scholarly journals Subclinical Atherosclerosis and Atherogenic Index of Plasma in Lichen Planus Patients- A Comparative Cross-sectional Study

2020 ◽  
Author(s):  
A Ramesh ◽  
P Deepavarshini
Keyword(s):  
Lipid Profile ◽  
Lichen Planus ◽  
Subclinical Atherosclerosis ◽  
Chronic Inflammatory Disease ◽  
Atherogenic Index ◽  
Healthy Controls ◽  
Lifestyle Modifications ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Increased Risk

Introduction: Lichen Planus (LP) is an idiopathic and chronic inflammatory disease that affects the skin and the mucous membranes, and studies have proven its association with increased risk for Cardiovascular (CV) diseases. Subclinical atherosclerosis and Atherogenic Index of Plasma (AIP) are strong predictors of CV risk. Aim: The primary aim of this study was the evaluation of Common Carotid artery mean Intima-Media wall Thickness (CIMT) and AIP which are predictors of CV risk in patients with LP. Materials and Methods: Fifty patients with LP and fifty age, gender and Body Mass Index (BMI) matched healthy controls (from the general population without the disease) were included in the study. CIMT was measured using ultrasound. Lipid profile was calculated by biochemical analysis. AIP was calculated from lipid profile using validated formula. Data was analysed using SPSS version 16.0 software. Results: Compared to healthy controls, patients had significantly higher CIMT. A 28% of patients had subclinical atherosclerosis compared to 2% of controls (p<0.001). Dyslipidemia was detected in 42% of patients and only 10% of controls (p<0.001). AIP was significantly elevated in LP patients compared to controls (p<0.001). A 36% of patients had high CV risk according to AIP versus 8% of controls. The 80% of controls had low CV risk versus 48% of patients (p<0.001). Conclusion: LP patients were found to have increased CV risk. CIMT, lipid profile and AIP can serve as important diagnostic markers of CV risk. Educating the patients about such a risk will enable them to follow lifestyle modifications so as to prevent further complications and morbidity.

scholarly journals The correlation between dietary fat quality indices and lipid profile with Atherogenic Index of Plasma in obese and non-obese Volunteers: a cross-sectional descriptive-analytic case-control study

2020 ◽  
Author(s):  
Maryam sadat Mousavi javardi ◽  
Zahra Madani ◽  
Majid Karandish ◽  
Ariyo Movahedi ◽  
Behnood Abbasi
Keyword(s):  
Lipid Profile ◽  
Dietary Fat ◽  
Case Control Study ◽  
Case Control ◽  
Atherogenic Index ◽  
Quality Indices ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Fat Quality ◽  
Control Study

Abstract Background and aim: Abnormalities in lipid metabolism are commonly observed in patients who were obese. Alongside dyslipidemia, one of the markers in predicting the risk of cardiovascular disease is the Atherogenic Index of Plasma (AIP), which is related to dietary intake. Healthy fat quality indices might affect on AIP. The purpose of this study is to find the possible relationship between dietary fat quality, and AIP and comparison of these indices among obese and non-obese volunteers.Methods: This study was a cross-sectional descriptive-analytic case-control study with 157 normal and overweight and obese volunteers (n=71 normal, Age: 38.90±10.976 vs n=86 overweight/obese, Age: 38.60±9.394) in the age range of 18-65 years. Food intake was measured using FFQ, anthropometric indices (weight, height, body mass index and waist to hip ratio), body composition (visceral fat level, total body water, body fat mass), and lipid profile were measured.Results: Based on the present results, comparable biochemical parameters including TC (P=0.580), TG (P=0.362), LDL (P=0.687) and HDL (P=0.151) among overweight/obese volunteers as compared to normal ones were noticed. Effects of dietary fat quality, including Atherogenicity (AI) and Thrombogenicity (TI) hypo/hypercholesterolemic ratio (h/H), the Cholesterol-Saturated Fat Index (CSI) showed significantly higher AI (P=0.012) in the overweight/obese group as compared to the normal group. Whereas, h/H (P=0.034) and ω-6/ω-3 ratio (P=0.004) were significantly higher in normal-weight volunteers. There was a positive correlation between AI, TI, CSI, SFA, MUFA, PUFA and ω-6/ω-3 ratio with AIP and negative correlation between h/H with AIP in both groups. Despite the significances of these correlations no strong relation was observed by doing multiple regression among normal and overweight/obese groups (R2=0.210, R2=0.387).Conclusions: In summary, the present work proposes a direct relationship between dietary fat quality, increased BMI, and lipid abnormalities with AIP. Nevertheless, further large-scale studies are required to sustain a clear conclusion in this wish.

