The discovery of “sale amarissimo antifebbrile” (“bitter febrifugal saline”) by Bartolommeo Rigatelli, i.e. the origins of pharmacoeconomics

2008 ◽  
Vol 9 (1) ◽  
pp. 15-18
Author(s):  
Piero Marson ◽  
Giampiero Pasero
Keyword(s):  
South America ◽  
Active Component ◽  
Management Policy ◽  
Drug Sale ◽  
The North ◽  
History Of ◽  
Willow Bark

When considering the history of salycilates, it has to be underlined that a number of Italian scientists made significant contributions on such a topic. Among these, two pharmacists, Bartolommeo Rigatelli in Verona and Francesco Fontana in Lazise, carried out the first extraction of the active component of willow bark in 1824. Rigatelli named the drug “sale amarissimo antifebbrile” (“bitter febrifugal saline”). In his report some references of pharmacoeconomics are sketched out, thus indicating the attention that the Austrian government on the North Italian districts gave to the management policy. In fact, Rigatelli carried out an economic account of the use of salicin extracts as an antipyretic agent instead of the chincona bark which had been imported from South America at that time and was very expensive. This historical report gives rise to outline a brief history of pharmacoeconomics.

Holocene glacier history of northeastern Cordillera Darwin, southernmost South America (55°S)

2021 ◽  
pp. 1-16
Author(s):  
Scott A. Reynhout ◽  
Michael R. Kaplan ◽  
Esteban A. Sagredo ◽  
Juan Carlos Aravena ◽  
Rodrigo L. Soteres ◽  
...  
Keyword(s):  
South America ◽  
Last Millennium ◽  
Glacial History ◽  
Dry Period ◽  
The North ◽  
Southward Shift ◽  
History Of ◽  
Glacial Expansion ◽  
The Antarctic ◽  
Glacial Advance

Abstract In the Cordillera Darwin, southernmost South America, we used 10Be and 14C dating, dendrochronology, and historical observations to reconstruct the glacial history of the Dalla Vedova valley from deglacial time to the present. After deglacial recession into northeastern Darwin and Dalla Vedova, by ~16 ka, evidence indicates a glacial advance at ~13 ka coeval with the Antarctic Cold Reversal. The next robustly dated glacial expansion occurred at 870 ± 60 calendar yr ago (approximately AD 1150), followed by less-extensive dendrochronologically constrained advances from shortly before AD 1836 to the mid-twentieth century. Our record is consistent with most studies within the Cordillera Darwin that show that the Holocene glacial maximum occurred during the last millennium. This pattern contrasts with the extensive early- and mid-Holocene glacier expansions farther north in Patagonia; furthermore, an advance at 870 ± 60 yr ago may suggest out-of-phase glacial advances occurred within the Cordillera Darwin relative to Patagonia. We speculate that a southward shift of westerlies and associated climate regimes toward the southernmost tip of the continent, about 900–800 yr ago, provides a mechanism by which some glaciers advanced in the Cordillera Darwin during what is generally considered a warm and dry period to the north in Patagonia.

South America—Andes

2017 ◽  
Author(s):  
George F. Lau
Keyword(s):  
South America ◽  
North Coast ◽  
Small Worlds ◽  
Fertility Status ◽  
The North ◽  
Form Function ◽  
History Of

This chapter details major figurine developments in the ancient Andes and discusses new understandings based on figurine form, function, and imagery. Great formal diversity characterizes the long history of their use. The most active traditions occurred along the coast, while data from the highlands and eastern slopes are more limited. Certain regions, especially the north coast, show longevity in the use of figurines, especially in household, funerary, and offering contexts. Figurines were important for their role in embodying identity (e.g. gender, fertility, status) as well as alterity. Production and ritual embued them with divine powers and agency. Figurine use and imagery also show dual structures, often manifested in gendered pairs or object sets. Finally, Andean figurines were important for their interactions with other contexts and things, including other figurine-like items: they inspired their own small worlds of sociality.

Ras al Khaimah: further archaeological discoveries

Antiquity ◽  
1976 ◽  
Vol 50 (200) ◽  
pp. 216-222
Author(s):  
Beatrice De Cardi
Keyword(s):  
United Arab Emirates ◽  
The State ◽  
Focused Attention ◽  
North East ◽  
The North ◽  
History Of ◽  
The City

Ras a1 Khaimah is the most northerly of the seven states comprising the United Arab Emirates and its Ruler, H. H. Sheikh Saqr bin Mohammad al-Qasimi, is keenly interested in the history of the state and its people. Survey carried out there jointly with Dr D. B. Doe in 1968 had focused attention on the site of JuIfar which lies just north of the present town of Ras a1 Khaimah (de Cardi, 1971, 230-2). Julfar was in existence in Abbasid times and its importance as an entrep6t during the sixteenth and seventeenth centuries-the Portuguese Period-is reflected by the quantity and variety of imported wares to be found among the ruins of the city. Most of the sites discovered during the survey dated from that period but a group of cairns near Ghalilah and some long gabled graves in the Shimal area to the north-east of the date-groves behind Ras a1 Khaimah (map, FIG. I) clearly represented a more distant past.

