scholarly journals Effect of various stabilizers on the stability of lansoprazole nanosuspension prepared using high shear homogenization: Preliminary investigation

2021 ◽  
Author(s):  
Ubgade Shobha ◽  
Bapat Aditi ◽  
Kilor Vaishali
Keyword(s):  
Preliminary Investigation ◽  
High Shear ◽  
High Shear Homogenization ◽  
The Stability

scholarly journals A preliminary investigation of the conditions which determine the stability of irreversible hydrosols

1900 ◽  
Vol 66 (424-433) ◽  
pp. 110-125 ◽  
Keyword(s):  
Slow Rate ◽  
Preliminary Investigation ◽  
Colloidal Solutions ◽  
Solid Matter ◽  
The Stability

It has long been held that a large number of colloidal solutions are related to or identical with suspensions of solid matter in a fluid in which the particles of solid are so small as to settle at an infinitely slow rate. Such solutions are the colloidal solutions of metals and of sulphides such as those of antimony, arsenic, and cadmium.

Stability of Controlled Road Vehicles: A Preliminary Fundamental Study

2015 ◽  
Author(s):  
Fabio della Rossa ◽  
Massimiliano Gobbi ◽  
Giampiero Mastinu ◽  
Carlo Piccardi ◽  
Giorgio Previati
Keyword(s):  
Autonomous Vehicles ◽  
Autonomous Vehicle ◽  
Preliminary Investigation ◽  
Basin Of Attraction ◽  
Lateral Acceleration ◽  
Steering Wheel ◽  
Vehicle Speed ◽  
Vehicle Model ◽  
The Stability ◽  
Positive Effect

A comparison of the lateral stability behaviour between an autonomous vehicle, a vehicle with driver and a vehicle without driver (fixed steering wheel) is made by introducing a simple mathematical model of a vehicle running on even road. The mechanical model of the vehicle has two degrees of freedom and the related equations of motion contain the nonlinear tyre characteristics. The driver is described by a well-known model proposed in the literature. The autonomous vehicle has a virtual driver (robot) that behaves substantially like a human, but with its proper reaction time and gain. The road vehicle model has been validated. The study of vehicle stability has to be based on bifurcation analysis and a preliminary investigation is proposed here. The accurate computation of steady-state equilibria is crucial to study the stability of the three kinds of vehicles here compared. The stability of the bare vehicle without driver (fixed steering wheel) is studied in a rather complete way referring to a number of combinations of tyre characteristics. The (known) conclusion is that the understeering vehicle is stable at each lateral acceleration level and at each vehicle speed. The additional (partially unknown) conclusion is that the vehicle (model) with degradated tyres may exhibit a huge number of different bifurcations. The driver has many effects on the stability of the vehicle. One positive effect is to eliminate the many possible different equilibria of the bare vehicle and keep active one single equilibrium only. Another positive effect is to broaden the basin of attraction of stable equilibria (at least at relatively low speed). A negative effect is that, even for straight running, the driver seem introducing a subcritical Hopf bifurcation which limits the maximum forward speed of some understeering vehicles (that could run faster with fixed steering wheel). Both the mentioned positive and negative effects appear to be applicable to autonomous vehicles as well. Further studies could be useful to overcome the limitations on the stability of current autonomous vehicles that have been identified in the present research.

A Comparison of the Stability and Curving Performance of Radial and Conventional Rail Vehicle Trucks

1981 ◽  
Vol 103 (3) ◽  
pp. 191-200 ◽  
Author(s):  
D. Horak ◽  
C. E. Bell ◽  
J. K. Hedrick
Keyword(s):  
Shear Stiffness ◽  
Bending Stiffness ◽  
Lateral Stability ◽  
High Shear ◽  
Wear Properties ◽  
Rail Vehicle ◽  
Curving Performance ◽  
Conventional Rail ◽  
The Stability ◽  
Total Shear

This paper compares the lateral stability and steady-state curving performance of radial and conventional rail vehicle trucks. The radial truck has two unique features, it allows direct elastic coupling between the wheelsets and it allows greater total truck shear stiffness for a given bending stiffness. It is shown that the first property allows the radial truck to achieve up to a 40 percent higher critical speed than the conventional truck for equivalent truck total shear and bending stiffness since the direct coupling between the wheelsets allows decoupling of the truck mass from the hunting wheelset masses. The second feature, i.e., greater shear stiffness capability, allows the radial truck to have improved wear properties during the negotiation of tight curves. It is shown that the high shear stiffness property combined with a low bending stiffness reduces the lateral flange force and wheelset angle of attack during flange contact. It is concluded that for routes where the majority of curves are less than 4 deg (greater than 400 m radius) the truck optimized for off-flange performance should have intermediate values of shear stiffness, bending stiffness, and conicity. On the other hand, for routes where the majority of curves are greater than 4 deg, the truck optimized for on-flange performance should have a high shear stiffness and low values of bending stiffness and conicity.

