scholarly journals COVID-19: An Epidemiological Puzzle

2020 ◽  
Author(s):  
Subrata Baidya ◽  
Debosmita Paul ◽  
Purvita Chowdhury
Keyword(s):  
Short Communication ◽  
Virus Disease ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Unknown Aetiology ◽  
Corona Virus ◽  
Agent Interaction ◽  
Epidemiological Characteristics ◽  
Associated Variables

A cluster of pneumonia cases of unknown aetiology was reported from Wuhan, Hubei province of China on 31st December, 2019. The World Health Organisation (WHO) declared the outbreak a Public Health Emergency of International Concern (PHEIC) on 30th January, 2020. Thereafter, it has spread through China and reached the level of a pandemic expanding to 210 countries with 77.9M confirmed cases and 1.71M deaths as per Corona virus Disease (COVID-19) situation report issued by WHO based on data received upto 23rdDecember, 2020. A number of questions remain unanswered regarding pathogen-associated variables for amplification dynamics, host environment and agent interaction. This short communication makes an effort to compile the information gathered from published articles of renowned journals and newsletters to explore the epidemiological characteristics of COVID-19. Hereby in this article, authors have tried to assemble the epidemiological lacunae created by the novel characteristics of the SARS-CoV-2 (Severe Acute Respiratory Syndrome-Corona Virus-2) which presently pose a rather puzzling transmission dynamics of COVID-19 that still remain unanswered.

scholarly journals Upaya Pemenuhan Vaksin Covid-19 Untuk Memutus Rantai Penyebaran Covid-19

2021 ◽  
Author(s):  
Sulton Ali Ma'ruf
Keyword(s):  
Virus Disease ◽  
World Health Organisation ◽  
World Health ◽  
Corona Virus

Tahun 2019 akhir, dunia digemparkan dengan kemunculan virus Corona Virus Disease 2019. Virus ini berasal dari kota Wuhan Provinsi Hubei, China. Perkembangan virus ini tergolong sangat cepat, oleh karena itu World Health Organisation (WHO) menyatakan Covid-19 sebagai pandemi global pada tanggal 11 Maret 2020. Penyebaran virus ini melalui udara atau droplet yang dihasilkan saat batuk ataupun saat bersin. Untuk mempercepat penanggulangan pandemi Covid-19, strategi yang dilakukan adalah pemberian vaksin untuk memberikan imun kepada setiap warga Negara. Pemberian vaksin ini adalah upaya Negara dalam melindungi hak atas kesehatan bagi setiap warga Negara di masa pandemic. Namun masih banyak masyarakat diindonesia yang menolak untuk diberikan vaksinasi Covid-19 karena beredarnya berita HOAX tentang vaksinasi Covid-19 yang menyebabkan masyarakat takut dan ragu untuk dilakukan vaksinasi karena masyarakat beranggapan bahwa vaksinasi Covid-19 itu berbahaya dan dapat menimbulkan kematian. Namun masyarakat Indonesia harus sadar bahwa vaksin Covid-19 sangat penting.

scholarly journals A Review on Automatic Covid-19 Lung Infection Detection from Different Imaging Techniques

2021 ◽  
Vol 9 (VII) ◽  
pp. 3850-3856
Author(s):  
Sangeeta Singh
Keyword(s):  
World Health Organization ◽  
Virus Disease ◽  
Imaging Techniques ◽  
World Health ◽  
The Novel ◽  
Corona Virus ◽  
The World ◽  
Health Organization ◽  
High Level ◽  
Precision Rate

Corona Virus Disease-2019 commonly known as COVID-19 which has been defined by the Novel Corona Virus. It is a family of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and was first detected during respiratory outbreak. It was first reported to the World Health Organization on December 31, 2019. On January 30, 2020, the World Health Organization declared the COVID-19 eruption a global health emergency. As of 27-May-2021 169,095,283 confirmed cases have been reported in the world and 2, 73, 67, 935 cases in India. It is required to identify the infection with high precision rate but there are lots of deficiency in the diagnosing system that may resulted false alarm rate. Initially it could be detected through throat saliva but now it can also be identified thought the impairment in lungs from computerized tomographical imaging technique. This paper reviewed various researches over COVID-19 diagnosis approach as well as the syndrome in respiratory organs. There are so many imaging techniques through which lungs impairments can be detected that may diagnose COVID-19 with high level of accuracy. CT scan image is the best alternative for diagnosing COVID-19.

