scholarly journals CONCEPTUAL REVIEW ON THE POTENTIAL OF PUNARNAVADYA GHRITA IN TACKLING THE SYMPTOMS OF COVID-19

2021 ◽  
Vol 12 (3) ◽  
pp. 157-163
Author(s):  
G Siva Ram
Keyword(s):  
Cannabis Sativa ◽  
Virus Disease ◽  
World Health Organisation ◽  
World Health ◽  
Corona Virus ◽  
Global Pandemic ◽  
Phytochemical Compounds ◽  
Effective Remedy

COVID-19 disease has created panic among all with respect to health and economy. On 11th March 2020 WHO (world health organisation) declared novel corona virus outbreak as global pandemic. Confirmed effective remedy to prevent or treat COVID-19 is not yet established. Ayurveda, the Indian system of medicine is the oldest medicinal literature known to mankind as old as 3000 BC and is recognised as medical system by WHO. There is a need to investigate time tested potent classical Ayurvedic formulations backed by contemporary scientific studies in treating symptoms of COVID-19 disease. Vijaya (Cannabis sativa Linn.) in Ayurveda notable for its Vyavayi (quick absorption) and Yogavahi (synergetic action) properties said to be originated from ambrosia as per Vedic mythology. Recent scientific research on the phytochemicals of Cannabis plant showed promising results in decreasing the pro-inflammatory cytokine storm and to an extent halting the replication of SARS-CoV-2. We have put forward one such classical Cannabis Ayurvedic formulation Punarnavadya Ghrita available in market which can be useful as an alternative remedy for prophylactic and curative to the symptoms of novel corona virus disease whose individual herbal phytochemical compounds are studied through in silico, in vitro and in vivo methods in treating COVID-19 with positive outcomes.

scholarly journals Upaya Pemenuhan Vaksin Covid-19 Untuk Memutus Rantai Penyebaran Covid-19

2021 ◽  
Author(s):  
Sulton Ali Ma'ruf
Keyword(s):  
Virus Disease ◽  
World Health Organisation ◽  
World Health ◽  
Corona Virus

Tahun 2019 akhir, dunia digemparkan dengan kemunculan virus Corona Virus Disease 2019. Virus ini berasal dari kota Wuhan Provinsi Hubei, China. Perkembangan virus ini tergolong sangat cepat, oleh karena itu World Health Organisation (WHO) menyatakan Covid-19 sebagai pandemi global pada tanggal 11 Maret 2020. Penyebaran virus ini melalui udara atau droplet yang dihasilkan saat batuk ataupun saat bersin. Untuk mempercepat penanggulangan pandemi Covid-19, strategi yang dilakukan adalah pemberian vaksin untuk memberikan imun kepada setiap warga Negara. Pemberian vaksin ini adalah upaya Negara dalam melindungi hak atas kesehatan bagi setiap warga Negara di masa pandemic. Namun masih banyak masyarakat diindonesia yang menolak untuk diberikan vaksinasi Covid-19 karena beredarnya berita HOAX tentang vaksinasi Covid-19 yang menyebabkan masyarakat takut dan ragu untuk dilakukan vaksinasi karena masyarakat beranggapan bahwa vaksinasi Covid-19 itu berbahaya dan dapat menimbulkan kematian. Namun masyarakat Indonesia harus sadar bahwa vaksin Covid-19 sangat penting.

scholarly journals Socio-Economic Implications of Novel Corona Virus Pandemic (COVID-19): The Indian Scenario

2020 ◽  
Vol 2 (12, 20) ◽  
Author(s):  
Pankaj Thakur ◽  
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Economic Implications ◽  
Transportation Services ◽  
Medical Supplies ◽  
Corona Virus ◽  
Global Pandemic ◽  
The People ◽  
Novel Virus ◽  
Indian Scenario

