scholarly journals Groups, groupoids, and information sources: models of mitochondrial deterioration and aging

Author(s):  
Rodrick Wallace

Using mitochondrial free energy delivery rate as a temperature analog, we examine the 'spontaneous symmetry breaking' of the group associated with the error minimization coding scheme related to protein folding, and characterize the phase transition that drives the collapse of normal folding to pathological amyloid production. Similarly, groupoids prove central to the study of analogous, often highly punctuated, 'ground state' failures in far more complex biological processes, adopting Maturana's perspective on the central role of cognition throughout the living state.

2014 ◽  
Author(s):  
Rodrick Wallace

Using mitochondrial free energy delivery rate as a temperature analog, we examine the 'spontaneous symmetry breaking' of the group associated with the error minimization coding scheme related to protein folding, and characterize the phase transition that drives the collapse of normal folding to pathological amyloid production. Similarly, groupoids prove central to the study of analogous, often highly punctuated, 'ground state' failures in far more complex biological processes, adopting Maturana's perspective on the central role of cognition throughout the living state.


1989 ◽  
Vol 04 (11) ◽  
pp. 1063-1067 ◽  
Author(s):  
G. CHAPLINE ◽  
F.R. KLINKHAMER

We discuss the role of XY-like vortices on the world-sheet for the free energy of strings at high temperatures. There is a Kosterlitz-Thouless phase transition at the Hagedorn temperature, above which the vortices contribute to the free energy in genus zero and generate a mass gap. We speculate that high-temperature “string” theory could be essentially discrete.


2021 ◽  
Vol 87 (6) ◽  
Author(s):  
Chjan C. Lim

An equilibrium statistical mechanics theory for the Hasegawa–Mima equations of toroidal plasmas, with canonical constraint on energy and microcanonical constraint on potential enstrophy, is solved exactly as a spherical model. The use of a canonical energy constraint instead of a fixed-energy microcanonical approach is justified by the preference for viewing real plasmas as an open system. A significant consequence of the results obtained from the partition function, free energy and critical temperature, is the condensation into a ground state exhibiting a blob-hole-like structure observed in real plasmas.


1994 ◽  
Vol 03 (03) ◽  
pp. 365-378 ◽  
Author(s):  
E. J. JANSE VAN RENSBURG

The role of topology in the statistical mechanics of surfaces in the lattice [Formula: see text] is considered. The possibility that a phase transition driven by the number of boundary components occurs is investigated. Bounds on the limiting free energy is derived and conditions for the existence of a critical point in the phase diagram are presented.


2021 ◽  
Vol 12 ◽  
Author(s):  
Elmarie Venter

In this paper, I argue for an embodied, embedded approach to predictive processing and thus align the framework with situated cognition. The recent popularity of theories conceiving of the brain as a predictive organ has given rise to two broad camps in the literature that I call free energy enactivism and cognitivist predictive processing. The two approaches vary in scope and methodology. The scope of cognitivist predictive processing is narrow and restricts cognition to brain processes and structures; it does not consider the body-beyond-brain and the environment as constituents of cognitive processes. Free energy enactivism, on the other hand, includes all self-organizing systems that minimize free energy (including non-living systems) and thus does not offer any unique explanations for more complex cognitive phenomena that are unique to human cognition. Furthermore, because of its strong commitment to the mind-life continuity thesis, it does not provide an explanation of what distinguishes more sophisticated cognitive systems from simple systems. The account that I develop in this paper rejects both of these radical extremes. Instead, I propose a compromise that highlights the necessary components of predictive processing by making use of a mechanistic methodology of explanation. The starting point of the argument in this paper is that despite the interchangeable use of the terms, prediction error minimization and the free energy principle are not identical. But this distinction does not need to disrupt the status quo of the literature if we consider an alternative approach: Embodied, Embedded Predictive Processing (EEPP). EEPP accommodates the free energy principle, as argued for by free energy enactivism, but it also allows for mental representations in its explanation of cognition. Furthermore, EEPP explains how prediction error minimization is realized but, unlike cognitivist PP, it allocates a constitutive role to the body in cognition. Despite highlighting concerns regarding cognitivist PP, I do not wish to discredit the role of the neural domain or representations as free energy enactivism does. Neural structures and processes undeniably contribute to the minimization of prediction error but the role of the body is equally important. On my account, prediction error minimization and free energy minimization are deeply dependent on the body of an agent, such that the body-beyond-brain plays a constitutive role in cognitive processing. I suggest that the body plays three constitutive roles in prediction error minimization: The body regulates cognitive activity, ensuring that cognition and action are intricately linked. The body acts as distributor in the sense that it carries some of the cognitive load by fulfilling the function of minimizing prediction error. Finally, the body serves to constrain the information that is processed by an agent. In fulfilling these three roles, the agent and environment enter into a bidirectional relation through influencing and modeling the structure of the other. This connects EEPP to the free energy principle because the whole embodied agent minimizes free energy in virtue of being a model of its econiche. This grants the body a constitutive role as part of the collection of mechanisms that minimize prediction error and free energy. The body can only fulfill its role when embedded in an environment, of which it is a model. In this sense, EEPP offers the most promising alternative to cognitivist predictive processing and free energy enactivism.


