scholarly journals Menstrual Irregularities Frequency in Reproductive Age Women with Chronic Parenteral Viral Hepatitis and Insufficiency of Antioxidant Factors

2020 ◽  
pp. 60-66
Author(s):  
M. A. Rashidova ◽  
L. F. Sholokhov ◽  
M. A. Darenskaya ◽  
S. I. Kolesnikov ◽  
L. I. Kolesnikova
Keyword(s):  
Viral Hepatitis ◽  
Family Health ◽  
Antioxidant Defense System ◽  
Chronic Viral Hepatitis ◽  
Alpha Tocopherol ◽  
Reproductive Age ◽  
Human Reproduction ◽  
Research Centre ◽  
Menstrual Disorders ◽  
Reproductive Age Women

Background: Our previous study of the lipid peroxidation and antioxidant defense system (LPO-AOS) state in women with chronic viral hepatitis (CVH) showed the content of fat-soluble vitamin alpha tocopherol significant reduction. Reproductive health of women with CVH needs special attention. The objectives of this study was to determine the frequency of menstrual disorders in the group of women with CVH with marked alpha tocopherol insufficiency. Study Design:  A case-control study. Place and Duration of Study: A study was conducted at Scientific Centre for Family Health and Human Reproduction Problems and in the hepatological department of the Irkutsk clinical hospital of infectious diseases from 2010 to 2014. This work was performed with the use of equipment of Collective research centre “Center for the development of progressive personalized technologies for health” SC FHHRP, Irkutsk. Methods and Results: Our study included 44 reproductive age women with CVH and comparable age 28 healthy women. All women underwent clinical examination and questionary survey. We found alpha tocopherol insufficiency in 95.5% cases of patients with CVH and menstrual disorders. Conclusion: Our results suggest that menstrual disorders in patients with CVH may be associated with alpha tocopherol insufficiency.

Predictors of Discontinuation of Modern Spacing Contraceptives in India

2020 ◽  
pp. 101053952098314
Author(s):  
Shahina Begum ◽  
Himanshu Chaurasia ◽  
Kusum V. Moray ◽  
Beena Joshi
Keyword(s):  
Contraceptive Use ◽  
Oral Contraceptive Pill ◽  
Family Health ◽  
Reproductive Age ◽  
Health Priorities ◽  
Unintended Pregnancies ◽  
Reproductive Age Women ◽  
One Year ◽  
Women In India

Data from National Family Health Survey (2015-2016) was analyzed to examine the contraceptive acceptance, discontinuation rates, and associated factors among reproductive age women in India over one year. Findings revealed that 11.7% accepted modern methods of which 68% were for spacing. Only 5% switched to other methods. Discontinuation rate was high among condom (56.8%) and oral contraceptive pill users (34.5%), among women aged less than 25 years, with parity less than 2, belonging to rural area, and having no education. Health concerns/side effects, husband’s disapproval, or method failure were most common reasons cited for discontinuation. The data show high discontinuation rates among some subgroups of women and for certain methods. Hence, women need to be provided options to switch methods to meet changing contraceptive needs and health priorities. Continuum of care with follow-up and counselling can facilitate sustained contraceptive use to avert unintended pregnancies.

scholarly journals Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis

2019 ◽  
Vol 4 (1) ◽  
pp. 31-35
Author(s):  
Maria A. Rashidova ◽  
Leonid F. Sholokhov ◽  
Marina A. Darenskaya ◽  
Lyubov I. Kolesnikova
Keyword(s):  
Lipid Peroxidation ◽  
Viral Hepatitis ◽  
Functional State ◽  
Chronic Viral Hepatitis ◽  
Protection System ◽  
Reproductive Age ◽  
Control Group ◽  
Antioxidant Protection ◽  
Chronic Form ◽  
Antioxidant Protection System

Background.Chronic viral hepatitis is a complex global problem and is still far from being solved. Many researchers point out influence of viral hepatitis on the reproductive system of women.Aim.To identify features of the functional state of pituitary-thyroid units of neuroendocrinal regulation, and to evaluate lipid peroxidation – antioxidant protection with determination of the oxidative stress coefficient in perimenopausal women with chronic form of hepatitis.Materials and methods. Study included 44 women with chronic viral hepatitis and 28 healthy women of the same age. Immunoabsorbent, spectrophotometric, fluorometric and statistical methods were used.Results.In patients with chronic viral hepatitis, we detected an increase in thyroxine levels – by 29.6% (р < 0.001) and free triiodothyronine values – by 65.7% (р = 0.008) in comparison with the control group. In the group with chronic viral hepatitis, the TBA-reactive products level increased by 1.9 times (р = 0.006), and superoxide dismutase activity decreased by 1.3 times (р < 0.001), total antioxidant activity – by 1.7 times (р < 0.001) and α-tocopherol level – by 1.3 times (р = 0.005) in comparison with the control group.Conclusions. The obtained data demonstrate the features of the pituitary-thyroid system functioning and the lipid peroxidation – antioxidant protection system in patients with chronic hepatitis. The chronic form of hepatitis is characterized by metabolic disorders that require a more careful approach in diagnosis and management.

scholarly journals Lipid Peroxidation State in Women of Reproductive Age with Acute Form of Viral Hepatitis

2016 ◽  
Vol 71 (1) ◽  
pp. 11-15
Author(s):  
L. I. Kolesnikova ◽  
M. A. Darenskaya ◽  
M. A. Rashidova ◽  
L. F. Sholokhov ◽  
L. A. Grebenkina ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Density Lipoprotein ◽  
Antioxidant Defense System ◽  
Cholesterol Content ◽  
Reproductive Age ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Acute Form