The global pandemic Covid-19 and its ill effects has created a fear all over the world. This novel virus has affected 216 countries across the globe. The number of confirmed cases and death are on the hype as per the daily reports by world health organisation and it has sparked an economic crisis. Due to self-isolation, social-distancing, restrictions on transportation services have put every sector of economy on downturn. The people in unorganised sectors are losing their jobs. The demand for manufactured goods and other commodities has been decreased. The demand for medical supplies and essential food items are on an increase. In this article, the socio-economic implications of Covid-19 on India has been summarized. Key Words: Corona Virus (Covid-19), Pandemic, Socio- Economic Implications & Indian Scenario

scholarly journals Remdesivir and Lopinavir/Ritonavir as Potential Drugs to Treat Corona Virus Disease 2019

2021 ◽  
Author(s):  
Reda Bzikha ◽  
Bouhmou Ayoub ◽  
Bzikha ilham ◽  
Sanaa Bouchnafati
Keyword(s):  
Virus Disease ◽  
Antiviral Drug ◽  
In Vitro Testing ◽  
Human Coronavirus ◽  
Corona Virus

Drugs that are efficacious against SARS-CoV-2 have yet to be established. Remdesivir and Lopinavir/ritonavir have garnered considerable attention for their potential to treat coronavirus disease 2019 (COVID-19). Remdesivir not only in vivo but also in vitro testing shows the inhibition of human coronavirus replication, including SARS-CoV aswell as Lopinavir/ritonavir that shows promising antiviral drug against SARS-CoV-2.

scholarly journals Upaya Pemenuhan Vaksin Covid-19 Untuk Memutus Rantai Penyebaran Covid-19

2021 ◽  
Author(s):  
Sulton Ali Ma'ruf
Keyword(s):  
Virus Disease ◽  
World Health Organisation ◽  
World Health ◽  
Corona Virus

Tahun 2019 akhir, dunia digemparkan dengan kemunculan virus Corona Virus Disease 2019. Virus ini berasal dari kota Wuhan Provinsi Hubei, China. Perkembangan virus ini tergolong sangat cepat, oleh karena itu World Health Organisation (WHO) menyatakan Covid-19 sebagai pandemi global pada tanggal 11 Maret 2020. Penyebaran virus ini melalui udara atau droplet yang dihasilkan saat batuk ataupun saat bersin. Untuk mempercepat penanggulangan pandemi Covid-19, strategi yang dilakukan adalah pemberian vaksin untuk memberikan imun kepada setiap warga Negara. Pemberian vaksin ini adalah upaya Negara dalam melindungi hak atas kesehatan bagi setiap warga Negara di masa pandemic. Namun masih banyak masyarakat diindonesia yang menolak untuk diberikan vaksinasi Covid-19 karena beredarnya berita HOAX tentang vaksinasi Covid-19 yang menyebabkan masyarakat takut dan ragu untuk dilakukan vaksinasi karena masyarakat beranggapan bahwa vaksinasi Covid-19 itu berbahaya dan dapat menimbulkan kematian. Namun masyarakat Indonesia harus sadar bahwa vaksin Covid-19 sangat penting.

scholarly journals Protease Inhibitors: Strategy to Disrupt COVID 19 Contagion

2020 ◽  
Author(s):  
Dhiman C Paul ◽  
minakshi bhattacharjee ◽  
Manash P Sarma
Keyword(s):  
Drug Targets ◽  
Virus Disease ◽  
In Silico Analysis ◽  
World Health Organisation ◽  
World Health ◽  
Plant Origin ◽  
Furin Cleavage ◽  
Corona Virus ◽  
Furin Cleavage Site ◽  
Therapeutic Measures

Abstract Background: The COVID 2019 (Corona Virus Disease) has been currently going pandemic as per WHO (World Health Organisation) situation reports. The major differentiating point in this virus is the presence of a unique furin cleavage site. Our insilico study points out to the effectiveness of a potent plant origin furin inhibitor. We exploited the aspect of the cleavage machinery of furin which is critical and indispensible for the entry of SARS-CoV-2 (Severe Acute Respiratory Syndrome –Corona Virus 2) in human cells and subsequent massive contagion. Most of the drugs are presently targeting ACEII (Angiotensin Converting Enzyme 2) receptor. But these options have injurious effects in diabetics and cardiac patients. Repurposing of old drugs are the current undergoing therapeutic measures as per the EUA (Emergency Usage Administration) of Food and Drug Administration. These aspects could be avoided if we develop a better and safer strategized drug . Methods In silico analysis of plant based protein analogs to inhibit furin protein. Results Significant interactions of proposed analogs of protease inhibitor of plant origin against furin protein. Furin inhibitors would be incredible drug targets against cancers, MERS CoV (Middle East Respiratory Syndrome) and most urgently SARS- CoV-2. Conclusion We report the first of its kind of furin inhibitor and believe that this major finding would fast track arenas for drug trials.

