Substitution therapy with levothyroxine in balancing of hormonal interactions at subclinical hypothyroidism in reproductive-age women

2018 ◽  
pp. 46-48
Author(s):  
B.M. Ventskovskii ◽  
◽  
L.M. Varchenko ◽  
Keyword(s):  
Reproductive System ◽  
Subclinical Hypothyroidism ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Menstrual Disorders ◽  
Substitution Therapy ◽  
Hormonal Profile ◽  
Reproductive Age Women ◽  
Selective Dopamine ◽  
Hormonal Interactions

6 months levothyroxine appointment in 80 reproductive-age women with subtypical hypothyroidism contributed to the normalization of hormonal interactions in the pituitary-ovarian axis with the elimination of reproductive system disorders in 58.8% cases. Hormonal disorders with hyperprolactinemia persisted in 41.2% of women, so they continued substitution therapy with the inclusion of selective dopamine receptor blocker of cabergoline. After 9, and even more after 12 months of this treatment, both the normalization of the hormonal profile and the elimination of clinical manifestations of disorders in the reproductive system were achieved. Key words: hyperprolactinemia, cabergoline, menstrual disorders, reproductive system, hormones.

THE NATURE OF REPRODUCTIVE DISORDERS IN WOMEN WITH HYPERANDROGENISM SYNDROMEq

2021 ◽  
Vol 2 (4) ◽  
pp. 13-16
Author(s):  
M. M Asatova ◽  
◽  
S. M. Safoeva
Keyword(s):  
Laboratory Data ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Reproductive Disorders ◽  
Menstrual Disorders ◽  
Women Of Reproductive Age ◽  
Perinatal Center ◽  
Androgen Secretion ◽  
The City ◽  
Anovulatory Infertility

PCOS occupies a leading place in the population of women with clinical manifestations of excessive androgen secretion and is detected in 72.1-82% of cases, while among women with anovulatory infertility-in 55-91% of cases (Lizneva D. (2016). The criteria, prevalence and phenotypes of PCOS. Fertil.Steril., 106 (1), 6-15). The article discusses the results of a study conducted based on the City Perinatal Center of Tashkent to study the frequency and nature of reproductive disorders in women with symptoms of hyperandrogenism. The study involved women of reproductive age with various menstrual disorders and infertility. The analysis of anamnestic, subjective and objective, clinical and laboratory data of patients was carried out

scholarly journals Menstrual Irregularities Frequency in Reproductive Age Women with Chronic Parenteral Viral Hepatitis and Insufficiency of Antioxidant Factors

2020 ◽  
pp. 60-66
Author(s):  
M. A. Rashidova ◽  
L. F. Sholokhov ◽  
M. A. Darenskaya ◽  
S. I. Kolesnikov ◽  
L. I. Kolesnikova
Keyword(s):  
Viral Hepatitis ◽  
Family Health ◽  
Antioxidant Defense System ◽  
Chronic Viral Hepatitis ◽  
Alpha Tocopherol ◽  
Reproductive Age ◽  
Human Reproduction ◽  
Research Centre ◽  
Menstrual Disorders ◽  
Reproductive Age Women

Background: Our previous study of the lipid peroxidation and antioxidant defense system (LPO-AOS) state in women with chronic viral hepatitis (CVH) showed the content of fat-soluble vitamin alpha tocopherol significant reduction. Reproductive health of women with CVH needs special attention. The objectives of this study was to determine the frequency of menstrual disorders in the group of women with CVH with marked alpha tocopherol insufficiency. Study Design:  A case-control study. Place and Duration of Study: A study was conducted at Scientific Centre for Family Health and Human Reproduction Problems and in the hepatological department of the Irkutsk clinical hospital of infectious diseases from 2010 to 2014. This work was performed with the use of equipment of Collective research centre “Center for the development of progressive personalized technologies for health” SC FHHRP, Irkutsk. Methods and Results: Our study included 44 reproductive age women with CVH and comparable age 28 healthy women. All women underwent clinical examination and questionary survey. We found alpha tocopherol insufficiency in 95.5% cases of patients with CVH and menstrual disorders. Conclusion: Our results suggest that menstrual disorders in patients with CVH may be associated with alpha tocopherol insufficiency.

scholarly journals Features of the hormonal profile in obese reproductive-age women

2020 ◽  
Vol 5 (3) ◽  
pp. 77-84
Author(s):  
N. V. Artymuk ◽  
O. A. Tachkova ◽  
N. A. Sukhova
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Dehydroepiandrosterone Sulfate ◽  
Reproductive Age ◽  
Obese Women ◽  
Women Of Reproductive Age ◽  
Hormonal Profile ◽  
Reproductive Age Women