Sequencing Analysis and Phylogenetic Tree of HPV Isolated from Breast Cancer Patients at Thi-Qar Province/Iraq

2020 ◽  
pp. 37-40
Keyword(s):  
Nucleotide Sequence ◽  
Phylogenetic Tree ◽  
Evolutionary Relationship ◽  
Nucleotide Sequencing ◽  
Sequencing Analysis ◽  
Breast Cancer Patients ◽  
The North ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
History Of

Genetic variety examination has demonstrated fundamental to the understanding of the epidemiological and developmental history of Papillomavirus (HPV), for the development of accurate diagnostic tests and for efficient vaccine design. The HPV nucleotide diversity has been investigated widely among high-risk HPV types. To make the nucleotide sequence of HPV and do the virus database in Thi-Qar province, and compare sequences of our isolates with previously described isolates from around the world and then draw its phylogenetic tree, this study done. A total of 6 breast formalin-fixed paraffin-embedded (FFPE) of the female patients were included in the study, divided as 4 FFPE malignant tumor and 2 FFPE of benign tumor. The PCR technique was implemented to detect the presence of HPV in breast tissue, and the real-time PCR used to determinant HPV genotypes, then determined a complete nucleotide sequence of HPV of L1 capsid gene, and draw its phylogenetic tree. The nucleotide sequencing finding detects a number of substitution mutation (SNPs) in (L1) gene, which have not been designated before, were identified once in this study population, and revealed that the HPV16 strains have the evolutionary relationship with the South African race, while, the HPV33 and HPV6 showing the evolutionary association with the North American and East Asian race, respectively.

Charles Waterton (1782–1865) and wourali

2017 ◽  
Vol 44 (1) ◽  
pp. 122-129 ◽  
Author(s):  
A. Padfield
Keyword(s):  
South America ◽  
British Guiana ◽  
History Of

Charles Waterton was the eccentric “Lord of Walton Hall” near Wakefield in Yorkshire. His Wanderings in South America was first published in 1826; translated into French, German and Spanish, it was a best seller. He brought back wourali used by the Macoushi natives of British Guiana (now Guyana) for killing prey; there is a piece of it in the Wakefield Museum. This paper traces the history of wourali which paralyses its victims; its attempted medical use for rabies and tetanus and, though different from curare, its belated use in modern anaesthesia.

“What Freedom?”

2019 ◽  
Vol 74 (3) ◽  
pp. 305-331
Author(s):  
John Owen Havard
Keyword(s):  
South America ◽  
French Revolution ◽  
The Political ◽  
The Novel ◽  
Free Condition ◽  
Narrative Design ◽  
Economic Liberalism ◽  
History Of ◽  
Ways Of Thinking ◽  
John Owen

John Owen Havard, “‘What Freedom?’: Frankenstein, Anti-Occidentalism, and English Liberty” (pp. 305–331) “If he were vanquished,” Victor Frankenstein states of his monstrous creation in Mary Shelley’s Frankenstein (1818), “I should be a free man.” But he goes on: “Alas! what freedom? such as the peasant enjoys when his family have been massacred before his eyes, his cottage burnt, his lands laid waste, and he is turned adrift, homeless, pennyless, and alone, but free.” Victor’s circumstances approximate the deracinated subject of an emergent economic liberalism, while looking to other destitute and shipwrecked heroes. Yet the ironic “freedom” described here carries an added charge, which Victor underscores when he concludes this account of his ravaged condition: “Such would be my liberty.” This essay revisits the geographic plotting of Frankenstein: the digression to the East in the nested “harem” episode, the voyage to England, the neglected episode of Victor’s imprisonment in Ireland, and the creature’s desire to live in South America. Locating Victor’s concluding appeal to his “free” condition within the novel’s expansive geography amplifies the political stakes of his downfall, calling attention to not only his own suffering but the wider trail of destruction left in his wake. Where existing critical accounts have emphasized the French Revolution and its violent aftermath, this obscures the novel’s pointed critique of a deep and tangled history of English liberty and its destructive legacies. Reexamining the novel’s geography in tandem with its use of form similarly allows us to rethink the overarching narrative design of Frankenstein, in ways that disrupt, if not more radically dislocate, existing rigid ways of thinking about the novel.

North American Association for the Study of Religion (NAASR)

2015 ◽  
Vol 44 (2) ◽  
pp. 29-30
Author(s):  
Matt Sheedy
Keyword(s):  
North American ◽  
American Association ◽  
The North ◽  
History Of

I interviewed Russell McCutcheon back in March 2015, about his new role as president of the North American Association for the Study of Religion (NAASR), asking him about the history of the organization, goals for his tenure, and developments for NAASR’s upcoming conference in Atlanta in November 2015.

A Synopsis of Dicliptera (Acanthaceae) in Brazil, with the Description of Two New Species

2020 ◽  
Vol 45 (2) ◽  
pp. 340-348
Author(s):  
James Lucas da Costa-Lima ◽  
Earl Celestino de Oliveira Chagas
Keyword(s):  
New Species ◽  
South America ◽  
The State ◽  
Northeastern Brazil ◽  
Mato Grosso ◽  
The North ◽  
New Synonyms ◽  
Two New Species ◽  
Mato Grosso Do Sul ◽  
A New Species

Abstract—A synopsis of Dicliptera (Acanthaceae) for Brazil is presented. Six species are recognized: Dicliptera ciliaris, D. sexangularis, and D. squarrosa, widely distributed in South America; D. purpurascens, which ranges from the North Region of Brazil (in the state of Acre) to eastern Bolivia; D. gracilirama, a new species from the Atlantic Forest of northeastern Brazil; and D. granchaquenha, a new species recorded in dry and semideciduous forests in Bolivia and western Brazil, in the state of Mato Grosso do Sul. Furthermore, we propose new synonyms and designate lectotypes for eleven names. An identification key to the six accepted Dicliptera species in Brazil is provided.

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