Review on Adverse effects or side effects of Remdisivir

2021 ◽  
pp. 162-166
Author(s):  
Ganesh G. Dhakad ◽  
Rohit V. Patil ◽  
Tejas I. Chaudhari ◽  
Paresh A. Patil.
Keyword(s):  
Side Effects ◽  
Ebola Virus ◽  
Clinical Symptoms ◽  
Virus Disease ◽  
Clinical Status ◽  
World Health ◽  
In Vivo Studies ◽  
Rater Agreement

In March 2020, the World Health Organization declared the spread of SARS-CoV-2 a global pandemic. To date, coronavirus disease-2019 (COVID-19) has spread to over 200 countries, leading to over 1.6 million cases and over 99,000 deaths. Given that there is neither a vaccine nor proven treatment for COVID-19, there is currently an urgent need for effective pharmacotherapy. To address the need for an effective treatment of SARS-CoV-2 during the worldwide pandemic, this systematic review of intravenous (IV) remdesivir was performed. Remdesivir, an anti-viral prodrug originally developed to treat Ebola virus disease, has shown broad spectrum activity against the Coronavirus family. A recent case report reported improvement of clinical symptoms with remdesivir in a patient with COVID-19. After conducting a systematic search of 18 clinical trial registries and three large scientific databases, we identified 86 potentially eligible items. Following removal of duplicates (n = 21), eligible studies were reviewed independently by two authors. After the first round of screening, inter-rater agreement was 98.5% (κ = 0.925). After the second round of full-text screening, inter-rater agreement was 100%. A total of seven ongoing and recruiting clinical trials of remdesivir (100–200 milligrams, intravenous [IV]) were included. We identified the following primary outcomes: patients discharged (n = 2); time to clinical status improvement (n = 2); improved O2 saturation (n = 2); body temperature normalization (n = 2); and clinical status (n = 1). Secondary outcomes in all identified studies included documentation of adverse events. Phase 3 trials are expected to be completed between April 2020–2023. Therefore, despite supportive data from in vitro and in vivo studies, the clinical effectiveness of IV remdesivir for treatment of COVID-19 and potential side effects remain incompletely defined in the human population. But the remdesivir is also harmful for the people because of it can have some side effects such as mentioned in the following information. There are so many type of disease started form the treatment of COVID-19 with the Remdesivir that also mentioned in the following review paper.

scholarly journals A human monoclonal antibody potently pan-neutralizes SARS-CoV-2 VOCs by targeting RBD invariant sites

2021 ◽  
Author(s):  
Xiaofei Wang ◽  
Ao Hu ◽  
Xiangyu Chen ◽  
Yixin Zhang ◽  
Fei Yu ◽  
...  
Keyword(s):  
Rational Design ◽  
Virus Disease ◽  
Human Monoclonal Antibody ◽  
Receptor Binding Domain ◽  
Wild Type ◽  
Cryo Electron Microscopy ◽  
Global Pandemic ◽  
Binding Epitope

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel corona virus disease (COVID-19). The neutralizing monoclonal antibodies (mAbs) targeting the receptor binding domain (RBD) of SARS-CoV-2 are among the most promising strategies to prevent and treat COVID-19. However, SARS-CoV-2 variants of concern (VOCs) profoundly reduced the efficacies of most of mAbs and vaccines approved for clinical use. Herein, we demonstrated mAb 35B5 efficiently neutralizes both wild-type (WT) SARS-CoV-2 and VOCs, including B.1.617.2 (delta) variant, in vitro and in vivo. Cryo-electron microscopy (cryo-EM) revealed that 35B5 neutralizes SARS-CoV-2 by targeting a unique epitope that avoids the prevailing mutation sites on RBD identified in circulating VOCs, providing the molecular basis for its pan-neutralizing efficacy. The 35B5-binding epitope could also be exploited for the rational design of a universal SARS-CoV-2 vaccine.

