scholarly journals Impact of Nutritional Intake on Function in People with Mild-to-Moderate Multiple Sclerosis

2019 ◽  
Vol 21 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Lacey Bromley ◽  
Peter J. Horvath ◽  
Susan E. Bennett ◽  
Bianca Weinstock-Guttman ◽  
Andrew D. Ray
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Physical Functioning ◽  
Daily Activity ◽  
Short Form ◽  
Self Report ◽  
Walk Test ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Sf 36

Abstract Background: We sought to assess the associations between nutrition and ambulation, daily activity, quality of life (QOL), and fatigue in individuals with mild-to-moderate disability with multiple sclerosis (MS). Methods: This cross-sectional pilot study included 20 ambulatory adult volunteers with MS (14 women and 6 men; mean ± SD age, 57.9 ± 10.2 years; mean ± SD Expanded Disability Status Scale score = 4.1 ± 1.8). Primary outcome variables included dietary assessment and the 6-Minute Walk Test (6MWT). Secondary measures included the Timed 25-Foot Walk test, Timed Up and Go test, daily activity, and three self-report questionnaires: the 12-item Multiple Sclerosis Walking Scale, the 36-item Short Form Health Survey (SF-36), and the Modified Fatigue Impact Scale. Results: Significant correlations were seen between the percentage of diet comprising fats and the 6MWT (r = 0.51, P = .02) and the physical functioning component of the SF-36 (r = 0.47, P = .03). The percentage of carbohydrates was significantly correlated with the 6MWT (r = −0.43, P = .05), daily activity (r = −0.59, P = .005), and the physical functioning component of the SF-36 (r = −0.47, P = .03). Cholesterol, folate, iron, and magnesium were significantly positively correlated with the physical functioning component of the SF-36 and the 6MWT. Conclusions: These findings indicate better ambulation, daily function, and QOL with increased fat intake, decreased carbohydrate intake, and increased intake of the micronutrients cholesterol, folate, iron, and magnesium in people with mild-to-moderate MS. This pilot study highlights the potential impact of diet on function and QOL in MS.

Disease Progression in Multiple Sclerosis II. Methods for the Determination of Walking Impairment and Its Impact on Activities and Social Participation

2010 ◽  
Vol 5 (1) ◽  
pp. 61 ◽  
Author(s):  
Jürg Kesselring ◽  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Progression ◽  
Social Participation ◽  
Short Form ◽  
Self Report ◽  
Walking Ability ◽  
Test Procedures ◽  
Timed Up And Go ◽  
Clinician Training ◽  
Sf 36

Walking ability is a vital component of validated test procedures to assess mobility impairment in multiple sclerosis (MS). The methods used to assess walking ability vary widely between treatment centres, and the accuracy of the methods used and numbers of parameters determined to analyse specific aspects of walking and gait are often limited. The questionnaire- and task-based methods used to assess walking in MS can be divided into different categories. First, there are the general-purpose tests such as the Expanded Disability Status Scale (EDSS), the Multiple Sclerosis Functional Composite (MSFC), the Family Assessment of Multiple Sclerosis Trial Outcome Index (FAMS-TOI) and the Short Form-36 (SF-36). These, particularly EDSS, are widely used in MS to assess limitations of all activities and social participation, of which walking is only a part. Others, such as SF-36, assess health-related quality of life (HRQoL). Second, there are methods designed to specifically assess walking or gait, including the timed 25-foot walk (T25FW), the Dynamic Gait Index (DGI), the 12-Item MS Walking Scale (MSWS-12) and the Timed Up and Go Test (TUGT). These test methods require minimal equipment to perform such as a stopwatch, a hallway or a chair, and can be completed at a medical centre in a few minutes. Most of these tests provide reliable and valid data but some lack accurate assessment of gait and some require clinician training. Third, there are tests that specifically measure balance, such as the Berg Balance Test, in which the patient completes a series of balance exercises while being observed. A recent development is the use of accelerometers to monitor MS patients over extended periods; these can provide more accurate data than patient self-report tools. In future, it is likely that more specific tests of walking ability will be more widely used as an important part of MS diagnosis and to more precisely monitor disease progression and assess patient needs.

