scholarly journals Evaluation of Serum Uric Acid, Serum Magnesium and Lipid Profiles in Type 2 Diabetes Mellitus Patients for the Risk Factor of Cardiovascular Disease

2020 ◽  
pp. 10-17
Author(s):  
Sonal Sogani ◽  
Navendru Kumar Gupta ◽  
Suman Jain
Keyword(s):  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Magnesium ◽  
Lipid Profiles ◽  
Healthy Controls ◽  
Mean Values ◽  
Type 2 Dm ◽  
The Mean

Background and Objective: Dyslipidemia is one of the common disorders which are seen in most of the diabetes patients, which causes cardio vascular diseases. However, serum uric acid and lipid profiles are considered as the potential risk factor for developing diabetes, hypertension, stroke and cardiovascular diseases. Also the direct association of trace elements such as serum magnesium and hs-CRP in type 2 diabetes has been observed. The aim of the present study is to evaluate serum uric acid, serum magnesium and lipid profiles in type 2 diabetes mellitus patients for the risk factor of cardiovascular disease and its comparison with non diabetic subjects. Materials and Methods: This case-control study was conducted in the Department of Biochemistry, PIMS, Udaipur. The study included 100 patients with type 2 Diabetes Mellitus (both males and females) who were recruited from the institute’s medicine OPD and wards and 100 healthy controls (both males and females) with normal plasma glucose and with no symptoms suggestive of DM were included in the study. All the Biochemical parameters analysis was done on fully automated analyzer-ERBA 360 EM. Results:  The mean values of serum lipid profiles (serum cholesterol, serum triglycerides, VLDL, LDL) were compared between healthy controls and patients with type 2 DM, showed highly significant difference in patients with type 2 DM as compared with healthy controls (p<0.001). However, on comparing HDL between healthy controls and patients with type 2 DM, the difference seems to be significant (p<0.05). The mean values of RBS, HbA1c, uric acid and hs-CRP were highly significant in patients with type 2 DM as compared with healthy controls (p<0.001). The mean values of serum magnesium showed significant difference between healthy controls and patients with type 2 DM p<0.05). Interpretation and Conclusion: The common lipid abnormalities seen during diabetes induce dyslipidemia causing the development of CVD’s among diabetic patients. Also elevated levels of hs-CRP, hyperuricemia, hypomagnesium suggest that it could be a better prognosis for CVD’s and stroke in diabetic patients.

scholarly journals EVALUATION OF SERUM URIC ACID, SERUM MAGNESIUM AND LIPID PROFILES IN TYPE 2 DIABETES MELLITUS PATIENTS FOR THE RISK FACTOR OF CARDIOVASCULAR DISEASE.

2021 ◽  
pp. 6-9
Author(s):  
Sonal Sogani ◽  
Suman Jain
Keyword(s):  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Magnesium ◽  
Healthy Controls ◽  
Mean Values ◽  
Type 2 Dm ◽  
The Mean ◽  
Hs Crp