scholarly journals COVID-19: An Epidemiological Puzzle

2020 ◽  
Author(s):  
Subrata Baidya ◽  
Debosmita Paul ◽  
Purvita Chowdhury
Keyword(s):  
Short Communication ◽  
Virus Disease ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Unknown Aetiology ◽  
Corona Virus ◽  
Agent Interaction ◽  
Epidemiological Characteristics ◽  
Associated Variables

A cluster of pneumonia cases of unknown aetiology was reported from Wuhan, Hubei province of China on 31st December, 2019. The World Health Organisation (WHO) declared the outbreak a Public Health Emergency of International Concern (PHEIC) on 30th January, 2020. Thereafter, it has spread through China and reached the level of a pandemic expanding to 210 countries with 77.9M confirmed cases and 1.71M deaths as per Corona virus Disease (COVID-19) situation report issued by WHO based on data received upto 23rdDecember, 2020. A number of questions remain unanswered regarding pathogen-associated variables for amplification dynamics, host environment and agent interaction. This short communication makes an effort to compile the information gathered from published articles of renowned journals and newsletters to explore the epidemiological characteristics of COVID-19. Hereby in this article, authors have tried to assemble the epidemiological lacunae created by the novel characteristics of the SARS-CoV-2 (Severe Acute Respiratory Syndrome-Corona Virus-2) which presently pose a rather puzzling transmission dynamics of COVID-19 that still remain unanswered.

scholarly journals An assessment of the efficacies and therapeutic interventions of homoeopathic medicines in combating viral disorders with implications in the treatment of SARS-CoV-2 (Covid-19), a global pandemic

2020 ◽  
Author(s):  
Joy Kumar Dey ◽  
Anupam Mukherjee ◽  
Sanjay Kumar Dey ◽  
Mukut Pratap Udayat ◽  
Abhishek Pramanik ◽  
...  
Keyword(s):  
Middle Eastern ◽  
Biologically Active ◽  
Therapeutic Interventions ◽  
In Vivo Studies ◽  
The Public ◽  
Corona Virus ◽  
Global Pandemic ◽  
Global Epidemiology

The prevalence of Severe Acute Respiratory Syndrome- Corona Virus-2 (SARS-CoV-2) has undergone a historic transition from December 2019 to April 2020. Under the current circumstances, SARS-CoV-2 has become a key problem for the public health and economic steadiness of the global fraternity. Based on ample of evidence from the global epidemiology of SARS-CoV-2 and MERS-CoV (Middle Eastern Respiratory Syndrome- Corona virus) scientists and physicians strappingly consider these viruses share structural and functional similarities of selected biologically active enzymes namely, 3CLpro, PLpro and RdRp. Ultra-diluted homoeopathic medicine has the legacy to combat infectious as well as viral diseases since last two centuries. Thus, existing antiviral homoeopathic therapies were meta-analysed in the current study and the need of appropriate clinical validation with proper in vitro as well as in vivo studies prior to make clinical endorsements in treating Covid-19 patients with homoeopathic medicines has been explained.

scholarly journals Combat to Corona Virus Disease 2019 COVID-19 Pandemic

2021 ◽  
pp. 406-409
Author(s):  
Arvind Sakwar
Keyword(s):  
Preventive Measures ◽  
Virus Disease ◽  
World Health Organisation ◽  
Mutant Virus ◽  
World Health ◽  
Who Guidelines ◽  
Corona Virus

This paper describes the information of Covid-19 its emergence and declaration of Pandemic by WHO (World Health Organisation). The symptoms and the precautions are also being discussed here. Covid-19 is highly mutant virus that transmits so rapidly and no particular treatment is there to stop it except preventive measures. The initiatives taken by Govt of India are being briefly explained along with WHO guidelines to stopping the expansion of Covid-19.

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