scholarly journals Upaya Pemenuhan Vaksin Covid-19 Untuk Memutus Rantai Penyebaran Covid-19

2021 ◽  
Author(s):  
Sulton Ali Ma'ruf
Keyword(s):  
Virus Disease ◽  
World Health Organisation ◽  
World Health ◽  
Corona Virus

Tahun 2019 akhir, dunia digemparkan dengan kemunculan virus Corona Virus Disease 2019. Virus ini berasal dari kota Wuhan Provinsi Hubei, China. Perkembangan virus ini tergolong sangat cepat, oleh karena itu World Health Organisation (WHO) menyatakan Covid-19 sebagai pandemi global pada tanggal 11 Maret 2020. Penyebaran virus ini melalui udara atau droplet yang dihasilkan saat batuk ataupun saat bersin. Untuk mempercepat penanggulangan pandemi Covid-19, strategi yang dilakukan adalah pemberian vaksin untuk memberikan imun kepada setiap warga Negara. Pemberian vaksin ini adalah upaya Negara dalam melindungi hak atas kesehatan bagi setiap warga Negara di masa pandemic. Namun masih banyak masyarakat diindonesia yang menolak untuk diberikan vaksinasi Covid-19 karena beredarnya berita HOAX tentang vaksinasi Covid-19 yang menyebabkan masyarakat takut dan ragu untuk dilakukan vaksinasi karena masyarakat beranggapan bahwa vaksinasi Covid-19 itu berbahaya dan dapat menimbulkan kematian. Namun masyarakat Indonesia harus sadar bahwa vaksin Covid-19 sangat penting.

scholarly journals Protease Inhibitors: Strategy to Disrupt COVID 19 Contagion

2020 ◽  
Author(s):  
Dhiman C Paul ◽  
minakshi bhattacharjee ◽  
Manash P Sarma
Keyword(s):  
Drug Targets ◽  
Virus Disease ◽  
In Silico Analysis ◽  
World Health Organisation ◽  
World Health ◽  
Plant Origin ◽  
Furin Cleavage ◽  
Corona Virus ◽  
Furin Cleavage Site ◽  
Therapeutic Measures

Abstract Background: The COVID 2019 (Corona Virus Disease) has been currently going pandemic as per WHO (World Health Organisation) situation reports. The major differentiating point in this virus is the presence of a unique furin cleavage site. Our insilico study points out to the effectiveness of a potent plant origin furin inhibitor. We exploited the aspect of the cleavage machinery of furin which is critical and indispensible for the entry of SARS-CoV-2 (Severe Acute Respiratory Syndrome –Corona Virus 2) in human cells and subsequent massive contagion. Most of the drugs are presently targeting ACEII (Angiotensin Converting Enzyme 2) receptor. But these options have injurious effects in diabetics and cardiac patients. Repurposing of old drugs are the current undergoing therapeutic measures as per the EUA (Emergency Usage Administration) of Food and Drug Administration. These aspects could be avoided if we develop a better and safer strategized drug . Methods In silico analysis of plant based protein analogs to inhibit furin protein. Results Significant interactions of proposed analogs of protease inhibitor of plant origin against furin protein. Furin inhibitors would be incredible drug targets against cancers, MERS CoV (Middle East Respiratory Syndrome) and most urgently SARS- CoV-2. Conclusion We report the first of its kind of furin inhibitor and believe that this major finding would fast track arenas for drug trials.

scholarly journals How prepared were we? A study to assess the knowledge, attitude and practice of dental surgeons regarding the Covid 19 pandemic in district Dehradun

2021 ◽  
Vol 7 (2) ◽  
pp. 123-130
Author(s):  
Yogeshwari ◽  
Anubha Agarwal ◽  
Himanshu Aeran
Keyword(s):  
Virus Disease ◽  
Good Practice ◽  
World Health ◽  
Good Knowledge ◽  
Family Welfare ◽  
The Novel ◽  
Global Public Health ◽  
Online Questionnaire ◽  
Corona Virus ◽  
Knowledge And Practice

