scholarly journals Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

2014 ◽  
Vol 4 (7) ◽  
pp. 810-818 ◽  
Author(s):  
Mwajuma Mahita
Keyword(s):  
Essential Oils ◽  
Gabaa Receptor ◽  
Melissa Officinalis ◽  
Lavandula Angustifolia ◽  
Receptor Channel

scholarly journals Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

2009 ◽  
Vol 61 (2) ◽  
pp. 267-267 ◽  
Author(s):  
Liping Huang ◽  
Sawsan Abuhamdah ◽  
Melanie-Jayne R. Howes ◽  
Christine L. Dixon ◽  
Mark S. J. Elliot ◽  
...  
Keyword(s):  
Essential Oils ◽  
Melissa Officinalis ◽  
Pharmacological Profile ◽  
Lavandula Angustifolia

Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

2008 ◽  
Vol 60 (11) ◽  
pp. 1515-1522 ◽  
Author(s):  
Liping Huang ◽  
Sawsan Abuhamdah ◽  
Melanie-Jayne R. Howes ◽  
Christine L. Dixon ◽  
Mark S. J. Elliot ◽  
...  
Keyword(s):  
Essential Oils ◽  
Melissa Officinalis ◽  
Pharmacological Profile ◽  
Lavandula Angustifolia

scholarly journals Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

2009 ◽  
Vol 61 (2) ◽  
pp. 267-267
Author(s):  
Liping Huang ◽  
Sawsan Abuhamdah ◽  
Melanie-Jayne R Howes ◽  
Christine L Dixon ◽  
Mark S. J Elliot ◽  
...  
Keyword(s):  
Essential Oils ◽  
Melissa Officinalis ◽  
Pharmacological Profile ◽  
Lavandula Angustifolia

Perspective on the relationship between GABAA receptor activity and the apparent potency of an inhibitor

2021 ◽  
Vol 19 ◽  
Author(s):  
Allison L. Germann ◽  
Spencer R. Pierce ◽  
Alex S. Evers ◽  
Joe Henry Steinbach ◽  
Gustav Akk
Keyword(s):  
Gabaa Receptor ◽  
Hill Equation ◽  
Response Relationship ◽  
Inhibition Concentration ◽  
Level Of Activity ◽  
Control Response ◽  
The Hill ◽  
The Relationship ◽  
Inhibition Curve ◽  
Receptor Channel

Background : In electrophysiological experiments inhibition of a receptor-channel, such as the GABAA receptor, is measured by co-applying an agonist producing a predefined control response with an inhibitor to calculate the fraction of the control response remaining in the presence of the inhibitor. The properties of the inhibitor are determined by fitting the inhibition concentration-response relationship to the Hill equation to estimate the midpoint (IC50) of the inhibition curve. Objective: We sought to estimate here the sensitivity of the fitted IC50 to the level of activity of the control response. Methods: The inhibition concentration-response relationships were calculated for models with distinct mechanisms of inhibition. In Model I, the inhibitor acts allosterically to stabilize the resting state of the receptor. In Model II, the inhibitor competes with the agonist for a shared binding site. In Model III, the inhibitor stabilizes the desensitized state. Results: The simulations indicate that the fitted IC50 of the inhibition curve is sensitive to the degree of activity of the control response. In Models I and II, the IC50 of inhibition was increased as the probability of being in the active state (PA) of the control response increased. In Model III, the IC50 of inhibition was reduced at higher PA. Conclusions: We infer that the apparent potency of an inhibitor depends on the PA of the control response. While the calculations were carried out using the activation and inhibition properties that are representative of the GABAA receptor, the principles and conclusions apply to a wide variety of receptor-channels.

Lavandula angustifolia and Lavandula latifolia Essential Oils from Spain: Aromatic Profile and Bioactivities

Planta Medica ◽  
2015 ◽  
Vol 82 (01/02) ◽  
pp. 163-170 ◽  
Author(s):  
Alejandro Carrasco ◽  
Ramiro Martinez-Gutierrez ◽  
Virginia Tomas ◽  
Jose Tudela
Keyword(s):  
Essential Oils ◽  
Lavandula Angustifolia ◽  
Lavandula Latifolia

scholarly journals Chemical Profile, In Vitro Biological Activity and Comparison of Essential Oils from Fresh and Dried Flowers of Lavandula angustifolia L.

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5317
Author(s):  
Claudio Caprari ◽  
Francesca Fantasma ◽  
Fabio Divino ◽  
Antonio Bucci ◽  
Maria Iorizzi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Essential Oils ◽  
Fruits And Vegetables ◽  
Central Italy ◽  
Radical Scavenging ◽  
Sclerotium Rolfsii ◽  
Bactericidal Effect ◽  
Phytopathogenic Fungus ◽  
Lavandula Angustifolia

The chemical composition of essential oils (EOs) from dried and fresh flowers of Lavandula angustifolia L. (lavender), named LA 2019 and LA 2020, respectively, grown in central Italy was analyzed and compared by GC and GC-MS. For both samples, 61 compounds were identified, corresponding to 97.9% and 98.1% of the total essential oils. Explorative data analysis, performed to compare the statistical composition of the samples, resulted in a high level of global similarity (around 93%). The compositions of both samples were characterized by 10 major compounds, with a predominance of Linalool (35.3–36.0%), Borneol (15.6–19.4%) and 1,8-Cineole (11.0–9.0%). The in vitro antibacterial activity assay by disk diffusion tests against Bacillus subtilis PY79 and Escherichia coli DH5α showed inhibition of growth in both indicator strains. In addition, plate counts revealed a bactericidal effect on E. coli, which was particularly noticeable when using oil from the fresh lavender flowers at the highest concentrations. An in vitro antifungal assay showed that the EOs inhibited the growth of Sclerotium rolfsii, a phytopathogenic fungus that causes post-harvest diseases in many fruits and vegetables. The antioxidant activity was also assessed using the ABTS free radical scavenging assay, which showed a different antioxidant activity in both EOs. In addition, the potential application of EOs as a green method to control biodeterioration phenomena on an artistic wood painting (XIX century) was evaluated.

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