scholarly journals Immunohistochemical Expression of the Tumor Suppressor Protein p16INK4a in Cervical Adenocarcinoma

2017 ◽  
Vol 39 (01) ◽  
pp. 21-25 ◽  
Author(s):  
José Eleutério Jr ◽  
Thiago Lima ◽  
Maria Cunha ◽  
Diane Cavalcante ◽  
Angélica Silva
Keyword(s):  
Strong Association ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Cervical Adenocarcinoma ◽  
Kappa Index ◽  
Immunohistochemical Expression ◽  
Invasive Adenocarcinoma ◽  
Cross Sectional ◽  
High Negative Predictive Value ◽  
Negative Controls

Objective To evaluate the diagnostic utility of the p16ink4a protein expression as a marker for adenocarcinoma of the cervix. Methods In a cross-sectional study, p16ink4a expression was evaluated in 30 cervical biopsies from patients diagnosed with invasive adenocarcinoma from 2 reference clinics in Brazil, and compared with 18 biopsies of endocervical polyps (control cases). The performance of the tests for p16ink4a was evaluated using a conventional contingency table, and the Kappa (κ) index was used to evaluate the agreement of the marker with the tissue diagnosis. Results In total, 66% of the invasive adenocarcinoma cases were positive for p16ink4a. All of the adenomatous polyps cases used as negative controls were shown to be negative for p16ink4a. The marker showed a high sensitivity and a high negative predictive value. The Kappa index was good for p16ink4a (κ = 0.6). Conclusion Considering the strong association between the p16ink4a marker and the cervical adenocarcinoma, its use represents an important tool for reducing incorrect diagnoses of adenocarcinoma and thereby avoiding overtreatment.

scholarly journals Sex Differences in the Association of Fat and Inflammation Among People with Treated HIV Infection

2019 ◽  
Vol 4 (1) ◽  
pp. 163
Author(s):  
Marcelo Chen ◽  
Chung-Lieh Hung ◽  
Chun-Ho Yun ◽  
Allison R. Webel ◽  
Chris T. Longenecker
Keyword(s):  
High Sensitivity ◽  
Cross Sectional Study ◽  
Ectopic Fat ◽  
Metabolic Risk ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Hs Crp ◽  
Ectopic Fat Deposition ◽  
Negative Controls

Introduction: Ectopic fat deposition may contribute to chronic inflammation in people with HIV (PWH). To inform future mechanistic studies of metabolic risk in this population, we sought to determine which fat measures relate more strongly to inflammation and whether the fat-inflammation relationship is modified by sex or HIV status.Methods: We conducted a cross-sectional study of 105 PWH and 20 age- and sex-matched HIV-negative controls. Interleukin-6 (IL-6) and high-sensitivity C reactive protein (hs-CRP) levels were measured from plasma. Pericardial fat (PCF) and thoracic periaortic adipose tissue (TAT) volumes and peri-right coronary artery (RCA), left atrium (LA) roof and liver densities were measured from cardiac CT scans. Unadjusted and multivariate adjusted linear regression models were used to determine the relationship between ectopic fat measures and inflammation biomarkers.Results: Forty subjects had BMI <25, 33 had BMI 25-30, and 52 had BMI >30. Systolic blood pressure and insulin resistance increased with BMI. Subjects with higher BMI had higher CD4+ count. In models adjusted for demographics, HIV status and metabolic risk factors, BMI was positively associated with IL-6 and hs-CRP. Ectopic PCF and TAT volumes were positively associated with IL-6 and hs-CRP; however, these relationships were somewhat attenuated in adjusted models. LA roof (but not peri-RCA) fat radiodensity was inversely associated with hs-CRP in fully adjusted models and the association with IL-6 was borderline statistically significant. IL-6 was more strongly associated with BMI and LA roof density in women than in men (p for interaction=0.05).Conclusions: Among PWH on antiretroviral therapy, higher BMI and excessive visceral fat burden were associated with circulating markers of systemic inflammation, and this relationship appears to be stronger in women compared to men.

