MTHFR C677T Polymorphism and smoking influence plasma homocysteine level in a North Indian population

2018 ◽  
Vol 12 (1) ◽  
pp. 66
Author(s):  
Suchita Rawat ◽  
Suniti Yadav ◽  
Shipra Joshi ◽  
Kallur Nava Saraswathy
Keyword(s):  
Indian Population ◽  
Homocysteine Level ◽  
Mthfr C677t ◽  
Plasma Homocysteine ◽  
North Indian Population ◽  
C677t Polymorphism ◽  
Plasma Homocysteine Level ◽  
Mthfr C677t Polymorphism

Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults

2010 ◽  
Vol 42 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Motoyuki Iemitsu ◽  
Haruka Murakami ◽  
Kiyoshi Sanada ◽  
Kenta Yamamoto ◽  
Hiroshi Kawano ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Cardiorespiratory Fitness ◽  
Methylenetetrahydrofolate Reductase ◽  
Homocysteine Level ◽  
Mthfr C677t ◽  
Plasma Homocysteine ◽  
C677t Polymorphism ◽  
Significant Interaction Effect ◽  
Mthfr C677t Polymorphism ◽  
Fitness Level

The TT genotype of C677T polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR) induces elevation of homocysteine level and leads to atherosclerosis and arterial stiffening. Furthermore, cardiorespiratory fitness level is also associated with arterial stiffness. In the present study, a cross-sectional investigation of 763 Japanese men and women (18–70 yr old) was performed to clarify the effects of cardiorespiratory fitness on the relationship between arterial stiffness and MTHFR C677T gene polymorphism. Arterial stiffness was assessed by carotid β-stiffness with ultrasonography and tonometry. The study subjects were divided into high-cardiorespiratory fitness (High-Fit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median value of peak oxygen uptake in each sex and decade. The plasma homocysteine level was higher in the TT genotype of MTHFR C677T polymorphism compared with CC and CT genotype individuals. MTHFR C677T polymorphism showed no effect on carotid β-stiffness, but there was a significant interaction effect between fitness and MTHFR C677T polymorphism on carotid β-stiffness ( P = 0.0017). In the Low-Fit subjects, carotid β-stiffness was significantly higher in individuals with the TT genotype than the CC and CT genotypes. However, there were no such differences in High-Fit subjects. In addition, β-stiffness and plasma homocysteine levels were positively correlated in Low-Fit subjects with the TT genotype ( r = 0.71, P < 0.0001), but no such correlations were observed in High-Fit subjects. In CC and CT genotype individuals, there were also no such correlations in either fitness level. These results suggest that the higher cardiorespiratory fitness may attenuate central artery stiffening associated with MTHFR C677T polymorphism.

MTHFR C677T Polymorphism and risk of nonsyndromic cleft in craniofacial region in a South Indian Population

2020 ◽  
Vol 69 (1) ◽  
pp. 15
Author(s):  
BettyAnna Jose ◽  
Varsha Mokhasi ◽  
SubramaniArumugam Subramani ◽  
Mahendrakar Shashirekha
Keyword(s):  
Indian Population ◽  
Mthfr C677t ◽  
South Indian Population ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
South Indian

Association of MTHFR C677T polymorphism with elevated homocysteine level and disease development in vitiligo

2020 ◽  
Vol 47 (4) ◽  
pp. 342-350 ◽  
Author(s):  
Arash Bagheri Hamidi ◽  
Nastaran Namazi ◽  
Mahsa Mohammad Amoli ◽  
Maliheh Amani ◽  
Morteza Gholami ◽  
...  
Keyword(s):  
Homocysteine Level ◽  
Mthfr C677t ◽  
Disease Development ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

scholarly journals Plasma Homocysteine Level And C677T Polymorphism In MTHFR Gene In Patients With Acute Coronary Syndrome