Background & Objective: Dyslipidemia is one of the common disorders which are seen in most of the diabetes patients, which causes cardio vascular diseases.However, serum uric acid and lipid profiles are considered as the potential risk factor for developing diabetes, hypertension, stroke and cardiovascular diseases. Also the direct association of trace elements such as serum magnesium and hs-CRP in type 2 diabetes has been observed.The aim of the present study is to evaluate serum uric acid, serum magnesium and lipid profiles in type 2 diabetes mellitus patients for the risk factor of cardiovascular disease and its comparison with non diabetic subjects. Material & Methods: This case-control study was conducted in the Department of Biochemistry,PIMS,Udaipur.The study included 100 patients with type 2 Diabetes Mellitus (both males and females) who were recruited from the institute's medicine OPD and wards and 100 healthy controls (both males and females) with normal plasma glucose and with no symptoms suggestive of DM were included in the study. All the Biochemical parameters analysis was done on fully automated analyzer-ERBA 360 EM. Results: The mean values of serum lipid profile (serum cholesterol,serum triglycerides,VLDL,LDL) were compared between healthy controls and patients with type 2 DM, showed highly significant difference in patients with type 2 DM as compared with healthy controls (p<0.001). However, on comparing HDL between healthy controls and patients with type 2 DM, the difference seems to be significant (p<0.05).The mean values of RBS,HbA1c,uric acid and hs-CRP were highly significant in patients with type 2 DM as compared with healthy controls (p<0.001).The mean values of serum magnesium showed significant difference between healthy controls and patients with type 2 DM p<0.05). Interpretation And Conclusion: The common lipid abnormalities seen during diabetes induce dyslipidemia causing the development of CVD's among diabetic patients. Also elevated levels of hs-CRP, hyperuricemia, hypomagnesium suggest that it could be a better prognosis for CVD's and stroke in diabetic patients.

scholarly journals Comparative Study of Level of Serum Uric Acid in Type 2 Diabetes Mellitus Associated with Hypertension

2018 ◽  
Vol 9 (2) ◽  
pp. 96-101
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Nazneen Sultana ◽  
Md Jamil Hasan Karami ◽  
Ayatunnessa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Exercise Time ◽  
The Mean ◽  
And Control

Background: The role of uric acid in the progression of prediabetes to diabetes has been known. Serum uric acid has been shown to beassociated with cardiovascular disease, hypertension, and chronic kidney disease. However, conflicting data exist asregards the serum uric acid (UA) levels in type 2 diabetes mellitus, which are associated with risk factors andcomplications.Material & Methods: The present study was designed to look for any association of serum uric acid with hypertension in type 2diabetes mellitus, taking into consideration the relevant clinical, biochemical and the anthropometric data. 110 patientswith type 2 male diabetes mellitus as case and 100 healthy malecontrols were included in this study.Results: This study shows that there were significant differences in mean of age, duration of DM, exercise time, waist hip ratio, systolic blood pressure and diastolic blood pressure within case and control but no significant differences of mean BMI was found between and control. The mean age, duration of DM, exercise time, waist hip ratio, systolic blood pressure and diastolic blood pressure and BMI were (51.83±9.911 years, 6.87±5.54 years, 1.94±.831 hours, .92±.03, 140±6.75 mm of Hg,90±2.41 mm of Hg and 25.43±3.19 Kg/m2 respectively), where as in controls these were (44.81±9.66 yrs, 00 years, 1.12±.327 hours, .91±.03, 130±1.28 mm of Hg, 80±6.18 mm of Hg and 24.96±3.02 Kg/m2 respectively). This table also shows that significant differences in mean of FBS, ABF, HbA1C and S. Uric acid between case and control, but there was no significant differences of mean TG, Cholesterol, HDL and LDL. The mean of FBS, ABF, HbA1C and S. Uric acid among the cases were (8.19±2.48 mmol/L, 11.29±3.47 mmol/L, 7.96±6.04 mg%, 189.72±111.36 mg/dl, 179±43 mg/dl, 38.38±13.77 mg/dl, 102.10±35.79 mg/dl and 8.39±2.61 mg/dl respectively, on the other hand among the control these were 5.91±1.13 mmol/L, 9.19±1.95 mmol/L, 5.93±1.01 mg%, 200±104.49 mg/dl, 183±42.25 mg/dl, 38.14±5.52 mg/dl, 110±33.23 mg/dl and 5.14±.84 mg/dl respectively.Anwer Khan Modern Medical College Journal Vol. 9, No. 2: Jul 2018, P 96-101

scholarly journals Evaluation of C-Reactive Protein, Endothelin-1, Adhesion Molecule(s), and Lipids as Inflammatory Markers in Type 2 Diabetes Mellitus Patients