scholarly journals Evaluation of clinical performance and survival rate of Straumann dental implants in Saudi Population based on cross-sectional study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Reham AL Jasser ◽  
Mohammed AlSarhan ◽  
Dalal Alotaibi ◽  
Saleh Aloraini ◽  
Pradeep Koppolu ◽  
...  
Keyword(s):  
Oral Hygiene ◽  
Strong Association ◽  
Tissue Level ◽  
Cross Sectional Study ◽  
Titanium Implants ◽  
Risk Indicators ◽  
Sectional Study ◽  
Poor Oral Hygiene ◽  
Cross Sectional ◽  
Keratinized Tissue

AbstractRisk indicators of peri-implantitis is still contradictory and somehow unclear in present literature therefore efforts should be done for better understanding of the exact etiology of peri-implant disease progression. The present study aimed to assess risk indicators associated with peri-implantitis by observing the changes in several periodontal parameters after implant placement. This cross-sectional study included 213 female and 271 male patients aged 26–87 years, who received 484 titanium implants (Straumann, Switzerland) at King Saud University’s Dental College, Saudi Arabia. Patients were called for dental visits. During these visits; full clinical and radiographic assessment of implants were done. The periodontal pocket depth (PPD) was greater around implants placed at grafted sites than non-grafted sites and around bone-level implants than tissue-level implants. The plaque index (PI) was associated with poor oral hygiene. There was a strong association between graft (yes/no) and bleeding on probing (BOP). Patients with good oral hygiene showed high radiographic bone stability. Keratinized tissue width < 2 mm was associated with a higher PPD, higher PI, higher BOP, more edematous gingiva, and more exposed implant threads on radiography. In patients receiving implants, poor oral hygiene status and inadequate keratinized tissue level can be proposed as risk indicators for developing periimplantitis due to strong association found between them and developments of peri-implantitis.

Prevalence of Gingival Pigmentation and its Association with Gingival Biotype and Skin Colour

2021 ◽  
Vol 5 (1) ◽  
pp. 19-25
Author(s):  
Arjun Hari Rijal ◽  
Bhageshwar Dhami ◽  
Nashib Pandey ◽  
Deepa Aryal
Keyword(s):  
Strong Association ◽  
Cross Sectional Study ◽  
Skin Colour ◽  
Facial Skin ◽  
Cross Sectional ◽  
Attached Gingiva ◽  
Ethical Approval ◽  
Gingival Epithelium ◽  
Interdental Papilla ◽  
Gingival Biotype

Introduction: The facial appearance depends on several oral and extraoral factors including colour of facial skin and pigmentation of gingival epithelium. The colour of the gingiva varies among individuals and is thought to be associated with cutaneous pigmentation which ranges from light to dark brown or black colour. Objective: To assess the prevalence of physiological gingival pigmentation, gingival biotype and their association with skin colur in Nepalese subjects visiting Kantipur Dental College and Hospital (KDCH). Methods: This was an analytical cross-sectional study which was carried out from February 2020 to June 2020 in all patients of age-group 16 to 80 years visiting the Department of Periodontics at KDCH after ethical approval. Patients were recruited by convenience sampling and examined thoroughly to find out gingival biotype and extent of gingival pigmentation intraorally as well as skin colour extraorally. Results: In this study, 210 patients were examined among which, 105 (50%) were males and 105 (50%) were females. Out of 210, 33 (15.7%) had pink tissue without pigmentation, 84 (40%) had pigmentation only in attached gingiva, 58 (27.6%) in attached gingiva and interdental papilla, 32 (15.2%) had diffuse pigmentation involving all parts of gingiva, 2 (1%) had in marginal gingiva only, and 1 (0.5%) in marginal gingiva and interdental papilla. Conclusion: A strong association was found between gingival pigmentation and facial skin colour in present study (P <0.001). Establishing the pattern of gingival pigmentation in Nepalese population will help to choose a specific depigmentation therapy that will harmonise with skin colour.  

