Macroscopic & Microscopic Molecular-associated Treatments of Monosodium Glutamate-induced Uterine Fibroid via Aqueous Extract of Ginger Rhizomes: A Study on Adult Female Wistar Rats

Abstract Background Purslane is a widely distributed shrub used for the treatment of different ailments. The increasing reproductive complications associated with herbal treatments have led to the need to critically evaluate the safety and/or reproductive potentials of commonly used plant extracts. This study investigated the reproductive effect of methanolic extracts of Portulaca oleracea (MEPO) in adult female Wistar rats. Results Group C showed a significant decrease both in relative ovarian weight (p = 0.000), and relative uterine weight (p = 0.037), when compared with the control. There were no significant (p ˃ 0.05) changes in the levels of follicle-stimulating hormone, luteinizing hormone, progesterone, and estradiol. When compared to the control, groups B and C showed abnormal estrous cycle and cycle arrest especially at the metestrus phase with mild congestion of a few blood vessels in the ovary and uterus. Conclusions MEPO may possess some anti-fertility effect, as it disrupts the estrous cycle of adult female Wistar rats; although it has no major effect on the reproductive hormones, uterus, and ovarian histology of adult female Wistar rats. However, high dose consumption should be taken with precaution.

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Locomotor sensitization to cocaine in adolescent and adult female Wistar rats

Behavioural Brain Research ◽

10.1016/j.bbr.2018.04.035 ◽

2018 ◽

Vol 349 ◽

pp. 158-162 ◽

Cited By ~ 3

Author(s):

Sydney A. Rowson ◽

Stephanie L. Foster ◽

David Weinshenker ◽

Gretchen N. Neigh

Keyword(s):

Adult Female ◽

Wistar Rats ◽

Locomotor Sensitization ◽

Female Wistar Rats

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Cyantraniliprole impairs reproductive parameters by inducing oxidative stress in adult female wistar rats

Reproductive Toxicology ◽

10.1016/j.reprotox.2021.12.009 ◽

2021 ◽

Author(s):

Suellen Ribeiro da Silva Scarton ◽

Felipe Tsuzuki ◽

Marina Trevizan Guerra ◽

Dayane Priscila dos Santos ◽

Aldair Casagrande dos Santos ◽

...

Keyword(s):

Oxidative Stress ◽

Adult Female ◽

Wistar Rats ◽

Reproductive Parameters ◽

Female Wistar Rats

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The Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibits Cell Proliferation Induced by Estradiol on the Uterus and Vagina of Ovariectomized Female Wistar Rats

Advances in Pharmacological and Pharmaceutical Sciences ◽

10.1155/2020/8869281 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Marius Trésor Wego Kamgaing ◽

Marie Alfrede Mvondo ◽

Sylviane Laure Poualeu Kamani ◽

Stéphane Minko Essono ◽

Sylvie Lea Wansi Ngnokam

Keyword(s):

Cell Proliferation ◽

Aqueous Extract ◽

Wistar Rats ◽

Estradiol Valerate ◽

Control Groups ◽

Natural Substances ◽

Ovx Rats ◽

Female Wistar Rats ◽

Potential Alternative ◽

Dacryodes Edulis

Proliferation is a cellular process strongly linked to the genesis of cancer. Natural substances with antiproliferative activities are currently potential alternatives in the treatment of cancers. Dacryodes edulis, for instance, is a medicinal plant traditionally used in the treatment of cancer. Scientific studies have reported the antioxidant activity of this plant. In addition, the presence of prostate cancer chemopreventive polyphenols was reported in D. edulis extracts. Therefore, this study was aimed to evaluate the effects of the aqueous extract of D. edulis leaves on cell proliferation induced by estradiol in ovariectomized female Wistar rats. In this regard, ovariectomized (OVX) rats were cotreated with estradiol valerate (E2V) (0.75 mg/kg) and the aqueous extract of D. edulis leaves. Control groups received either the vehicle (sham-operated animals and the OVX control), E2V (0.75 mg/kg) only, or E2V (0.75 mg/kg) and tamoxifen (10 mg/kg). Treatments were administered orally for 3 consecutive days, and animals were sacrificed thereafter. Epithelial heights of the uterus and vagina were assessed. Uterine levels of total cholesterol and estradiol were determined as well. Results showed that the aqueous extract of D. edulis leaves reversed the effects of estradiol as it reduced uterine weight ( p < 0.05 ), uterine ( p < 0.05 ), and vaginal ( p < 0.001 ) epithelium heights. This antiproliferative effect of D. edulis was associated with reduced tissue (uterine) levels of estradiol ( p < 0.001 ). These results suggest that the aqueous extract of D. edulis leaves could be a potential alternative treatment for proliferation-related diseases.