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Hala El-Mesallamy ◽  
Salwa Suwailem ◽  
Nadia Hamdy
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adhesion Molecule ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Endothelin 1 ◽  
Reactive Protein ◽  
Type 2 Dm

This study compared lipids, the product of lipid peroxidation malondialdehyde (MDA), the acute phase reactant high sensitive C-reactive protein (hsCRP), endothelin-1 (ET-1),P-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) between healthy controls, subjects with ischemic heart disease (IHD) and type 2 diabetes mellitus (DM) subjects who did not perform coronary artery bypass graft (CABG) surgery as well as type 2 DM subjects who performed CABG.HbA1c, lipids, MDA, hsCRP, ET-1,P-selectin, ICAM-1, and VCAM-1 levels were significantly higher in the diabetic groups than in either healthy controls or IHD subjects. In the diabetic groups, there was a negative association among hsCRP and HDL-C. ET-1, ICAM-1 levels and TAG were positively correlated, as do the association betweenP-selectin, VCAM-1 andHbA1c%. Also a positive relation was found among hsCRP levels and ICAM-1, as well as MDA and ET-1.P-selectin and ICAM-1 were significantly positively correlated. This study indicates that increased level of oxidative stress marker, proinflammatory markers and their downstream effectors adhesion molecules occurs in type 2 DM.

scholarly journals Associations of serum uric acid level with diabetic retinopathy and albuminuria in patients with type 2 diabetes mellitus

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052096398
Author(s):  
Lin Hou ◽  
Yingzhou Shi ◽  
Sichao Wang ◽  
Qing Chen ◽  
Qiu Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Microvascular Complications ◽  
Multivariate Logistic Regression Analysis ◽  
Type 2 Dm

Objectives To analyze the associations of serum uric acid (SUA) level with diabetic microvascular complications, including diabetic retinopathy (DR) and diabetic nephropathy (DN), in patients with type 2 diabetes mellitus (DM). Methods Three hundred eighty-nine inpatients with type 2 DM were included in this retrospective analysis. Nonmydriatic fundus cameras were used to identify DR. Urinary albumin creatinine ratio was used to identify DN. Patients were divided into four groups according to SUA quartiles. Results The prevalences of DR and albuminuria increased with increasing SUA level. Multivariate logistic regression analysis showed that, following adjustment for other risk factors, higher levels of SUA (Q3 and Q4) were associated with greater risk for DR, compared with the lower level (Q1) (odds ratio [OR]: 3.056, 95% confidence interval [CI]: 1.506–6.198; OR: 3.417, 95% CI: 1.635–7.139, respectively). Moreover, higher levels of SUA (Q2, Q3, and Q4) were associated with greater risk for albuminuria (OR: 2.418, 95% CI: 1.059–5.522; OR: 7.233, 95% CI: 3.145–16.635; and OR: 8.911, 95% CI: 3.755–21.147, respectively). Conclusions SUA level was independently associated with DR and albuminuria in patients with type 2 DM. Elevated SUA level might be predictive for the occurrence of DR and DN.

scholarly journals The rs1014290 Polymorphism of the SLC2A9 Gene Is Associated with Type 2 Diabetes Mellitus in Han Chinese

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Wan-Chun Liu ◽  
Chi-Chih Hung ◽  
Szu-Chia Chen ◽  
Ming-Yen Lin ◽  
Ling-I Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Glucose Transporter ◽  
Serum Glucose ◽  
Han Chinese ◽  
Nucleotide Polymorphisms ◽  
Type 2 Dm

Aims. TheSLC2A9gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. The single nucleotide polymorphisms (SNPs) ofSLC2A9accounted for 5% variance of serum uric acid (UA). UA was identified as a risk factor for type 2 diabetes mellitus (DM). We investigated whether theSLC2A9gene variations are associated with type 2 DM in Han Chinese.Methods. Three common SNPs of theSLC2A9, rs1014290, rs2280205, and rs3733591, were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan.Results. The variant SNP rs1014290 is associated with decreased 0.12-fold risk of type 2 DM (P=.002). Per-copy increase in the minor C-allele results in 0.13 mmol/L (P=.037) and 10.03 μmol/L (P=.016) decrease in serum glucose and UA, respectively.Conclusions. The SNP rs1014290 within theSLC2A9gene is associated with type 2 DM in Han Chinese.

