scholarly journals Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

2015 ◽  
Vol 38 (4) ◽  
pp. 629-633 ◽  
Author(s):  
Hiroko Uchida-Maruki ◽  
Hiroyuki Inagaki ◽  
Ryouichi Ito ◽  
Ikuko Kurita ◽  
Masahiko Sai ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Mice

The Effects of Soyferment-Tempeh on Lipid Profile, Retinol-Binding Protein 4 (RBP4), and Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression in Type 2 Diabetic Mice

2021 ◽  
pp. 193-200
Author(s):  
Prasetyastuti Prasetyastuti ◽  
Dian Setiawan Ghozali
Keyword(s):  
Gene Expression ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Glucose Level ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Retinol Binding Protein ◽  
Atherogenic Index ◽  
Diabetic Mice

Diabetes Type 2 can cause oxidative stress leading to the accumulation of reactive oxygen species. Soyferment-Tempeh, a fermented soybean product with aerobic and anaerobic R. oligosporus incubation has a high antioxidant content of isoflavones that can regulate oxidative stress in diabetes. In this study, we evaluate the effects of Soyferment-Tempeh on lipid profile, Retinol-Binding Protein 4 (RBP4), and Phosphoenolpyruvate Carboxykinase (PEPCK) gene expression in type 2 diabetic mice. A total of 30 mice with the age of eight weeks were divided into six groups as follows: A) nondiabetic, B) diabetic mice, C) diabetic mice with metformin, D), E), and F) diabetic mice with Soyferment-Tempeh doses of 10, 20, or 40mg/100g body weight (BW), respectively, were administered treatments orally by gavages. Blood was collected for assessment of blood glucose level, and lipid profile before and after 3 weeks of the administration. After sacrificing the mice, livers were used for RBP4 and PEPCK gene expression assessment. Supplementation with three different doses of Soyferment-Tempeh in streptozotocin-induced diabetic mice for 21 days significantly (p<0.001) reduced blood glucose level, total cholesterol, triglycerides, low-density lipoprotein level, atherogenic index, and increased high-density lipoprotein level. There was a significant decrease in RBP4 gene expression in the Soyferment-Tempeh of dose 10mg/100g BW treatment groups (p<0.05), while the PEPCK gene expression did not significantly differ (p>0.05). These results demonstrate that supplementation with Soyferment-Tempeh decreases blood glucose level, atherogenic index, improves lipid profile, and decreases RBP4.

scholarly journals Hypoglycemic Effect of Scarlet Spiral Flag (Costus woodsonii) to Alloxan-Induced Diabetic Mice: An In Vivo Study

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Roderic John R. Magtulis ◽  
Emvie Loyd P. Itable, RN, MAN
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Alloxan Monohydrate

<p class="AbstractContent"><strong>Objective:</strong> Diabetes Mellitus is a leading illness to the society and despite of a lot of researches, not a single cure has been discovered. Most of the time, people focused on fighting diabetes and medicinal plants were utilized. The purpose of this study was to investigate the hypoglycemic effect of Scarlet Spiral Flag (<em>Costus woodsonii</em>) and to be reviewed for preclinical trials.</p><p class="AbstractContent"><strong>Methods: </strong>20 male Swiss mice were made diabetic by inducing Alloxan monohydrate. Then separated randomly into 4 groups with different treatments administered daily for 7 days; Control, Positive Control (600 µg/kg Glibenclamide), T1 (250mg/kg Scarlet Spiral Flag ethanolic extract) and T2 (500mg/kg Scarlet Spiral Flag ethanolic extract). Their blood sugar was monitored onset after 1<sup>st</sup> treatment (6<sup>th</sup>, 12<sup>th</sup> and 24<sup>th</sup> hours) and during the week within the 1<sup>st</sup>, 4<sup>th</sup> and 8<sup>th</sup> day.</p><p class="AbstractContent"><strong>Results:</strong> Both the onset and fasting blood sugar monitoring showed a significant decrease in the mean average blood glucose level of the mice.<strong></strong></p><p class="AbstractContent"><strong>Conclusion: </strong>The ethanolic extract of Scarlet Spiral Flag (<em>Costus woodsonii</em>) has a potent antidiabetic effect in Alloxan-induced diabetic mice. Since it is under the same Genus of the Insulin plant, it has a common effect in terms of lowering the blood glucose level.</p><p class="AbstractContent"><strong>Keywords: </strong>Acclimatization, Alloxan, <em>Costus woodsonii, </em>Ethanolic Extract, Oral Gavage</p>