Objective: The objective of this study was to identify features of the lipid status and lipid peroxidation-antioxidant defense system in women of reproductive age with acute form of hepatitis. Methods: The study involved 36 women with acute viral hepatitis and 28 healthy women of the same age. Spectrophotometric and fluorometric methods were used. Results: In patients with acute viral hepatitis we detected an increase in triglycerides levels ― by 21% and very low density lipoprotein values — by 17% in relative to control group, high-density lipoprotein cholesterol content reduced by 38%. In group with acute viral hepatitis the TBA-reactive products level increased by 2.21 times and superoxide dismutase activity decreased by 1.43 times in comparison with control group. Conclusion: The acute form of hepatitis is characterized by series of metabolic disorders that require a more careful approach in therapeutic and diagnostic administration. 

Substitution therapy with levothyroxine in balancing of hormonal interactions at subclinical hypothyroidism in reproductive-age women

2018 ◽  
pp. 46-48
Author(s):  
B.M. Ventskovskii ◽  
◽  
L.M. Varchenko ◽  
Keyword(s):  
Reproductive System ◽  
Subclinical Hypothyroidism ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Menstrual Disorders ◽  
Substitution Therapy ◽  
Hormonal Profile ◽  
Reproductive Age Women ◽  
Selective Dopamine ◽  
Hormonal Interactions

6 months levothyroxine appointment in 80 reproductive-age women with subtypical hypothyroidism contributed to the normalization of hormonal interactions in the pituitary-ovarian axis with the elimination of reproductive system disorders in 58.8% cases. Hormonal disorders with hyperprolactinemia persisted in 41.2% of women, so they continued substitution therapy with the inclusion of selective dopamine receptor blocker of cabergoline. After 9, and even more after 12 months of this treatment, both the normalization of the hormonal profile and the elimination of clinical manifestations of disorders in the reproductive system were achieved. Key words: hyperprolactinemia, cabergoline, menstrual disorders, reproductive system, hormones.

scholarly journals An update on endometriosis associated subfertility: what does the most recent evidence say?

2018 ◽  
Vol 7 (12) ◽  
pp. 5226
Author(s):  
Karim Abdallah
Keyword(s):  
Best Practice ◽  
Clinical Excellence ◽  
Reproductive Age ◽  
Human Reproduction ◽  
Surgical Approaches ◽  
Reproductive Age Women ◽  
Obstetrics And Gynaecology ◽  
Spontaneous Pregnancy ◽  
Cochrane Reviews ◽  
American Society

Endometriosis is a chronic debilitating disease that affects 10% of women in the reproductive age. Women with endometriosis present with pain, subfertility or both. The prevalence of endometriosis in women with subfertility is estimated to be within the range of 40%-50%. This is a review of the evidence published in the literature. The review was conducted via searching the databases of the Cochrane reviews, European Society of Human Reproduction and Embryology (ESHRE), American Society of Obstetrics and Gynaecology (ACOG), National Institute for Clinical Excellence (NICE) and British Medical Journal (BMJ) best practice articles. Management of women with endometriosis and subfertility has been extensively assessed in the literature. Medical management, surgical approaches and a combination of both improve the spontaneous pregnancy rates for this cohort of patients.

scholarly journals Evaluation of lipid peroxidation processes in patients with chronic parenteral viral hepatitis and HIV co-infection depending on degree of inflammatory process activity in the liver

2018 ◽  
Vol 90 (11) ◽  
pp. 37-43 ◽  
Author(s):  
L I Kolesnikova ◽  
M A Darenskaya ◽  
S I Kolesnikov ◽  
L A Grebenkina ◽  
M A Rashidova ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Hiv Infection ◽  
Viral Hepatitis ◽  
Inflammatory Process ◽  
Chronic Viral Hepatitis ◽  
Reproductive Age ◽  
Inflammatory Activity ◽  
Control Group ◽  
Diene Conjugates ◽  
Peroxidation Processes

The aim of the study. To evaluate of parameters of lipid peroxidation - antioxidant defense changes in women of fertile age with chronic viral hepatitis (CVH) and with HIV (human immunodeficiency virus) infection, depending on the degree of inflammatory process activity in the liver. Materials and methods. 99 women of reproductive age were examined, of them 44 patients with chronic parenteral viral hepatitis, 27 patients with HIV co-infection (HIV + hepatitis B and/or C) and 28 practically healthy women (control group). Results. Patients with CVH in combination with HIV-infection with the presence of minimal and low degree of inflammatory activity in comparison with patients with CVH-monoinfection had a higher content of lipid peroxidation products (an increase in the content of diene conjugates and ketodienes and conjugated trienes), reduced values of total antioxidant activity, superoxide dismutase activity, as well as the concentration of fat-soluble vitamins α-tocopherol and retinol. In the group with CVH and HIV with moderate and high degree of activity, similar, but even more pronounced changes in the system of lipid peroxidation were observed. Conclusion. The presence of co-infection - CVH in combination with HIV infection with minimal and low, as well as moderate and high inflammatory activity, is characterized by more intensive lipid peroxidation processes and a pronounced lack of antioxidant factors than with CVH-monoinfection.

Management of Chronic Viral Hepatitis

2002 ◽  
Vol 123 (6) ◽  
pp. 2154-2155
Author(s):  
Satheesh Nair
Keyword(s):  
Viral Hepatitis ◽  
Chronic Viral Hepatitis
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