scholarly journals Association of High Serum Ferritin Level in Early Pregnancy with Development of Gestational Diabetes Mellitus- A Prospective Observational Study

2021 ◽  
Author(s):  
Abhijit Das ◽  
Shreyasi Karmakar ◽  
Sabyasachi Bid ◽  
Sudip Kumar Saha
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Observational Study ◽  
Serum Ferritin ◽  
Prospective Observational Study ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
High Serum ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration

Introduction: Gestational Diabetes Mellitus (GDM) has a negative impact on maternal and perinatal outcome and several long-term complications. The evidence from different experimental studies have shown that high serum ferritin concentration can lead to pancreatic β-cell dysfunction and impaired glucose metabolism leading to GDM. Aim: To determine the association of increased serum ferritin level in first trimester and GDM in course of pregnancy. Materials and Methods: A prospective observational study was conducted in 204 women in Institute of Post Graduate Medical Education and Research and SSKM Hospital, West Bengal, India, during the period from January 2015 to December 2015. The blood samples were collected and screened for GDM by Oral Glucose Tolerance Test (OGTT) at the beginning of the study and then assayed for serum ferritin level who were screened negative. The women were divided into four groups by quartiles of serum ferritin levels (Q1 to Q4). Then they were followed-up with OGTT at 24-28 weeks and again at 32-34 weeks. Statistical analysis was done by using paired t-test, Chi-square test and Fisher’s- exact test. Results: The participants had an average serum ferritin concentration of 77.44 ng/mL. GDM prevalence within each serum ferritin quartile was 7.84%, 11.76%, 19.61% and 23.53% respectively (p-value=0.016). The odds ratio for GDM in the ferritin Q2-Q4 was 1.57 (CI=0.41-5.92), 2.87 (CI=0.84-9.83) and 3.62 (CI=1.08-12.11) compared with Q1, respectively. In addition, primigravida and women with high Haemoglobin (Hb) level (>13 gm%) have an increased risk of developing GDM. Conclusion: Elevated serum ferritin level is associated with increased incidence of GDM irrespective of other risk factors. Iron supplementation should therefore be individualised based on serum ferritin in early pregnancy to minimise the risk of GDM.

scholarly journals LIVER IRON CONTENT (LIC) IN ADULTS WITH NON-TRANSFUSION DEPENDENT SICKLE CELL DISEASE (NT-SCD). CORRELATION WITH SERUM FERRITIN AND LIVER ENZYMES CONCENTRATIONS

2017 ◽  
Vol 9 (1) ◽  
pp. 2017037 ◽  
Author(s):  
Vincenzo De Sanctis
Keyword(s):  
Serum Ferritin ◽  
Iron Content ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
High Serum ◽  
Liver Iron ◽  
Ferritin Concentration ◽  
Liver Iron Content ◽  
Serum Ferritin Concentration ◽  
High Liver

Abstract. Introduction: Sickle cell disease (SCD) is an important cause of morbidity and mortality worldwide, causing damage and dysfunction in multiple organs. The complications of this disease are numerous, affect every organ and/or tissue in the body and vary considerably among patients over the time which challenge its management. Aim of our study: To determine the iron status of 17 patients with NT-SCD patients and 6 patients with TD- SCD using both serum ferritin level (SF ) and Ferriscan® evaluation of liver iron content (LIC) and correlate values of LIC on the one hand with SF levels and some hepatic functions (ALT, AST, ALP and albumin).  Results: 17 adults with NT-SCD (n = 17, age: 32±15 years) were studied.  Seven of NT-SCD had serum ferritin > 500 μg/L, 4 out of the seven had high liver iron measured by FerriScan®  (> 30 mg/kg/ tissue dry weight - DW).  Two patients had high liver iron content despite a concomitant serum ferritin concentration < 500 μg/L.  Two patients had high serum ferritin (1.117 μg/L and 675 μg/L) while their LIC was normal (< 30 mg/kg/DW).  5 patients had elevated ALT and/or AST concentrations. In TD-SCD (n = 6, age = 25 ±11 years), 2 patients had serum ferritin <500 μg/L, one of them had high LIC (127 mg/kg/DW). Liver enzymes were high in two patients.  Serum ferritin concentration was correlated significantly with LIC  (r = 0.85, p < 0.001). Neither serum ferritin level, nor LIC was correlated significantly with hepatic enzyme levels. Conclusions:  A significant number of our patients with ND-SCD had high LIC , high serum ferritin and elevated hepatic enzymes (ALT and AST). Despite some  limitations of our study (small NT-SCD cohort),  these findings have important clinical implications. We recommend  to measure serum ferritin and LIC in NT-SCD patients to apply therapeutic preventive measures with iron chelation therapy in patients with high LIC.  

