scholarly journals Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4862 ◽  
Author(s):  
Lenka Urbankova ◽  
Pavel Horky ◽  
Jiri Skladanka ◽  
Magdalena Pribilova ◽  
Vendula Smolikova ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Sodium Selenite ◽  
Model Organism ◽  
Essential Element ◽  
Selenium Nanoparticles ◽  
Control Group ◽  
Positive Effects ◽  
Rat Strain ◽  
Higher Doses ◽  
Total Selenium

Background Selenium is an essential element; however, at higher doses, it can be toxic. Therefore, alternative nanotechnological solutions are required to overcome toxicological issues, rather than conventional alternatives. Nanoparticles show new and promising properties that may be able to suppress toxicity while maintaining the positive effects of selenium on an organism. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles (SeNPs) on the antioxidant status of rats. Methods The males of the outbreed rat strain Wistar albino were selected as a model organism. Animals were fed different forms of selenium. The control group was given a mixture without selenium addition, whereas other groups were fed a mixture containing sodium selenite, Se-49, and Se-100 SeNPs respectively. The duration of the trial was 30 days. Results Analysis of blood and liver was performed where the concentration of reduced (GSH) and oxidised (GSSG) glutathione, and total selenium content were measured. In the liver, a significant reduction in GSSG was found for all experiment groups. Blood samples showed a significant reduction in GSH and an increase in GSSG. Discussion These results show that SeNPs may be an alternative to dietary selenium for animal organisms.

scholarly journals Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles

2018 ◽  
Author(s):  
Lenka Urbankova ◽  
Pavel Horky ◽  
Jiri Skladanka ◽  
Magdalena Pribilova ◽  
Vendula Smolikova ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Sodium Selenite ◽  
Model Organism ◽  
Selenium Nanoparticles ◽  
Control Group ◽  
Selenium Content ◽  
Blood Samples ◽  
Dietary Selenium ◽  
Animal Organism ◽  
Total Selenium

Background. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles on antioxidant status of rats. Methods. The males of outbreed strain Wistar albino were selected as a model organism. Animals were fed with different forms of selenium. The control group was given mixture without selenium addition, whereas other groups were fed with mixture containing sodium selenite, Se-49 and Se-100 selenium nanoparticles, respectively. The duration of the trial was 30 days. Results. The analysis of blood and liver was performed where concentration of reduced (GSH) and oxidized (GSSG) glutathione, and the total selenium content were measured. In liver, a significant reduction in GSSG was found in all experimental groups. Blood samples showed a significant reduction in GSH and an increase in GSSG. Discussion. These results show that selenium nanoparticles may be an alternative to dietary selenium for the animal organism.

scholarly journals Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles

2018 ◽  
Author(s):  
Lenka Urbankova ◽  
Pavel Horky ◽  
Jiri Skladanka ◽  
Magdalena Pribilova ◽  
Vendula Smolikova ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Sodium Selenite ◽  
Model Organism ◽  
Selenium Nanoparticles ◽  
Control Group ◽  
Selenium Content ◽  
Blood Samples ◽  
Dietary Selenium ◽  
Animal Organism ◽  
Total Selenium

Background. The aim of the experiment was to determine the influence of sodium selenite and selenium nanoparticles on antioxidant status of rats. Methods. The males of outbreed strain Wistar albino were selected as a model organism. Animals were fed with different forms of selenium. The control group was given mixture without selenium addition, whereas other groups were fed with mixture containing sodium selenite, Se-49 and Se-100 selenium nanoparticles, respectively. The duration of the trial was 30 days. Results. The analysis of blood and liver was performed where concentration of reduced (GSH) and oxidized (GSSG) glutathione, and the total selenium content were measured. In liver, a significant reduction in GSSG was found in all experimental groups. Blood samples showed a significant reduction in GSH and an increase in GSSG. Discussion. These results show that selenium nanoparticles may be an alternative to dietary selenium for the animal organism.

Pro-oxidant effects of a high α-tocopherol dose on kidney antioxidant biomarkers and histopathological aspects

2017 ◽  
Vol 87 (3-4) ◽  
pp. 179-190
Author(s):  
Amel Kanane ◽  
Fayrouz Rouaki ◽  
Mohamed Brahim Errahmani ◽  
Abdenour Laraba ◽  
Hayet Mesbah ◽  
...  
Keyword(s):  
Sunflower Oil ◽  
Antioxidant Status ◽  
Basal Diet ◽  
Inflammatory Cells ◽  
Significant Rise ◽  
Control Group ◽  
Histopathological Changes ◽  
Group 5 ◽  
Oxidant Effect ◽  
Higher Doses