Aim. To assess the hormonal profile features in obese reproductive-age women. Materials and Methods. We consecutively enrolled 163 women of reproductive age (140 women with body mass index ≥ 30 kg/m2 and 23 women with normal body mass index) who have been admitted to Podgorbunskiy Regional Emergency Medicine Hospital. All patients of both groups underwent general and gynecological examination. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, estrone, testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone, free triiodothyronine, total and free thyroxine, cortisol, leptin, immunoreactive insulin, and progesterone were assessed on days 5-6 and 21-22 of the menstrual cycle. Results. Obese women of reproductive age were characterised by higher values of LH, LH/ FSH ratio, testosterone, estradiol, estrone, leptin, IRI and by lower levels of FSH and progesterone compared with normal weight women. A direct correlation was found between the level of leptin and estrone (r = 0.21, p = 0.014), insulin resistance (r = 0.18, p = 0.039), triglycerides (r = 0.20, p = 0.030), and low-density lipoprotein cholesterol (r = 0.22, p = 0.016). There was a statistically significant inverse correlation between the level of leptin and high-density lipoprotein cholesterol (r = -0.18, p = 0.043). A direct correlation was established between insulin and LH (r = 0.24, p = 0.030), testosterone (r = 0.32, p = 0.037), dehydroepiandrosterone sulfate (r = 0.56, p = 0.003), insulin resistance (r = 0.95, p < 0.001), cholesterol (r = 0.20, p = 0.024), triglycerides (r = 0.29, p < 0.001). Conclusion. Obese women of reproductive age have certain hormonal features that underlie menstrual and reproductive disorders in these patients.

scholarly journals Peculiarities of a girl`s sexual development in pubertal age with primary dysmenorrhea of different somatotypes

2018 ◽  
Vol 22 (1) ◽  
pp. 33-38
Author(s):  
B.A. Markevich ◽  
G.V. Chayka
Keyword(s):  
Sexual Development ◽  
Reproductive System ◽  
Clinical Manifestations ◽  
Statistical Processing ◽  
Direct Consequence ◽  
Reproductive Age ◽  
Reproductive Capacity ◽  
Control Group ◽  
Primary Dysmenorrhea ◽  
Medical University

Most of the problems of the female reproductive system in fertile age are a direct consequence of those pathologies that have arisen in puberty age, in the period of the establishment of its functions. Therefore, the formation of the normal physical and sexual development of adolescent girls depends on the formation of reproductive capacity, the improvement of the demographic situation and the health of future generations. The aim of the study — detection of the relationship between the features of sexual development in healthy and girls with primary dysmenorrhea of puberty age. The results of researches of 306 girls of puberty age of different somatotypes are analyzed, defined by the Hit-Carter method. Statistical processing of the results obtained was carried out in a licensed package “Statistica 6.1”. The study group included 76 girls with primary dysmenorrhea, and the control group consisted of 230 healthy girls (data were taken from the database of the SRC National Pirogov Memorial Medical University, Vinnytsya). We investigated the peculiarities of the development of the reproductive system of girls of pubertal age with primary dysmenorrhea of different somatotypes. The results of our research show that there is a connection between the age-depending dynamics of sexual development: the thelarche, axillary hair growth, the formation of menstrual function in girls of pubertal age who suffer from primary dysmenorrhea in comparison with healthy girls. The results of our study should be taken for the diagnosing of primary dysmenorrhea of girls of pubertal age in order to reduce clinical manifestations and further development of complications in reproductive age.

Clinical manifestations of reproductive health and life quality in fertile age women with subclinical hypothyroidism in conditions of comorbidity

2017 ◽  
pp. 54-56
Author(s):  
L.M. Varchenko ◽  
Keyword(s):  
Quality Of Life ◽  
Reproductive Health ◽  
Subclinical Hypothyroidism ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Sf 36 ◽  
Menstrual Irregularities ◽  
High Comorbidity

The objective: to evaluate the clinical manifestations of reproductive health and quality of life (QOL) disorders in women of reproductive age with high comorbidity against subclinical hypothyroidism (SHT) and manifest hypothyroidism (MHT). Materials and methods. 113 cases of SHT (1st group) and 65 cases of MHT (2 nd group) in women of reproductive age were analyzed. The diagnosis of hypothyroidism is established on the basis of data of anamnesis, physical examination, ultrasound of the thyroid gland and determination of thyroid-stimulating hormone levels and free thyroxine in the blood by electroluminescence. Results. Assessment of QoL using the MOS SF-36 questionnaire was performed in women of reproductive age with SHT, with a high (61.9%) level of menstrual irregularities, gynecological (74.3%) and extragenital (82.3%) diseases, which indicates High comorbidity. It was revealed mainly the average values of QoL on almost all scales, except for emotional functioning. In women with MHT, with extremely high comorbidity (in 100% of cases), the QL values were reduced and only on the scale of "pain" - within the average. The conclusion. The data obtained make it possible to recommend the definition of quality of life indicators in women of reproductive age with subclinical hypothyroidism in the practice of a gynecologist as an integral characteristic of health. Key words: subclinical hypothyroidism, menstrual irregularities, comorbid conditions, quality of life, MOS SF-36 questionnaire, integral health indicators.

