scholarly journals Long-term trends of liver cancer mortality by gender in urban and rural areas in China: an age-period-cohort analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e020490 ◽  
Author(s):  
Yuanyuan Sun ◽  
Yanhong Wang ◽  
Mengmeng Li ◽  
Kailiang Cheng ◽  
Xinyu Zhao ◽  
...  

ObjectivesTo provide an up-to-date overview of long-term trends of liver cancer mortality and evaluate the effects attributable to age, period and cohort in Chinese population stratified by gender and urban/rural areas.MethodsPopulation and liver cancer mortality data were obtained based on the Disease Surveillance Points in China from 1991 to 2014. To examine the time trends of liver cancer mortality by gender in urban and rural areas in China, Joinpoint analysis was used to estimate the annual per cent change. The intrinsic estimator, a method of age-period-cohort analysis to estimate age, period and cohort effects simultaneously, was used to analyse the underlying mechanisms for liver cancer mortality trends in the aforementioned four groups.ResultsWe observed a significant decline in liver cancer mortality for urban men (average annual per cent change (AAPC)=−1.1%, P<0.05) and urban women (AAPC=−1.4%, P<0.05), while the liver cancer mortality remained stable for rural men (AAPC=−0.1%, P>0.05) and rural women (AAPC=−0.9%, P>0.05). Compared with the 15–19 age group, the liver cancer mortality risk of the 85 and above age group increased 65 and 42 times for urban and rural men, and 102 and 70 times for urban and rural women. From the 1990–1994 period to the 2005–2009 period, the risk increased 56% and 92% for urban and rural men, and 30% and 74% for urban and rural women. Compared with period and cohort effects, age effects were the most influential factor in liver cancer mortality.ConclusionsAs the status of ageing population in China gets worse, the burden caused by liver cancer mortality could still be a great challenge for China in the future. The disparity of liver cancer mortality trends between urban and rural residents can be attributed to period effects, referring to the unequal medical levels and resources between urban and rural areas.

Healthcare ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 283
Author(s):  
Irena Ilic ◽  
Sandra Sipetic Grujicic ◽  
Jovan Grujicic ◽  
Djordje Radovanovic ◽  
Ivana Zivanovic Macuzic ◽  
...  

Background and Objectives: Trends of liver cancer mortality vary widely around the world. The purpose of this study was to assess the trend of liver cancer mortality in Serbia. Material and Methods: Descriptive epidemiological study design was used in this research. The age-standardized rates (ASRs, per 100,000) were calculated using the direct method, according to the World standard population. Temporal trends were assessed using the average annual percent change (AAPC) with 95% confidence interval (95% CI), according to joinpoint regression. An age-period-cohort analysis was used to evaluate the underlying factors for liver cancer mortality trends. Results: In Serbia from 1991 to 2015, over 11,000 men and nearly 8000 women died from liver cancer. The trend in liver cancer mortality significantly decreased both in men (AAPC = −1.3%; 95% CI = −1.7 to −0.9) and women (AAPC = −1.5%; 95% CI = −1.9 to −1.1). For liver cancer mortality, statistically significant cohort and period effects were observed in both genders. Conclusions: The downward trends in liver cancer mortality in Serbia are recorded during the past decades.


2021 ◽  
Vol 17 (1) ◽  
pp. 53-57
Author(s):  
T.  N. Chimitdorzhieva ◽  
E.   A. Shukhoeva

Objective: to study the incidence of cervical cancer in women in urban and rural areas of the Republic of Buryatia.Materials and methods. The material of registered cases of cervical cancer for 30 years (1987–2019) is taken from the documentation of the Republican Oncological Dispensary, and calculations are carried out in intensive indicators of morbidity per 100,000 women in the whole Republic, in cities, in rural areas using data from the annual population. The prognostic assessment of the incidence of cervical cancer was carried out using the method of regression analysis by extrapolating the trend. All materials were processed using the programs Statistica 8.0 and Excel 2003 with a statistically significant level of p <0.05.Results. In the region, during the analyzed period, the incidence of cervical cancer among women is high, mainly in urban than in rural areas. However, the latter also have an upward trend. The most susceptible to this pathology is the age group active in the labor and social plan – 35–54 years. Conclusions. A feature of the morbidity process of women in the city was its earlier age, 25–29 years, and its peakthe period of 45–49 years. When forming high-risk groups, it is necessary to pay close attention to the category of rural women and take into account the age group most susceptible to this pathology.