scholarly journals Atherogenic index of plasma is a novel and strong predictor associated with fatty liver: a cross-sectional study in the Chinese Han population

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Fangfei Xie ◽  
Hong Zhou ◽  
Yun Wang
Keyword(s):  
Fatty Liver ◽  
Strong Predictor ◽  
Chinese Han Population ◽  
Atherogenic Index ◽  
Chinese Han ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Han Population ◽  
Discrimination Ability ◽  
Increased Risk

Abstract Background Atherogenic index of plasma (AIP) has been reported to be an important predictor for coronary artery disease and obesity. However, few studies has yet systematically evaluated the association between AIP and Fatty Liver (FL) and its advantage in FL prediction compared with BMI, waist, SBP, DBP, BG, ALT and AST. Methods A total of 7838 participants aged from 19 to 93 years were included in this study. Height, weight, waist, SBP, DBP, BG, ALT and AST were measured. Difference analyses, odds ratio calculation, logistic and predictive analyses were used to evaluate the association and discrimination ability between AIP, BMI, waist, SBP, DBP, BG, ALT, AST and FL. Results Compared with non-FL, AIP in FL people showed a significant increase. Subjects in the higher quartiles of AIP had a significantly increased risk of fatty liver compared with those in the lowest quartile (P < 0.01) after adjustment of gender and age. ORs were grown faster in female and youth group. AIP contributed most in the logistic eq. (B = 2.64, P < 0.01) and showed high ability in risk prediction for FL (AUC = 0.810, P < 0.01). Conclusions AIP might be a novel and strong predictor associated with FL in Chinese Han population. Higher AIP level was positively and strongly associated with FL.

scholarly journals Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

2014 ◽  
Vol 13 (2) ◽  
pp. 47-50 ◽  
Author(s):  
Monowara Khanam ◽  
Md Aminul Haque Khan ◽  
Md Rewanur Rahman ◽  
Rukhsana Parvin ◽  
Selima Akhter ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Postmenopausal Women ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Obese Women ◽  
Lipid Parameter ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Significant Difference

Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. Atherogenic index of plasma (AIP) calculated as log (TG/HDL-C) has been used as some practitioners as a significant predictor of atherosclerosis. So, we designed this study to observe the pattern of lipid profile parameters and to find out AIP in postmenopausal central obese women and to compare these between postmenopausal women with central obesity and postmenopausal nonobese women. Objectives: To assess the lipid profile status and AIP of postmenopausal women with central obesity and to compare these parameters with that of postmenopausal nonobese women.Materials & Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Sixty six postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8 and BMI <25.0. All statistical analyses were done by SPSS 18.0. p values <0.05 were considered significant.Results: Statistically no significant difference was observed between the central obese women and nonobese women in lipid profile parameters. But AIP was found significantly higher in postmenopausal central obese women.Conclusion: Central obese postmenopausal women may be at higher risk of cardiovascular events compared with postmenopausal nonobese women in spite of no difference in lipid profile parameters as their AIP values are significantly different.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i2.21064

scholarly journals The correlation between dietary fat quality indices and lipid profile with Atherogenic Index of Plasma in obese and non-obese Volunteers: a cross-sectional descriptive-analytic case-control study

