scholarly journals Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

2009 ◽  
Vol 61 (2) ◽  
pp. 267-267 ◽  
Author(s):  
Liping Huang ◽  
Sawsan Abuhamdah ◽  
Melanie-Jayne R. Howes ◽  
Christine L. Dixon ◽  
Mark S. J. Elliot ◽  
...  
2008 ◽  
Vol 60 (11) ◽  
pp. 1515-1522 ◽  
Author(s):  
Liping Huang ◽  
Sawsan Abuhamdah ◽  
Melanie-Jayne R. Howes ◽  
Christine L. Dixon ◽  
Mark S. J. Elliot ◽  
...  

2009 ◽  
Vol 61 (2) ◽  
pp. 267-267
Author(s):  
Liping Huang ◽  
Sawsan Abuhamdah ◽  
Melanie-Jayne R Howes ◽  
Christine L Dixon ◽  
Mark S. J Elliot ◽  
...  

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 850
Author(s):  
Kristine Guran ◽  
Roxana Buzatu ◽  
Iulia Pinzaru ◽  
Madalina Boruga ◽  
Iasmina Marcovici ◽  
...  

Melissa officinalis is a medicinal herb with an extensive pharmacological profile that has been proven to have beneficial effects in oral and gastrointestinal disorders. However, the effects of this plant in oral, pharyngeal, and colorectal malignancies, types of cancer with an increased incidence in recent years, are less investigated. The present study aims to evaluate the pharmacological profile of a Melissa officinalis total extract for potential benefits in oral, pharynx and colorectal carcinoma. The LC-MS profile of MO total extract (MOte) indicated a rich content in polyphenols, data that support the potent antioxidant capacity exhibited and the antimicrobial activity against both Gram-negative and Gram-positive bacteria. In addition, MOte triggered a dose-dependent and selective decrease in the viability of tumor cells (tongue and pharynx squamous cell carcinomas, and colorectal adenocarcinoma), with the most significant effect being recorded at 100 µg/mL. At the same concentration, MOte exhibited an antiangiogenic effect by inhibiting the process of angiogenesis in ovo. Overall, our findings support the potential benefits of Melissa officinalis leaf total extract as a valuable candidate for the prophylaxis of oral, pharyngeal and colorectal neoplasms.


Planta Medica ◽  
2015 ◽  
Vol 82 (01/02) ◽  
pp. 163-170 ◽  
Author(s):  
Alejandro Carrasco ◽  
Ramiro Martinez-Gutierrez ◽  
Virginia Tomas ◽  
Jose Tudela

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5317
Author(s):  
Claudio Caprari ◽  
Francesca Fantasma ◽  
Fabio Divino ◽  
Antonio Bucci ◽  
Maria Iorizzi ◽  
...  

The chemical composition of essential oils (EOs) from dried and fresh flowers of Lavandula angustifolia L. (lavender), named LA 2019 and LA 2020, respectively, grown in central Italy was analyzed and compared by GC and GC-MS. For both samples, 61 compounds were identified, corresponding to 97.9% and 98.1% of the total essential oils. Explorative data analysis, performed to compare the statistical composition of the samples, resulted in a high level of global similarity (around 93%). The compositions of both samples were characterized by 10 major compounds, with a predominance of Linalool (35.3–36.0%), Borneol (15.6–19.4%) and 1,8-Cineole (11.0–9.0%). The in vitro antibacterial activity assay by disk diffusion tests against Bacillus subtilis PY79 and Escherichia coli DH5α showed inhibition of growth in both indicator strains. In addition, plate counts revealed a bactericidal effect on E. coli, which was particularly noticeable when using oil from the fresh lavender flowers at the highest concentrations. An in vitro antifungal assay showed that the EOs inhibited the growth of Sclerotium rolfsii, a phytopathogenic fungus that causes post-harvest diseases in many fruits and vegetables. The antioxidant activity was also assessed using the ABTS free radical scavenging assay, which showed a different antioxidant activity in both EOs. In addition, the potential application of EOs as a green method to control biodeterioration phenomena on an artistic wood painting (XIX century) was evaluated.


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