scholarly journals Normalization of Blood Glucose after Islet Cografting with Placental Tissues in Diabetic Mice

2002 ◽  
Vol 11 (5) ◽  
pp. 455-457 ◽  
Author(s):  
Kazuhisa Suzuki ◽  
Hiroo Ueda ◽  
Koichi Yokono ◽  
Hiroshi Taniguchi
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Left Kidney ◽  
Immunosuppressive Agents ◽  
Underlying Mechanism ◽  
Diabetic Mice ◽  
Kidney Capsule ◽  
Left Behind ◽  
Gestational Period

A fetus in the uterus is not rejected at any time during the entire gestational period, even without the administration of immunosuppressive agents, though fetus is a kind of allograft. This prevention of rejection is considered to be associated with the presence of placental tissues. This hypothesis was tested by the allografting of islets together with placental tissues (trophoblasts) in streptozotocin (STZ)-induced diabetic mice. Placentae were harvested from the mice at the 14th postgestation day by being peeled off carefully and with the maternal decidua left behind, and cut into small pieces. Five hundred freshly isolated islets together with placental tissues obtained from ICR mice were placed under the left kidney capsule of STZ-induced diabetic C57BL/6J mice. The nonfasting blood glucose level was reduced from 477 ± 41 mg/dl at the time of pretransplant to that of the intact normal mice (161 ± 18 mg/dl) soon after the cografting, and did not return to the pretransplant level before the 14th posttransplant day. The grafting of the same number of islets alone and/or liver tissues dropped the blood glucose level, but not to that of the intact normal mice. It returned to the pretransplant level within 1 week. This is the first successful prolongation of survival of allografted islets without immunosuppressive agents through cotransplantation of allogenic placental tissues. The underlying mechanism remains to be clarified.

scholarly journals Prunus mumeleaf extract lowers blood glucose level in diabetic mice

2016 ◽  
Vol 54 (10) ◽  
pp. 2135-2140 ◽  
Author(s):  
Min Woo Lee ◽  
Jung Eun Kwon ◽  
Young-Jong Lee ◽  
Yong Joon Jeong ◽  
Inhye Kim ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Mice

The Anti-Hyperglycemic Effect of Plants in Genus Gynura Cass.

2009 ◽  
Vol 37 (05) ◽  
pp. 961-966 ◽  
Author(s):  
Wei-Lin Li ◽  
Bing-Ru Ren ◽  
Min-Zhuo ◽  
Yong Hu ◽  
Chang-Gen Lu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Ethyl Acetate ◽  
Glucose Level ◽  
Ethanol Extract ◽  
Diabetic Mice ◽  
Crude Drug ◽  
Pharmacological Tests ◽  
Ethanol Extracts ◽  
Hyperglycemic Effect

Gynura divaricata (L.) DC and G. bicolor DC are used as secret recipes to treat diabetes mellitus in some parts of China. Pharmacological tests were performed to prove the anti-hyperglycemic effect of these two plants of genus Gynura Cass. in this study. Both water and 95% ethanol extracts of fresh G. divaricata had significant effects on lowering blood glucose level in normal mice, in which the dose of 0.4 g (crude drug)/kg of 95% ethanol extract was more effective than 50 mg/kg glyburide. The ethyl acetate and n-butanol extracts of dried G. divaricata had significant effects on lowering blood glucose level in normal and alloxan diabetic mice too. Both ethyl acetate and n-butanol extracts of dried G. bicolor showed very significant effect on lowering blood glucose level to normal and alloxan-diabetic mice, and the dose 4.0 g (crude drug)/kg had a more hypoglycemic effect than 50 mg/kg glyburide in normal mice.