scholarly journals Зміни деяких показників імунітету в самок білих щурів за умов експериментального токсичного гепатиту та їх вплив на репродуктивну функцію

2015 ◽  
Author(s):  
Л. Є. Лимар
Keyword(s):  
Immune System ◽  
Reproductive System ◽  
Toxic Hepatitis ◽  
Clinical Manifestations ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Albino Rats ◽  
White Rats ◽  
Chronic Toxic Hepatitis ◽  
Experimental Toxic Hepatitis

ЗМІНИ ДЕЯКИХ ПОКАЗНИКІВ ІМУНІТЕТУ В САМОК БІЛИХ ЩУРІВ ЗА УМОВ ЕКСПЕРИМЕНТАЛЬНОГО ТОКСИЧНОГО ГЕПАТИТУ ТАЇХ ВПЛИВ НА РЕПРОДУКТИВНУ ФУНКЦІЮ - Проблема порушень функції репродуктивної системи у жінок залишається актуальною впродовждесятиліть. Значну роль в цьому відіграють не лише генетично детерміновані особливості організму, але й наявність супутньої екстрагенітальної патології. Зростання захворюваності жінок призводить не лише до порушення їх працездатності, але й до зниження репродуктивної функції. У жінок репродуктивного віку часто спостерігається поєднання порушень функції репродуктивної системи з хронічними гепатитами різного генезу. Саме ці обставини спонукали нас до проведення експериментальної роботи з метою детального вивчення і аналізу вказаної проблеми. Ми змоделювали хронічний токсичний гепатит у самок білих щурів репродуктивного віку. Вивчали результати клінічних, гістологічних досліджень, показники імунного статусу в піддослідних тварин, а також їх репродуктивну функцію за умов експериментального токсичного гепатиту. Обстежено 65 самок білих щурів репродуктивного віку, яким змоде- льовано хронічний токсичний гепатит (ХТГ). Вивчено клінічні прояви захворювання, стан імунної системи та репродуктивну функцію цих тварин.<br />ИЗМЕНЕНИЯ НЕКОТОРЫХ ПОКАЗАТЕЛЕЙ ИММУНИТЕТА В САМОК БЕЛЫХ КРЫС В УСЛОВИЯХ ЭКСПЕРИМЕНТАЛЬНОГО ТОКСИЧЕСКОГО ГЕПАТИТА И ИХ ВЛИЯНИЕ НА РЕПРОДУКТИВНУЮ ФУНКЦИЮ - Проблема нарушений функции репродуктивной системы у женщин остается актуальной на протяжении десятилетий. Значительную роль в этом играют не только генетически детерминированные особенности организма, но и наличие сопутствующей экстрагенитальной патологии. Рост заболеваемости женщин приводит не только к нарушению их работоспособности, но и к снижению репродуктивной функции. У женщин репродуктивного возраста часто наблюдается сочетание нарушений функции репродуктивной системы схроническими гепатитами различной этиологии. Именно эти обстоятельства побудили нас к проведению экспериментальной работы с целью детального изучения и анализа указанной проблемы. Мы смоделировали хронический токсический гепатит у самок белых крыс репродуктивного возраста. Изучали результаты клинических, гистологических исследований, показатели иммунного статуса у подопытных животных, а также их репродуктивную функцию в условиях экспериментального токсического гепатита. Обследовано 65 самок белых крыс репродуктивного возраста, которым смоделирован хронический токсический гепатит (ХТГ). Изучены клинические проявления заболевания, состояние иммунной системы и репродуктивная функция этих животных.<br />CHANGES OF SOME PARAMETERS OF IMMUNITY IN FEMALE OF WHITE RATS IN CONDITIONS OF EXPERIMENTAL TOXIC HEPATITIS AND THEIR INFLUENCE ON REPRODUCTIVE FUNCTION - The problem of violation of the functions of the reproductive system in women remains relevant over the decades. Significant role in this play not only genetically determined characteristics of the organism, but also the presence of concomitant extragenital pathology. The increase in the incidence of women not only leads to violation of their health, but also a decrease in reproductive function. In women of reproductive age, there is often a combination of dysfunctions of the reproductive system with chronic hepatitis of different etiology. These circumstances prompted us to conduct experimental work with the purpose of detailed study and analysis of this problem. We<br />simulated chronic toxic hepatitis in female albino rats of reproductive age. We studied the clinical, histological studies, indicators of immune status in experimental animals and their reproductive function in conditions of experimental toxic hepatitis. 65 female albino rats of reproductive age, which simulated chronic toxic hepatitis (HTG) were surveyed. The clinical manifestations of the disease, the immune system and reproductive function of these animals were investigated.<br />Ключові слова: імунна система, хронічний токсичний гепатит, репродуктивна функція.<br />Ключевые слова: иммунная система, хронический токсический гепатит, репродуктивная функция.<br />Key words: immune system, chronic toxic hepatitis, reproductive function.

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