scholarly journals Age-Period-Cohort Analysis of Liver Cancer Mortality in Korea

2016 ◽  
Vol 16 (18) ◽  
pp. 8589-8594 ◽  
Author(s):  
Jihwan Park ◽  
Yon Ho Jee
Keyword(s):  
Liver Cancer ◽  
Cancer Mortality ◽  
Cohort Analysis

scholarly journals Long-Term Trend of Liver Cancer Mortality in Serbia, 1991–2015: An Age-Period-Cohort and Joinpoint Regression Analysis

Healthcare ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 283
Author(s):  
Irena Ilic ◽  
Sandra Sipetic Grujicic ◽  
Jovan Grujicic ◽  
Djordje Radovanovic ◽  
Ivana Zivanovic Macuzic ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Mortality ◽  
Direct Method ◽  
Cohort Analysis ◽  
Temporal Trends ◽  
Joinpoint Regression ◽  
Mortality Trends ◽  
Annual Percent Change ◽  
Period Effects ◽  
The World

Background and Objectives: Trends of liver cancer mortality vary widely around the world. The purpose of this study was to assess the trend of liver cancer mortality in Serbia. Material and Methods: Descriptive epidemiological study design was used in this research. The age-standardized rates (ASRs, per 100,000) were calculated using the direct method, according to the World standard population. Temporal trends were assessed using the average annual percent change (AAPC) with 95% confidence interval (95% CI), according to joinpoint regression. An age-period-cohort analysis was used to evaluate the underlying factors for liver cancer mortality trends. Results: In Serbia from 1991 to 2015, over 11,000 men and nearly 8000 women died from liver cancer. The trend in liver cancer mortality significantly decreased both in men (AAPC = −1.3%; 95% CI = −1.7 to −0.9) and women (AAPC = −1.5%; 95% CI = −1.9 to −1.1). For liver cancer mortality, statistically significant cohort and period effects were observed in both genders. Conclusions: The downward trends in liver cancer mortality in Serbia are recorded during the past decades.

scholarly journals Liver cancer mortality over six decades in an epidemic area: what we have learned

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10600
Author(s):  
Jian-Guo Chen ◽  
Jian Zhu ◽  
Yong-Hui Zhang ◽  
Yong-Sheng Chen ◽  
Jian-Hua Lu ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Liver Cancer ◽  
Cancer Mortality ◽  
Malignant Tumors ◽  
Cohort Analysis ◽  
Cancer Registration ◽  
Mortality Data ◽  
Cancer Etiology ◽  
The Past ◽  
Epidemic Area

Background and aims: Liver cancer is one of the most dominant malignant tumors in the world. The trends of liver cancer mortality over the past six decades have been tracked in the epidemic region of Qidong, China. Using epidemiological tools, we explore the dynamic changes in age-standardized rates to characterize important aspects of liver cancer etiology and prevention. Methods Mortality data of liver cancer in Qidong from 1958 to 1971 (death retrospective survey) and from 1972 to 2017 (cancer registration) were tabulated for the crude rate (CR), and age-standardized rate and age-birth cohorts. The average annual percentage change was calculated by the Joinpoint Regression Program. Results The natural death rate during 1958–2017 decreased from 9‰ to 5.4‰ and then increased to 8‰ as the population aged; cancer mortality rates rose continuously from 57/105 to 240/105. Liver cancer mortality increased from 20/105 to 80/105, and then dropped to less than 52/105 in 2017. Liver cancer deaths in 1972–2017 accounted for 30.53% of all cancers, with a CR of 60.48/105, age-standardized rate China (ASRC) of 34.78/105, and ASRW (world) of 45.71/105. Other key features were the CR for males and females of 91.86/105 and 29.92/105, respectively, with a sex ratio of 3.07:1. Period analysis showed that the ASRs for mortality of the age groups under 54 years old had a significant decreasing trend. Importantly, birth cohort analysis showed that the mortality rate of liver cancer in 40–44, 35–39, 30–34, 25–29, 20–24, 15–19 years cohort decreased considerably, but the rates in 70–74, and 75+ increased. Conclusions The crude mortality rate of liver cancer in Qidong has experienced trends from lower to higher levels, and from continued increase at a high plateau to most recently a gradual decline, and a change greatest in younger people. Many years of comprehensive prevention and intervention measures have influenced the decline of the liver cancer epidemic in this area. The reduction of intake levels of aflatoxin might be one of the most significant factors as evidenced by the dramatic decline of exposure biomarkers in this population during the past three decades.