scholarly journals Serum paraoxonase-1 activity is associated with light to moderate alcohol consumption: the PREVEND cohort study

2018 ◽  
Vol 108 (6) ◽  
pp. 1283-1290 ◽  
Author(s):  
Eke G Gruppen ◽  
Stephan J L Bakker ◽  
Richard W James ◽  
Robin P F Dullaart
Keyword(s):  
Alcohol Consumption ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Population Based ◽  
Cross Sectional Study ◽  
Paraoxonase 1 ◽  
Phenyl Acetate ◽  
Cross Sectional

ABSTRACT Background Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-associated enzyme with antioxidative properties, which may protect against the development of cardiovascular disease. Alcohol consumption increases HDL cholesterol, but the extent to which alcohol consumption gives rise to higher serum PON-1 activity is uncertain. Objective In a population-based study, we determined the relation of serum PON-1 activity with alcohol consumption when taking account of HDL cholesterol and apolipoprotein A-I (apoA-I), its major apolipoprotein. Design A cross-sectional study was performed in 8224 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort. Alcohol consumption was categorized as 1) no/rarely (25.3%); 2) 0.1–10 g/d (49.3%); 3) 10–30 g/d (20.1%); and 4) >30 g/d (5.2%) with 1 drink equivalent to 10 g alcohol. Serum PON-1 activity was measured as its arylesterase activity (phenyl acetate as substrate). Results Median serum PON-1 activity was 50.8, 53.1, 54.4, and 55.7 U/L in the 4 categories of alcohol consumption, respectively (P < 0.001). Its increase paralleled the increments in HDL cholesterol and apoA-I. Notably, there was no further increase in PON-1 activity, HDL cholesterol, and apoA-I when alcohol consumption was increased from 10–30 g/d to >30 g/d. Multivariable linear regression analysis demonstrated that PON-1 activity was related to alcohol consumption independently from clinical covariates, high sensitivity C-reactive protein, and lipid concentrations, including HDL cholesterol (P < 0.001 for each category of alcohol consumption with no alcohol consumption as the reference category). Notably, as inferred from standardized β-coefficients, there was no difference in PON-1 activity between 10–30 g alcohol/d and >30 g alcohol/d. Conclusions Alcohol consumption is associated with an increase in serum PON-1 activity, but its effect seems to reach a plateau with alcohol consumption of 10–30 g/d.

scholarly journals Overweight and obesity of children in a brazilian elementary school: a comparison of three references

2016 ◽  
Vol 26 (3) ◽  
pp. 341
Author(s):  
Marcella Evangelista Melo ◽  
Giovanna Lima Miguéis ◽  
Mikaela Silva Almeida ◽  
Tatiane Dalamaria ◽  
Wagner De Jesus Pinto ◽  
...  
Keyword(s):  
Elementary School ◽  
Task Force ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
World Health ◽  
Sectional Study ◽  
Kappa Index ◽  
International Obesity Task Force ◽  
Cross Sectional ◽  
Health Organization

Introduction: In the diagnosis of overweight and obesity based on body mass index in children and adolescents, several national and international anthropometric references are recommended. However, there is a divergence in the estimated prevalence of overweight and obesity among the references. Objective: To identify the prevalence of overweight and obesity and to analyse the magnitude of agreement among the three references. Methods: A cross-sectional study with 975 students from the early grades of elementary school. The prevalence of overweight and obesity were estimated according to the criteria of the World Health Organization (WHO), the International Obesity Task Force (IOTF) and Conde and Monteiro. The Kappa weighted index was calculated to assess the agreement magnitude among the three references. Results: The highest prevalence of overweight and obesity was estimated by the Conde and Monteiro and WHO references, respectively. Overall, the IOTF revealed lower a magnitude of prevalence than the two other references. The agreement among the references identified by the Kappa index had a range of 0.66 to 0.94. Conclusion: Despite the satisfactory agreement among the three references, this research highlighted the differing magnitudes of the prevalence of overweight and obesity. This fact limits the ability to make comparisons among populations and impairs the development of overweight and obesity prevention actions.