scholarly journals Childhood mouth-breathing consequences at adult age: ventilatory function and quality of life

2014 ◽  
Vol 27 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Jovana de Moura Milanesi ◽  
Priscila Weber ◽  
Luana Cristina Berwig ◽  
Rodrigo Agne Ritzel ◽  
Ana Maria Toniolo da Silva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Mouth Breathing ◽  
Walk Test ◽  
Ventilatory Function ◽  
Nasal Breathing ◽  
Cross Sectional ◽  
Adult Age ◽  
Sf 36

Introduction Mouth breathing can affect the functions of the respiratory systems and quality of life. For this reason, children who grow up with this stimulus may have implications on physical and psychological aspects at adult age.Objective To evaluate childhood mouth-breathing consequences for the ventilatory function and quality of life at adult age.Materials and methods Prospective, observational and cross-sectional study with 24 adults, between 18 and 30 years old, mouth breathers during childhood, comprised the childhood mouth-breathing group (CMB). The childhood nasal-breathing (CNB) group was composed of 20 adults of the same age, without history of respiratory disease during all their lives. Measurements of maximal respiratory pressures, peak expiratory flow and 6-minute walk test were assessed. In addition, all the volunteers answered the Short Form-36 questionnaire (SF-36).Results The maximal inspiratory (p = 0.001) and expiratory (p = 0.000) pressures as well as the distance in the walk test (p = 0.003) were lower in the COB. The COB also presented lower score in the General Health domain of the SF-36 Questionnaire (p = 0.002).Conclusion Childhood mouth-breathing yields consequences for the ventilatory function at adult age, with lower respiratory muscle strength and functional exercise capacity. Conversely, the quality of life was little affected by the mouth breathing in this study.

scholarly journals Validation of the 2-Minute Walk Test with the 6-Minute Walk Test and Other Functional Measures in Persons with Multiple Sclerosis

2018 ◽  
Vol 20 (4) ◽  
pp. 158-163 ◽  
Author(s):  
David A. Scalzitti ◽  
Kenneth J. Harwood ◽  
Joyce R. Maring ◽  
Susan J. Leach ◽  
Elizabeth A. Ruckert ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gait Speed ◽  
Discriminant Validity ◽  
Alternative Measure ◽  
Walk Test ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Functional Measures ◽  
6 Minute Walk Test ◽  
Minute Walk

Abstract Background: Persons with multiple sclerosis (MS) commonly have difficulty walking. The 6-Minute Walk Test (6MWT) assesses functional capacity but may be considered burdensome for persons with MS, especially those with higher disability levels. The 2-Minute Walk Test (2MWT) may be an alternative measure to the 6MWT. The purpose of this study was to investigate the validity of the 2MWT in persons with MS. Methods: Twenty-eight ambulatory persons with MS aged 18 to 64 years participated in this cross-sectional study. Participants completed five measures of walking performance (2MWT, 6MWT, usual and fast gait speed, and Timed Up and Go test) and two functional measures (Berg Balance Scale and five-times sit-to-stand test) during a testing session. Participants were classified into two subgroups based on Disease Steps scale classification. Results: The 2MWT was significantly correlated with the 6MWT (r = 0.947), usual gait speed (r = 0.920), fast gait speed (r = 0.942), the Timed Up and Go test (r = −0.911), and other functional measures. The 2MWT explained 89% of the variance seen during the 6MWT. The distances completed on the 2MWT and 6MWT accurately distinguished the subgroups. Conclusions: This study demonstrated good construct and discriminant validity of the 2MWT in persons with MS, providing an efficient and practical alternative to the 6MWT. Validation of the 2MWT with other functional measures further supports these findings.

scholarly journals Validity and Reliability of Four Clinical Gait Measures in Patients with Multiple Sclerosis

2017 ◽  
Vol 19 (5) ◽  
pp. 247-252 ◽  
Author(s):  
Susan E. Bennett ◽  
Lacey E. Bromley ◽  
Nadine M. Fisher ◽  
Machiko R. Tomita ◽  
Paulette Niewczyk
Keyword(s):  
Multiple Sclerosis ◽  
Reliability And Validity ◽  
Time Of Day ◽  
Self Report ◽  
Walk Test ◽  
Validity And Reliability ◽  
Timed Up And Go ◽  
Edss Score ◽  
6 Minute Walk Test ◽  
Minute Walk