2020 ◽  
Author(s):  
Maryam sadat Mousavi javardi ◽  
Zahra Madani ◽  
Majid Karandish ◽  
Ariyo Movahedi ◽  
Behnood Abbasi
Keyword(s):  
Lipid Profile ◽  
Dietary Fat ◽  
Case Control Study ◽  
Case Control ◽  
Atherogenic Index ◽  
Quality Indices ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Fat Quality ◽  
Control Study

Abstract Background and aim: Abnormalities in lipid metabolism are commonly observed in patients who were obese. Alongside dyslipidemia, one of the markers in predicting the risk of cardiovascular disease is the Atherogenic Index of Plasma (AIP), which is related to dietary intake. Healthy fat quality indices might affect on AIP. The purpose of this study is to find the possible relationship between dietary fat quality, and AIP and comparison of these indices among obese and non-obese volunteers.Methods: This study was a cross-sectional descriptive-analytic case-control study with 157 normal and overweight and obese volunteers (n=71 normal, Age: 38.90±10.976 vs n=86 overweight/obese, Age: 38.60±9.394) in the age range of 18-65 years. Food intake was measured using FFQ, anthropometric indices (weight, height, body mass index and waist to hip ratio), body composition (visceral fat level, total body water, body fat mass), and lipid profile were measured. Results: Based on the present results, comparable biochemical parameters including TC (P=0.580), TG (P=0.362), LDL (P=0.687) and HDL (P=0.151) among overweight/obese volunteers as compared to normal ones were noticed. Effects of dietary fat quality, including Atherogenicity (AI) and Thrombogenicity (TI) hypo/hypercholesterolemic ratio (h/H), the Cholesterol-Saturated Fat Index (CSI) showed significantly higher AI (P=0.012) in the overweight/obese group as compared to the normal group. Whereas, h/H (P=0.034) and ω-6/ω-3 ratio (P=0.004) were significantly higher in normal-weight volunteers. There was a positive correlation between AI, TI, CSI, SFA, MUFA, PUFA and ω-6/ω-3 ratio with AIP and negative correlation between h/H with AIP in both groups. Despite the significances of these correlations no strong relation was observed by doing multiple regression among normal and overweight/obese groups (R2=0.210, R2=0.387).Conclusions: In summary, the present work proposes a direct relationship between dietary fat quality, increased BMI, and lipid abnormalities with AIP. Nevertheless, further large-scale studies are required to sustain a clear conclusion in this wish.

scholarly journals Correlation of Lipid Parameters and Markers of Insulin Resistance: Does Smoking Make a Difference?

2014 ◽  
pp. S387-S393 ◽  
Author(s):  
Ľ. CIBIČKOVÁ ◽  
D. KARÁSEK ◽  
K. LANGOVÁ ◽  
H. VAVERKOVÁ ◽  
J. ORSÁG ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Correlation Coefficients ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Fasting Glycemia ◽  
Lipid Parameters

Insulin resistance associated with dyslipidemia enhances cardiovascular risk. Several atherogenic indexes have been suggested to give more precise information about the risk. The aim of our study was to estimate, which atherogenic index correlates better with parameters of insulin resistance. Furthermore, we compared the parameters of lipid metabolism and insulin resistance between smokers and non-smokers. In our cross-sectional study we enrolled 729 patients with dyslipidemia which were divided into two groups – non-smokers (586) and smokers (143). We measured lipid profile, parameters of insulin resistance (fasting glycemia, insulin, HOMA-IR, C-peptide, proinsulin) and calculated atherogenic indexes – atherogenic index of plasma (log (TAG/HDL-C), AIP), ApoB/ApoA1 index and nonHDL-C. AIP was found out to show stronger correlations with parameters of insulin resistance (p<0.001, correlation coefficients ranging between 0.457 and 0.243) than other indexes (ApoB/ApoA1 or nonHDL cholesterol). AIP correlated with parameters of insulin resistance both in smokers and non-smokers, but after adjustment (for age, body mass index, waist circumference) persisting only in non-smokers. Smokers had a wider waist circumference and a proatherogenic lipid profile. Smoking increases the risk of developing metabolic syndrome. AIP can be used in daily praxis for predicting insulin resistance in patients with dyslipidemia, predominantly in non-smokers.

