Efficacy of Budesonide, Epinephrine and Salbutamol Inhalation for Treatment of Transient Tachypnea of Newborn: Prospective Controlled Study

Background: Transient tachypnea of the newborn (TTN) is a neonatal lung disease which has a picture of lung edema due to delayed resorption of lung fluids. It is commonly seen in full-term or late-preterm infants with an occurrence rate of 5.7 in 1,000 infants. The aim of this work was to compare the efficacy of inhaled budesonide, epinephrine and salbutamol for treatment of TTN. Methods: This prospective controlled study was conducted on a100 full term neonates with presumed diagnosis of TTN. They were randomly assigned into four groups equally. Group I received nebulized budesonide, Group I received nebulized epinephrine, Group III received nebulized salbutamol and Group IV received nebulized normal saline. Results: Salbutamol significantly decreased respiratory rate and TTN clinical score, duration of respiratory support along with hospitalization time and helped with reaching full feeding earlier compared to other groups. Conclusions: Inhaled salbutamol significantly decreased TTN clinical score, shorter duration of respiratory support, hospitalization and earlier initiation of enteral feeding compared to placebo. Inhaled budesonide and epinephrine did not significantly reduce the duration of oxygen treatment, with no other significant effect on TTN.

Download Full-text

The effect of Head Covering on Phototherapy-Induced Hypocalcemia in Jaundiced Full-Term Neonates

QJM ◽

10.1093/qjmed/hcab113.009 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Amira Said Mohamed ◽

Sherein M Abd El fattah ◽

Safaa S Imam ◽

Basma M Shehata

Keyword(s):

Full Term ◽

Controlled Study ◽

Led Phototherapy ◽

Group I ◽

Group A ◽

Rate Of Decline ◽

Group B ◽

Head Cover ◽

Group D ◽

Head Covering

Abstract Background Phototherapy is the main method used in treatment of significant indirect hyperbilirubinemia and it reduces the risk of exchange transfusion. Hypocalcemia is one of the side effects of phototherapy due to inhibition of pineal gland via transcranial illumination, resulting in decline of melatonin secretion that further inhibits the effect of cortisol on bone calcium and ultimately increase the bone uptake. Aim To assess the effect of head covering to ameliorate hypocalcemic effect of different types of phototherapy in full term jaundiced neonates. Patients and Methods A prospective randomized controlled study that included 120 jaundiced neonates requiring phototherapy which divided into two main groups; group I (treated with lamp phototherapy) which was equally subdivided into two groups, group A (without head cover) and group B (with head cover) and group Il (treated with LED phototherapy) which was equally subdivided into group C (without head cover) and group D (with head cover). Results Head cover reduced the incidence of phototherapy induced hypocalcemia without affecting rate of decline of bilirubin on both types of phototherapy used. In lamp hypocalcemia (<8mg/dl) was detected in 33.3% in jaundiced neonates without head cover which was significant higher than those with head cover 6.7%. As for LED, yet not statistically significant hypocalcemia was detected in 13.3% in jaundiced neonates without head cover, which was higher than those with head cover 3.3%. Conclusion Incidence of phototherapy induced hypocalcemia is reduced by using head cover especially while using lamp phototherapy.

Download Full-text

Polydrug- and Methadone-Addicted Newborns: A Continuum of Impairment?

PEDIATRICS ◽

10.1542/peds.70.2.210 ◽

1982 ◽

Vol 70 (2) ◽

pp. 210-213 ◽

Cited By ~ 5

Author(s):

Ira J. Chasnoff ◽

Roger Hatcher ◽

William J. Burns

Keyword(s):

Methadone Maintenance ◽

Behavioral Assessment ◽

Controlled Study ◽

Control Group ◽

Group Iii ◽

Group I ◽

Outcome Group ◽

Group Ii ◽

Prospective Controlled Study ◽

Control Group Group

Two groups of infants born to drug-addicted mothers were evaluated in a prospective controlled study and compared with a third control group. Group I infants (N = 39) were born to mothers on well-controlled low-dose methadone maintenance. Group II infants (N = 19) were born to polydrug-abusing mothers, and group III infants (N = 27) were born to control mothers who had no history or evidence of drug abuse. All three groups were matched for maternal factors that might affect neonatal outcome. Group I infants were significantly smaller than control infants for all growth measurements and had a significantly smaller head circumference than group II infants. Utilizing the Brazelton Neonatal Behavioral Assessment Scale, group I infants showed more depression of interactive behaviors and state controls than group II infants, who in turn were more depressed than group III infants. The effects of nonnarcotic drugs on intrauterine growth and neonatal behavior appear to place the polydrug-addicted newborn in an intermediate zone of deficit between normal and opiate-addicted newborns.

Download Full-text