Background: The gold standards for assessing ambulation are the Expanded Disability Status Scale (EDSS) and the Timed 25-Foot Walk (T25FW) test. In relation with these measures, we assessed the reliability and validity of four clinical gait measures: the Timed Up and Go (TUG) test, the Dynamic Gait Index (DGI), the 2-Minute Walk Test (2MWT), and the 6-Minute Walk Test (6MWT). Patient self-report of gait was also assessed using the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Methods: Individuals 20 years or older with a diagnosis of multiple sclerosis (MS) and an EDSS score of 2.0 to 6.5 completed the MSWS-12, T25FW test, TUG test, DGI, 2MWT, and 6MWT. All the tests were repeated 2 weeks later at the same time of day to establish their reliability and concurrent validity. Predictive validity was established using the EDSS. Results: Forty-two patients with MS were included. All measures showed high test-retest reliability. The TUG test, 2MWT, and 6MWT were significantly correlated with the T25FW test (Spearman ρ = −0.902, −0.919, and −0.905, respectively). The EDSS was also significantly correlated with all the walking tests. The MSWS-12 demonstrated the highest correlation to the EDSS (ρ = 0.788). Conclusions: The TUG test, the DGI, the 2MWT, and the 6MWT exhibited strong psychometric properties and were found to be significant predictors of the EDSS score. Use of these tests to prospectively monitor the effects of medical and rehabilitation treatment should be considered in the comprehensive care of patients with MS.

scholarly journals Ο ρόλος της θεραπευτικής άσκησης στο νερό στη λειτουργική ικανότητα και ποιότητα ζωής ασθενών υπό περιοδική αιμοκάθαρση

2013 ◽  
Author(s):  
Αναστασία Σαμαρά
Keyword(s):  
Short Form ◽  
Walk Test ◽  
Timed Up And Go ◽  
Stand Test ◽  
Short Form 36 ◽  
Sit To Stand ◽  
Hand Grip ◽  
Sf 36 ◽  
Grip Test

