scholarly journals Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

2014 ◽  
Vol 13 (2) ◽  
pp. 47-50 ◽  
Author(s):  
Monowara Khanam ◽  
Md Aminul Haque Khan ◽  
Md Rewanur Rahman ◽  
Rukhsana Parvin ◽  
Selima Akhter ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Postmenopausal Women ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Obese Women ◽  
Lipid Parameter ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Significant Difference

Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. Atherogenic index of plasma (AIP) calculated as log (TG/HDL-C) has been used as some practitioners as a significant predictor of atherosclerosis. So, we designed this study to observe the pattern of lipid profile parameters and to find out AIP in postmenopausal central obese women and to compare these between postmenopausal women with central obesity and postmenopausal nonobese women. Objectives: To assess the lipid profile status and AIP of postmenopausal women with central obesity and to compare these parameters with that of postmenopausal nonobese women.Materials & Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Sixty six postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8 and BMI <25.0. All statistical analyses were done by SPSS 18.0. p values <0.05 were considered significant.Results: Statistically no significant difference was observed between the central obese women and nonobese women in lipid profile parameters. But AIP was found significantly higher in postmenopausal central obese women.Conclusion: Central obese postmenopausal women may be at higher risk of cardiovascular events compared with postmenopausal nonobese women in spite of no difference in lipid profile parameters as their AIP values are significantly different.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i2.21064

scholarly journals Lipid Profile of Postmenopausal Women with Central Obesity

2013 ◽  
Vol 3 (1) ◽  
pp. 8-12
Author(s):  
Monowara Khanam ◽  
Md Aminul Haque Khan ◽  
Md Rezwanur Rahman ◽  
Selima Akhter ◽  
Md Mozammel Hoque
Keyword(s):  
Lipid Profile ◽  
Postmenopausal Women ◽  
Central Obesity ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Obese Women ◽  
Lipid Parameter ◽  
Cross Sectional ◽  
Significant Difference ◽  
Parameter Values

Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. So, we designed this study to observe the pattern of lipid profile parameters in postmenopausal central obese women.Objective: To assess the lipid profile status of postmenopausal women with central obesity. Materials and Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period of January 2005 to December 2005. Seventy four postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8. All statistical analyses were done by SPSS 12.0. p values <0.05 were considered significant. Results: Statistically no significant difference was observed between the central obese women and nonobese women in total cholesterol and LDL-cholesterol levels. But HDL-cholesterol was found lower and triacylglycerol was found higher in postmenopausal central obese women. Conclusion: Dyslipidaemia is a feature of postmenopausal women with central obesity. DOI: http://dx.doi.org/10.3329/jemc.v3i1.13836 J Enam Med Col 2013; 3(1): 08-12

scholarly journals Correlation of Lipid Parameters and Markers of Insulin Resistance: Does Smoking Make a Difference?

2014 ◽  
pp. S387-S393 ◽  
Author(s):  
Ľ. CIBIČKOVÁ ◽  
D. KARÁSEK ◽  
K. LANGOVÁ ◽  
H. VAVERKOVÁ ◽  
J. ORSÁG ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Correlation Coefficients ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma ◽  
Fasting Glycemia ◽  
Lipid Parameters

Insulin resistance associated with dyslipidemia enhances cardiovascular risk. Several atherogenic indexes have been suggested to give more precise information about the risk. The aim of our study was to estimate, which atherogenic index correlates better with parameters of insulin resistance. Furthermore, we compared the parameters of lipid metabolism and insulin resistance between smokers and non-smokers. In our cross-sectional study we enrolled 729 patients with dyslipidemia which were divided into two groups – non-smokers (586) and smokers (143). We measured lipid profile, parameters of insulin resistance (fasting glycemia, insulin, HOMA-IR, C-peptide, proinsulin) and calculated atherogenic indexes – atherogenic index of plasma (log (TAG/HDL-C), AIP), ApoB/ApoA1 index and nonHDL-C. AIP was found out to show stronger correlations with parameters of insulin resistance (p<0.001, correlation coefficients ranging between 0.457 and 0.243) than other indexes (ApoB/ApoA1 or nonHDL cholesterol). AIP correlated with parameters of insulin resistance both in smokers and non-smokers, but after adjustment (for age, body mass index, waist circumference) persisting only in non-smokers. Smokers had a wider waist circumference and a proatherogenic lipid profile. Smoking increases the risk of developing metabolic syndrome. AIP can be used in daily praxis for predicting insulin resistance in patients with dyslipidemia, predominantly in non-smokers.

