scholarly journals The Role of Transferrin and Laminin Biomarkers in the Diagnosis of Diabetic Nephropathy in Type II Diabetic Patients

2021 ◽  
pp. 69-80
Author(s):  
Mohy Eldin Abd EL-Fattah ◽  
Laila Ahmed Rashed ◽  
Suzan Magdy Mohammed Nasr
Keyword(s):  
Diabetic Nephropathy ◽  
Significant Positive Correlation ◽  
Inverse Correlation ◽  
Healthy Control Subject ◽  
P Value ◽  
Diabetic Patients ◽  
Serum Transferrin ◽  
Type Ii ◽  
Significant Inverse Correlation ◽  
Healthy Control

Background/Aim: Diabetic nephropathy is one of the most important microvascular complications associated with type II diabetic patients. It occurs in 20-40% patients with diabetes mellitus, and microalbuminuria is still considered as the first sign of diabetic nephropathy. Low sensitivity and specificity of microalbuminuria leads to more sensitive biomarkers that may be used to detect diabetic nephropathy at an earlier stage with higher accuracy. This study was carried out to detect the validity of using serum Transferrin and Laminin as a diagnostic biomarkers for diabetic nephropathy in type ΙΙ diabetic patients. Methods: Egyptian patients (n=96) included 72 type 2 diabetic patients who were classified into three groups: group 1 - normoalbuminuric patients (uACR up to 30 mg/g), group 2 - microalbuminuric patients (uACR from 30 – 300 mg/g), group 3 - macroalbuminuric patients (uACR from >300 mg/g) and 24 healthy control were surveyed in a cross-sectional study over a period of 6 months at biochemistry department, KASR ALAINY Hospital of Cairo University. Patients were subjected to measurement of Albumin creatinine ratio, eGFR, Serum creatinine, glycosylated hemoglobin (HbA1c) and lipid profile. The serum concentrations of transferrin and lamnin were measured using a highly sensitive one-step sandwich enzyme immunoassay kit. Results: Serum laminin was significantly higher in macroalbuminuric patients than in the microalbuminuric and in microalbuminuric patients than in the normoalbuminuric and healthy control subject. By comparing these goups according to serum laminin concentration we found statistically significant positive correlation (p value <0.001, r= 0.670), serum transferrin was significantly lower in macroalbuminuric patients than in the microalbuminuric and in microalbuminuric patients than in the normoalbuminuric and healthy control subject. By comparing these goups according to serum transferrin concentration we found statistically significant inverse correlation (p value <0.001, r= -0.579). There was no correlation between level of serum transferrin /laminin and glycoregulation, and statistically significant positive correlation was found between serum laminin and duration of diabetes and statistically significant inverse correlation was found between serum transferrin and duration of diabetes. Conclusions: The results from this study provide the evidence that serum laminin and transferrin could be used as a diagnostic markers of diabetic nephropathy.

scholarly journals Secondary hyperparathyroidism in association with malnutrition - inflammation complex syndrome in chronic hemodialysis

2016 ◽  
Vol 11 (3) ◽  
Author(s):  
Hamid Nasri ◽  
Azar Baradaran
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Significant Positive Correlation ◽  
Serum Triglyceride ◽  
Inverse Correlation ◽  
Serum Phosphorus ◽  
Diabetic Patients ◽  
Significant Inverse Correlation ◽  
Positive Correlation ◽  
Serum Ipth ◽  
Serum Crp

To found the association of high PTH levels with some indexes of malnutrition-inflammation complex syndrome (MICS), a study was carried out a group of maintenance hemodialysis patients(MHPs) consisting of nondiabetic and diabetic patients. Intact serum PTH (iPTH) and serum C-reactive protein(CRP), serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), serum cholesterol (chol)and serum triglyceride (Tg) were measured .Body mass index (BMI) was also calculated . Total patients were 36(f=15 m=21), consisting of 25 non-diabetic HD patients and 11 diabetic HD patients. The mean patient`s age was 44(17) years. The value of serum iPTH of total HD patients was 434455 (median:309)pg/nd, the value of serum iPTH of diabetic and nondiabetic-dialysis patients were 201277(median:41) and 537483(median:340)pg/ml respectively. In this study we found a near significant positive correlation of serum iPTH with serum CRP, a significant inverse correlation of serum iPTH with BMI and a near significant positive correlation of serum ALP with Logarithm of CRP, a significant positive correlation of serum phosphorus with serum CRP and also a significant inverse correlation of serum phosphorus with BMI were found. A near significant inverse correlation of serum cholestrol with serum phosphorus as well as a near significant inverse correlation of serum cholestrol with serum CRP were existed too. When patients with iPTH below than 200 pg/ml were deleted, the correlation of iPTH with CRP was positive (r =0.42, p =0.085) and when patients with iPTH more than 500pg/ml were deleted, this correlation was found to be negative(r = -0.42, p =0.047), means that a low iPTH values is an index of malnutrition while higher values is associated with inflammation, Further attention needs to better control of hyperphosphatemia and maintaining the iPTH levels 1.5 times of normal to avoid the sides effects of secondary hyperparathyroidism.