Τα προγράμματα αποκατάστασης σε νερό έχουν αποδειχθεί ότι καλύπτουν μία ευρεία κλίμακα παθήσεων, από οξείς τραυματισμούς έως χρόνια νοσήματα. Οι ασθενείς με ΧΝΝ τελικού σταδίου που υποβάλλονται σε περιοδική αιμοκάθαρση, εμφανίζουν μειωμένη φυσική επάρκεια και χαμηλά ποσοστά συμμετοχής σε προγράμματα άσκησης, λόγω των πολλαπλών προβλημάτων υγείας που αντιμετωπίζουν και του φόβου εμφάνισης επιπλοκών. Σκοπός της παρούσας έρευνας ήταν η διερεύνηση και αξιολόγηση της επίδρασης ενός προγράμματος άσκησης στο νερό στην λειτουργική ικανότητα και ποιότητα ζωής αιμοκαθαιρόμενων ασθενών τελικού σταδίου και η σύγκριση αυτού του τύπου άσκησης με τη γύμναση κατά τη διάρκεια της αιμοκάθαρσης. Στη μελέτη συμμετείχαν 42 ασθενείς, που χωρίστηκαν τυχαία σε τρεις ομάδες, σύμφωνα με το πρωτόκολλο άσκησης που ακολούθησαν. Στην ομάδα Α εντάχθηκαν δεκαπέντε ασθενείς που ακολούθησαν πρόγραμμα άσκησης σε πισίνα, με κλασική κολύμβηση και υδρογυμναστική. Το πρόγραμμα περιελάμβανε αερόβια άσκηση για 30-40 λεπτά και ασκήσεις ενδυνάμωσης για 10-15 λεπτά, επί 4 μήνες, 3 φορές την εβδομάδα. Στην ομάδα Β συμμετείχαν επίσης δεκαπέντε ασθενείς που ασκήθηκαν κατά την διάρκεια της αιμοκάθαρσης στην μονάδα Τεχνητού Νεφρού της Νεφρολογικής κλινικής, με πρόγραμμα αερόβιας άσκησης και ασκήσεις ενδυνάμωσης άνω και κάτω άκρων. Το πρόγραμμα περιελάμβανε αερόβια άσκηση σε εργοποδήλατο, διάρκειας 20-40 λεπτά και ασκήσεις ενδυνάμωσης με λάστιχα και βαράκια, επί 4 επίσης μήνες, 3 φορές την εβδομάδα. Η ομάδα Γ (άτομα 12) αποτέλεσε την ομάδα ελέγχου, με αντίστοιχης ηλικίας αιμοκαθαιρόμενους ασθενείς που διήγαν καθιστική ζωή. Σε όλους κατά την έναρξη της μελέτης πραγματοποιήθηκε κλινικός έλεγχος, που περιελάμβανε κλινική εξέταση, λήψη ιστορικού, και δοκιμασίες πεδίου για την εκτίμηση της λειτουργικής τους ικανότητας. Τα τεστ που εξετάσθηκαν οι ασθενείς ήταν 1) η 6λεπτη δοκιμασία βαδίσματος (6 min walk test-6MWT), για εκτίμηση της καρδιαγγειακής αντοχής και της λειτουργικής ικανότητας, 2) η δοκιμασία «Κάθισμα-όρθια θέση –κάθισμα» (sit to stand test) για τον καθορισμό της μυϊκής δύναμης 3) η δοκιμασία «Sit and Reach» για αξιολόγηση της ευλυγισίας των οπίσθιων μηριαίων, 4) το ισομετρικό «Hand Grip test» για την αποτίμηση της δύναμης χειρολαβής, και 5) η δοκιμασία «Έγερση και απομάκρυνση» (“Timed Up and Go”) για την εκτίμηση της κινητικότητας τους. Επίσης όλοι οι συμμετέχοντες κλήθηκαν να συμπληρώσουν το ερωτηματολόγιο Short Form-36 Questionnaire (SF-36), για την εκτίμηση της ποιότητας ζωής τους. Όλοι οι συμμετέχοντες ασθενείς εξετάστηκαν στις ίδιες δοκιμασίες μετά το τέλος των τεσσάρων μηνών και το πέρας των προγραμμάτων άσκησης. Κατά την έναρξη της μελέτης όλες οι τιμές των ασθενών ήταν παρεμφερείς, χωρίς στατιστικά σημαντικές διαφορές. Με