Author(s):  
Fang Wang ◽  
Sumaira Mubarik ◽  
Yu Zhang ◽  
Lu Wang ◽  
Yafeng Wang ◽  
...  

Liver cancer (LC) is one of the most common causes of cancer-related deaths: this study aims to present the long-term trends and age–period–cohort effects of the incidence of and mortality from LC in China during 1990–2017. Incidence and mortality data were obtained from the Global Burden of Disease Study 2017. We determined trends in the age-standardized incidence rate (ASIR) and mortality rate (ASMR) using Joinpoint regression. An age–period–cohort (APC) analysis was performed to describe the long-term trends with intrinsic estimator methods. The ASMR decreased markedly before 2013 and increased thereafter, with overall average annual percent change (AAPC) values of −0.5% (95% confidence interval (CI): −0.6%, −0.3%) for men and −1.3% (−1.6%, −1.0%) for women during 1990–2017. The ASIR significantly increased by 0.2% (0.1%, 0.3%) in men and decreased by 1.1% (−1.2%, −1.0%) in women from 1990 to 2017. The risks of LC incidence and mortality increased with age in both genders. The period effect risk ratios (RRs) of incidence and mortality displayed similar monotonic increasing trends in men and remained stable in women. The cohort effect showed an overall downward trend and almost overlapping incidence and mortality in both genders, and later birth cohorts experienced lower RRs than previous birth cohorts. Older age, recent period, and birth before 1923 were associated with a higher risk of liver cancer incidence and mortality. The net age and period effects showed an increasing trend, while the cohort effects presented a decreasing trend in incidence and mortality risk. As China’s population aging worsens and with the popularization of unhealthy lifestyles, the burden caused by liver cancer will remain a huge challenge in China’s future.


BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Daniel Mak ◽  
Mazvita Sengayi ◽  
Wenlong C. Chen ◽  
Chantal Babb de Villiers ◽  
Elvira Singh ◽  
...  

2016 ◽  
Vol 3 (3) ◽  
pp. 159-162
Author(s):  
Gopalakrishnan Tharani ◽  
Mohamed Sameem Roshan Akther ◽  
Nanthakumaran Ananthini

An attempt was made to assess the women contribution towards agriculture in Vavuniya district, Sri Lanka. 60 farm family households' women were randomly selected from rural and urban area of Kovilkulam AI region of Vavuniya district in Sri Lanka and the data were collected by constructed questionnaire. The objectives of this study are to identify the factors contributing women participation in agriculture, to identify the constraints faced by the women in participating agriculture and to evaluate the women participation in decision making activity in agriculture. Minitab 15 and MS excel were used for data analysis. The level of women participation in agricultural activities was found out using chi-square test and the factors contributing for women participation in agricultural activities were identified using multiple regression analysis in urban and rural areas separately (α=0.05). The results revealed that 90% of the rural women respondents and 50% of the urban respondents participated in the agricultural activities which is a significant difference. The mean values of women participation in agricultural activities in urban and rural areas were 77 hours and 836 hours per annum respectively. The multiple regression model for women participation in urban area found that the participation of women negatively correlated with status of employment, age and education level (p=0.000). In rural area, age and educational level were negatively influencing on women participation in agricultural activities (p=0.000). R-square values of fitted regression models were 72 % and 91% in urban and rural area respectively 72% and 91% variation in respective women participation were explained by these models. The obstacles for the women in participation in agricultural activities were reported as lack of knowledge and training in agriculture field, family burden, cultural and social barriers and physical constraints. 60% of women from rural areas and 90% of women from urban areas were involved in decision making especially in the selection of crops and varieties for planting and livestock rearing. Enhancing the awareness and the technical knowledge to the women in the field of agriculture would contribute to increase income from agriculture at household level, district level and finally at national level. Int. J. Soc. Sc. Manage. Vol. 3, Issue-3: 159-162