scholarly journals Elabela levels in patients with type 2 diabetes: can it be a marker for diabetic nephropathy?

2020 ◽  
Vol 20 (2) ◽  
pp. 833-840
Author(s):  
Erhan Onalan ◽  
Yusuf Doğan ◽  
Ebru Onalan ◽  
Nevzat Gozel ◽  
Ilay Buran ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
High Serum ◽  
Control Group ◽  
Diabetic Patients ◽  
Healthy Individuals ◽  
Urine Albumin ◽  
Healthy Control ◽  
Group 2

Backround: Elabela (ELA) is a hormone that is secreted at high levels in the kidneys of a healthy adult. This study aims to investigate whether serum ELA levels of patients with Type 2 Diabetes vary with the severity of renal damage. Methods: Our study included 50 healthy control subjects and 100 diabetic patients, who were categorized into groups based on urine albumin/creatinine ratios (ACR). Patients included in the study were assigned to four groups: Group 1 (healthy control), Group 2 (ACR<29mg/g), Group 3 (ACR=30-299 mg/g), and Group 4 (ACR>300 mg/g normal or high serum creatinine). Physical examination findings, demographic characteristics of the study group were recorded, and serum ELA levels and other laboratory parameters were assessed using appropriate methods. Results: The results of the study indicated that ELA levels determined in healthy individuals gradually decreased through stages of normal albuminuria, microalbuminuria, and macroalbuminuria. Moreover, ELA had a significant negative corre- lation with LDL-C (r=-0.201, p=0.014), glucose (r=-0.437, P<0.001), retinopathy (r=-0.222, P=0.006), serum BUN (r=- 0.161, P=0.049), and a positive correlation with eGFR (r=0.250, P=0.002). Conclusions: The fact that ELA levels are higher in healthy individuals compared to diabetic patients without microalbu- minuria, and higher in diabetic patients without microalbuminuria compared to patients with advanced albuminuria and kidney damage, suggests that the ELA level can be an important clinical prognostic variable and even a promising agent for the treatment of diabetic nephropathy patients. Keywords: Elabela, diabetes, diabetic kidney disease, albuminuria.

Association Between Diabetic Nephropathy Grade and Quality of Life among Type II Diabetic Patients

2021 ◽  
Vol 23 (4) ◽  
pp. 268-294
Author(s):  
Amina Badawy Othman ◽  
Seham Abd Elalem ◽  
Dalia Elsherbini ◽  
Neima Riad
Keyword(s):  
Quality Of Life ◽  
Diabetic Nephropathy ◽  
Diabetic Patients ◽  
Type Ii

Corticosteroid receptors and lymphocyte subsets in mononuclear leukocytes in aging

1992 ◽  
Vol 262 (4) ◽  
pp. E464-E466 ◽  
Author(s):  
D. Armanini ◽  
I. Karbowiak ◽  
M. Scali ◽  
E. Orlandini ◽  
V. Zampollo ◽  
...  
Keyword(s):  
Lymphocyte Subsets ◽  
Inverse Correlation ◽  
Plasma Aldosterone ◽  
Mononuclear Leukocytes ◽  
Type I ◽  
Type Ii ◽  
Significant Inverse Correlation ◽  
Corticosteroid Receptors ◽  
The Mean ◽  
Aged Subjects