scholarly journals The correlation between dietary fat quality indices and lipid profile with Atherogenic Index of Plasma in obese and non-obese Volunteers

2020 ◽  
Author(s):  
Maryam sadat Mousavi javardi ◽  
Zahra Madani ◽  
Majid Karandish ◽  
Ariyo Movahedi ◽  
Behnood Abbasi
Keyword(s):  
Lipid Profile ◽  
Dietary Fat ◽  
Large Scale ◽  
Normal Group ◽  
Obese Group ◽  
Atherogenic Index ◽  
Quality Indices ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Fat Quality

Abstract Background and aim: Abnormalities in lipid metabolism are very commonly observed in patients who were obese. Alongside dyslipidemia, one of the markers in predicting the risk of cardiovascular disease is the Atherogenic Index of Plasma (AIP), which is related to dietary intake. Healthy fat quality indices, including Atherogenicity (AI) and Thrombogenicity (TI) hypo/hypercholesterolemic ratio (h/H), the Cholesterol-Saturated Fat Index (CSI) and ω-3/ω-6 ratio might have effect on AIP. The purpose of this study is to find the possible relationship between dietary fat quality, and AIP and comparison of these indices among obese and non-obese volunteers. Methods This study was a cross-sectional descriptive-analytic case-control study with 157 normal and overweight and obese volunteers (n = 71 normal vs n = 86 overweight and obese) in the age range of 18–65 years. Food intake, anthropometric indices, body composition, and lipid profile were measured. Results Based on the present results, higher but not significant biochemical parameters including TC (P = 0.580), TG (P = 0.362) and LDL (P = 0.687) and HDL (P = 0.151) among overweight/obese volunteers as compared to normal ones. Results of dietary fat quality showed significantly higher AI (P = 0.012) in the overweight/obese group as compared to normal group. Whereas, h/H (P = 0.034) and ω-6/ω-3 ratio (p = 0.004) were higher significantly in normal weight volunteers. There was a positive correlation between AI, TI, CSI, SFA, MUFA, PUFA and ω-6/ω-3 ratio with AIP and negative correlation between h/H with AIP in both groups. These correlations were significant just for the AI (cc = 0.859, p = 0.014), h/H (cc=-0.596, p = 0.033) and SFA (cc = 0.602, p = 0.043) in overweight/obese group and were significant just for the AI (cc = 0.701, p = 0.031) and h/H (cc=-0.710, p = 0.023) in normal group. Conclusions In summary, the present study suggest a direct relationship between dietary fat quality, increased BMI, and lipid abnormalities with AIP. However, further large-scale studies are needed to have a clear conclusion in this regard.

scholarly journals The correlation between dietary fat quality indices and lipid profile with Atherogenic index of plasma in obese and non-obese volunteers: a cross-sectional descriptive-analytic case-control study

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Maryam Sadat Moussavi Javardi ◽  
Zahra Madani ◽  
Ariyo Movahedi ◽  
Majid Karandish ◽  
Behnood Abbasi
Keyword(s):  
Lipid Profile ◽  
Dietary Fat ◽  
Case Control Study ◽  
Case Control ◽  
Atherogenic Index ◽  
Quality Indices ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Fat Quality ◽  
Control Study