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Effects of chia (Salvia hispanica L.) on oxidative stress and inflammation in ovariectomized adult female Wistar rats

Food & Function ◽

10.1039/c9fo00862d ◽

2019 ◽

Vol 10 (7) ◽

pp. 4036-4045 ◽

Cited By ~ 3

Author(s):

Bárbara Pereira da Silva ◽

Renata Celi Lopes Toledo ◽

Marcella Duarte Villas Mishima ◽

Maria Eliza de Castro Moreira ◽

Christiane Mileib Vasconcelos ◽

...

Keyword(s):

Oxidative Stress ◽

Adult Female ◽

High Fat Diet ◽

Wistar Rats ◽

Lipid Profiles ◽

Ovariectomized Rats ◽

High Fat ◽

Salvia Hispanica ◽

Female Wistar Rats ◽

Salvia Hispanica L

The study investigated the influence of chia consumption on inflammation, oxidative stress, and lipid profiles in female ovariectomized rats fed a high-fat diet.

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Mung bean sprout extract suppresses Monosodium Glutamate (MSG) effect on the reproductive hormones (FSH and Estrogen) in female Wistar rats

Majalah Obstetri & Ginekologi ◽

10.20473/mog.v1i12019.24-27 ◽

2019 ◽

Vol 27 (1) ◽

pp. 24 ◽

Cited By ~ 1

Author(s):

Widati Fatmaningrum ◽

Woro Setia Ningtyas

Keyword(s):

Rattus Norvegicus ◽

Mung Bean ◽

Wistar Rats ◽

Monosodium Glutamate ◽

Follicle Stimulating Hormone ◽

Control Group ◽

Bean Sprout ◽

Mung Bean Sprouts ◽

Female Wistar Rats ◽

Bean Sprouts

Objectives: The purpose of this study was to analyze the effects of mung bean sprout extracts on Follicle stimulating hormone (FSH) and estrogen hormone in female Wistar rats (Rattus norvegicus) exposed to monosodium glutamate (MSG).Materials and Methods: This true experimental study was conducted by using post-test only control group design in the laboratory for animal experimentation of Faculty of Veterinary Medicine - Airlangga University in which Wistar rats (Rattus norvegicus) aged 2 months weighing 150-200 grams were used in this experiment. The samples comprised of 5 rats distributed in each group, totaling 7 groups. I Control Group (P1) was provided with Aquades for 37 days; II (P2) was provided with Aquades for 7 days + MSG 0.03 mg/g of weight on day 8-37; III (P3) was provided with extract of mung bean sprouts 72mg/200g of weight on day 1-37 + MSG 0,03mg/g of weight; IV (P4) was provided with extract of mung bean sprouts 144mg/200g of weight on day 1-37 + MSG 0.03mg/g of weight; V (P5) was provided with Aquades for 7 days + MSG 0.7 mg/g of weight on day 8-37; VI (P6) was provided with extract of mung bean sprouts 72mg/200g of weight on day 1-37 + MSG 0.7mg/g of weight; VII (P7) was provided with extract of mung bean sprouts 144mg/200g of weight on day 1-37 + MSG 0.7mg/g of weight.Serum samples were taken for Follicle Stimulating Hormone (FSH) and Estrogen with ELISA method. Data analysis to test the differences between groups was done by using one way Anova statistical test.Results: MSG dosage 0,03mg/gBB or 0,7mg/g BB was significant difference in FSH (p = 0,011) and estrogen (p = 0,008).Conclusion: obtained from this research that giving green bean sprout extract influence to the level of FSH and estrogen hormone.

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