Determination of Nitrite and Nitrate in Brazilian Meats Using High Shear Homogenization

2011 ◽  
Vol 5 (4) ◽  
pp. 637-642 ◽  
Author(s):  
Elisabete Alves Pereira ◽  
João F. S. Petruci ◽  
Arnaldo Alves Cardoso
Keyword(s):  
High Shear ◽  
High Shear Homogenization

Optimization of Curcumin Loaded Lipid Nanoparticles Formulated Using High Shear Homogenization (HSH) and Ultrasonication (US) Methods

2013 ◽  
Vol 13 (10) ◽  
pp. 6888-6893 ◽  
Author(s):  
Carmelo Puglia ◽  
Alessia Offerta ◽  
Luisa Rizza ◽  
Giuseppe Zingale ◽  
Francesco Bonina ◽  
...  
Keyword(s):  
Lipid Nanoparticles ◽  
High Shear ◽  
High Shear Homogenization

scholarly journals A preliminary investigation of in vitro anti-thrombotic and anti-platelet activity of Pinus Gerardiana

2017 ◽  
Vol 4 (1) ◽  
pp. 1098 ◽  
Author(s):  
Atta-ur Rehman ◽  
Sara Naz ◽  
Muhammad Zaman ◽  
Syed Saeed-ul-Hassan ◽  
Javed Iqbal ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Blood Clot ◽  
Preliminary Investigation ◽  
Circulatory System ◽  
Clot Lysis ◽  
Platelet Activity ◽  
In Vivo Models ◽  
The Stability

Introduction: Hemostasis is a process which preserves the stability of a closed and high-pressure circulatory system after any vascular injury. Circulating platelets are recruited to the site of injury, where they develop a major component of the developing thrombus, blood clotting, started by tissue factor, concludes in the generation of thrombin and fibrin. Thrombosis is a serious event in the arterial diseases and a major cause in the development of myocardial infarction, stroke and venous thrombo-embolism which justify prominent morbidity and mortality rate. The knowledge of molecular and cellular mechanism of the formation of thrombus has developed considerably in the recent studies by using different in-vitro and in-vivo models of diseases. P. gerardiana nut oil has been reported to possess anti-bacterial, anti-fungal, anti-viral, anti-septic, anti-neuralgic, diuretic, expectorant, hypertensive properties. However, hardly, any data is available regarding effects of nut oil on platelet function. In this study, fibrinolytic activity and effect on platelet aggregation were investigated. Method: P. gerardiana nut oil was extracted by using n-Hexane and then concentrated by rotary evaporator. Anti-thrombotic and fibrinolytic activities were evaluated on blood clot formation. Effects on platelet aggregation of the oil were determined based on collagen or epinephrine induced platelet aggregation. Results: P. gerardiana caused blood clot lysis in-vitro. P. gerardiana nut oil inhibited collagen dependent platelet aggregation while accelerated the epinephrine dependent platelet aggregation. In vitro whole blood coagulation was also reduced. In vivo P. gerardiana nut oil has no significant effect on blood cell indices. Conclusion: P. gerardiana nuts oil can be an effective therapy for the treatment of cardiovascular disorders and thromboembolism.

scholarly journals Caseinate-Stabilized Emulsions of Black Cumin and Tamanu Oils: Preparation, Characterization and Antibacterial Activity

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1951 ◽  
Author(s):  
Urbánková ◽  
Kašpárková ◽  
Egner ◽  
Rudolf ◽  
Korábková
Keyword(s):  
Nigella Sativa ◽  
Antibacterial Properties ◽  
Sodium Caseinate ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
High Shear ◽  
Disk Diffusion Method ◽  
Black Cumin ◽  
Spoilage Bacteria ◽  
High Shear Homogenization

Caseinate-stabilized emulsions of black cumin (Nigella sativa) and tamanu (Calophyllum inophyllum) oils were studied in terms of preparation, characterization, and antibacterial properties. The oils were described while using their basic characteristics, including fatty acid composition and scavenging activity. The oil-in-water (o/w) emulsions containing the studied oils were formulated, and the influence of protein stabilizer (sodium caseinate (CAS), 1–12 wt%), oil contents (5–30 wt%), and emulsification methods (high-shear homogenization vs sonication) on the emulsion properties were investigated. It was observed that, under both preparation methods, emulsions of small, initial droplet sizes were predominantly formed with CAS content that was higher than 7.5 wt%. Sonication was a more efficient emulsification procedure and was afforded emulsions with smaller droplet size throughout the entire used concentration ranges of oils and CAS when compared to high-shear homogenization. At native pH of ~ 6.5, all of the emulsions exhibited negative zeta potential that originated from the presence of caseinate. The antibacterial activities of both oils and their emulsions were investigated with respect to the growth suppression of common spoilage bacteria while using the disk diffusion method. The oils and selected emulsions were proven to act against gram positive strains, mainly against Staphylococcus aureus (S. aureus) and Bacillus cereus (B. cereus); regrettably, the gram negative species were fully resistant against their action.

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