Abstract. The aim of this study is to evaluate the effect of α-tocopherol supplementation at two doses (600 and 1200 mg × kg–1) on kidney antioxidant status and the histopathological changes in Wistar rats after 12 weeks of exposure at different diets. Forty rats has been divided into 4 groups of 10 rats each, the control group received basal diet with 5 % fresh sunflower oil (FSO), the second group: 5 % oxidized sunflower oil (OSO), the third group: 5 % OSO supplemented with 600 mg × kg–1 α-tocopherol and the fourth group: 5 % OSO supplemented with 1200 mg × kg–1 α-tocopherol. In OSO groups, the results showed highly significant increases of LPO (from 31.3 ± 0.9 to 53.8 ± 1.2 nmol of MDA formed/min/mg protein, p < 0.0001) with a significant decrease (p < = 0.001) of the antioxidant enzymatic activities (CAT, SOD, GPX, GR and G6PDH), body weight (339 ± 9 to 290 ± 3 g) and α-tocopherol levels (13.6 ± 0.6 to 6.5 ± 0.4 μg/mg protein). In OSO groups with 600 mg × kg–1 α-tocopherol, an antioxidant effect was found, reflected by a return of the parameters to values similar to those of the control group. However, higher doses of α-tocopherol (1200 mg × kg–1) induced a depletion of antioxidant status, α-tocopherol levels (6.0 ± 0.3 μg/mg protein, p < 0.001) and a very highly significant rise (p < 0.0001) of LPO content (54.86 ± 0.01 nmol of MDA formed/min/mg protein). The kidney tissues also showed changes in glomerular, severe inflammatory cells infiltration, and formation of novel vessels. So, we can conclude that the oxidative stress is attenuated by a moderate administration of 600 mg × kg–1 α-tocopherol, while a pro-oxidant effect occurs at 1200 mg × kg–1 α-tocopherol.

Neurobehavioral changes in mice offspring induced by prenatal exposure to acute toxicity of sodium selenite

Biologia ◽  
2011 ◽  
Vol 66 (2) ◽  
Author(s):  
Jamaan Ajarem ◽  
Gada Basher ◽  
Hossam Ebaid
Keyword(s):  
Atomic Absorption ◽  
Prenatal Exposure ◽  
Active Avoidance ◽  
Sodium Selenite ◽  
Essential Element ◽  
The Body ◽  
Control Group ◽  
Dependent Manner ◽  
Sensory Motor ◽  
Dose Dependent

AbstractSelenium is an essential element with a narrow margin between beneficial and toxic effects. This study was aimed to determine the neurobehavioral changes resulted from the prenatal exposure of mice to high doses of sodium selenite during fetal and early postnatal development. Atomic absorption for monitoring the placental transfer of selenium to offspring was employed. The developmental observations as well as the behavioral tests, such as sensory motor reflexes, and learning and memory test in automatic reflex conditioner (shuttle box) (active avoidance responses) were applied. Adult mice was assigned into three groups: the first group was remained as a control group given phosphate buffered saline; the second and the third groups were orally administrated sodium selenite at doses of 1 mg/kg and 4 mg/kg of the diet, respectively started from the 7th day to the end of the gestation period. Appearance of body hair and opening of eyes of the pups from treated mothers were delayed in a dose-dependent manner. The body weight gain came significantly lower than those of the control especially at the higher dose. Selenite also inhibited the sensory motor reflexes in all elements of acts and postures in a dose dependent manner. The active avoidance training-test indicated that selenite exposure was associated with learning impairment. Acetylcholine recorded a significant decrease in almost all the period of this study. By using atomic absorption, we found a significant high concentration of selenium in the brain, liver and kidney until the 40th postnatal day, indicating active transfer of selenium from mothers to embryos.

scholarly journals Agronomic biofortification with selenium improves the yield and nutraceutical quality in tomato under soilless conditions

2020 ◽  
Vol 48 (3) ◽  
pp. 1221-1232
Author(s):  
Jazmín M. GAUCIN-DELGADO ◽  
Luis G. HERNÁNDEZ-MONTIEL ◽  
Esteban SÁNCHEZ-CHAVEZ ◽  
Hortensia ORTEGA-ORTIZ ◽  
Manuel FORTIS-HERNÁNDEZ ◽  
...  
Keyword(s):  
Nutritional Quality ◽  
Sodium Selenite ◽  
Tomato Fruit ◽  
Essential Element ◽  
Bioactive Compound ◽  
Positive Influence ◽  
Anthropogenic Sources ◽  
Hydroponic System ◽  
Higher Doses ◽  
Agronomic Biofortification

