The Anti-oxidant Activity and Anti-inflammatory Effect of Rubus buergeri Miguel Leaf Extract

KSBB Journal ◽  
2019 ◽  
Vol 34 (4) ◽  
pp. 331-337
Author(s):  
Min-Seon Kim ◽  
Kyongwol Yang ◽  
Seung-Young Kim
Keyword(s):  
Leaf Extract ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-oxidant and anti-inflammatory effect of polar extracts obtained from waste product of wine making

2020 ◽  
pp. 1-5
Author(s):  
M. J. Germanó ◽  
M. D. Muñoz ◽  
M. C. Della-Vedova ◽  
G. E. Feresin ◽  
M. Rinaldi-Tosi ◽  
...  
Keyword(s):  
Waste Product ◽  
Wine Making ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Polar Extracts ◽  
Inflammatory Effect

Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals

2015 ◽  
Vol 26 (5) ◽  
Author(s):  
Adeolu Alex Adedapo ◽  
Olufunke Olubunmi Falayi ◽  
Ademola Adetokunbo Oyagbemi
Keyword(s):  
Leaf Extract ◽  
Moringa Oleifera ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Laboratory Animals ◽  
Phytochemical Analysis ◽  
Writhing Test ◽  
Analgesic Effects ◽  
Anti Oxidant ◽  
Anti Inflammatory

AbstractThe commercially processedThe phytochemical analysis showed that the extract contained flavonoids, terpenoids, glycosides, tannins and saponins. In the acetic acid-induced writhing test, the extract significantly reduced the number of writhes at 100 and 200 mg/kg but not so much at 50 mg/kg. In the formalin-induced paw lick test, the effect was similar to that of the acetic writhing test. The analgesic effects were comparable to that of indomethacin used at 10 mg/kg. In the anti-inflammatory test, the extract reduced the formation of oedema especially at a dose of 200 mg/kg. In the anti-oxidant test, the extract was found to possess a free radical-scavenging property and is concentration related.The use of this extract for medicinal and nutritional purposes may have thus been justified; however, caution must be exercised in its use to prevent the toxic effect.

scholarly journals Efecto antiinflamatorio de extractos etanólicos de Morinda citrifolia L. en conejos

Tequio ◽  
2019 ◽  
Vol 2 (6) ◽  
pp. 26-34
Author(s):  
Irma Cecilia Regino Álvarez ◽  
María de la Luz Ríos Vásquez ◽  
Héctor Ulises Bernardino Hernández ◽  
Arturo Zapién Martínez
Keyword(s):  
Secondary Metabolites ◽  
Leaf Extract ◽  
Adverse Reactions ◽  
Morinda Citrifolia ◽  
San Jose ◽  
Mature Leaves ◽  
Therapeutic Properties ◽  
Anti Inflammatory ◽  
Ethanol Extracts ◽  
Inflammatory Effect

Morinda citrifolia L. has multiple therapeutic properties, particularly as an anti-inflammatory. The species has been widely studied, however, it is necessary to expand studies to document the presence of secondary metabolites and the anti-inflammatory effect of its extracts in animal models. The objective of the present paper was to identify the secondary metabolites present in the ethanol extracts of leaves and fruit of Morinda citrifolia L. collected in the community of San José Rio Manso, municipality of Lalana Choapam, Oaxaca, as well as the evaluation of its anti-inflammatory effect in rabbits. Ethanol extracts were obtained from the green and mature leaves, as well as the juice of the fruit. Green leaf extract gels were prepared and used in a completely randomized experiment in rabbits. The presence of alkaloids, leucoantacionins, amino acids, coumarins, cardiotonics, flavonoids, terpenes and tannins was identified. The 0.5% extract was more efficient at reducing the inflamed area by 55.6% compared to 28.6% of the control, 48 hours after the induction of inflammation. No signs of adverse reactions due to the use of the pharmaceutical forms evaluated were observed.

Effect of Topical Noni (Morinda citrifolia L.) Leaf Extract Paste in Carrageenan-induced Paw Edema on Wistar Rats