scholarly journals Correlation of glycosylated hemoglobin with urinary albuminuria for early detection and progression of nephropathy in patients with type 2 diabetes millitus

2021 ◽  
Vol 8 (4) ◽  
pp. 433-436
Author(s):  
Ravikumar Malladad ◽  
Rashmi G S Basavaraj
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Early Detection ◽  
Continuous Monitoring ◽  
Glycosylated Hemoglobin ◽  
Urinary Albumin ◽  
Healthy Controls

diabetic nephropathy is a one of the most leading disorder in patients with type 2 diabetes mellitus. Urinary albuminuria used for detection of nephropathy in type 2 diabetes mellitus but its not an a sensitive and specific biomarker for DN. Recent studies found some of the sensitive and specific biomarker for early detection and progression of nephropathy in type 2 diabetes mellitus patients. A total 150 subjects included in the present study in that 100 patients diagnosed with type 2 diabetes mellitus and 50 healthy controls. All the subjects included after informed consent and blood, urine samples were collected from the all the subjects. FBS, PPBS, Urea, Creatinine, Uric acid, HbA1C and Urinary Albumin was analysed by using laboratory standard methods. statistically elevated levels of plasma FBS, PPBS, HbA1C in both the groups of type 2 diabetes mellitus when compared to healthy controls. Serum Urea, Creatinine and Uric Acid levels elevated in type 2 diabetes mellitus with microalbuminuria when compared to other two groups of study subjects. The Glycosylated hemoglobin positively correlated with urinary microalbuminuria in patients with two groups of type 2 diabetes mellitus. This study suggest that the poor glycemic control leads to increased further complications in patients with type 2 diabetes mellitus. Continuous monitoring of HbA1C and Urinary Albumin Levels were useful for progression and treatment of patients with type 2 diabetes mellitus.

scholarly journals Correlation of Uric Acid with Oxidative Stress and Endothelial Dysfunction in Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Siva Prasad Palem
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Endothelial Dysfunction ◽  
P Value ◽  
Healthy Controls ◽  
Antioxidant Power

Objective: To evaluate the correlation of uric acid with oxidative stress and endothelial dysfunction in type 2 diabetic subjects.Material and Methods: The study included 120 subjects, among when 60 were type 2 diabetes subjects and the remaining 60 were age and gender matched healthy controls. The biochemical parameters, blood glucose, lipid profile, uric acid and homocysteine, were measured by standard kits in an autoanalyzer. Oxidative stress was evaluated by measuring malondialdehyde (MDA) and total antioxidant power by manual methods such as thio-barbituric acid reactive substances and ferric reducing ability of plasma (FRAP). Endothelial dysfunction was assessed by measuring nitric oxide (NO) by the kinetic cadmium method.Results: A significant elevation of triglycerides, low density lipoprotein (LDL), and MDA were observed in the type 2 diabetes mellitus patients while FRAP and NO were significantly reduced compared to the healthy controls. In addition, the uric acid levels had a highly significant correlation with FRAP (r=0.212, p-value=0.020), and moderately significant correlation with triglycerides (r=0.173, p-value=0.057) and homocysteine (r=0.178, p-value=0.051). Uric acid was negatively correlated with MDA and positively correlated with NO, but not statistically significant.Conclusion: Our findings suggest that uric acid may have antioxidant properties since it had a significant positive correlation with FRAP.

scholarly journals Correlation between Serum Magnesium Levels and HbA1C in Type 2 Diabetes Mellitus