scholarly journals UJI AKTIVITAS ANTIOKSIDAN SOSIS ANALOG TEMPE DENGAN PENAMBAHAN TEPUNG UBI JALAR UNGU TERHADAP PENURUNAN KADAR GULA DARAH MENCIT DIABETES

Pro Food ◽  
2018 ◽  
Vol 4 (2) ◽  
pp. 383
Author(s):  
Maelan Hairani ◽  
Satrijo Saloko ◽  
Dody Handito
Keyword(s):  
Antioxidant Activity ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Sweet Potato ◽  
Glucose Level ◽  
Potato Flour ◽  
Diabetic Mice ◽  
Glucose Content ◽  
Sweet Potato Flour ◽  
Purple Sweet Potato

ABSTRACT This research was aimed to observe the effect of the addition of purple sweet potato flour in the making of tempeh analog sausage on antioxidant activity, anthocyanin total, reducing sugar content and antioxidant capability on decreasing of blood glucose level in diabetic mice. The method that was used in this research was Completely Randomized Design (CRD) which consist of five treatments i.e. 0%; 10%; 15%; 20% and 25% addition of purple sweet potato flour by four replications. The data were analyzed by Analysis of Variance (ANOVA) at α = 5% using Co-stat and SPSS 21 for windows software by further analyzed Polynomial Orthogonal Method (POM). The results showed that the addition of purple sweet potato flour treatments gave significant effect on antioxidant activity, anthocyanin total, and decreasing of blood glucose level in diabetic mice which feed by the tempeh analog sausage, however gave non significant effect on the reducing glucose content of the tempeh analog sausage. The 25% addition of  purple sweet potato flour was the best treatment by 31.44% of antioxidant activity; 8.22 mg/L of anthocyanin total; 1.13% of reducing glucose content and could decrease blood glucose level in diabetic mice equal to 387 mg/dL. Keywords : anthocyanin, blood glucose, purple sweet potato, tempeh analog sausage. ABSTRAK Penelitian ini bertujuan untuk menguji pengaruh penambahan tepung ubi jalar ungu pada pembuatan sosis analog tempe terhadap aktivitas antioksidan, total antosianin, kadar gula reduksi dan kemampuan antioksidannya untuk menurunkan kadar gula darah mencit diabetes. Metode yang digunakan adalah Rancangan Acak Lengkap (RAL) yang terdiri dari lima perlakuan yakni penambahan tepung ubi jalar ungu 0%, 10%, 15%, 20% dan 25% dengan 4 kali ulangan. Hasil pengamatan dianalisis menggunakan Analysis of Variance (ANOVA) pada α = 5% menggunakan software Co-Stat dan SPSS 21 for windows dengan uji lanjut menggunakan metode ortogonal polinomial (MOP). Hasil penelitian menunjukkan bahwa perlakuan penambahan tepung ubi jalar ungu memberikan pengaruh yang signifikan terhadap aktivitas antioksidan, total antosianin dan penurunan kadar gula darah mencit diabetes yang diberi makan sosis analog tempe, namun memberikan pengaruh yang tidak signifikan terhadap kadar gula reduksi sosis analog tempe. Penambahan 25% tepung ubi jalar ungu merupakan perlakuan terbaik dengan karakteristik aktivitas antioksidan 31,44%; total antosianin 8,22 mg/L; kadar gula reduksi 1,13% dan mampu menurunkan kadar gula darah mencit diabetes sebesar 387 mg/dL. Kata kunci : antosianin, gula darah, sosis analog tempe, ubi jalar ungu

scholarly journals EFEKTIVITAS BUBUK KOPI ROBUSTA FUNGSIONAL DIFORTIFIKASI BUBUK DAUN KERSEN TERHADAP PENURUNAN KADAR GULA DARAH MENCIT DIABETES