scholarly journals Long-term trends of liver cancer mortality by gender in urban and rural areas in China: an age-period-cohort analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e020490 ◽  
Author(s):  
Yuanyuan Sun ◽  
Yanhong Wang ◽  
Mengmeng Li ◽  
Kailiang Cheng ◽  
Xinyu Zhao ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rural Women ◽  
Rural Areas ◽  
Cancer Mortality ◽  
Cohort Analysis ◽  
Age Group ◽  
Mortality Trends ◽  
Long Term Trends ◽  
Urban And Rural Areas

ObjectivesTo provide an up-to-date overview of long-term trends of liver cancer mortality and evaluate the effects attributable to age, period and cohort in Chinese population stratified by gender and urban/rural areas.MethodsPopulation and liver cancer mortality data were obtained based on the Disease Surveillance Points in China from 1991 to 2014. To examine the time trends of liver cancer mortality by gender in urban and rural areas in China, Joinpoint analysis was used to estimate the annual per cent change. The intrinsic estimator, a method of age-period-cohort analysis to estimate age, period and cohort effects simultaneously, was used to analyse the underlying mechanisms for liver cancer mortality trends in the aforementioned four groups.ResultsWe observed a significant decline in liver cancer mortality for urban men (average annual per cent change (AAPC)=−1.1%, P<0.05) and urban women (AAPC=−1.4%, P<0.05), while the liver cancer mortality remained stable for rural men (AAPC=−0.1%, P>0.05) and rural women (AAPC=−0.9%, P>0.05). Compared with the 15–19 age group, the liver cancer mortality risk of the 85 and above age group increased 65 and 42 times for urban and rural men, and 102 and 70 times for urban and rural women. From the 1990–1994 period to the 2005–2009 period, the risk increased 56% and 92% for urban and rural men, and 30% and 74% for urban and rural women. Compared with period and cohort effects, age effects were the most influential factor in liver cancer mortality.ConclusionsAs the status of ageing population in China gets worse, the burden caused by liver cancer mortality could still be a great challenge for China in the future. The disparity of liver cancer mortality trends between urban and rural residents can be attributed to period effects, referring to the unequal medical levels and resources between urban and rural areas.

scholarly journals Beta-adrenergic receptor blockers and liver cancer mortality in a national cohort of hepatocellular carcinoma patients

2020 ◽  
Vol 55 (5) ◽  
pp. 597-605
Author(s):  
Ruzan Udumyan ◽  
Scott Montgomery ◽  
Ann-Sofi Duberg ◽  
Fang Fang ◽  
Unnur Valdimarsdottir ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cancer Mortality ◽  
Adrenergic Receptor ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
National Cohort ◽  
Receptor Blockers

scholarly journals Liver cancer mortality trends in South Africa: 1999–2015

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Daniel Mak ◽  
Mazvita Sengayi ◽  
Wenlong C. Chen ◽  
Chantal Babb de Villiers ◽  
Elvira Singh ◽  
...  
Keyword(s):  
South Africa ◽  
Liver Cancer ◽  
Cancer Mortality ◽  
Mortality Trends

scholarly journals Cohort analysis of colorectal cancer mortality in the Republic of Serbia over the period 1971-1996

2002 ◽  
Vol 130 (5-6) ◽  
pp. 173-177 ◽  
Author(s):  
Olga Gajic-Veljanoski ◽  
Mirjana Jarebinski ◽  
Ana Jovicevic-Bekic ◽  
Tatjana Pekmezovic
Keyword(s):  
Colorectal Cancer ◽  
Mortality Risk ◽  
Cancer Mortality ◽  
Cohort Analysis ◽  
Age Groups ◽  
Birth Cohorts ◽  
Mortality Trends ◽  
Death Rates ◽  
The Republic ◽  
Colorectal Cancer Mortality