The novel corona virus disease 2019 has been declared a global public health emergency & is affecting people across the globe. Dental Surgeons are at an invariably high risk of contracting COVID 19. Since all dentists are slowly resuming their full practice they shall be fully prepared. Aim of the study is to assess the knowledge, attitude & practise of Dental Surgeons regarding the novel Corona Virus Disease 2019 in District, Dehradun. An online Questionnaire was circulated among dental surgeons in District, Dehradun. The Questionnaire consisted of 5 sections: 1. Consent, 2. Epidemiological Data, 3. Knowledge Based Questions (11 Questions), 4. Attitude Based Questions (8 Questions), 5. Practice Based Questions (11 Questions). 107 responses were collected in total. Most dental surgeons had a degree of MDS (Masters of Dental Science): 60.7%. Good knowledge and practice scores were observed among 92.7% and 79.5% of the dental surgeons. Significant association of good knowledge scores with qualifications (p = 0.04) and years of practice (p = 0.02) was found; while good practice scores were associated with qualifications only (p = 0.03). Dental surgeons in district Dehradun were found to have good knowledge and practice scores, which is important to skirmish COVID-19. They are hence advised to follow the Center of Disease Control and Prevention (CDC) World Health Organization (WHO), Ministry of Health & Family Welfare (MoHFW) guidelines in their clinics and should sensitize their staff as well. So that they themselves, their staff and patients all remain safe.

The novel coronavirus and its possible treatment by vaccines, therapeutics and drug delivery systems: Current status and future perspectives

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 54-61 ◽  
Author(s):  
Madhurya Kadavakollu ◽  
Veera Venkata Satyanarayana Reddy Karri ◽  
Kuppusamy Gowthamarajan ◽  
Arun Radhakrishnan ◽  
Dhanabal Palanisamy ◽  
...  
Keyword(s):  
Virus Disease ◽  
World Health ◽  
Current Status ◽  
The Novel ◽  
Future Perspectives ◽  
Epidemic Disease ◽  
Wuhan City ◽  
Corona Virus ◽  
Novel Coronavirus ◽  
Health Organization

In the mid-end of December 2019, several cases of pneumonia outbreak of unknown cause and etiology were identified in Wuhan City of Hubei province in China, a city with a population of over 11 million.Till date(April 2020) around 1,051,635 confirmed cases of coronavirus disease 2019(COVID-19) and 56,985 confirmed deaths have been reported according to COVID-19 Situation Report – 75 by WHO. On 7th January 2020, the causative agent was identified and named consequently as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by the Chinese Centre for Disease Control and Prevention (CCDC) from throat swab samples. Later, on 12th January 2020, this coronavirus was named as 2019-novel coronavirus (2019-nCoV) by World Health Organization (WHO) and in 11th February 2020,it has been declared the epidemic disease caused by SARS-CoV-2 as Corona Virus Disease 2019(COVID-19) as it is spreading rapidly from its origin in Wuhan City to the rest of the world. In this context, the current review provides a landscape of the novel Corona Virus including its origin, transmission, epidemiology, drugs and vaccines in clinical trials for better understanding to the reads and peoples the status and future perspectives of this pandemic disease

Novel corona virus-2019 (SARS CoV-2)

2020 ◽  
Vol 10 (1) ◽  
pp. 1-13
Author(s):  
Dwarakesh B ◽  
Ananda Deepak V ◽  
Asifa Nikhat M ◽  
Bhaskar Reddy K ◽  
Brito Raj S
Keyword(s):  
Virus Disease ◽  
Large Family ◽  
World Health ◽  
The Novel ◽  
Health Crisis ◽  
Medical Practitioners ◽  
Corona Virus ◽  
The People ◽  
Serious Infection ◽  
Health Organization

Among disparate infectious diseases viral infection in particular challenges survival of mankind across the globe. By superseding those events, 2019 novel (CoVID-19) or SARS-CoV-2 has become a new human health crisis threatening the world. Corona viruses (CoV) are large family of viruses that affects birds and mammals. In humans, Corona virus can cause respiratory tract infection ranging from the common cold to more serious infection such as SARS (Severe acute respiratory syndrome), MERS (Middle East Respiratory Syndrome) and CoVID-19 (Corona Virus Disease 2019) which can also become lethal. The Novel corona virus (CoVID-19) originated in 2019, is a novel virus which has not been identified in humans since past. At present, the source of CoVID-19 is not known. Although the infection is presumed to be in origin, person to person transmission is evident. Many supportive and symptomatic therapies where being carried out by the Medical practitioners as per the instructions of World Health Organization (WHO) with a hypothesis and there is no evidence that it works against CoVID-19. best to lower the current crises of infection is prevention and many measures that boosts the immunity are following by the people as directed by the Ministry of AYUSH.