το πέρας της 4-μηνης γύμνασης διαφορές εμφανίστηκαν σχεδόν σε όλες τις μετρούμενες παραμέτρους από την αρχική στη τελική μέτρηση, με τις ασκούμενες ομάδες να βελτιώνουν τις επιδόσεις τους. Συγκεκριμένα μετά το πέρας των 4 μηνών, οι ασθενείς που συμμετείχαν στο πρόγραμμα άσκησης στο νερό, παρουσίασαν σημαντική αύξηση στην απόσταση που διένυσαν στην «6-λεπτη δοκιμασία βαδίσματος» κατά 12%, (p<0,05) και η ομάδα Γ εμφάνισε μείωση της επίδοσής της κατά 9,74% (p<0,05) σε σχέση με την αρχική της μέτρηση. Η ομάδα Β δεν εμφάνισε στατιστικά σημαντικές διαφορές. Στη δοκιμασία «κάθισμα-όρθια θέση-κάθισμα» η ομάδα Α βελτίωσε κατά 13,63% (p<0,05) την επίδοσή της, η ομάδα Β κατά 7,36% (p<0,05) και η ομάδα Α συγκριτικά με την ομάδα Γ κατά 39,47% (p<0,05). Στη δοκιμασία «δύναμης χειρολαβής» η ομάδα Α αύξησε κατά 7,51% (p<0,05), και η ομάδα Γ εμφάνισε στατιστικά σημαντική μείωση κατά 5,84% (p<0,05), αλλά παρ’όλα αυτά δεν παρουσιάστηκαν στατιστικά σημαντικές διαφορές μεταξύ των τριών ομάδων. Στη δοκιμασία «Sit and Reach» η ομάδα Α βελτίωσε την αρχική μέτρηση κατά 87,24% (p<0,05) και εμφάνισε μεγάλη διαφορά σε σχέση με την ομάδα Γ. Στη δοκιμασία «Έγερση και απομάκρυνση» η ομάδα Α βελτίωσε την αρχική της μέτρηση κατά 16,36% (p<0,05) και κατά 50% συγκριτικά με την ομάδα Γ (p<0,05). Επίσης η ομάδα Γ εμφάνισε μείωση κατά 13,11% (p<0,05) συγκριτικά με την αρχική της μέτρηση. Τέλος, η ομάδα Α βελτίωσε τη συνεχόμενη διανυόμενη απόσταση κολύμβησης κατά 290,1% (p<0,05). Όσον αφορά την εκτίμηση της ποιότητας ζωής μέσω των ερωτηματολογίων, υπήρξαν στατιστικά σημαντικές διαφορές μεταξύ των αρχικών και των τελικών μετρήσεων. Για τις μεν ομάδες Α και Β διότι βελτίωσαν την αρχική τους βαθμολογία, τη δε ομάδα Γ διότι μειώθηκε η αρχική βαθμολογία. Συγκεκριμένα, όσον αφορά τη σωματική υγεία, στατιστικά σημαντική βελτίωση παρουσίασαν η ομάδα Α και Β κατά 9,67% (p<0,05) και 5,14% (p<0,05) αντίστοιχα. Αντίθετα, ενώ η ομάδα Γ εμφάνισε μείωση κατά 5,19% δεν θεωρήθηκε στατιστικά σημαντική διαφορά. Όσον αφορά τη πνευματική υγεία η ομάδα Α εμφάνισε βελτίωση κατά 19,77% (p<0,05) και 16,53% (p<0,05) σε σχέση με την ομάδα Β και 26,83% (p<0,05) σε σχέση με την ομάδα Γ. Συμπεραίνεται λοιπόν ότι η θεραπευτική άσκηση στο νερό, με τη μορφή της κλασικής κολύμβησης και της υδρογυμναστικής επιφέρει σημαντικές βελτιώσεις τόσο στην λειτουργική ικανότητα όσο και στην ποιότητα ζωής ασθενών με χρόνια νεφρική νόσο υπό περιοδική αιμοκάθαρση. Ακόμη, η άσκηση στο νερό επιφέρει μεγαλύτερες προσαρμογές στον οργανισμό των ασθενών με χρόνια νεφρική νόσο υπό περιοδική αιμοκάθαρση, συγκριτικά με την άσκηση κατά τη διάρκεια της αιμοκάθαρσης, όπως αυτές οι προσαρμογές αποτιμώνται μέσα από δοκιμασίες πεδίου και συμπλήρωση ερωτηματολογίου ποιότητας ζωής.