Selenium (Se) is an essential element for humans. Its consumption comes from food of animal or vegetal origin; whose content varies widely depending on its availability in soil or anthropogenic sources. Biofortification improves food nutritional quality, and its consumption has a positive influence in human health. Thus, the objective of this research was to assess agricultural biofortification with Se in tomato fruit and its effects on yield, nutraceutical quality, and antioxidant capacity.  Five Se doses (0, 2, 4, 6, and 8 mg L-1) in the form of sodium selenite (Na2SeO3) were added in a nutritional solution in a hydroponic system.  The results obtained indicated that agricultural biofortification with Se applied in the nutritional solution improved yield, nutraceutical quality, and Se concentration in tomato fruit. The optimum Se dose that maximized yield and nutraceutical quality, as well as the recommended consumption concentration in tomato fruit in this study was 2 mg L-1 (Na2SeO4) because higher doses decreased yield and bioactive compound biosynthesis. Incorporating Se in the nutritional solution is an alternative to increase phytochemical compound biosynthesis in tomato fruit and yield with the possibility of improving public health with its consumption.

scholarly journals Effect of dietary Salvia officinalis essential oil and sodium selenite supplementation on antioxidative status and blood phagocytic activity in broiler chickens

2013 ◽  
Vol 82 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Miroslav Ryzner ◽  
Jana Takáčová ◽  
Klaudia Čobanová ◽  
Iveta Plachá ◽  
Katarína Venglovská ◽  
...  
Keyword(s):  
Essential Oil ◽  
Phagocytic Activity ◽  
Broiler Chickens ◽  
Antioxidant Status ◽  
Sodium Selenite ◽  
Total Antioxidant Status ◽  
Basal Diet ◽  
Salvia Officinalis ◽  
Control Group ◽  
Antioxidative Status

Selected indicators of the antioxidant status and blood phagocytic activity were investigated in broiler chickens fed diets enriched with essential oil from Salvia officinalis and/or sodium selenite for 5 weeks. Twenty four one-day-old Ross 308 hybrid broilers were randomly divided into four groups according to dietary treatments. The control group was fed unsupplemented basal diet, whereas the feeds of three treatment groups were supplemented with essential oil (0.05%), sodium selenite (0.4 mg Se/kg dry matter) or their combination, respectively. The intake of diets containing essential oil alone or together with Se significantly elevated (P < 0.05) the total antioxidant status in plasma. The combination of essential oil and sodium selenite added to the basal diet resulted in significant reduction (P < 0.05) of superoxide dismutase activity in erythrocytes, increased activities of glutathione peroxidase in liver (P < 0.001) and duodenal mucosa (P < 0.05) compared to the control. Higher malondialdehyde concentrations in kidney tissues (P < 0.01) of chickens supplemented with sodium selenite were reduced by addition of essential oil to their diet. Blood phagocytic activity was significantly (P < 0.001) increased in both groups supplemented with selenium. The presented results demonstrate that Salvia officinalis essential oil and sodium selenite jointly added to diets had a more positive effect on the antioxidant status of broilers than when both additives were administered separately.

Effects of a 6-Week Straw Phonation in Water Exercise Program on the Aging Voice

2020 ◽  
Vol 63 (4) ◽  
pp. 1018-1032
Author(s):  
Chia-Hsin Wu ◽  
Roger W. Chan
Keyword(s):  
Acoustic Analysis ◽  
Vocal Tract ◽  
Exercise Program ◽  
Analysis Of Covariance ◽  
Elderly Subjects ◽  
Control Group ◽  
Perceptual Evaluation ◽  
Positive Effects ◽  
Aging Voice ◽  
Before And After

Purpose Semi-occluded vocal tract (SOVT) exercises with tubes or straws have been widely used for a variety of voice disorders. Yet, the effects of longer periods of SOVT exercises (lasting for weeks) on the aging voice are not well understood. This study investigated the effects of a 6-week straw phonation in water (SPW) exercise program. Method Thirty-seven elderly subjects with self-perceived voice problems were assigned into two groups: (a) SPW exercises with six weekly sessions and home practice (experimental group) and (b) vocal hygiene education (control group). Before and after intervention (2 weeks after the completion of the exercise program), acoustic analysis, auditory–perceptual evaluation, and self-assessment of vocal impairment were conducted. Results Analysis of covariance revealed significant differences between the two groups in smoothed cepstral peak prominence measures, harmonics-to-noise ratio, the auditory–perceptual parameter of breathiness, and Voice Handicap Index-10 scores postintervention. No significant differences between the two groups were found for other measures. Conclusions Our results supported the positive effects of SOVT exercises for the aging voice, with a 6-week SPW exercise program being a clinical option. Future studies should involve long-term follow-up and additional outcome measures to better understand the efficacy of SOVT exercises, particularly SPW exercises, for the aging voice.

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