scholarly journals Predictors of COVID-19 Fatality: A Worldwide Analysis of the Pandemic over Time and in Latin America

2022 ◽  
Author(s):  
Dayana Rojas ◽  
Jorge Saavedra ◽  
Mariya Petrova ◽  
Yue Pan ◽  
José Szapocznik
Keyword(s):  
Latin America ◽  
Latin American ◽  
Strong Association ◽  
Case Fatality ◽  
Cross Sectional Study ◽  
Fatality Rate ◽  
Cross Sectional ◽  
The Difference ◽  
Latin American Countries ◽  
Risk Ratios

AbstractSARS-CoV-2 has infected over one hundred million people worldwide and has affected Latin America particularly severely in terms of both cases and deaths. This study aims to determine the association between SARS-CoV-2 testing and COVID-19 fatality rate worldwide over 8 months and to examine how this relationship differs between Latin America and all other countries. This cross-sectional study used March 2021 data from 169 countries. Multivariate regressions predicted COVID-19 fatality (outcome) from the number of SARS-CoV-2 tests (exposure), while controlling for other predictors. Results for March 2021 were compared to results from June 2020. Additionally, results for Latin America were also compared to all other countries except Latin American for March 2021. SARS-CoV-2 testing was associated with a significant decrease in COVID-19 fatality rate in both June 2020 and March 2021 (RR = 0.92; 95% CI 0.87–0.96 and RR = 0.86; 95% CI 0.74–1.00, respectively). SARS-CoV-2 testing was associated with a significant decrease in COVID-19 fatality rate in Latin American countries but not in all other countries (RR = 0.45; 95% CI 0.23–0.89 and RR = 0.95; 95% CI 0.82–1.11, respectively). However, the difference between the risk ratios for June 2020 and March 2021 and between the risk ratios for Latin America and all other countries were not statistically significant. Increased SARS-CoV-2 testing may be a significant predictor of lower COVID-19 case fatality rate, specifically in Latin American countries, due to the existence of a strong association, which may have driven the worldwide results.

scholarly journals Liver Biomarkers Assay in COVID-19 Cases: A Comparison Study between Alive and Dead Patients

2022 ◽  
Author(s):  
Amir Emami ◽  
Fatemeh Javanmardi ◽  
Ali Akbari ◽  
Babak Shirazi Yeganeh ◽  
Tahereh Rezaei ◽  
...  
Keyword(s):  
Serum Albumin Level ◽  
Critical Role ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
Hospital Death ◽  
Comparison Study ◽  
Sectional Study ◽  
Laboratory Findings ◽  
Cross Sectional

Background: Identifying effective biomarkers plays a critical role on screening; rapid diagnosis; proper managements and therapeutic options, which is helpful in preventing serious complications. The present study aimed to compare the liver laboratory tests between alive and dead hospitalized cases for prediction and proper management of the patients. Methods: This retrospective, cross sectional study consists of all deceased patients admitted in one center in Shiraz, Iran during 19 Feb 2020 to 22 Aug 2021. For further comparison, we selected a 1:2 ratios alive group randomly. Results: Overall, 875 hospitalized cases died due to COVID-19. We selected 1750 alive group randomly. The median age was significantly higher in died group (65.96 vs 51.20). Regarding the laboratory findings during the hospitalization ALT, AST, Bili.D were significantly higher in non-survivors than survivors but Albumin was less in deceased patients. It was revealed elevated levels of Albumin, AST, Bili.T and Bili.D were associated with increasing the risk of in hospital death. Moreover, the predictive effect of ALP and Bili.D had significantly more than others with high sensitivity and specify. Conclusion: We found patients with COVID-19 have reduced serum albumin level, and increase ALT and AST. The current results revealed abnormal liver chemistries is associated with poor outcome, which highlighted the importance of monitoring these patients more carefully and should be given more caution.