Pro Food ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. 581
Author(s):  
Imam Adriansyah ◽  
Dody Handito ◽  
Rucitra Widyasari
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Positive Control ◽  
The Body ◽  
Control Group ◽  
Diabetic Mice ◽  
Robusta Coffee ◽  
Coffee Powder ◽  
Muntingia Calabura

ABSTRACT The aim of this present study was to determine the effectiveness of fucntional Robusta coffee powder fortified by Muntingia calabura L. leaves to lower blood glucose level in diabetic mice according to the antioxidant activity and total phenolic content, and the effectivness of the chosen ratio of the antidiabetic functional coffee beverage to the body weight and blood glucose level in diabetic mice. This research was conducted in two stages. First, determining the best ratio of the antidiabetic functional coffee beverage using randomized complete design. Second, testing the best ratio to the speciment using the randomized post test-only control group design to perform the chosen ratio of the antidiabetic functional coffee beverage to diabetic mice in seven days treatment. The results showed that the best ratio of the antidiabetic functional coffee beverage was 25% robusta coffee powder and 75% Muntingia calabura L. leaves powder with 88.26% antioxidant activity and 1.05 mg GAE/g sample, and the chosen ratio of the antidiabetic functional coffee beverage proved the activity to reduce the blood glucose level in diabetic mice with the decrease level was 266 mg/dl or 45% effective to reduced the blood glucose level in diabetic mice. This blood glucose reduced activity was not significant to the positive control group given glibenclamid, but it was found significant to the negative control group that given aquades per oral. While the body weight of the diabetic mice given aquades only decreased twice higher than positive control group and antidiabetic functional coffee beverage group. Keywords: blood glucose level, diabetic, Muntingia calabura L. leaves, robusta coffee   ABSTRAK Tujuan dari penelitian ini adalah untuk menentukan rasio terbaik antara bubuk kopi robusta dan bubuk daun kersen sebagai minuman fungsional yang difortifikasi bubuk daun kersen terhadap penurunan kadar gula darah mencit diabetes, yang ditinjau dari aktivitas antioksidan dan kadar fenolik total, serta pengaruh rasio terpilih terhadap berat badan dan penurunan kadar gula darah mencit diabetes. Penelitian ini dilakukan dalam dua tahap, yang pertama yaitu penentuan rasio terbaik antara bubuk kopi robusta dan bubuk daun kersen menggunakan metode rancangan acak lengkap (RAL) dengan faktor tunggal berupa rasio bubuk kopi robusta dan bubuk daun kersen. Kedua, yaitu pengujian rasio terbaik pada hewan percobaan menggunakan metode rancangan acak dengan tes akhir dan kelompok kontrol dengan parameter kadar gula darah dan berat badan mencit selama tujuh hari perlakuan. Hasil dari penelitian ini adalah rasio terbaik dari kopi fungsional antidiabetes diperoleh dari rasio 25% bubuk kopi robusta dan 75% bubuk daun kersen dengan aktivitas antioksidan sebesar 88,26% dan kadar fenolik total sebesar 1,05 mg GAE/g bahan. Berdasarkan uji in vivo, produk kopi fungsional antidiabetes mampu menurunkan kadar gula darah mencit diabetes sebesar 266 mg/dl atau sekitar 45%, tidak berbeda nyata dengan perlakuan kontrol positif yang diberikan obat glibenklamid dengan penurunan sebesar 268 mg/dl atau sekitar 47%, namun berbeda nyata dengan kelompok perlakuan kontrol negaif menggunakan aquades yang mengalami peningkatan kadar gula darah sebsar 4,2%. Sedangkan untuk parameter berat badan, bahwa penurunan berat badan mencit kelompok perlakuan kontrol negatif menggunakan aquades mengalami penurunan dua kali lebih besar dibandingkan kelompok kontrol positif dan kelompok produk kopi fungsional. Kata kunci: daun kersen, diabetes, kadar gula darah, kopi robusta

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