Colorectal cancer is one of the most frequent malignant neoplasms in both sexes within developed countries. In the Republic of Serbia(Serbia) colorectal cancer mortality in 1971 ranged 5 in females, and 4 in males; it became the second leading malignancy in 1982 in females (after breast cancer), and in 1992 in males (after lung cancer). The objective of this descriptive-epidemiological study was to examine colorectal cancer mortality in Serbian population, particularly the effect of cohort variations on death rates in defined age groups over the period 1971-1996. Mortality rates were calculated from unpublished national vital statistics data of the Institute of Statistics of the Republic of Serbia. To estimate the age effect on colorectal cancer mortality, specific death rates were computed for cohorts born between 1892-96 and 1972-76, and died at subsequent time periods. The mortality rates were adjusted by direct method, using the world standard population. Confidence intervals (CI) for death rates were assessed with 95% level of probability. In time trend analysis of mortality, Fisher's test was used as a significance test for linear regression coefficient. In the study period (1971-1996), a share of all digestive tumors in cancer mortality has decreased from 42.0% to 32.3%. However, the mortality risk of colorectal cancer and its share in cancer mortality have increased. For example, in men, the share of colorectal cancer in digestive cancer mortality increased from 20.7% (1971) to 32.8% (1996) and in overall cancer mortality from 7.5% to 10.5%. In women, the share of colorectal cancer in digestive cancer mortality increased from 23.0%(1971) to 35.6%(1996), and in overall cancer mortality from 8.5% to 11.6%. The average colorectal cancer age-adjusted death rates (1971-1996) were 11.2 per 100,000 men (95% CI: 10.1-12.3), and 8.3 per 100,000 women (95% CI: 7.7-8.9). The secular linear mortality trends showed significant increase both in males (y = 11.2 + 0.2x; ? = 0.000), and females (y = 8.3 + 0.1 ?; ? = 0.000). The highest rise in age-specific death rates, according to linear mortality trends, was observed in males over 65 years (7.8% annually), and females between 60 and 69 years (5.9% annually). In cohort analysis of age-specific rates in males, younger birth cohorts were compared with older ones. The increasing colorectal cancer mortality risk has been observed for ages over 40, with statistical significance in age groups over 45. In ages between 45 and 59, and over 60, the youngest birth cohorts were at 2 and 2.5-fold higher cancer mortality risk than birth cohorts of the oldest generations. For example, the age specific colorectal cancer death rates in a 70-74 year group were 2.5-fold higher in men born between 1922 and 1926 (139.3/100,000) than in cohorts born 25 years earlier (58.7/100,000). In cohort analysis of age-specific rates in females, changes in the age under 50 were not so expressive. In all age groups over 50, women of younger generations were at 2-fold higher cancer mortality risk than the oldest ones. The age specific colorectal cancer death rates in a 65-69 year group were doubled in women born between 1927 and 1931 (61.0/100 000), than in cohorts born 25 years earlier (30.5/100 000). According to the present mortality trends, the further increase in colorectal cancer death rates especially in the ages over 40, should be expected in future generations. Consistent increase in mortality risk in all younger birth cohorts of older ages, as well as in successive five-year age groups of the observed generations, could reflect the continuous increase in colorectal cancer incidence attributed to predominantly environmental exposures.

scholarly journals All-Cause and Cancer Mortality Trends in Macheng, China (1984–2013): An Age-Period-Cohort Analysis

2018 ◽  
Vol 15 (10) ◽  
pp. 2068
Author(s):  
Chunhui Li ◽  
Songbo Hu ◽  
Chuanhua Yu
Keyword(s):  
Cancer Mortality ◽  
Disease Surveillance ◽  
Cohort Analysis ◽  
Cohort Effect ◽  
Age Effect ◽  
Mortality Data ◽  
Period Effect ◽  
Mortality Trends ◽  
All Cause Mortality ◽  
Males And Females

The aim was to study the variation trends of all-cause and cancer mortality during 1984–2013 in Macheng City, China. The mortality data were collected from Macheng City disease surveillance points system and Hubei Center for Disease Control and Prevention. The model life table system was used to adjust mortality rates due to an under-reporting problem. An age-period-cohort model and intrinsic estimator algorithm were used to estimate the age effect, period effect, and cohort effect of all-cause mortality and cancer mortality for males and females. Age effect of all-cause mortality for both sexes increased with age, while the age effect of cancer mortality for both sexes reached a peak at the age group of 55–59 years old and then decreased. The relative risks (RRs) of all-cause mortality for males and females declined with the period and decreased by 51.13% and 63.27% during the whole study period, respectively. Furthermore, the period effect of cancer mortality in both sexes decreased at first and then increased. The cohort effect of all-cause and cancer mortality for both sexes born after 1904 presented the pattern of “rise first and then fall,” and decreased by 82.18% and 90.77% from cohort 1904–1908 to 1989–1993, respectively; especially, the risk of all-cause and cancer mortality for both sexes born before 1949 was much higher than that for those born after 1949.

Geographical Variation of Liver Cancer Mortality in Korea (1992-1998)

2001 ◽  
Vol 33 (5) ◽  
pp. 420-426 ◽  
Author(s):  
Duk Hee Lee ◽  
Jin Ha Kim ◽  
Byung Hun Han ◽  
Sang Ook Lee ◽  
Hai Rim Shin ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Mortality ◽  
Geographical Variation
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