scholarly journals Association of Retinopathy with Chronic Kidney Disease in Diabetes Mellitus

2018 ◽  
Vol 8 (3) ◽  
pp. 210-214
Author(s):  
Rushda Sharmin Binte Rouf ◽  
SM Ashrafuzzaman ◽  
Zafar Ahmed Latif
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Strong Association ◽  
Albumin Excretion Rate ◽  
Cross Sectional Study ◽  
Fundus Photography ◽  
Diabetic Patients ◽  
Cross Sectional

Background: Diabetic retinopathy (DR) and nephropathy are two major complications of diabetes mellitus carrying significant morbidity and mortality. In this study DR was investigated in different stages of chronic kidney disease (CKD) to find out possible association of these two devastating complications.Methods: This cross-sectional study was conducted in 150 diabetic patients having CKD in BIRDEM. CKD was defined as estimated glomerular filtration rate (eGFR) of <60ml/min/1.73m2and/or urinary albumin excretion rate (UAER) >30 mg/day in at least two occasions in 3 months apart. Retinopathy was assessed by direct fundoscopic examination and confirmed by color fundus photography. Severe DR (SDR) included proliferative diabetic retinopathy, severe non-proliferative DR and maculopathy; whereas microaneurysm regarded as non-severe retinopathy.Results: Majority (68%) of the respondents had some form of retinopathy (38.35% SDR and 29.65% nonsevere). There was strong association between different levels of albuminuria (UAER) and DR (p<0.0001). On the contrary DR did not correspond with stages of CKD (P=0.349). Hypertension (79.5%) and dyslipidaemia (59%) were common co-morbidities.Conclusion: This study concluded that DR prevalence was more in nephropathy along with significant association with UAER. Whereas different stages of CKD was not associated with stages of DR . This finding focused the necessity of regular retinal examination irrespective of the stage of renal involvement.Birdem Med J 2018; 8(3): 210-214

scholarly journals A STUDY ON ASSOCIATION BETWEEN WORKRELATED FACTORS AND HYPERTENSION AMONG BUS DRIVERS IN TAMILNADU – A CROSS-SECTIONAL STUDY

2020 ◽  
pp. 59-61
Author(s):  
Imtiaz Ahmed S ◽  
PK Govindrajan ◽  
Felix Felix
Keyword(s):  
Blood Pressure ◽  
Strong Association ◽  
Treatment Compliance ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Lifestyle Modifications ◽  
Bus Drivers ◽  
Related Factors ◽  
Cross Sectional ◽  
Work Related

Background and Objective Hypertension is a Leading cause of Morbidity and Mortality in developing nations. This study aims to Find the Association between Work related risk factors and Hypertension among transport Bus Drivers Method This study was a Cross Sectional Study carried out in Bus Depot and Bus Stand, Chidambaram, in Cuddalore district of Tamilnadu. The approximate prevalence of HTN among Adults in Tamilnadu was 31.5% (5). The estimated sample size for the study was 205. The Study tool included were Risk factor questionnaire and Physical measurement of Height, Weight and Blood pressure. Results Study showed significant Association between work-related factors or variables with Hypertension. Factors like Duration of Service in Present Job, Bus route travelling, Number of Hours at work, Family history of Hypertension are significantly associated with rise in Blood Pressure Conclusion Strong Association between work related factors like Service duration, travelling bus route, Duration of work hours, Shift duties and Hypertension was noted. Study recommends need for Periodic screening and follow up for Early diagnosis and treatment compliance. Lifestyle modifications and Periodic shift in duty patterns is also needed for the benefit of Bus drivers

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