scholarly journals A COMPARATIVE STUDY OF THE ASSOCIATION OF SERUM FERRITIN LEVEL WITH GESTATIONAL DIABETES MELLITUS IN THE DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY AT SMS MEDICAL COLLEGE & ATTACHED GROUP OF HOSPITALS, JAIPUR

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Priyanka Inaniya ◽  
B S Meena ◽  
Manju Sharma ◽  
Mohan Lal Meena ◽  
Rashma Gera ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Pregnant Female ◽  
Antenatal Visit ◽  
Medical College ◽  
Obstetrics And Gynaecology

Background: The present study aimed to study the association of Serum Ferritin level with gestational diabetes mellitus Methods: All Pregnant Females in Gestational age of 16 to 32 weeks presenting to the Ante natal clinic of Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur.  Based on Oral Glucose tolerance test, study participants were divided into two groups, Pregnant female with Gestational Diabetes (GDM group) and Pregnant female without Gestational Diabetes (Controls) Results: Mean ferritin level was significantly higher in GDM group (33.51 ng/ml)) as compared to control group (24.97 ng/ml). This difference in mean ferritin level among the two groups was found to be statistically significant (p<0.001). This indicates that higher ferritin level is significantly associated with risk of GDM. Conclusion: Serum ferritin in this study had a significant correlation with development of GDM. High ferritin range was found in females with GDM. Routine use of monitoring of serum ferritin levels, during the antenatal visit in the mid trimester should be carried out, for early prediction of developing GDM. Keywords: GDM, Serum ferrtin, Metabolic conditions.

scholarly journals Diagnostic value of ferritin for the severity of dengue infection in children

2019 ◽  
Vol 12 (3) ◽  
pp. 146-149
Author(s):  
Farzana Ahmed ◽  
Nargis Ara Begum ◽  
Md.  Moshiur Rahman ◽  
Md.  Salim Shakur ◽  
Shabrina Sharmin
Keyword(s):  
Platelet Count ◽  
Observational Study ◽  
Dengue Fever ◽  
Serum Ferritin ◽  
Prospective Observational Study ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Dengue Infection ◽  
Diagnostic Value ◽  
Hematocrit Level

The study was conducted to evaluate whether the severity of dengue fever can be predicted by serum ferritin level or not. This prospective observational study was conducted during the endemic period of dengue fever in 2019. A total of 30 diagnosed cases of dengue fever who presented with bicytopenia during febrile phase of the disease were enrolled in this study. Pearson’s correlation coefficient was calculated to compare ferritin levels with lowest platelet count and highest hematocrit level and it showed that there was significant correlation. There was no difference between lowest total count of white blood cell and serum ferritin level. The severity of dengue fever can be predicted by raised level of serum ferritin.