2015 ◽  
Vol 8 (1) ◽  
pp. 46-51
Author(s):  
Andrey V. Grek ◽  
Lyudmyla N. Prystupa ◽  
Tatiana V. Sytnik
Keyword(s):  
Acute Coronary Syndrome ◽  
Endothelial Dysfunction ◽  
Homocysteine Level ◽  
Mthfr C677t ◽  
Mthfr Gene ◽  
Control Group ◽  
C677t Polymorphism ◽  
Mthfr Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
Coronary Syndrome

SummaryCardiovascular diseases (CVD) of atherosclerotic origin and accompanying complications are a major cause of mortality in the world and Ukraine, in particular. Endothelial dysfunction is the key cause of atherosclerosis and atherothrombosis. One of the causes of endothelial dysfunction is hyperhomocysteinemia that may occur on the background of MTHFR (methylenetetrahydrofolate reductase) mutation.Thus, the goal of the study was to investigate the interrelation between homocysteine (Hc) level and MTHFR polymorphism in patients with acute coronary syndrome (ACS).161 patients with ischemic heart disease and ACS have been examined. The control group comprised 87 healthy individuals. Homocysteine level was the highest in the patients having ACS with ST-segment elevation and complicated course, and was 1.8 times higher than Hc level in the control group. The patients with the most severe ACS course comprised 27 % of homozygotes for the major allele C and 41 % of homozygotes for the minor allele T. Comparing the distribution of MTHFR gene C677T polymorphism in patients with ACS that were stratified by plasma Hc level, we observed a statistically significant association, P < 0.030 by chi-square test. We confirmed that these patients had a high T/T genotype frequency of MTHFR C677T polymorphism. The obtained data proved the association of T/T genotype of MTHFR C677T polymorphism with increased Hc level as well as ACS severity.

scholarly journals Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease

2007 ◽  
Vol 125 (1) ◽  
pp. 4-8 ◽  
Author(s):  
Alexandre Rodrigues Guerzoni ◽  
Érika Cristina Pavarino-Bertelli ◽  
Moacir Fernandes de Godoy ◽  
Carla Renata Graça ◽  
Patrícia Matos Biselli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Methylenetetrahydrofolate Reductase ◽  
Mthfr C677t ◽  
Plasma Homocysteine ◽  
C677t Polymorphism ◽  
Specific Patient ◽  
Mthfr C677t Polymorphism ◽  
Artery Disease

CONTEXT AND OBJECTIVE: Obstructive coronary artery disease (CAD) is characterized by the deposition of atherosclerotic plaque on the coronary artery wall. Its manifestations depend on interactions between environmental and genetic risk factors. The aim of this work was to analyze the frequency of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in patients with CAD and its association with plasma homocysteine levels. Risk factors for CAD were also evaluated. DESIGN AND SETTING: Retrospective with blind quantitative analysis, at Hospital de Base, Faculdade de Medicina de São José do Rio Preto. METHODS: One hundred and twenty-seven individuals were studied. All completed a questionnaire to analyze risk factors for CAD. MTHFR polymorphism was investigated by restriction fragment length analysis and correlated with the number of affected arteries and degree of arterial obstruction determined by coronary cineangiography, and with plasma homocysteine levels measured by liquid chromatography/sequential mass spectrometry. RESULTS: Smoking (p = 0.02) and high-density lipoprotein cholesterol (p = 0.01) were associated with CAD. The C allele was the most prevalent in patients (0.61) and controls (0.66). There was no correlation between MTHFR/C677T polymorphism and plasma homocysteine levels. However, in patients with the TT genotype there was a correlation with the prevalence of coronary obstruction greater than 95% (p = 0.02) and the presence of two affected arteries (p = 0.04). CONCLUSIONS: The TT genotype is associated with coronary artery obstruction greater than 95% and the presence of two affected arteries. This confirms the relationship between genetic variants in specific patient subgroups and cardiovascular diseases.

Sign in / Sign up

Export Citation Format

Share Document