scholarly journals The relationship between the atherogenic index of plasma and arterial stiffness in essential hypertensive patients from China: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Juan Yin ◽  
Minghui Li ◽  
Lingling Yu ◽  
Feng Hu ◽  
Yu Yu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Arterial Stiffness ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Chinese Patients ◽  
Multivariate Linear Regression Analysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma

Abstract Background The atherogenic index of plasma (AIP) always remains in a potential association with arterial stiffness, however, this association has not been fully discovered and needs to be studied in depth in large hypertensive patient populations. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in Chinese patients diagnosed with arterial hypertension. Methods This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides to high-density lipoprotein cholesterol levels indicated in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV). Results Data were adjusted for potential confounding variables, and multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, the same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05). Conclusion AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2. Clinical trial registration ChiCTR1800017274.

scholarly journals The Relationship Between the Atherogenic Index of Plasma and Arterial Stiffness in Essential Hypertensive Patients from China: A Cross-Sectional Study

2021 ◽  
Author(s):  
Juan Yin ◽  
Minghui Li ◽  
Lingling Yu ◽  
Feng Hu ◽  
Yu Yu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Arterial Stiffness ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Multivariate Linear Regression Analysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma

Abstract Background: The atherogenic index of plasma (AIP) always remains in a potential association with the arterial stiffness, however, in large hypertensive patient populations, this relation is not fully discovered and needs to be studied in depth. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in patients diagnosed with arterial hypertension in China.Methods: This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-c) levels indicates as in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV).Results: Data were adjusted for potential confounding variables, after which a multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, this same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05).Conclusion: AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2.

scholarly journals perbandingan kadar HDL dan LDL akseptor Depo Medroksi Progesteron Asetat dengan IUD

2019 ◽  
Vol 7 (2) ◽  
pp. 47-51
Author(s):  
Suci Syahril ◽  
Meldafia Idaman ◽  
Dewi Fransisca
Keyword(s):  
Weight Gain ◽  
Lipid Profile ◽  
Medroxyprogesterone Acetate ◽  
Colorimetric Method ◽  
Cross Sectional Study ◽  
First Year ◽  
Sectional Study ◽  
Normal Range ◽  
Cross Sectional ◽  
Significant Difference

Abstract The use of contraceptive depot medroxyprogesterone acetate (DMPA) increasing lately, but some studies suggest has the side effects of weight gain and contraceptives that have side effect in lipid metabolism. Therefore, about 35% of acceptors of DMPA in the first year to stop the use of DMPA. The objective of this study was to determine the differences of lipid profile between acceptors DMPA with acceptors IUD. This was a obcervational study with cross sectional study. The study wasdone at health center Lubuk Buaya in Padang and at laboratory of Biochemistry Departement in Medical Faculty of Andalas University from Januari until September 2016. The subjects were consisted of two groups, each group had 26 subjects. The examination for LDL and HDL used an enzymatic colorimetric method CHOD-PAP.  Data was analyzed using analysis of t-test with p < 0.05 was considered to be significantly different. HDL levels average in Depo Medroxyprogesterone Acetate was 87,54±14,28 mg/dl and IUD was 75,90±8,67 mg/dl with p < 0.05 (significantly difference). Levels of  LDL means there is no significantly difference between DMPA and IUD acceptors (p> 0.05). This research concluded that there isa significant difference on average levels of HDL in the Depo Medroxyprogesterone Acetate and IUD but levels of LDL there is no significantly difference. The clinically lipid profile in the two groups is in normal range.  

scholarly journals Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study

2010 ◽  
Vol 128 (4) ◽  
pp. 211-214 ◽  
Author(s):  
Patrícia Magda Soares ◽  
César Cabello ◽  
Luis Alberto Magna ◽  
Eduardo Tinois ◽  
Cristina Laguna Benetti-Pinto
Keyword(s):  
Hormone Therapy ◽  
Postmenopausal Women ◽  
Breast Density ◽  
Premature Ovarian Failure ◽  
Cross Sectional Study ◽  
Ovarian Failure ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Impact

