scholarly journals Impairment of Erythrocyte Deformability Observed in Type 2 Diabetic Patients with Clustering Diabetic Complications

2020 ◽  
pp. 27-37
Author(s):  
Takeshi Arita ◽  
Taku Yokoyama ◽  
Shohei Moriyama ◽  
Mitsuhiro Fukata ◽  
Kei Irie ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Statistical Significance ◽  
Microvascular Dysfunction ◽  
Erythrocyte Deformability ◽  
Control Group ◽  
Diabetic Patients ◽  
Qtc Interval ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Aims: Hemorheologic and microvascular dysfunction are interdependent in type 2 diabetic patients. However, exact mechanisms explaining this interaction remains unclear. This study aimed to investigate the impairment of erythrocyte deformability under concurrent recording of electrocardiogram (ECG), since heart-rate-corrected QT interval (QTc interval) prolongation reflects autonomic and microvascular dysfunction in diabetic patients. Methodology: The erythrocyte deformability was investigated on the day of digital ECG recording in diabetic (n = 215) and control (n = 88) groups of outpatients using specific filtration technique. Significant contributors to the erythrocyte deformability were analyzed by multivariate analysis. Results: Difference of mean erythrocyte deformability in the diabetic vs. control group did not reach the statistical significance, but the difference was significant in comparison of diabetic smokers vs. non-smokers and of diabetic patients with vs. without diabetic complications. Impaired diabetic erythrocyte deformability was dependent mostly on the glycated hemoglobin (HbA1c), and negative correlation between QTc interval and the deformability was marginal. Conclusions: Erythrocyte deformability was not necessarily impaired in diabetic patients under the intensive antidiabetic medication. However, this deformability was impaired in diabetic smokers and diabetic patients with clustering of complications. Future studies are required for hemorheologic and microvascular interaction leading to the impaired diabetic microcirculation.

scholarly journals Olfactory disfunction and diabetic complications in type 2 diabetic patients: a pilot study

Endocrine ◽  
2021 ◽  
Author(s):  
Francesco Mozzanica ◽  
Anna Ferrulli ◽  
Stela Vujosevic ◽  
Alessandro Montuori ◽  
Arianna Cardella ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Diabetic Complications ◽  
Control Group ◽  
Subjective Perception ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
Olfactory Abilities ◽  
Type 2 Diabetic

Abstract Purpose Scarce information on the prevalence and characteristics of olfactory disfunction (OD) in type 2 diabetic (T2D) patients are available. The aims of this study were (1) to assess the olfactory function in T2D patients and to compare it with a control group of individuals without T2D, and (2) to evaluate the differences in OD within T2D patients according to the presence of diabetic complications. Methods A group of 39 T2D patients and a control group of 39 healthy individuals were enrolled. Each subject underwent an evaluation of the olfactory performance using the Sniffing Olfactory Screening Test (SOST) and completed a questionnaire assessing the subjective perception of olfaction. According to the presence of diabetic complications, the group of T2D patients was divided into two subgroups. Non-parametric tests and regression analysis were used for statistical analysis. Results No differences in the subjective perception of olfaction were demonstrated among T2D patients (with and without complications) and controls. A significant difference for the SOST score was demonstrated among the different groups. In particular, OD was more frequent in T2D patients than in controls. In addition, OD was far more frequent in T2D patients with complications. Regression analysis did not demonstrate any significant association between OD and clinical/demographic characteristics of T2D patients. Conclusion T2D patients were more frequently affected by OD. The subgroup analysis suggested a possible relationship between OD and diabetic complications since patients with T2D diabetic complications demonstrated lower olfactory abilities than controls subjects and T2D patients without diabetic complications.

Prevalence of diabetic complications in fibrocalculous pancreatic diabetic patients and type 2 diabetic patients

2004 ◽  
Vol 18 (5) ◽  
pp. 264-270 ◽  
Author(s):  
Karuna Kanta Barman ◽  
Mahesh Padmanabhan ◽  
Gopal Premalatha ◽  
Raj Deepa ◽  
Mohan Rema ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Awareness of Diabetic Complications in Type 2 Diabetic Patients

2016 ◽  
Vol 10 (2) ◽  
pp. 65-69
Author(s):  
Nadia Aziz Ather ◽  
Shahid Aziz ◽  
Aqib Javed ◽  
Muhammad Tariq Karim
Keyword(s):  
Diabetic Complications ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Evaluation of urinary L-FABP as an early marker for diabetic nephropathy in type 2 diabetic patients

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Duong Thi Thuy Ngan ◽  
Nguyen Gia Binh ◽  
Le Thi Huong Lan ◽  
Cuc Thi Thu Nguyen ◽  
Phung Thanh Huong
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Early Detection ◽  
Urinary Albumin ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Fatty Acid Binding ◽  
Type 2 Diabetic

