Diagnostic Utility of Immunohistochemical Expression of HE4 in Epithelial Ovarian Neoplasm: A Cross-sectional Prospective Study

2021 ◽  
pp. 91-99
Author(s):  
Begum Afrin Nahar ◽  
Rama Saha ◽  
Chhanda Das ◽  
Gourishankar Kamilya
Keyword(s):  
Prospective Study ◽  
Ovarian Neoplasm ◽  
Diagnostic Utility ◽  
Immunohistochemical Expression ◽  
Cross Sectional ◽  
Epithelial Ovarian Neoplasm

scholarly journals Diagnostic utility of immunohistochemical expression of HE4 in Epithelial Ovarian Neoplasm

2019 ◽  
Vol 6 (11) ◽  
pp. A567-571
Author(s):  
Begum Afrin Nahar ◽  
◽  
Rama Saha ◽  
Chhanda Das ◽  
Gourishankar Kamilya ◽  
...  
Keyword(s):  
Ovarian Neoplasm ◽  
Diagnostic Utility ◽  
Immunohistochemical Expression ◽  
Epithelial Ovarian Neoplasm

Binge Eating and Problem Gambling are Associated with Common and Distinct Deficits in Emotion Regulation among Community Women: Results from a Prospective Study

2020 ◽  
Author(s):  
Sarah Farstad ◽  
Kristin M. von Ranson
Keyword(s):  
At Risk ◽  
Emotion Regulation ◽  
Binge Eating ◽  
Problem Gambling ◽  
Prospective Study ◽  
Emotion Dysregulation ◽  
Behavioral Addiction ◽  
Negative Urgency ◽  
Cross Sectional ◽  
Severe Problem

To elucidate similarities and differences between binge eating and a behavioral addiction, this prospective study compared facets of emotion regulation that were associated with problem gambling, the only formally recognized behavioral addiction, and binge eating. Community-based women (N = 202) who engaged in at-risk binge eating (n = 79), at-risk gambling (n = 36), or both (n = 87) completed four online assessments over six months. Baseline and six-month surveys assessed self-reported emotion dysregulation (using the DERS and UPPS-P), binge eating (using the EDE-Q), and gambling (using the PGSI); abbreviated two- and four-month surveys assessed only binge eating and gambling. Binge eating and problem gambling were both associated with emotion dysregulation, and greater positive urgency was correlated with more severe problem gambling but less frequent binge eating. Negative urgency explained no unique variance in binge eating or problem gambling changes over time, once other facets of emotion dysregulation (i.e., positive urgency and facets assessed by the DERS) were included. Thus, previous cross-sectional research may have overestimated the association of negative urgency with both binge eating and problem gambling. Overall, these findings suggest that binge eating and problem gambling are associated with common as well as distinct emotion regulation deficits.

scholarly journals Maternal stress and depressive symptoms and adolescents’ body mass index: a prospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Maaike Koning ◽  
Jacqueline Vink ◽  
Tommy L. S. Visscher ◽  
Junilla Larsen
Keyword(s):  
Mental Health ◽  
Depressive Symptoms ◽  
Prospective Study ◽  
Perceived Stress ◽  
Maternal Stress ◽  
Maternal Mental Health ◽  
Cross Sectional ◽  
Domain Specific ◽  
General Stress ◽  
Adolescent Offspring

Abstract Background Growing evidence suggests that maternal mental health issues are associated with (young) children’s weight outcomes. However, most studies have been limited by cross-sectional designs and have been aimed at (younger) children. The current prospective study focuses on the link between maternal mental health (i.e., psychological stress and depressive symptoms) and adolescents’ zBMI development. Methods The participants in the present study were part of wave 1 and 2 of a longitudinal study on Dutch adolescents’ and their parents’ health behavior. Adolescents (aged 10–14) and their parents were recruited through six secondary schools in the South and the East of the Netherlands. For this study, we only included biological mothers and their adolescent children who participated in both waves, with data on the main measures in both waves, leaving a final sample of 336 biological mother-child dyads. Adolescents height and weight were measured, and both parents and adolescents filled in validated questionnaires on perceived stress and depressive symptoms and answered additional questions concerning domain-specific stress. Regression analyses were performed in R to examine longitudinal links between maternal stress and depressive symptoms at baseline (T1) and adolescents’ BMI standard deviation scores (zBMI) 6 months later (T2), corrected for baseline zBMI and covariates. Results Maternal general perceived stress (β = .20, p = .002) at T1 preceded higher adolescents’ zBMI at T2, after controlling for baseline zBMI and other covariates, whereas maternal depressive symptoms at T1 (β = −.05, p = .44) and other domain-specific stress did not (maternal financial stress, maternal stress at work, maternal stress at home). Additionally, lower educational level among adolescents (β = .16, p = .001) and adolescent depressive symptoms (β = .16, p = .001) was associated with a higher zBMI at T2. Conclusions Results suggest that maternal general stress, but not depressive symptoms, may influence adolescents’ weight development. Our findings warrant future investigation on whether and how general stress among mothers may predict weight increases of their adolescent offspring.

