Epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome in southern Anhui Province, 2011-2020

SUMMARYSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by a novel bunyavirus, SFTSV. The study aimed to disclose the epidemiological and clinical characteristics of SFTSV infection in China so far. An integrated clinical database comprising 1920 SFTS patients was constructed by combining first-hand clinical information collected from SFTS sentinel hospitals (n = 1159) and extracted data (n = 761) from published literature. The considered variables comprised clinical manifestations, routine laboratory tests of acute infection, hospitalization duration and disease outcome. SFTSV-IgG data from 19 119 healthy subjects were extracted from the published papers. The key clinical variables, case-fatality rate (CFR) and seroprevalence were estimated by meta-analysis. The most commonly seen clinical manifestations of SFTSV infection were fever, anorexia, myalgia, chill and lymphadenopathy. The major laboratory findings were elevated lactate dehydrogenase, aminotransferase, followed by thrombocytopenia, lymphocytopenia, elevated alanine transaminase and creatine kinase. A CFR of 12·2% was estimated, significantly higher than that obtained from national reporting data, but showing no geographical difference. In our paper, the mortality rate was about 1·9 parts per million. Older age and longer delay to hospitalization were significantly associated with fatal outcome. A pooled seroprevalence of 3·0% was obtained, which increased with age, while comparable for gender. This study represents a clinical characterization on the largest group of SFTS patients up to now. A higher than expected CFR was obtained. A wider spectrum of clinical index was suggested to be used to identify SFTSV infection, while the useful predictor for fatal outcome was found to be restricted.

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Epidemiological characteristics of severe fever with thrombocytopenia syndrome in Hefei of Anhui Province: a population-based surveillance study from 2011 to 2018

European Journal of Clinical Microbiology & Infectious Diseases ◽

10.1007/s10096-020-04098-x ◽

2020 ◽

Author(s):

Enqing You ◽

Ling Wang ◽

Lei Zhang ◽

Jinju Wu ◽

Kefu Zhao ◽

...

Keyword(s):

Population Based ◽

Anhui Province ◽

Surveillance Study ◽

Epidemiological Characteristics ◽

Severe Fever

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Epidemiological and Clinical Characteristics of Confirmed Cases of Severe Fever With Thrombocytopenia Syndrome in Jeju Province, Korea, 2014-2018

Journal of Preventive Medicine and Public Health ◽

10.3961/jpmph.18.289 ◽

2019 ◽

Vol 52 (3) ◽

pp. 195-199 ◽

Cited By ~ 4

Author(s):

Jinhee Kim ◽

Jong-Myon Bae

Keyword(s):

Clinical Characteristics ◽

Severe Fever

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Epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome bunyavirus human-to-human transmission

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0009037 ◽

2021 ◽

Vol 15 (4) ◽

pp. e0009037

Author(s):

Xinyu Fang ◽

Jianli Hu ◽

Zhihang Peng ◽

Qigang Dai ◽

Wendong Liu ◽

...

Keyword(s):

South Korea ◽

Clinical Characteristics ◽

Eastern China ◽

Transmission Risk ◽

Basic Reproductive Number ◽

World Health ◽

Reproductive Number ◽

Health Organization ◽

Associated Risk Factors ◽

Severe Fever

Background Severe fever with thrombocytopenia syndrome (SFTS) was listed as one of the most severe infectious disease by world health organization in 2017. It can mostly be transmitted by tick bite, while human-to-human transmission has occurred on multiple occasions. This study aimed to explore the epidemiological and clinical characteristics and make risk analysis of SFTS human-to-human transmission. Methods Descriptive and spatial methods were employed to illustrate the epidemiological and clinical characteristics of SFTS human-to-human transmission. The risk of SFTS human-to-human transmission was accessed through secondary attack rate (SAR) and basic reproductive number (R0). Logistic regression analysis was used to identify the associated risk factors. Results A total of 27 clusters of SFTS human-to-human transmission were reported in China and South Korea during 1996–2019. It mainly occurred among elder people in May, June and October in central and eastern China. The secondary cases developed milder clinical manifestation and better outcome than the index cases. The incubation period was 10.0 days (IQR:8.0–12.0), SAR was 1.72%-55.00%, and the average R0 to be 0.13 (95%CI:0.11–0.16). Being blood relatives of the index case, direct blood/bloody secretion contact and bloody droplet contact had more risk of infection (OR = 6.35(95%CI:3.26–12.37), 38.01 (95%CI,19.73–73.23), 2.27 (95%CI,1.01–5.19)). Conclusions SFTS human-to-human transmission in China and South Korea during 1996–2019 had obvious spatio-temporal distinction. Ongoing assessment of this transmission risk is crucial for public health authorities though it continues to be low now.

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Urban–Rural Differences in Clinical Characteristics of Prostate Cancer at Initial Diagnosis: A Single-Center Observational Study in Anhui Province, China

Frontiers in Oncology ◽

10.3389/fonc.2021.704645 ◽

2021 ◽

Vol 11 ◽

Author(s):

Qi Long Song ◽

Yinfeng Qian ◽

Xuhong Min ◽

Xiao Wang ◽

Jing Wu ◽

...