2002 ◽  
Vol 130 (5-6) ◽  
pp. 173-177 ◽  
Author(s):  
Olga Gajic-Veljanoski ◽  
Mirjana Jarebinski ◽  
Ana Jovicevic-Bekic ◽  
Tatjana Pekmezovic

Colorectal cancer is one of the most frequent malignant neoplasms in both sexes within developed countries. In the Republic of Serbia(Serbia) colorectal cancer mortality in 1971 ranged 5 in females, and 4 in males; it became the second leading malignancy in 1982 in females (after breast cancer), and in 1992 in males (after lung cancer). The objective of this descriptive-epidemiological study was to examine colorectal cancer mortality in Serbian population, particularly the effect of cohort variations on death rates in defined age groups over the period 1971-1996. Mortality rates were calculated from unpublished national vital statistics data of the Institute of Statistics of the Republic of Serbia. To estimate the age effect on colorectal cancer mortality, specific death rates were computed for cohorts born between 1892-96 and 1972-76, and died at subsequent time periods. The mortality rates were adjusted by direct method, using the world standard population. Confidence intervals (CI) for death rates were assessed with 95% level of probability. In time trend analysis of mortality, Fisher's test was used as a significance test for linear regression coefficient. In the study period (1971-1996), a share of all digestive tumors in cancer mortality has decreased from 42.0% to 32.3%. However, the mortality risk of colorectal cancer and its share in cancer mortality have increased. For example, in men, the share of colorectal cancer in digestive cancer mortality increased from 20.7% (1971) to 32.8% (1996) and in overall cancer mortality from 7.5% to 10.5%. In women, the share of colorectal cancer in digestive cancer mortality increased from 23.0%(1971) to 35.6%(1996), and in overall cancer mortality from 8.5% to 11.6%. The average colorectal cancer age-adjusted death rates (1971-1996) were 11.2 per 100,000 men (95% CI: 10.1-12.3), and 8.3 per 100,000 women (95% CI: 7.7-8.9). The secular linear mortality trends showed significant increase both in males (y = 11.2 + 0.2x; ? = 0.000), and females (y = 8.3 + 0.1 ?; ? = 0.000). The highest rise in age-specific death rates, according to linear mortality trends, was observed in males over 65 years (7.8% annually), and females between 60 and 69 years (5.9% annually). In cohort analysis of age-specific rates in males, younger birth cohorts were compared with older ones. The increasing colorectal cancer mortality risk has been observed for ages over 40, with statistical significance in age groups over 45. In ages between 45 and 59, and over 60, the youngest birth cohorts were at 2 and 2.5-fold higher cancer mortality risk than birth cohorts of the oldest generations. For example, the age specific colorectal cancer death rates in a 70-74 year group were 2.5-fold higher in men born between 1922 and 1926 (139.3/100,000) than in cohorts born 25 years earlier (58.7/100,000). In cohort analysis of age-specific rates in females, changes in the age under 50 were not so expressive. In all age groups over 50, women of younger generations were at 2-fold higher cancer mortality risk than the oldest ones. The age specific colorectal cancer death rates in a 65-69 year group were doubled in women born between 1927 and 1931 (61.0/100 000), than in cohorts born 25 years earlier (30.5/100 000). According to the present mortality trends, the further increase in colorectal cancer death rates especially in the ages over 40, should be expected in future generations. Consistent increase in mortality risk in all younger birth cohorts of older ages, as well as in successive five-year age groups of the observed generations, could reflect the continuous increase in colorectal cancer incidence attributed to predominantly environmental exposures.


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