scholarly journals Normative penile anthropometry in term newborns in Kumasi, Ghana: a cross-sectional prospective study

2017 ◽  
Vol 2017 (1) ◽  
Author(s):  
Serwah Bonsu Asafo-Agyei ◽  
Emmanuel Ameyaw ◽  
Jean-Pierre Chanoine ◽  
Samuel Blay Nguah
Keyword(s):  
Prospective Study ◽  
Cross Sectional ◽  
Term Newborns

scholarly journals The Epidemiology of Bruxism in Relation to Psychological Factors

2022 ◽  
Vol 19 (2) ◽  
pp. 691
Author(s):  
Mirela Ioana Flueraşu ◽  
Ioana Corina Bocşan ◽  
Ioan-Andrei Țig ◽  
Simona Maria Iacob ◽  
Daniela Popa ◽  
...  
Keyword(s):  
Prospective Study ◽  
Muscle Activity ◽  
Psychological Factors ◽  
Sleep Bruxism ◽  
Cross Sectional ◽  
Female Sex ◽  
Anonymous Questionnaire ◽  
Observational Cohort ◽  
High Degree ◽  
Awake Bruxism

The aim of the present study was to establish the prevalence of sleep/awake bruxism among young students in Transylvania and to correlate the presence of this muscle activity with behavioral variations. This analytical, observational, cohort, cross-sectional, and prospective study involved 308 volunteers aged between 19 and 30 years of different nationalities, all students of the “Iuliu Hațieganu” University of Medicine and Pharmacy in Cluj-Napoca, Romania. Subjects were asked to complete an anonymous questionnaire which was structured in five sections. The results obtained from the questionnaires were analyzed separately for sleep bruxism and for awake bruxism. We did not find any statistically significant correlation between awake bruxism or sleep bruxism and age (p = 0.30 and p = 0.37, respectively), sex (p = 0.44 and p = 0.48, respectively), or nationality (p = 0.55 and p = 0.67, respectively). Only a high degree of stress and frustration (p = 0.035 and p = 0.020) was observed in European subjects except for the Romanians and the French, likely related to the difficulties of adapting to the language and lifestyle in Romania. Female sex was statistically significantly associated with an increased level of stress (p = 0.004), duty-related depression (p = 0.006), and duty-related anxiety (p = 0.003). Stress and anxiety can be favorable factors in the appearance of both types of bruxism; however, depression is associated only with awake bruxism.

scholarly journals Prediction of Mental Illness Using Indian Astrology: Cross-Sectional Findings from a Prospective Study

2018 ◽  
Vol 32 (3) ◽  
pp. 555-578
Author(s):  
Rajeshkrishna Bhandary ◽  
Podila Satya Sharma ◽  
Hema Tharoor
Keyword(s):  
Mental Illness ◽  
Prospective Study ◽  
Cross Sectional ◽  
A Prospective Study

scholarly journals Immunohistochemical Expression of the Tumor Suppressor Protein p16INK4a in Cervical Adenocarcinoma

2017 ◽  
Vol 39 (01) ◽  
pp. 21-25 ◽  
Author(s):  
José Eleutério Jr ◽  
Thiago Lima ◽  
Maria Cunha ◽  
Diane Cavalcante ◽  
Angélica Silva
Keyword(s):  
Strong Association ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Cervical Adenocarcinoma ◽  
Kappa Index ◽  
Immunohistochemical Expression ◽  
Invasive Adenocarcinoma ◽  
Cross Sectional ◽  
High Negative Predictive Value ◽  
Negative Controls

Objective To evaluate the diagnostic utility of the p16ink4a protein expression as a marker for adenocarcinoma of the cervix. Methods In a cross-sectional study, p16ink4a expression was evaluated in 30 cervical biopsies from patients diagnosed with invasive adenocarcinoma from 2 reference clinics in Brazil, and compared with 18 biopsies of endocervical polyps (control cases). The performance of the tests for p16ink4a was evaluated using a conventional contingency table, and the Kappa (κ) index was used to evaluate the agreement of the marker with the tissue diagnosis. Results In total, 66% of the invasive adenocarcinoma cases were positive for p16ink4a. All of the adenomatous polyps cases used as negative controls were shown to be negative for p16ink4a. The marker showed a high sensitivity and a high negative predictive value. The Kappa index was good for p16ink4a (κ = 0.6). Conclusion Considering the strong association between the p16ink4a marker and the cervical adenocarcinoma, its use represents an important tool for reducing incorrect diagnoses of adenocarcinoma and thereby avoiding overtreatment.

Sign in / Sign up

Export Citation Format

Share Document