PREDICTIVE SIGNIFICANCE OF HIGH SERUM FERRITIN LEVELS IN THE DEBUT OF MALIGNANT LYMPHOMA

2020 ◽  
pp. 74-81
Author(s):  
Babaeva T.N. ◽  
Seregina O.B. ◽  
Pospelova T.I.
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Prognostic Significance ◽  
Average Concentration ◽  
High Serum ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Significant Prognostic Factor ◽  
Malignant Lymphomas

At present, the serum ferritin level is not included in the list of prognostic factors; however, it is known that its increased serum level in patients with malignant neoplasms relates with the tumor burden, the degree of disease activity and correlates with a worse prognosis in patients with hematologic malignancies.The normalization of serum ferritin level during remission period confirms the involving of hyperferritinemia in mechanisms of tumor progression and may testify for clinical importance of measurement of serum ferritin level in patients, including those with malignant lymphomas. Objective:The aim of this study was to assess of the prognostic significance of high ferritin levels at the onset of the disease in patients with malignant lymphomas. Materials and methods:98 patients with malignant lymphomaswere enrolled in this study, including 72 patients (73.5%) with non-Hodgkins lymphomas (NHL) and 26 patients (26.5%) with Hodgkin’s lymphoma (HL). The increased serum ferritin level (more than 350 ng/ml) was found in 53 (54.2%) patients with malignant lymphomas at the onset of disease and its average concentration was 587,62±131,6 ng/ml (8.3 times higher values of control group, p<0.001).Also the positive statistical correlationsbetween increased ferritin level and increased level of LDH (r=0.47, p<0.001, n=98) and C-reactive protein (r=0.41, p<0.001, n=98) as well as the presence of B-symptomswere found. The median OS was significantly shorter in the group of patients with increased ferritin level (more than 350 ng/ml) at the onset of disease in comparison with group of patients with normal ferritin level, where the median OS was not reach during the observation period. Patients with increased ferritin level before starting chemotherapy also showed worse results of overall survival and increased mortality risk (OR 8.122; 95% CI, 1.764-37.396;р<0.05) compare with a group of patients with ferritin level ˂350 hg/ml at the onset of disease. Conclusion:These results make it possible to include lymphomas’s patients with increased ferritin level at the onset of disease in the group with poor prognosis and lower OS, while the increased ferritin level in patients without previous blood transfusions should be considered as a significant prognostic factor.

scholarly journals Serum ferritin and red blood cell indices in infants of diabetic mothers

2020 ◽  
Vol 10 (3) ◽  
pp. 182-186
Author(s):  
Md Abdul Baki ◽  
Shahida Akhter ◽  
Jebun Nahar ◽  
Fauzia Mohsin ◽  
Shareen Khan
Keyword(s):  
Diabetes Mellitus ◽  
Iron Deficiency ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Corpuscular Hemoglobin ◽  
Red Cell Indices ◽  
Diabetic Mothers

Background: Fetal iron stores are affected by maternal diabetes and it is lower at birth in infants of diabetic mothers (IDMs). Risks for developing iron deficiency and neurocognitive impairment are reported in IDMs. This study was done to assess serum ferritin and red cell indices in IDMs and to compare the values with infants born to mothers without diabetes mellitus. Methods: This cross-sectional study was carried out at BIRDEM General Hospital from March to October, 2018. Total 102 full term neonates were included in this study. Among them 70 neonates were IDMs and 32 were infants born to mother without diabetes mellitus. Serum ferritin and red cell indices like hemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW) were measured within 48 hours of birth. Comparison of red cell indices and serum ferritin level were done between IDMs and infants of non-diabetes mothers. Statistical analysis was performed by using Epi info, and p value of <0.05 was considered statistically significant. Results: IDMs had significantly higher value of Hb% (19.00 vs 17.47 g/dl), PCV (57.60 vs 52.67 %) and RDW (20.09 vs17.77 %) than infant of non-diabetic mother (p <0.05). But there was no significant difference regarding the values of MCV, MCH and MCHC between IDMs and infants of non-diabetic mothers (p >0.05). Serum ferritin level was found significantly low in IDMs (94.51 vs 307.50 ng/ml, p <0.001). Conclusion: Iron stores of IDMs were found significantly lower at birth despite higher hemoglobin content, as indicated by lower serum ferritin level. Further studies and long-term follow up are needed to determine whether these infants are at risk for developing iron deficiency anemia or iron-deficient neurocognitive disorder Birdem Med J 2020; 10(3): 182-186

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