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Indah Puti Rahmayani Sabirin ◽  
Euis Reni Yuslianti
Keyword(s):  
Inflammatory Response ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
The Body ◽  
Morinda Citrifolia ◽  
Paw Edema ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The inflammatory response is one of natural process in the body to protect itself following tissue injury, but it can cause discomfort. Noni (Morinda citrifolia L.) leaf known as a traditional medicament to help reduce the inflammatory effect. The leaves empirically applied as a wrapping on fever or wound. The purpose of this study was to identify the anti-inflammatory effect of topical noni leaf extract paste in 5% and 10% concentration by examination of Wistar rat paw edema induced by λ-carrageenan. Twenty-four Wistar rats divided into four groups, which were negative control, positive control with diclofenac sodium 1% gel, 5% noni leaf, and 10% noni leaf paste groups. Paw edema was induced by intraplantar injection of 1% λ-carrageenan to every rat. Every treatment subsequently applied in the plantar area before injection, and the changed paw volume measured with plethysmometer at minutes 0, 30, 60, and 90. This study was at the Animal Laboratory, Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi city in October–December 2017. The result displayed that the minimum volume after 90 minutes was on 5% and 10% noni leaf paste group, which is 1.00 mL. Kruskal-Wallis test result of inflammatory percentage was significantly different among every group in each examination time (p<0.05). Post-hoc test showed that inflammatory reduction on paw edema with noni leaf paste application on both concentrations were significantly different compared to the negative control. However, it was not different from the positive control group. This study showed that application of noni leaf paste in 5% and 10% concentration could help reduce inflammatory response on skin possibly by the active anti-inflammatory ingredients of noni leaf. EFEK PASTA EKSTRAK DAUN MENGKUDU (MORINDA CITRIFOLIA L.) TOPIKAL TERHADAP EDEMA KAKI TIKUS GALUR WISTAR YANG DIINDUKSI KARAGENANInflamasi adalah proses alami tubuh untuk melindunginya setelah cedera, namun hal tersebut dapat menyebabkan ketidaknyamanan. Daun mengkudu (Morinda citrifolia L.) dikenal sebagai obat tradisional untuk menurunkan efek inflamasi yang secara empiris digunakan untuk mengobati demam dan luka. Tujuan penelitian ini adalah mengetahui efek anti-inflamasi pasta ekstrak daun mengkudu melalui pemeriksaan edema kaki tikus yang diinduksi karagenan-λ. Dua puluh empat tikus galur Wistar dibagi menjadi 4 kelompok, yaitu kontrol negatif dengan akuades, kontrol positif (aplikasi gel Na diklofenak 1%), serta perlakuan pasta daun mengkudu 5% dan 10%. Edema dibuat dengan menginjeksi intraplantar tikus dengan 1% karagenan-λ pada tiap kelompok. Tiap-tiap perlakuan diaplikasikan sebelum tikus diinjeksi dan perubahan volume kaki tikus diukur dengan pletismometer di menit ke-0, 30, 60, dan 90. Penelitian ini dilakukan di Laboratorium Hewan, Fakultas Kedokteran, Universitas Jenderal Achmad Yani, Kota Cimahi pada Oktober–Desember 2017. Hasil pengukuran memperlihatkan penurunan volume edema kaki terkecil setelah 90 menit pada kelompok pasta daun mengkudu 10%, yaitu 1,00 mL. Hasil Uji Kruskal-Wallis terhadap persentase inflamasi berbeda nyata pada tiap kelompok dan tiap waktu pengamatan (p<0,05). Hasil uji beda menunjukkan bahwa penurunan inflamasi kaki tikus pada perlakuan pasta daun mengkudu kedua konsentrasi berbeda nyata dibanding dengan kontrol negatif, tetapi tidak berbeda dengan kontrol positif. Penelitian ini menunjukkan bahwa pasta daun mengkudu 5% dan 10% dapat membantu menurunkan reaksi inflamasi kulit dan efeknya sejalan dengan Na diklofenak karena zat aktif yang bersifat anti-inflamasi dalam daun mengkudu.

Antinociceptive and anti-inflammatory properties of Tetracera alnifolia Willd. (Dilleniaceae) hydroethanolic leaf extract

2018 ◽  
Vol 30 (2) ◽  
pp. 173-184 ◽  
Author(s):  
Olufunmilayo O. Adeyemi ◽  
Ismail O. Ishola ◽  
Elizabeth T. Adesanya ◽  
Destiny O. Alohan
Keyword(s):  
Nitric Oxide ◽  
Acetic Acid ◽  
Potassium Channel ◽  
Leaf Extract ◽  
Paw Edema ◽  
Hot Plate ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Tetracera Alnifolia ◽  
Inflammatory Effect

Abstract Background Tetracera alnifolia Willd. (Dilleniaceae) is used in traditional African Medicine for the treatment of headache, abdominal pain, and rheumatism. Hence, this study sought to investigate the antinociceptive and anti-inflammatory effects of the hydroethanolic leaf extract of T. alnifolia (HeTA) in rodents. Methods Antinociceptive activity was evaluated using the acetic acid-induced writhing, formalin-/capsaicin-induced paw licking and hot plate tests in mice. The contribution of opioidergic, l-arginine-nitric oxide, and ATP-sensitive potassium channel pathways in HeTA-induced antinociception was also evaluated. The anti-inflammatory effect was assessed using the carrageenan-induced paw edema, xylene ear edema, cotton pellet granuloma, and complete Freund’s adjuvant (CFA)-induced arthritis in rats. Results HeTA (100, 200, and 400 mg/kg, p.o.) produced significant (p<0.05) decrease in mean number of acetic acid-induced writhing, time spent licking paw in formalin, and capsaicin tests as well as time course increase in nociceptive reaction latency in hot plate test. HeTA-induced antinociception was prevented by pretreatment of mice with naloxone (non-selective opioid receptor antagonist), l-arginine (nitric oxide precursor), or glibenclamide (ATP-sensitive potassium channel blocker). HeTA (100 mg/kg, p.o.) produced a significant anti-inflammatory effect against carrageenan-induced rat paw edema (1–5 h), xylene-induced ear edema, cotton pellet-induced granuloma formation, and CFA-induced arthritis in rats. The effects of HeTA in various models were similar to the effect of the standard reference drugs. Conclusions Findings from this study showed that HeTA possesses antinociceptive effect possibly mediated through peripheral opioid receptors with activation of l-arginine-nitric oxide and ATP-sensitive potassium channel pathway as well as anti-inflammatory activity.

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