2020 ◽  
Vol 1 (2) ◽  
pp. 136-144
Author(s):  
Madhavi Kondeti ◽  
Thejaswini Lalitha ◽  
Sathyam Durgam ◽  
Anuswaru M
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Serum Magnesium ◽  
Poor Glycemic Control ◽  
Good Glycemic Control ◽  
Mean Values ◽  
Group A

Background and Objective: Type 2 Diabetes Mellitus is a chronic disease resulting from acomplex inheritance, environmental interaction along with risk factors such as obesity andsedentary life style. Magnesium has been stated to have potential role in improving insulinsensitivity and preventing diabetes related complications. Hypomagnesaemia is proposed as oneof the factor in the pathogenesis of diabetic complications. The aim of our study is to estimatethe correlation between serum Magnesium levels and the level of Glycemic control (HbA1c) inpatients with Type 2 Diabetes Mellitus.Methods: This is an observational study conducted in SVRRGGH and SVMC, Tirupati, AndhraPradesh which included 94 patients with type 2 Diabetes mellitus of more than 5 years duration.These patients were divided into 2 groups based on level of Diabetic control. Group A included30 patients with HbA1c below 7.0mg/dL (good glycemic control) and Group B included 64patients with HbA1c above 7.0mg/dL (poor glycemic control). In both the groups SerumMagnesium levels were estimated.Results: Mean Serum Magnesium levels in Group A was 2.280±0.3955mg/dL while in Group Bit was 2.087±0.5834 mg/dL with a p-value 0.0379 (<0.05) which is statistically significant. Inour study though the mean values of serum Magnesium are within normal reference range, meanvalues of serum Magnesium levels in patients with poor glycemic control(HbA1c>7.0) arestatistically low as compared to patients with good glycemic control (HbA1c <7.0).Discussion: It has been reported that Serum Magnesium levels are lower in uncontrolleddiabetics when compared to controlled diabetics and also serum magnesium levels vary withtreatment for diabetes. In our study, although the mean values of serum magnesium in bothgroups are within Normal reference range (1.7-2.2mg/dL), they are statistically low in groupwith poor glycemic control (HbA1c >7.0mg/dL) when to group with good glycemic control(HbA1c< 7.0mg/dL).Thus this gives an insight into the association of hypomagnesaemia andlevel of diabetic control.Conclusion: This effective comparative study of deals with varying Magnesium levels inspecific diabetic therapies and analysed the effect of urinary magnesium detected inHypermagnesuria with Magnesium supplementation.

scholarly journals Uric Acid Levels in Type 2 Diabetes Mellitus Patients

2021 ◽  
Vol 3 (2) ◽  
pp. 83-89
Author(s):  
Linda Ramadhanti ◽  
Devi Etivia Purlinda
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Acid Value ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Exercise Activity

Type 2 diabetes mellitus accounts for about 90% of all diabetes cases worldwide. Type 2 DM is caused by the body's inability to respond well to insulin or called insulin resistance. Insulin resistance causes hyperglycemia and hyperinsulinemia which results in decreased uric acid excretion function in the kidney tubules, so that there will be an increase in uric acid in the blood or hyperuricemia. Type of research including descriptive with cross sectional approach. The examination was carried out at Dr. Adhyatma, MPH. The research respondents were 24 people, uric acid levels were examined with a TMS 50i Superior device. The data obtained is processed and presented in the form of diagrams and percentages. Type 2 DM respondents numbered 24 people. The highest hyperuricemia is based on the characteristics of the respondents, those are above 55 years old (25%), female sex (25%), high blood pressure (25%), and exercise activity 1x / day (21%). Of the 24 respondents, 14 people (58.3%) had normal uric acid levels and 10 people (41.6%) had hyperuricemia, with an average female uric acid value of 5.54 mg / dL and men of 6,48 mg / dL.

Sign in / Sign up

Export Citation Format

Share Document