Abstract Background and aim Abnormalities in lipid metabolism are commonly observed in patients who were obese. Alongside dyslipidemia, one of the markers in predicting the risk of cardiovascular disease is the Atherogenic Index of Plasma (AIP), which is related to dietary intake. Healthy fat quality indices might affect on AIP. The purpose of this study is to find the possible relationship between dietary fat quality, and AIP and comparison of these indices among obese and non-obese volunteers. Methods This study was a cross-sectional descriptive-analytic case-control study with 157 normal and overweight and obese volunteers (n = 71 normal, Age: 38.90 ± 10.976 vs n = 86 overweight/obese, Age: 38.60 ± 9.394) in the age range of 18–65 years. Food intake was measured using FFQ, anthropometric indices (weight, height, body mass index and waist to hip ratio), body composition (visceral fat level, total body water, body fat mass), and lipid profile were measured. Results Based on the present results, comparable biochemical parameters including TC (P = 0.580), TG (P = 0.362), LDL (P = 0.687) and HDL (P = 0.151) among overweight/obese volunteers as compared to normal ones were noticed. Effects of dietary fat quality, including Atherogenicity (AI) and Thrombogenicity (TI) hypo/hypercholesterolemic ratio (h/H), the Cholesterol-Saturated Fat Index (CSI) showed significantly higher AI (P = 0.012) in the overweight/obese group as compared to the normal group. Whereas, h/H (P = 0.034) and ω-6/ω-3 ratio (P = 0.004) were significantly higher in normal-weight volunteers. There was a positive correlation between AI, TI, CSI, SFA, MUFA, PUFA and ω-6/ω-3 ratio with AIP and negative correlation between h/H with AIP in both groups. Despite the significances of these correlations no strong relation was observed by doing multiple regression among normal and overweight/obese groups (R2 = 0.210, R2 = 0.387). Conclusions In summary, the present work proposes a direct relationship between dietary fat quality, increased BMI, and lipid abnormalities with AIP. Nevertheless, further large-scale studies are required to sustain a clear conclusion in this wish.

scholarly journals Lipid Profile and Atherogenic Index of Plasma (AIP) in Vegetarians

2015 ◽  
Vol 5 (1) ◽  
pp. 30-33
Author(s):  
AN Wahida Sultana ◽  
Noortaj Begum ◽  
Abu Sadique Abdullah ◽  
Md Aminul Haque Khan ◽  
Md Rezwanur Rahman ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Fruits And Vegetables ◽  
Oxidized Ldl ◽  
Hdl Cholesterol ◽  
Vegetarian Diet ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma ◽  
Increased Risk ◽  
Control And Prevention

Background: Diet deficient in fresh fruits and vegetables are associated with an increased risk of coronary diseases. Low levels of vitamin C, vitamin E and other antioxidants may enhance the production of oxidized LDL and are important independent risk factors for coronary disease. Objective: To make a comparative evaluation of lipid profile and atherogenic index of plasma (AIP) between vegetarians and nonvegetarians. Materials and Methods: This case-control study was carried out in the Department of Biochemistry of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka between July 2011 to June 2012. Vegetarian and nonvegetarian subjects of male sex were the study population. Vegetarians were considered as cases while nonvegetarians as controls. After proper ethical consideration a total of 30 vegetarians and 40 nonvegetarians were consecutively included in the study based on predefined inclusion and exclusion criteria. Laboratory investigations were done in the Department of Biochemistry, BSMMU, Dhaka. Results: The vegetarians had significantly lower total cholesterol and LDLcholesterol than the nonvegetarians (p=0.000 and p=0.000 respectively). Serum HDL cholesterol was also lower among the vegetarians (p=0.002) and triglycerides were almost identical in both the groups (p=0.272). Conclusion: The study reveals lower level of total cholesterol, LDLcholesterol and HDL-cholesterol in vegetarians. No difference regarding triglycerides and AIP was found between the groups. So, the findings of this study do not indicate any superiority of vegetarian diet in control and prevention of cardiac diseases. DOI: http://dx.doi.org/10.3329/jemc.v5i1.21494 J Enam Med Col 2015; 5(1): 30-33

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