scholarly journals Protective Effect of Ipomoea biloba on Myocardial Antioxidant Status in Isoproterenol Induced Myocardial Infarction Male Albino Rats

2021 ◽  
pp. 36-45
Author(s):  
R. Vallipriya ◽  
M. Shabana Begum
Keyword(s):  
Myocardial Infarction ◽  
Vitamin C ◽  
Protective Effect ◽  
Leaf Extract ◽  
Oral Treatment ◽  
Albino Rats ◽  
Heart Homogenate ◽  
Significant Difference ◽  
Myocardial Infraction ◽  
Ethanolic Leaf Extract

The protective effect of ethanolic leaf extract of Ipomoea biloba in isoproterenol (ISO)-induced cardiotoxicity and the antioxidant activity involved in this protection were investigated in rats. Myocardial infraction was produced in rats with 20 mg/kg b.wt of ISO administered subcutaneously twice at an interval of 24 h. Effect of EEIB oral treatment for 28 days at two doses (100 mg and 200 mg/kg body weight) was evaluated against ISO – induced cardiac necrosis. Level of enzymatic (SOD, CAT, GPx and GST), non-enzymatic (GSH, Vitamin C and E) and of membrane bound ATPases (Na+K+ATPase, Mg2+ATPase and Ca2+ATPase) were assayed in heart homogenate. Significant myocardial infarction, depletion of endogenous antioxidants enzymatic and non-enzymatic were observed in ISO-treated animals when compared with the normal animals. Rats induced with ISO, showed a significant (P<0.05), decrease in the activities of GSH, Vitamin C and Eon comparison with normal rats.   EEIB elicited a significant cardioprotective activity by elevated the levels of GSH, SOD, CAT, GPx and GR. A significant decrease in the activity of Na+/K+ ATPase and a corresponding increase in the activities of Ca2+ ATPase and Mg2+ ATPase were observed in isoproterenol induced rats when compared to normal control rats. Pretreatment with EEIB was able to efficiently prevent the increase in activity of Mg2+ ATPase and maintain the activities of Na+ /K+ ATPase and Ca2+ ATPase at near normality. There is no significant difference between the control and plant alone treated rats. The aim of this investigation is to evaluate the antioxidant effects on the main cardioprotective activity of ethanolic leaf extract Ipomoea biloba.

Acute Toxicity Assessment of Ethanolic Leaf Extract of Macrotyloma uniflorum L. on Wistar Albino Rats

2017 ◽  
Vol 24 (1) ◽  
pp. 22 ◽  
Author(s):  
S. Priyanga ◽  
S. Hemmalakshmi ◽  
B. Vidya ◽  
P. Chella Perumal ◽  
V. K. Gopalakrishnan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Leaf Extract ◽  
Toxicity Assessment ◽  
Albino Rats ◽  
Macrotyloma Uniflorum ◽  
Wistar Albino Rats ◽  
Ethanolic Leaf Extract

Evaluation of the toxic effect of silver nanoparticles and the possible protective effect of ascorbic acid on the parotid glands of albino rats: An in vivo study

2020 ◽  
Vol 36 (6) ◽  
pp. 446-453
Author(s):  
Salma Awad Taghyan ◽  
Hend El Messiry ◽  
Medhat Ahmed El Zainy
Keyword(s):  
Silver Nanoparticles ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Protective Effect ◽  
Toxic Effect ◽  
Toxic Effects ◽  
Control Group ◽  
Albino Rats ◽  
Parotid Glands ◽  
Ductal Cells

This study aimed to evaluate the toxic effect of silver nanoparticles (AgNPs) on the parotid glands (PGs) of albino rats histologically and ultrastructurally and assess the possible protective effect of ascorbic acid as an antioxidant. Thirty male albino rats weighing between 150 mg and 200 mg were divided into three groups: the control group (C1) contained 10 rats that received 2 mg/kg (body weight (bw)) of aqueous nitrate buffer by intraperitoneal (IP) injection daily for 28 days; the AgNPs group contained 10 rats that received 2 mg/kg (bw) IP AgNPs daily for 28 days; and the AgNPs-vitamin C group contained 10 albino rats that received 2 mg/kg (bw) AgNPs IP daily for 28 days with oral administration of 100 mg/kg (bw) vitamin C in drinking water daily for 28 days. The PG acinar and ductal cells of the AgNPs group showed signs of toxicity and degeneration characterized as pleomorphic nuclei, binucleation, cytoplasmic vacuolations, and stagnated secretion in the ductal lumen. In addition to degenerated mitochondria, dilated rough endoplasmic reticulum and lysosomes were filled with AgNPs ( p < 0.001). The AgNPs-vitamin C group showed significantly less degenerative changes histologically and ultrastructurally compared to the AgNPs group ( p = 0.002). AgNPs produced significant toxic effects on the PG of albino rats, presumably through the generation of reactive oxygen species and toxic ion release, and administration of vitamin C was shown effective in decreasing these toxic effects.

scholarly journals Phyto-nutrient composition and antioxidative potential of ethanolic leaf extract of Sida acuta in wistar albino rats

2015 ◽  
Vol 14 (49) ◽  
pp. 3264-3269 ◽  
Author(s):  
P. Nwankpa ◽  
O. G. Chukwuemeka ◽  
G. C. Uloneme ◽  
C. C. Etteh ◽  
P. Ugwuezumba ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Nutrient Composition ◽  
Albino Rats ◽  
Sida Acuta ◽  
Wistar Albino Rats ◽  
Ethanolic Leaf Extract

scholarly journals Evaluation of potentials of aqueous ethanolic extract of Psidium guajava on reproductive functions of male Albino rats

2021 ◽  
Vol 19 (3) ◽  
pp. 174-181
Author(s):  
S.A. Abwage ◽  
S.T. Agu ◽  
S.A. Saganuwan ◽  
A.H. Abu
Keyword(s):  
Body Weight ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
Psidium Guajava ◽  
Reproductive Organs ◽  
Sperm Parameters ◽  
Albino Rats ◽  
Reproductive Parameters ◽  
Aqueous Ethanolic Extract ◽  
Ethanolic Leaf Extract

The therapeutic utilization of plants for managing several diseases by people of all continents, especially Africa, is as old as tradition. The objective of this study was to evaluate the potentials of aqueous ethanolic leaf extract of Psidium guajava on male reproductive parameters. Twenty-four male Albino rats were randomly assigned into four groups of six rats per group. Rats in the control group were administered Tween 20®. Rats in groups 2, 3, and 4 were administered Psidium guajava aqueous ethanolic leaf extract orally at the doses of 100, 200, and 400 mg/kg body weight, respectively, once daily for 60 days. The body weights of the rats were determined at the beginning and end of the experiment. Sperm parameters and some reproductive organs weight of each rat was also determined, some organs were collected for histopathology. Assay for follicle-stimulating hormone, luteinizing hormone, and testosterone was done using Enzyme-Linked Immunosorbent methods. Some reproductive organs were collected for histopathological analyses. The results showed a dose-dependent increase (p<0.05) in the weight of male reproductive organs, sperm parameters, and hormones. The extract significantly increased (P < 0.05) serum testosterone in the group treated 400 mg/kg body weight when treated groups were compared with control. Furthermore, the results of FSH and LH revealed a significant (p < 0.05) increase when the treated groups were compared with the control. The histopathological analysis did not reveal any form of damage to the architectural integrity of the testis. However, there was degenerating germinal epithelium in the group administered 400 mg/kg of the aqueous ethanolic leaf extract of P. guajava. Conclusion: aqueous ethanolic extract of P. guajava has positive effects on male reproductive parameters.

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