Summary Background Albuminuria is the standard biomarker for the diagnosis of diabetic nephropathy (DN). However, some patients with persistent microalbuminuria still progress to chronic kidney disease, raising the question of finding a better biomarker. This study aimed to evaluate the correlation of urinary liver-type fatty acid-binding protein (L-FABP) levels with renal function and to compare the role of urinary albumin-to-creatinine ratio (ACR) with urinary L-FABP in early detection of DN in type 2 diabetic patients. Methods The cross-sectional study was done on 106 type 2 diabetic patients and 30 non-diabetic people. L-FABP was measured with the Latex enhanced immunoturbidimetric technique. Results There was a strong and negative correlation between the urine L-FABP levels and eGFR (r = -0.606, p<0.001). The urinary L-FABP levels were significantly higher (p<0.001) in the normoalbuminuria diabetic group than the non-diabetic control group. The ROC-curve analyses in the diabetic patients and the normoalbuminuria diabetic patients showed that the AUCL-FABP was remarkably higher (p<0.001) than the AUCACR. An optimal cutoff value of 5 mg L-FABP/g Cr (with the sensitivity of 98.1% and specificity of 90%) and of 4.3 mg L-FABP/g Cr (with the sensitivity of 100% and specificity of 86.67%) was set to detect DN in the diabetic patients and the normoalbuminuria diabetic patients, respectively. Conclusions The change in urinary L-FABP levels happened earlier than in urinary albumin during renal function impairment. Urinary L-FABP can be used as a better indicator than ACR for early detection of DN in type 2 diabetes.

Irisin level in type 2 diabetic patients and its relation to glycemic control and diabetic complications

2019 ◽  
Vol 39 (4) ◽  
pp. 641-646 ◽  
Author(s):  
Hemmat El Haddad ◽  
Heba Sedrak ◽  
Mervat Naguib ◽  
Elham Yousief ◽  
Dalia R. Ibrahim ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Diabetic Complications ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

EFFECTS OF ISOLATED AND COMBINED EFFECTS OF AEROBIC DANCING AND RESISTANCE TRAINING ON RESTING PULSE RATE OF TYPE-2 DIABETIC PATIENTS

2021 ◽  
pp. 59-60
Author(s):  
Maniazhagu Dharuman
Keyword(s):  
Resistance Training ◽  
Pulse Rate ◽  
Control Group ◽  
Diabetic Patients ◽  
Combined Effects ◽  
Type 2 Diabetic Patients ◽  
Random Group ◽  
Experimental Group ◽  
Type 2 Diabetic

The purpose of study was to nd out the effects of isolated and combined effects of aerobic dancing and resistance training on resting pulse rate of type-2 diabetic patients. To achieve the purpose of the study, 60 type 2 diabetic patients with the age of 40-45 years from Karaikudi town, Sivaganga District, Tamilnadu were selected as subject at random. The study was formulated as pre and post test random group design, in which sixty subject were divided into four equal groups. The experimental group-1 (n=15, AD) underwent aerobic dancing, experimental group-2 (n=15, RT) underwent resistance training, experimental group – 3 (n=15, COM-T) underwent combined practice of aerobic dancing and resistance training and group-4 (n=15, CG) served as a control group. In this study, three training programme were adopted as independent variable, i.e., aerobic dancing, resistance training and combined training. The resting pulse rate was chosen as dependent variable. It was tested by number of beats per minute, scores recorded in number. The collected pre and post data was critically analyzed with apt statistical tool of analysis of co-variance. The Scheffe's post hoc test was used to nd out pair-wise comparisons between groups. The results of the present study proved that the three training interventions have signicantly altered the resting pulse rate.

Myocardial insulin resistance associated with chronic hypertriglyceridemia and increased FFA levels in Type 2 diabetic patients

2004 ◽  
Vol 287 (3) ◽  
pp. H1225-H1231 ◽  
Author(s):  
Lucilla D. Monti ◽  
Claudio Landoni ◽  
Emanuela Setola ◽  
Elena Galluccio ◽  
Pietro Lucotti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Insulin Resistance ◽  
Control Group ◽  
Diabetic Patients ◽  
Control Groups ◽  
Type 2 Diabetic Patients ◽  
Myocardial Insulin Resistance ◽  
And Control ◽  
Type 2 Diabetic

We evaluated the influence of chronic hypertriglyceridemia and endothelial dysfunction on myocardial glucose uptake (MGU) in Type 2 diabetic patients without coronary heart disease. Patients were divided into two groups according to fasting triglyceride (TG) levels: 5.4 ± 1.1 and 1.5 ± 0.3 mmol/l for high- and normal-TG groups, respectively. Five subjects were assigned to the high-TG group and 11 to the normal-TG group. Age, gender, body mass index, systolic and diastolic blood pressure, glucose, insulin, HbA1c, cholesterol, and HDL cholesterol were similar in the two groups, whereas free fatty acid (FFA) levels were higher in the high-TG group basally and at the end of the clamp. Furthermore, five healthy subjects were subjected to the same protocol and used as the control group. MGU was assessed by using 18F-labeled 2-fluoro-2-deoxy-d-glucose under hyperglycemic-hyperinsulinemic conditions. Basal endothelin-1 and nitric oxide levels were significantly higher in the high-TG group than in the normal-TG and control groups, and cGMP and maximal postischemic vasodilation were significantly decreased in the high-TG group compared with the normal-TG and control groups. However, significant alterations were found in the same parameters in the normal-TG group compared with the control group. By the end of the hyperglycemic clamp, in the high-TG group, MGU was ∼40 and 65% of that in the normal-TG and control groups. MGU negatively correlated with TG, FFA, and endothelin-1, whereas a positive correlation was found with cGMP and maximal postischemic vasodilation. In conclusion, increased TG and FFA levels are risks, in addition to Type 2 diabetes mellitus, for myocardial insulin resistance, endothelial dysfunction, and alteration of nitric oxide/cGMP levels.

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