Keyword(s):

Prostate Cancer ◽

Logistic Regression ◽

Calibration Curve ◽

Clinical Characteristics ◽

Disease Free Survival ◽

Initial Diagnosis ◽

Anhui Province ◽

High Grade ◽

Place Of Residence ◽

Urban Rural

BackgroundPeople residing in rural areas have higher prostate cancer (PCa) mortality to incidence ratio (M/I) and worse prognosis than those in urban areas of China. Clinical characteristics at initial diagnosis are significantly associated with biochemical recurrence, overall survival, and PCa disease-free survival.ObjectiveThis study aimed at investigating the clinical characteristics at initial diagnosis of urban and rural PCa patients and to establish a logistic regression model for identifying independent predictors for high-grade PCa.Materials and MethodsClinical characteristics for PCa patients were collected from the largest prostate biopsy center in Anhui province, China, from December 2015 to March 2019. First, urban–rural disparities in clinical characteristics were evaluated at initial diagnosis. Second, based on pathological findings, we classified all participants into the benign+ low/intermediate-grade PCa or high-grade PCa groups. Univariate and multivariate logistic regression analyses were performed to identify independent factors for predicting high-grade PCa, while a nomogram for predicting high-grade PCa was generated based on all independent factors. The model was evaluated using area under receiver-operating characteristic (ROC) curve as well as calibration curve analyses and compared to a model without the place of residence factor of individuals.ResultsStatistically significant differences were observed between urban and rural PCa patients with regard to tPSA, PSA density (PSAD), and Gleason score (GS) (p < 0.05). Logistic regression analysis revealed that tPSA [OR = 1.060, 95% confidence interval (CI): 1.024, 1.098], PSAD (OR = 14.678, 95%CI: 4.137, 52.071), place of residence of individuals (OR = 5.900, 95%CI: 1.068, 32.601), and prostate imaging reporting and data system version 2 (PI-RADS v2) (OR = 4.360, 95%CI: 1.953, 9.733) were independent predictive factors for high-grade PCa. The area under the curve (AUC) of the nomogram was greater than that of the model without the place of residence of individuals. The calibration curve of the nomogram indicated that the prediction curve was basically fitted to the standard curve, suggesting that the prediction model had a better calibration ability.ConclusionsCompared to urban PCa patients, rural PCa patients presented elevated tPSA, PSAD levels, and higher pathological grades. The place of residence of the individuals was an independent predictor for high-grade PCa in Anhui Province, China. Therefore, appropriate strategies, such as narrowing urban-rural gaps in access to health care and increasing awareness on the importance of early detection should be implemented to reduce PCa mortality rates.

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Prognostic Factors of Severe Fever with Thrombocytopenia Syndrome in South Korea

Viruses ◽

10.3390/v13010010 ◽

2020 ◽

Vol 13 (1) ◽

pp. 10

Author(s):

Misun Kim ◽

Sang Taek Heo ◽

Hyunjoo Oh ◽

Suhyun Oh ◽

Keun Hwa Lee ◽

...

Keyword(s):

Ambient Temperature ◽

Clinical Characteristics ◽

Climatic Factors ◽

Univariate Analysis ◽

Oral Intake ◽

Positive Group ◽

Reactive Protein ◽

Creatinine Kinase Level ◽

Clinical Scoring ◽

Severe Fever

Severe fever with thrombocytopenia syndrome (SFTS), a tick-borne infectious disease, is difficult to differentiate from other common febrile diseases. Clinically distinctive features and climate variates associated with tick growth can be useful predictors for SFTS. This retrospective study (2013–2019) demonstrated the role of climatic factors as predictors of SFTS and developed a clinical scoring system for SFTS using climate variables and clinical characteristics. The presence of the SFTS virus was confirmed using reverse transcription polymerase chain reaction (RT-PCR) tests. In the univariate analysis, the SFTS-positive group was significantly associated with higher mean ambient temperature and humidity compared with the SFTS-negative group (22.5 °C vs. 18.9 °C; 77.9% vs. 70.7%, all p < 0.001). In the multivariate analysis, poor oral intake (Odds ratio [OR] 5.87, 95% CI: 2.42–8.25), lymphadenopathy (OR 7.20, 95% CI: 6.24–11.76), mean ambient temperature ≥ 20 °C (OR 4.62, 95% CI: 1.46–10.28), absolute neutrophil count ≤ 2000 cells/μL (OR 8.95, 95% CI: 2.30–21.25), C-reactive protein level ≤ 1.2 mg/dL (OR 6.42, 95% CI: 4.02–24.21), and creatinine kinase level ≥ 200 IU/L (OR 5.94, 95% CI: 1.42–24.92) were significantly associated with the SFTS-positive group. This study presents the risk factors, including ambient temperature and clinical characteristics, that physicians should consider when suspecting SFTS.

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