Plasma cortisol and aldosterone levels and number of related receptors in mononuclear leukocytes were measured in 49 healthy aged subjects (62-97 yr) and in 21 adult controls (21-50 yr). In all subjects, in addition, lymphocyte subsets were determined as an index of corticosteroid action. The mean number of type I and type II receptors was significantly lower in aged subjects than in controls (respectively, 198 +/- 96 and 272 +/- 97 receptors/cell for type I, and 1,794 +/- 803 and 3,339 +/- 918 for type II receptors). Plasma aldosterone and cortisol and lymphocyte subsets were not different in the two groups. All of the parameters were also tested for correlation, and a significant inverse correlation was found between age and type I and type II receptors when all subjects were plotted and between aged and CD4 and age and CD4/CD8 in the aged group. These data show that aged subjects have reductions of corticosteroid receptors that are not associated with increase of related steroids and that this situation probably represents a concomitant of the normal aging process.

scholarly journals Serum chromium, glycosylated hemoglobin level and body mass index among control and uncontrol sudanese patients with type II diabetes mellitus: Correlation study

2021 ◽  
Vol 16 (2) ◽  
pp. 196-203
Author(s):  
Nassr Eldin M. A. shrif ◽  
Ahmed Mohamed Ahmed Dawood ◽  
Abdelmahmoud Mokhtar Bashir ◽  
Hassan Mohammed Khair Ibrahim ◽  
Abd Elgadir A Altoum
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Glycosylated Hemoglobin ◽  
Type Ii Diabetes Mellitus ◽  
P Value ◽  
Diabetic Patients ◽  
Type Ii ◽  
Chromium Level ◽  
Serum Chromium ◽  
R Value

Background: Chromium is an essential micronutrient which is required for the normal functioning of insulin and regulation of blood sugar levels. It acts as a vital antioxidant for maintaining insulin homeostasis. In diabetes mellitus, the free radical production is increased and levels of antioxidants like chromium, vanadium, selenium and manganese are reduced. Aim: To study the level of serum chromium level in patients with type 2 diabetes mellitus and its association with glycemic control. Materials and Methods: One hundred and twenty individuals were enrolled in this study, classified into 60 type II diabetes mellitus (type II DM) patients and 60 apparently health as control group. Serum chromium and Glycosylated Hemoglobin (HbA1c) level were measured using atomic absorption spectrometry and Ichroma. Results: The results showed significant decrease in serum chromium level in type II DM patients (0.0151±0.005) when compared with healthy group (0.122±0.691) with p-value (0.002). In addition to that there was significant decrease in mean concentration of serum chromium level in controlled diabetic patients (0.0206± 0.003) when compared with uncontrolled diabetic patients (0.0120±0.002) with P-value (0.04).Also there was significant positive correlation between chromium level and Body Mass Index (BMI) (R-value 0.450, P-value 0.014), and significant negative correlation between chromium level and age (R-value- 0.660, P-value 0.011) , a significant strong negative correlation between chromium level and HbA1c (R-value -0.843, P-value 0.0260). Conclusion: The study concluded that, serum chromium level is significantly decrease in type II DM.

scholarly journals Relationship Between Family Support and Self Care Agency with the Quality of Living Type II Diabetes Patients

2019 ◽  
Vol 3 (1) ◽  
pp. 22-32
Author(s):  
Ferawati ◽  
Mei Fitria Kurniati
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Family Support ◽  
Type Ii Diabetes ◽  
Self Care ◽  
P Value ◽  
Diabetic Patients ◽  
Type Ii ◽  
Care Agency

Background: Diabetes Mellitus is a chronic disease characterized by high blood sugar level and is caused by an increase in glucose levels due to a progressive decrease in insulin secretion caused by insulin resistance. The ability of diabetic patients to do appropriate and succesful self-care habits is closely related to morbidity and mortality and significantly affect productivity and quality of life. Purpose: The purpose of this study is to determie the correlation between family support and self care agency with quality of life of diabetes mellitus patient type II.Method: This study uses analitycal methods, namely research that explores how and why health phenomena occur with a cross-sectional approach.Result: The results of the Spearman-Rho test that the P-value in te sig (2-tailed) column 0.123 is more than the level of significance α 0,05 ( 0,000 < 0,05 ) so it can be concluded that H0 is accepted and H1 is rejected.Conclusion: There is no relationship between self care agency and the quality of life of people with type II diabetes mellitus in prolanic patients

Sign in / Sign up

Export Citation Format

Share Document