CONTEXT AND OBJECTIVE: Studies on postmenopausal women have reported increased risk of breast cancer relating to the type and duration of hormone therapy (HT) used. Women with premature ovarian failure (POF) represent a challenge, since they require prolonged HT. Little is known about the impact of prolonged HT use on these women's breasts. This study aimed to evaluate the effects of one type of HT on the breast density of women with POF, compared with postmenopausal women. DESIGN AND SETTING: Cross-sectional study at the Department of Obstetrics and Gynecology, Universidade Estadual de Campinas (Unicamp). METHODS: 31 women with POF and 31 postmenopausal women, all using HT consisting of conjugated equine estrogen combined with medroxyprogesterone acetate, and matched according to HT duration, were studied. Mammography was performed on all subjects and was analyzed by means of digitization or Wolfe's classification, stratified into two categories: non-dense (N1 and P1 patterns) and dense (P2 and Dy). RESULTS: No significant difference in breast density was found between the two groups through digitization or Wolfe's classification. From digitization, the mean breast density was 24.1% ± 14.6 and 18.1% ± 17.2 in the POF and postmenopausal groups, respectively (P = 0.15). Wolfe's classification identified dense breasts in 51.6% and 29.0%, respectively (P = 0.171). CONCLUSION: There was no difference in breast density between the women with POF and postmenopausal women, who had used HT for the same length of time. These results may help towards compliance with HT use among women with POF.

scholarly journals Perbedaan Profil Lipid pada Akseptor Depo Medroksi Progesteron Asetat dengan Implant Levonorgestrel di Wilayah Kerja Puskesmas Air Tawar Padang Tahun 2014

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Rafika Oktova ◽  
Desmiwarti Desmiwarti ◽  
Arni Amir
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Medroxyprogesterone Acetate ◽  
Colorimetric Method ◽  
Cross Sectional Study ◽  
Hormonal Contraceptives ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference

AbstrakDepo Medroksiprogesteron Asetat dan Implant Levonorgestrel merupakan kontrasepsi hormonal progestin sintetik yang memiliki efek samping yaitu peningkatan berat badan dan mempengaruhi metabolisme lipid. Tujuan penelitian ini adalah untuk mengetahui perbedaan profil lipid pada akseptor Depo Medroksiprogesteron Asetat dengan Implant Levonorgestrel. Ini adalah studi observasional dengan desain cross sectional comparative. Penelitian dilakukan di laboratorium Bagian Biokimia Fakultas Universitas Andalas dari Maret sampai Mei 2014. Subjek penelitian terdiri dari dua kelompok, masing-masing 20 subjek. Pemeriksaan dengan metode enzimatis kolorimetri yaitu GPO-PAP untuk trigliserida, dan CHOD-PAP untuk kolesterol total, HDL dan LDL. Data dianalisis menggunakan uji t dengan nilai p<0.05 dianggap bermakna secara statistik. Rerata kadar LDL pada Depo Medroksiprogesteron Asetat lebih tinggi (95,51 ± 20,47) mg/dl daripada Implant Levonorgestrel (79,35 ± 12,55) mg/dl dengan nilai p<0,05 artinya terdapat perbedaan yang bermakna sedangkan kadar trigliserida, kolesterol total dan HDL tidak bermakna. Kesimpulan penelitian in adalah terdapat perbedaan yang bermakna rerata kadar LDL pada Depo MedroksiprogesteronAsetat dan Implant Levonorgestrel, sedangkan kadar trigliserida, kolesterol total dan HDL tidak bermakna. Secara klinis profil lipid pada kedua kelompok dalam keadaan normal.Kata kunci: profil lipid, depo medroksiprogesteron asetat, implant levonorgestrelAbstractDepo Medroxyprogesterone Acetate and Levonorgestrel Implants are synthetic progestine hormonal contraceptives that have side effect in body weight and lipid metabolism. The objective of this study was to determine the differences of lipid profile between acceptors Depo Medroxyprogesterone Acetate and Levonorgestrel Implants. This was a comparative cross sectional study. The study was done at laboratory of Biochemistry Departement in Medical Faculty of Andalas University from March until May 2014. The subjects were consisted of two groups, each group had 20 subjects. The examination used an enzymatic colorimetric method GPO-PAP for trygliserides and CHOD-PAP for total cholesterol, HDL and LDL. Data was analyzed using analysis of t-test with p<0.05 was considered to be significantly different. LDL levels average in Depo Medroxyprogesterone Acetate was (95,51 ± 20,47) mg/dl and Levonorgestrel Implants was (79,35 ± 12,55) mg/dl with p-value, it means there is a significantly difference, but levels of trygliserides, total cholesterol and HDL means there is no significantly difference. This research concluded that there is a significant difference on average levels of LDL in the Depo Medroxyprogesterone Acetate and Levonorgestrel Implants but levels of trygliserides, total cholesterol and HDL there is no significantly difference. The clinically lipid profile in the two groups is in normal range.Keywords: lipid profile, depo medroxyprogesterone acetate and levonorgestrel implants

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