scholarly journals Feasibility and Impact of an 8-Week Integrative Yoga Program in People with Moderate Multiple Sclerosis–Related Disability

2017 ◽  
Vol 19 (1) ◽  
pp. 30-39 ◽  
Author(s):  
Evan T. Cohen ◽  
David Kietrys ◽  
Susan Gould Fogerite ◽  
Mariella Silva ◽  
Kristen Logan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Short Form ◽  
Repeated Measurements ◽  
Walk Test ◽  
Sf 36 ◽  
Serial Addition ◽  
And Performance

Background: This pilot study determined the feasibility of a specifically designed 8-week yoga program for people with moderate multiple sclerosis (MS)–related disability. We explored the program's effect on quality of life (QOL) and physical and mental performance. Methods: We used a single-group design with repeated measurements at baseline, postintervention, and 8-week follow-up. Feasibility was examined through cost, recruitment, retention, attendance, and safety. Outcomes included the Multiple Sclerosis Quality of Life Inventory (MSQLI), 12-item Multiple Sclerosis Walking Scale (MSWS-12), Timed 25-Foot Walk test (T25FW), 6-Minute Walk Test (6MWT), Nine-Hole Peg Test (NHPT), Five-Times Sit-to-Stand Test (FTSTS), Multidirectional Reach Test (MDRT), maximum expiratory pressure, and Paced Auditory Serial Addition Test-3″ (PASAT-3″). Results: Fourteen participants completed the study. The program was feasible. There were significant main effects on the 36-item Short Form Health Status Survey Mental Component Summary (SF-36 MCS), Modified Fatigue Impact Scale (MFIS), Bladder Control Scale (BLCS), Perceived Deficits Questionnaire (PDQ), Mental Health Inventory (MHI), MSWS-12, T25FW, NHPT, PASAT-3″, 6MWT, FTSTS, and MDRT-Back. Improvements were found on the SF-36 MCS, MFIS, BLCS, PDQ, MHI, and MSWS-12 between baseline and postintervention. The effect on PDQ persisted at follow-up. Improvements were found on the T25FW, NHPT, 6MWT, FTSTS, and MDRT-Back between baseline and postintervention that persisted at follow-up. The PASAT-3″ did not change between baseline and postintervention but did between postintervention and follow-up. Conclusions: The yoga program was safe and feasible. Improvements in certain measures of QOL and performance were seen at postintervention and follow-up.

scholarly journals Introducing a Formula for Obtaining the Total Deviation Index in Aging Studies

Salmand ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 278-285
Author(s):  
Andisheh Bakhshi ◽  
◽  
Enayatollah Bakhshi ◽  
Keyword(s):  
Measurement Error ◽  
Physical Functioning ◽  
Measurement Errors ◽  
Short Form ◽  
Intraclass Correlation ◽  
Emotional Problems ◽  
Cross Sectional ◽  
Total Deviation ◽  
Deviation Index ◽  
Sf 36

Objectives: Since the study on the elderly people and recording related data requires more accuracy, the calculation of measurement error is very important. This study aims to introduce a simple formula to obtain and interpret the Total Deviation Index (TDI) and encourage researchers to use it as a suitable tool to determine the reliability in psychometrics studies. Methods & Materials: In this cross-sectional study conducted in 2019, participants were 105 older adults living in Tehran, Iran. The 36-Item Short Form Health Survey (SF-36) questionnaire was completed by them within two weeks. The Intraclass Correlation Coefficient (ICC) and TDI values were calculated and compared for each subscale of the SF-36. Results: The lowest TDI value belonged to the “physical functioning” subscale, while the “emotional problems” subscale had the highest TDI value. At a 95% confidence interval, the maximum measurement errors in physical functioning and emotional problems were reported 22 and 34 (out of 100), respectively. Conclusion: Since the ICC cannot determine how much of the difference in the subscale scores is related to the measurement error, and given the simple interpretation of the TDI, it is recommended that researchers use the proposed formula and obtain the TDI value for the reliability in psychometrics studies.

scholarly journals Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

2021 ◽  
Vol 7 (1) ◽  
pp. 205521732199604
Author(s):  
Sabina David Ruban ◽  
Claudia Christina Hilt ◽  
Thor Petersen
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Short Form ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cognitive Fatigue ◽  
Cross Sectional ◽  
Impact Scale ◽  
Assessment And Treatment

Background Multiple sclerosis is a chronic disease leading to reduced quality of life. Objectives To investigate whether motor and cognitive fatigue impact differently on aspects of quality of life among patients with multiple sclerosis, independently from bodily disability. Methods 79 patients with multiple sclerosis from Aalborg University Hospital, Denmark were included in an observational, cross-sectional study. Each subject completed two separate questionnaires regarding fatigue (Fatigue Scale for Motor and Cognitive Functions and Modified Fatigue Impact Scale) and one regarding quality of life (Short Form 36). Disability was measured with the Expanded Disability Status Scale (EDSS)-scores obtained from patient records. Results All fatigue scores were significantly correlated to all areas of quality of life (p < 0,05). This remained significant after adjustment for age, disease duration and EDSS-score. When looking at each type of fatigue separately, cognitive fatigue correlated mainly with mental health aspects of quality of life and motor fatigue with physical health areas of quality of life. Conclusion Increased motor and cognitive fatigue lead to a differential reduction in physical and mental quality of life, independently of bodily disability. This underlines the importance of proper assessment and treatment of fatigue among patients with multiple sclerosis.