scholarly journals Time to negative PCR in various disease categories of COVID-19 infection in Pakistani population

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Kaleem Ullah Toori ◽  
Asma Chaudhry ◽  
Muhammad Arsalan Qureshi
Keyword(s):  
Disease Severity ◽  
Virus Disease ◽  
World Health ◽  
P Value ◽  
Common Symptom ◽  
Cross Sectional ◽  
Pakistani Population ◽  
Corona Virus ◽  
Co Morbidity ◽  
Epidemiological Characteristics

Objectives: To identify association of epidemiological characteristics, presence of underlying pre-morbidities and disease severity with time to first negative PCR in Corona virus disease 2019. Methods: Total 842 Corona Virus Real Time Polymerase-Chain-Reaction positive patients were included in this cross-sectional study. Patients were admitted to Department of Medicine at KRL Hospital Islamabad from April to August 2020. Age, gender, symptoms, pre-morbidities and disease severity were recorded. Outcome (recovered versus died) was documented. World Health Organization categories to classify disease severity (asymptomatic, mild, moderate and severe) were used. Time to negative PCR was documented as time between first positive PCR to first negative PCR. Results: The mean age of patients was 39.04 ± 11.32 years with 99.8% being males. Majority of patients (78.4%) were asymptomatic. Amongst symptoms, fever was the most common symptom. Diabetes mellitus and hypertension were the most commonly recorded co-morbidity. Mean time to negative PCR was 8.8 ± 3.1 days. A large proportion of patients recovered (99.9%). Significant positive correlation (p value < 0.05) was found between age, gender, presence of underlying pre-morbidities and disease severity categories with time to first negative PCR. Conclusion: The underlying epidemiological factors, pre-morbidities and disease severity are associated with time to negative PCR and hence affect frequency of recovery samples. doi: https://doi.org/10.12669/pjms.38.1.4476 How to cite this:Toori KU, Chaudhry A, Qureshi MA. Time to negative PCR in various disease categories of COVID-19 infection in Pakistani population. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4476 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Combat to Corona Virus Disease 2019 COVID-19 Pandemic

2021 ◽  
pp. 406-409
Author(s):  
Arvind Sakwar
Keyword(s):  
Preventive Measures ◽  
Virus Disease ◽  
World Health Organisation ◽  
Mutant Virus ◽  
World Health ◽  
Who Guidelines ◽  
Corona Virus

This paper describes the information of Covid-19 its emergence and declaration of Pandemic by WHO (World Health Organisation). The symptoms and the precautions are also being discussed here. Covid-19 is highly mutant virus that transmits so rapidly and no particular treatment is there to stop it except preventive measures. The initiatives taken by Govt of India are being briefly explained along with WHO guidelines to stopping the expansion of Covid-19.

Tackling COVID-19 Using Blockchain Technology

2021 ◽  
pp. 75-93
Author(s):  
Padmavathi U. ◽  
Narendran Rajagopalan
Keyword(s):  
Virus Disease ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Health Crisis ◽  
Record Keeping ◽  
The Public ◽  
Blockchain Technology ◽  
Novel Virus ◽  
Novel Coronavirus

In December 2019, the outbreak of novel coronavirus disease was first reported in Wuhan City, the capital of Hubei Province, China, and the virus started to exacerbate throughout the world. This new world health crisis threatens the public with its ongoing pandemic across the globe. This chapter first discusses the novel coronavirus disease (COVID-19) pandemic, symptoms and its preventive measures. A timeline of this virus disease by World Health Organisation (WHO) is depicted in this chapter. The authors enlighten the global impact of coronavirus on healthcare systems and the need for technology-empowered solutions to control the spread of this novel virus. In particular, this chapter focuses on the pioneering blockchain technology that has the potential to mitigate and fight against this pandemic outbreak. In addition, this chapter manifests how this distributed record keeping technology and its enriched features could help the healthcare professionals to combat the crisis.

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