effectiveness of a combined index exceeded that of a single variable for evaluating the ovarian reserve and response of infertile women.

scholarly journals Vitamin D levels are not associated with ovarian reserve in a group of infertile women with a high prevalance of diminished ovarian reserve

2018 ◽  
Vol 110 (4) ◽  
pp. 761-766.e1 ◽  
Author(s):  
Alice J. Shapiro ◽  
Sarah K. Darmon ◽  
David H. Barad ◽  
Norbert Gleicher ◽  
Vitaly A. Kushnir
Keyword(s):  
Vitamin D ◽  
Ovarian Reserve ◽  
Diminished Ovarian Reserve ◽  
Infertile Women ◽  
Vitamin D Levels

scholarly journals The effect of vitamin D status on ovarian reserve markers in infertile women: A prospective cross-sectional study

2020 ◽  
Author(s):  
Nazanin Alavi ◽  
Mahbod Ebrahimi ◽  
Firoozeh Akbari-Asbagh
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Ovarian Reserve ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Infertile Women ◽  
Vitamin D Levels ◽  
The Impact

Background: Vitamin D deficiency and infertility are two important health problems in Iran. Some studies suggest that vitamin D may influence Anti-Müllerian hormone (AMH) and antral follicle count (AFC) as an ovarian reserve. Objective: The present study aimed to investigate the impact of vitamin D on AMH serum concentrations/AFC. Materials and Methods: three hundred and five infertile women referred to the IVF Unit of Yas hospital, between July and December 2017, were enrolled in this cross-sectional study. The demographic characteristics of the participants, as well as the serum levels of vitamin D, AMH, and ultrasonic examination of AFC were recorded. Results: Finally, 287 infertile women were included in the analysis with a mean age of 29.95 ± 4.73 yr (18-45 yr) and a mean Body mass indexof 25.11 ± 4.41 kg/m2. The median AMH and vitamin D levels were 3.20 and 22.82 ng/ml, respectively. Considering the cut-off level of 20 ng/ml, 58.7% were vitamin D deficient. Regression analysis showed no association between AMH and vitamin D levels (p = 0.161), even after adjusting for baseline variables (p = 0.182). A total of 120 patients had an AFC < 6 and 164 ≥ 6, which was not statistically different between the groups with normal level or deficient vitamin D (p = 0.133). Conclusion: The present cross-sectional study showed no significant association between serum levels of vitamin D and AMH or AFC in infertile women, even after adjusting for baseline variables. Key words: Anti-Müllerian hormone, Infertility, Vitamin D deficiency, Ovarian follicle.

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