Quality of life in multiple sclerosis patients in Spain

2002 ◽  
Vol 8 (6) ◽  
pp. 527-531 ◽  
Author(s):  
C-H Chang ◽  
D Cella ◽  
O Fernández ◽  
G Luque ◽  
P de Castro ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Well Being ◽  
Cross Sectional Study ◽  
Self Report ◽  
Regression Analyses ◽  
Cross Sectional ◽  
Scale Scores ◽  
Multiple Sclerosis Patients

Objective: The cross-sectional study evaluated the psychometric properties of the Functional Assessment of Multiple Sclerosis (FAMS) Spanish version and its use in measuring quality of life (QOL) of multiple sclerosis (MS) patients in Spain. Methods: The FAMS is a factorially derived self-report scale designed to assess six primary aspects of QOL of patients with MS: Mobility, Symptoms, Emotional Well-Being, General Contentment, Thinking and Fatigue, and Family/Social Well-Being. Its Spanish translated version was used to assess QOL of 625 MS patients recruited in an outpatient clinic setting from 58 hospitals in Spain. Internal consistency of the Spanish FAMS was evaluated. Multiple regression analyses were performed to identify significant predictors from demographic, clinical and treatment characteristics, and Kurtzke Expanded Disability Status Scale (EDSS) scores in predicting FAMS scale scores. Results: Most of the patients are females (66%), and 74% were of the relapsing-remitting (RR) clinical subtype. Cronbach’s alpha coefficients were high (range=0.78-0.96), indicating subscale homogeneity comparable to that of the original English version. Linear multivariate regression analyses revealed that the EDSS is a dominant variable in predicting all the FAMS subscales, especially mobility (R2=0.51) and the total scores. Conclusions: The Spanish FAMS is a psychometrically valid instrument that allows clinicians and clinical researchers the ability to measure the QOL concerns of MS patients in Spain.

scholarly journals Predictors of quality of life among patients on dialysis in southern Brazil

2008 ◽  
Vol 126 (5) ◽  
pp. 252-256 ◽  
Author(s):  
Maristela Bohlke ◽  
Diego Leite Nunes ◽  
Stela Scaglioni Marini ◽  
Cleison Kitamura ◽  
Marcia Andrade ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Peritoneal Dialysis ◽  
Short Form ◽  
Outcome Measurement ◽  
Cross Sectional Study ◽  
Southern Brazil ◽  
Cross Sectional ◽  
Sf 36 ◽  
Dialysis Facilities

CONTEXT AND OBJECTIVE: Quality of life (QoL) is considered important as an outcome measurement, especially for long-term diseases such as chronic renal failure. The present study searched for predictors of QoL in a sample of patients undergoing dialysis in southern Brazil. DESIGN AND SETTING: This was a cross-sectional study developed in three southern Brazilian dialysis facilities. METHODS: Health-related QoL of patients on hemodialysis or peritoneal dialysis was measured using the generic Short Form-36 (SF-36) health survey questionnaire. The results were correlated with sociodemographic, clinical and laboratory variables. The analysis was adjusted through multiple linear regression. RESULTS: A total of 140 patients were assessed: 94 on hemodialysis and 46 on peritoneal dialysis. The mean age was 54.2 ± 15.4 years, 48% were men and 76% were white. The predictors of higher (better) physical component summary in SF-36 were: younger age (β-0.16; 95% confidence interval, CI: -0.27 to -0.05), shorter time on dialysis (β-0.06; 95% CI: -0.09 to -0.02) and lower Khan comorbidity-age index (β 5.16; 95% CI: 1.7-8.6). The predictors of higher mental component summary were: being employed (β 8.4; 95% CI: 1.7-15.1), being married or having a marriage-like relationship (β 4.56; 95% CI: 0.9-8.2), being on peritoneal dialysis (β 4.9; 95% CI: 0.9-8.8) and not having high blood pressure (β 3.9; 95% CI: 0.3-7.6). CONCLUSIONS: Age, comorbidity and length of time on dialysis were the main predictors of physical QoL, whereas socioeconomic issues especially determined mental QoL.

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