2020 ◽  
Vol 27 (6) ◽  
pp. 105-113
Author(s):  
T. G. Nekhaeva

The article examines publication of statistical data commemorating the anniversaries of the USSR Victory in the Great Patriotic War as the most important information sources for an objective analysis of historical events. The reason for writing this article was the release of the statistical handbook of Rosstat, dedicated to the 75th anniversary of the Great Victory. In the introduction, the author argues the current urgency of issues addressed in the article caused by information warfare aimed at distorting the historical truth about the role of our country in the anti-Hitler coalition and the defeat of fascism in the World War II. The body of the article describes the concept and content of the anniversary edition. An important point of the article is the analysis of data sources used in the preparation of the handbook. The author reviews the anniversary handbook structure that includes a preface and the following sections: Population, Economic, Living conditions, Mobilization of population, Partisan movement, Evacuation during the war, Casualties and losses during the war, Military memorials and cemeteries, State awards, References. It is noted that the handbook maintains the tradition of previous statistical publications dedicated to the anniversaries of the Great Victory. Lastly, the author substantiates the novelty of data presented in the anniversary handbook and the logical structure of statistical materials in it. The author draws conclusions about the paramount importance of, and need to continue popularization of data on the great exploits of the Soviet people during the war and to introduce new statistical information into scientific circulation, which is causing further comprehension of primary information sources about the Great Patriotic War of 1941-1945.


2013 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Noar Muda Satyawan ◽  
Shelly Tutupoho ◽  
Yusli Wardiatno ◽  
Makoto Tsuchiya

Erosion rate on corals due to activities of other biota is called bioerosion. The rock-boring urchin, Echinometra mathaei, when it is abundant, plays a significant role in benthic ecosystems, including biological processes like coral erosion. During feeding, E. mathaei erodes calcium carbonate besides grazing on algae living on coral, so it plays an important role in both organic and inorganic carbons in coral reefs. The urchin E. mathaei actively feeds during the night time (nocturnal grazer). Although in Okinawa four types (A-D) of the urchin exist, the research only focused on the types A and B. Type A of E. mathaei produced 0.44951 g feces per day on average while type B produced 0.38030 g feces per day. CaCO3 analysis in feces and gut contents showed bioerosion rate of E. mathaei type A was 0.64492 g/individu/day, and 0.54436 g/individu/day in type B. There were no significant differences in bioerosion impact of E. mathaei type A and B© Laju erosi pada karang yang disebabkan oleh biota, dikenal dengan bioerosi. Bulu babi jenis Echinometra mathaei, ketika melimpah, menjadi sangat berpengaruh terhadap ekosistem bentik termasuk proses biologi seperti erosi karang. Selama aktivitas makan, E. mathaei menggerus kalsium karbonat dalam proporsi yang besar di samping alga yang tumbuh menempel pada karang sehingga memiliki peran penting dalam siklus karbon organik dan anorganik di ekosistem terumbu karang. Bulu babi E. mathaei aktif mencari makan pada malam hari (nocturnal grazer). Meskipun di Okinanawa ada 4 tipe (A-D), pada eksperimen kali ini memfokuskan pada tipe A dan B saja. Tipe A E. mathaei rata-rata memproduksi 0,44951 g feses/hari dan tipe B memproduksi 0,38030 g feses/hari. Berdasarkan analisis CaCO3 yang dilakukan pada feses dan isi lambung, laju bioerosi yang disebabkan oleh E. mathaei tipe A sebesar 0,64492 g/individu/hari sedangkan tipe B sebesar 0,54436 g/individu/hari. Tidak terdapat perbedaan dampak bioerosi yang signifikan antara E. mathaei tipe A dan B©


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